Abstract: An ablation apparatus for creating a lesion in target tissue, the ablation apparatus having an ablation shaft including a handle, a first portion, an ablation portion, distal tip, at least one ablation energy delivery lumen, at least one ablation energy return lumen, and a stylet lumen that extends substantially along a length of the ablation shaft from the handle to at least the ablation portion. The ablation apparatus also includes a stylet that is capable of being inserted into the stylet lumen where the stylet is made of a shape-memory material.

Abstract: A system for accessing a switch for a ladder of a work machine includes a cover movable between a closed position and an open position. In the closed position of the cover, the cover encloses the switch. The cover includes a lip portion. The system also includes a retention assembly. The retention assembly includes a spring member. The retention assembly also includes a lever coupled to the spring member. The lever includes a retention portion. The lever is movable between a first position and a second position. In the first position of the lever, the lever engages with the lip portion of the cover. In the second position of the lever, the lever disengages from the lip portion of the cover.

Abstract: A system, method, and computer-readable medium are disclosed for performing a pre-boot configuration operation. The pre-boot configuration operation includes performing a pre-boot system configuration operation using an ancillary integrated processor system, the pre-boot system configuration operation configuration certain parameters prior to initiation of a primary system boot operation; and, configuring an information handling system to automatically operate in a particular system configuration mode after performance of the pre-boot system configuration operation.

Abstract: Disclosed is an input buffer with hysteresis-integrated voltage protection devices for avoiding violations of maximum gate-to-source voltage limitations when the maximum input voltage is greater than the maximum gate-to-source voltage limitation. The input buffer includes a chain of transistors including two P-channel FETs (PFETs) and two N-channel FETs (NFETs). The data input to the input buffer controls the gates of the transistors in the chain so the data output from the input buffer at the junction between the PFETs and NFETs is inverted. The input buffer also includes a hysteresis feedback loop to prevent noise-induced switching of the output. The hysteresis feedback loop also includes voltage protection devices integrated therein to avoid maximum gate-to-source violations when the loop results in a hysteresis voltage being fed back into the chain at the source region of a transistor in the chain. Also disclosed is a receiver incorporating the input buffer.

Abstract: The present disclosure relates to an RF amplifier device including an IC chip including at least one transistor formed on a substrate, at least one operational circuit formed on the substrate and electrically coupled to the transistor, and a port configured to electrically couple the at least one operational circuit with operational circuitry outside the IC chip to adjust operation of the operational circuitry.

Abstract: Certain embodiments are directed to the use of d9-methadone as an alternative formulation for methadone, the d9-methadone having an improved absorption-distribution-metabolism-excretion profile, analgetic efficacy, and safety for the management of pain following injury such as trauma, disease, and surgery.

Abstract: A multimodality or hybrid ablation system includes an ablation apparatus for creating a lesion in target tissue. The ablation apparatus has an ablation shaft including a handle, a first portion, an ablation portion, distal tip, at least one ablation energy delivery lumen, at least one ablation energy return lumen, and a stylet lumen that extends substantially along a length of the ablation shaft from the handle to at least the ablation portion. The ablation apparatus also includes a stylet that is capable of being inserted into the stylet lumen where the stylet is made of a shape-memory material. A plurality of electrodes are arranged on the ablation portion for measuring or verifying tissue contact with the tissue and applying a pulsed electric field. Optionally, the pulsed electric field may be applied after or in parallel with freezing the target tissue.

Abstract: This invention relates generally to the synthesis of ?12-Prostaglandin J product using stereoretentive ruthenium olefin metathesis catalysts supported by dithiolate ligands. ?12-Prostaglandin J products were generated with excellent selectivity (>99% Z) and in moderate to high/good yields (47% to 80% yield; 58% to 80% yield).

Abstract: An information handling system includes a memory to store data associated with metrics of an individual and gaming performance metrics, and a processor. The processor correlates the metrics of an individual with the gaming performance metrics. Based on the correlation, the processor creates a gaming performance score. The processor determines changes to implement based on the gaming performance score. When the changes are implemented, the changes improve the gaming performance score. The processor provides the changes to the individual in a non-intrusive manner.

Abstract: A highly efficient, Z-selective ring-closing metathesis system for the formation of macrocycles using a stereoretentive, ruthenium-based catalyst supported by a dithiolate ligand is reported. This catalyst is demonstrated to be remarkably active as observed in initiation experiments showing complete catalyst initiation at ?20° C. within 10 min. Using easily accessible diene starting materials bearing a Z-olefin moiety, macrocyclization reactions generated products with significantly higher Z-selectivity in appreciably shorter reaction times, in higher yield, and with much lower catalyst loadings than in previously reported systems. Macrocyclic lactones ranging in size from twelve-membered to seventeen-membered rings are synthesized in moderate to high yields (68-79% yield) with excellent Z-selectivity (95%-99% Z).

Abstract: The present invention relates to a compounds according to general formula (I), which acts as an inverse agonist of PqsR (the currently only known receptor for the Pseudomonas Quinolone Signal (PQS), sometimes also referred to as MvfR); to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to uses of said compound(s), including the use as a medicament, e.g. the use in the treatment or prophylaxis of a bacterial infection, especially a Pseudomonasaeruginosa or Burkholderia infection.

Abstract: A main housing portion of a portable information handing system. The main housing portion includes: a bottom cover portion; and, a top cover portion coupled to the bottom cover portion, the top cover portion comprising a full palm rest trackpad, the full palm rest trackpad comprising a touch printed circuit board; a sensor film portion electrically coupled to the touch printed circuit board; and, a plurality of piezo components extending across a width of the full palm rest trackpad, the plurality of piezo components being electrically coupled to the touch printed circuit board, the plurality of piezo components, each of the plurality of piezo components performing a haptic function.

Abstract: An ablation apparatus for creating a lesion in target tissue, the ablation apparatus having an ablation shaft including a handle, a first portion, an ablation portion, distal tip, at least one ablation energy delivery lumen, at least one ablation energy return lumen, and a stylet lumen that extends substantially along a length of the ablation shaft from the handle to at least the ablation portion. The ablation apparatus also includes a stylet that is capable of being inserted into the stylet lumen where the stylet is made of a shape-memory material.

Abstract: A main housing portion of a portable information handing system. The main housing portion includes: a bottom cover portion; and, a top cover portion coupled to the bottom cover portion, the top cover portion comprising a full palm rest trackpad, the full palm rest trackpad comprising a touch printed circuit board; a sensor film portion electrically coupled to the touch printed circuit board; and, a plurality of piezo components extending across a width of the full palm rest trackpad, the plurality of piezo components being electrically coupled to the touch printed circuit board, the plurality of piezo components, each of the plurality of piezo components performing a haptic function.

Abstract: A system, method, and computer-readable medium are disclosed for performing a system event classification operation. The system event classification operation includes providing an information handling system with a primary integrated processor system and an ancillary integrated processor system, the primary integrated processor system executing a primary control point service, the ancillary integrated processor system executing an ancillary control point service; classifying a system event by a particular control point action mode; and, configuring the information handling system to automatically operate in a particular control point action mode based upon the classification of the particular control point action mode.

Abstract: The present invention relates to a compound according to general formula (I), which acts as an inverse agonist of PqsR (the currently only known receptor for the Pseudomonas Quinolone Signal (PQS), sometimes also referred to as MvfR); to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to uses of said compound(s), including the use as a medicament, e.g. the use in the treatment or prophylaxis of a bacterial infection, especially a Pseudomonas aeruginosa or Burkholderia infection.

Abstract: A system, method, and computer-readable medium are disclosed for performing a pre-boot configuration operation. The pre-boot configuration operation includes performing a pre-boot system configuration operation using an ancillary integrated processor system, the pre-boot system configuration operation configuration certain parameters prior to initiation of a primary system boot operation; and, configuring an information handling system to automatically operate in a particular system configuration mode after performance of the pre-boot system configuration operation.

Abstract: Methods and compositions for inducing cell death in cells with FET-fused oncogenes, as well as methods for treating tumors with FET-fused oncogenes, such as cells and tumors associated with Ewing's sarcoma and fibromyxoid Iposarcoma. Oncogenes may include the EWS-FLI1 oncogene, FUS-FLI1 oncogene, FUS-CHOP oncogene, etc. The methods feature herein administering to a patient with a FET-fused oncogene tumor a combination of a DNA damaging agent and a transcription inhibitor. The combination of the transcription inhibitor and DNA damaging agent causes death of cells in the tumor.

Abstract: An ablation apparatus for creating a lesion in target tissue, the ablation apparatus having an ablation shaft including a handle, a first portion, an ablation portion, distal tip, at least one ablation energy delivery lumen, at least one ablation energy return lumen, and a stylet lumen that extends substantially along a length of the ablation shaft from the handle to at least the ablation portion. The ablation apparatus also includes a stylet that is capable of being inserted into the stylet lumen where the stylet is made of a shape-memory material.

Abstract: An information handling system includes a memory to store data associated with metrics of an individual and gaming performance metrics, and a processor. The processor correlates the metrics of an individual with the gaming performance metrics. Based on the correlation, the processor creates a gaming performance score. The processor determines changes to implement based on the gaming performance score. When the changes are implemented, the changes improve the gaming performance score. The processor provides the changes to the individual in a non-intrusive manner.