Abstract: D-serine is effective for inhibiting neuron loss due to an immune response by glial cells to a brain injury. An example of a method includes artificially administering a composition including D-serine to brain cells after an injury thereto, the composition including an amount of D-serine effective to inhibit death of neurons.

Abstract: Systems, methods, and computer-readable media for managing storing of data in a data storage system using a client tag. In some examples, a first portion of a data load as part of a transaction and a client identifier that uniquely identifies a client is received from the client at a data storage system. The transaction can be tagged with a client tag including the client identifier and the first portion of the data load can be stored in storage at the data storage system. A first log entry including the client tag is added to a data storage log in response to storing the first portion of the data load in the storage. The first log entry is then written from the data storage log to a persistent storage log in persistent memory which is used to track progress of storing the data load in the storage.

Abstract: In some examples, an apparatus includes a battery and a dynamic voltage source coupled in series with the battery. The dynamic voltage source is to maintain (or clamp) a system voltage from going below a minimum system voltage.

Abstract: A plurality of triggers may be presented and a selection of a predefined trigger may be accepted. Corresponding actions for the selected trigger may then be presented and an assignment of building control components may be accepted for the corresponding actions. During subsequent operation of a building automation system, the selected trigger may be detected and the corresponding actions may then be performed on the assigned building control components.

Abstract: A method comprises receiving one or more inputs captured by a camera of a device, and determining, using one or more machine learning models, whether the one or more inputs depict at least one object configured to capture a visual representation of a screen of the device. A recommendation is generated responsive to an affirmative determination, the recommendation comprising at least one action to prevent the capture of the visual representation of the screen of the device.

Abstract: A method comprises receiving at least one natural language input, converting the at least one natural language input to a graphical input, retrieving relationship data from a graph database based at least in part on the graphical input, and generating at least one natural language response of a virtual assistant to the at least one natural language input based at least in part on the relationship data from the graph database. At least the generating is performed using one or more machine learning models.

Abstract: A proportional solenoid-controlled fluid valve assembly having a fluid pressure balancing arrangement includes a poppet and diaphragm. The valve assembly also includes a solenoid coil assembly having a cylindrical conduit and a magnetic orifice piece positioned within the conduit. A plunger is positioned within the conduit and is movable within the conduit between a de-actuated position and an actuated position. A valve poppet is provided having a top cylindrical upstanding portion and a poppet face configured to abut the valve seat. Further, a diaphragm is positioned within the valve base with the top cylindrical upstanding portion of the poppet extending through a diaphragm opening.

Abstract: Techniques are provided for data size based replication. In an example, a replication daemon registers to receive notifications about data changes from a protocol driver. The replication daemon can maintain a counter for each of one or more replication policies, where a counter tracks how much data has changed that corresponds to a replication policy, since the prior replication for that replication policy. Where the daemon receives a notification for the protocol driver, it can determine whether the notification applies to any replication policy, and update any counters accordingly. Where an amount of data changed since the prior replication exceeds a threshold for a replication policy, a replication can be started. Upon successful completion of the replication, the corresponding counter can be reset.

Abstract: A telemetry master (TM) system provides automatic monitoring and maintenance of equipment by automatically generating predictive actions of a certain confidence threshold to backend systems which maintain a full duplex communication channel with the TM system. Data entries including context information that are generated by applications corresponding to the backend systems during the functioning of the backend systems are collected, analyzed and actionable items such as alerts, alarms of particular messages cause the telemetry master system to generate a predictive action of a minimum confidence threshold using a pre-trained first data model. A second data model is employed to identify particular equipment from the backend systems that is to implement the action. Results from implementing the action are collected and again used to train the data models. Certain applications can include intelligent agents which enable automatic execution of the actions.

Abstract: Techniques are provided for tracking a virus footprint in data copies. Data copies can be made in a variety of ways, like with snapshots, backups, replications, and simple copies. As copies of files that have not been scanned since they were last modified are made, these copies can be kept track of, and associated with the original file. When the original file is later scanned and found to be clean or infected, this information can be propagated through the copies.

Abstract: The invention provides combination therapies for the treatment of cancer. The combination therapies include a first agent that alters a metabolic pathway and a second agent that targets the metabolic pathway. The combination therapies are useful for treating cancers having tumor cells with different phenotypes, such as cancers of the blood, breast, colon, and prostate.

Abstract: The invention provides therapeutic methods that include providing to a subject an inhibitor of dihydroorotate dehydrogenase (DHODH) and a second therapeutic agent. The methods are useful for treating cancers, such as leukemias.

Abstract: Techniques are provided for user-based data tiering. In an example, a computer maintains a first-in-first-out queue that logs a finite set of users that have most-recently modified a file. This queue can be maintained in an extended attribute of an Mode that corresponds to a file. A computer can also maintain a policy that defines how to perform storage tiering on a file based on which users have accessed the file. When a tiering operation is performed, the files specified by a corresponding tiering policy can be evaluated for which users have recently accessed them. When a user specified by the tiering policy has recently modified a file, the file can be placed in tiering queue for tiering.

Abstract: Techniques are provided for tracking users modifying, writing, or editing a file. In an example, a file system maintains a first-in-first-out queue that logs a finite set of users that have most-recently modified a file. This queue can be maintained in an extended attribute of an Mode that corresponds to a file. Where a user modifies a file, and the user is currently identified in the queue, the user can be removed from the queue. Where the user modifies a file, is not currently identified in the queue, and the queue is full, an oldest user in the queue can be removed from the queue. Then, the user can be added to the back of the queue.

Abstract: The invention provides therapeutic compositions that contain an inhibitor of dihydroorotate dehydrogenase (DHODH) and promote sustained elevation of dihydroorotate (DHO) levels in a patient. The compositions are useful for treating disorders associated with unregulated DHODH activity, such as acute myeloid leukemia. The invention also provides methods of determining therapeutically effective doses of compositions that contain a DHODH inhibitor. The invention further provides methods of synthesis of 2-(2?-halo-1-1?-biphenyl-4-yl)-quinoline carboxylic acids, which are useful as DHODH inhibitors.

Abstract: A dynamically self-indexing database-management system selects database indexes associated with table columns that are most frequently accessed by user queries, deleting all other indexes. The system periodically reviews database-performance figures and data-usage patterns for each table of its database and revises its selection of indexes in order to ensure that only the most frequently accessed columns continue to be indexed and that the omission of other indexes does not degrade performance. The total number of selected indexes, the overall percent of selected indexes, or the selection itself is optimized over time through continued monitoring of database transaction logs. Optimization may comprise cognitive analytics or other methods of artificial intelligence by which the system learns over time how to best determine whether its current selection of indexes is likely to provide the best overall performance.

Abstract: A method comprises receiving at least one natural language input, and determining an intent of the at least one natural language input. In the method, a virtual assistant of a plurality of virtual assistants is recommended to respond to the at least one natural language input based at least in part on the determined intent, and the at least one natural language input is transmitted to the recommended virtual assistant. The determining and recommending are performed using one or more machine learning models, and the plurality of virtual assistants respectively correspond to a plurality of different functions of an enterprise.

Abstract: The invention provides compositions and methods for treating conditions in a subject by providing an inhibitor of inosine phosphate dehydrogenase that promotes decreased levels of guanosine triphosphate and/or increased levels of hypoxanthine.

Abstract: Techniques are provided for data size and time based replication. In an example, a first daemon monitors data changes that corresponds to a first replication policy, and a second daemon monitors an amount of time since performing a replication for the first replication policy. Where either a data modification threshold is met, or a time threshold is met, the daemons can perform a replication, and reset both a data counter and a timer that determine when next to perform a replication.

Abstract: Techniques are provided for data size based replication. In an example, a replication daemon registers to receive notifications about data changes from a protocol driver. The replication daemon can maintain a counter for each of one or more replication policies, where a counter tracks how much data has changed that corresponds to a replication policy, since the prior replication for that replication policy. Where the daemon receives a notification for the protocol driver, it can determine whether the notification applies to any replication policy, and update any counters accordingly. Where an amount of data changed since the prior replication exceeds a threshold for a replication policy, a replication can be started. Upon successful completion of the replication, the corresponding counter can be reset.