Abstract: A sealed enclosure power control system for controlling power to an electrical component within an enclosure. The sealed enclosure power control system generally includes an electrical component within the sealed enclosure, a first connector on the sealed enclosure adapted to provide a sealed electrical interface to the electrical component. The first connector has at least one first connector conductor element, and the system further includes a battery within the sealed enclosure, and the system also has a second connector, wherein when the first connector and the second connector are connected together, electrical power from the battery is applied to the electrical component, and when the first connector and the second connector are not connected together, the electrical power is not applied to the electrical component.

Abstract: The present disclosure provides crystalline forms of apalutamide. Specific crystalline forms provided by the disclosure include apalutamide Form APO-I, a cocrystal solvate of apalutamide, vanillin, and n-butyl acetate; apalutamide Form APO-II, a cocrystal solvate of apalutamide, ethylvanillin, and n-butyl acetate; apalutamide Form APO-III, a cocrystal of apalutamide and 4-aminobenzoic acid; and apalutamide Form APO-IV, a cocrystal of apalutamide and vanillin. Also provided are pharmaceutical compositions including the apalutamide crystalline forms and the use of these forms in the treatment of prostate cancer, and in particular metastatic and non-metastatic castration-resistant prostate cancer.

Abstract: The present disclosure describes various aspects of remote presence interfaces (RPIs) for use on portable electronic devices (PEDs) to interface with remote presence devices. An RPI may allow a user to interact with a telepresence device, view a live video feed, provide navigational instructions, and/or otherwise interact with the telepresence device. The RPI may allow a user to manually, semi-autonomously, or autonomously control the movement of the telepresence device. One or more panels associated with a video feed, patient data, calendars, date, time, telemetry data, PED data, telepresence device data, healthcare facility information, healthcare practitioner information, menu tabs, settings controls, and/or other features may be utilized via the RPI.

Abstract: The present disclosure relates, in general, to non-viral methods for generating engineered B cell, and use of such B cells as cell-based therapeutics to treat disease.

Abstract: A distributed security system includes a detection unit disposed at a first location. The detection unit includes a particle sensor that is configured to detect a particle count in first location. The detection unit also includes a housing enclosing a portion of the particle sensor. The security system also includes a camera disposed at a second location and having a field of vision encompassing the first location. The camera is configured to capture a video of the first location. The system also includes a server communicatively connected to the detection unit and the camera and configured to associate the particle count with the video.

Abstract: An infant car seat includes a seat base and a stability leg. The stability leg is rotatably disposed under the seat base. The stability leg includes an upper leg tube, a rotary member and a first latch. The upper leg tube includes at least one opening. The rotary member includes a pivoting portion and an encircling portion. The pivoting portion is rotatably connected to the seat base. The encircling portion is connected to the pivoting portion and slidably disposed on the upper leg tube. The first latch is disposed on the rotary member, and adapted to detachably engage with the at least one opening for constraining a movement between the rotary member and the upper leg tube.

Abstract: A system for monitoring, in real time, properties of an object and an environment proximate to the object includes a flexible covering, a plurality of sensors, a control module, and a display. The flexible covering is configured to conform to one or more surfaces of the object. The plurality of sensors are disposed at regular intervals across the flexible covering. Each of the sensors is configured to measure one or more properties. The sensors are configured to transmit property data amongst each other. The control module is configured to receive the property data from each of the plurality of sensors. The control module includes a processor and a non-transitory computer-readable medium having executable instructions encoded thereon such that, when executed, cause the processor to produce a visual representation of the property data. The display is configured to show the visual representation of the property data.

Abstract: Disclosed are prodrug compounds that can be converted to mesembrine under biologically relevant conditions, such as hydrolysis in vivo; and related methods of preparing and using these compounds. Stable preparations of isolated mesembrine stereoisomers are also provided.

Abstract: An actuating mechanism including: a base having a helically shaped passage; a movable mass having a helically shaped projection, a first surface of the helically shaped projection mating with a corresponding second surface of the helically shaped passage; and a spring biasing the first surface against the second surface when the base is not being accelerated. Wherein the helically shaped passage, the helically shaped projection and the spring are configured to maintain the helically shaped projection in a first portion of the helically shaped passage upon the base experiencing a first acceleration profile having a first magnitude and a first duration and allow the mass to move to a second portion of the helically shaped passage upon the base experiencing a second acceleration profile having a second acceleration lower than the first acceleration and a second duration greater than the first duration.

Abstract: A dishwasher includes a tub with an access opening to a treating chamber, a sump, at least one sprayer emitting liquid into the treating chamber, a pump, a conduit fluidly coupling the sump to the pump and the pump to the at least one sprayer, thereby defining a recirculation circuit through which the liquid sprayed into the treating chamber collects in the sump and is pumped back to the at least one sprayer. The dishwasher also includes a filter assembly in the sump for filtering the liquid in the recirculation circuit including a cleaning element and a dome shaped displacement body positioned adjacent the filter wall for raising a liquid level within the filter and configured to fill more than 50% of a percentage of a volume of the filter.

Abstract: An electrochemical reactor comprising a source of a magnetic field positioned in proximity to a cathode and configured to generate a magnetic field; and an electrochemical cell comprising an anode and the cathode, and further comprising a catholyte channel configured to direct a catholyte stream comprising an iron-containing feedstock to the cathode; an anolyte channel configured to direct an anolyte stream comprising a metal chloride to the anode, wherein the catholyte channel and the anolyte channel are disposed between the cathode and the anode; and a separator disposed between the catholyte channel and the anolyte channel, wherein the electrochemical reactor is configured to electrochemically oxidize chloride anions to chlorine gas at a surface of the anode, and wherein the electrochemical reactor is further configured to electrochemically reduce the iron-containing feedstock to an iron particle comprising iron metal at the surface of the cathode and in the magnetic field.

Abstract: The present invention relates to a yeast cell producing at least one secreted protein of interest, wherein said cell comprises at least one additional fungal gene showing increased expression and/or overexpression, showing reduced expression and/or inactivation, wherein said gene improves the production of the at least one secreted protein of interest. The present invention further relates to respective methods for production and uses of the yeast cell.

Abstract: An immune suppressor cell modified to include an innate immune effector is described. Methods of using the modified immune suppressor cell to treat cancer are also described.

Abstract: The present disclosure provides a multivalent biomolecule comprising three or more covalently linked common ?-chain receptor cytokines (e.g., IL-2, IL-4, IL-7, IL-9, IL-15 or IL-21, or an immunologically active fragment thereof). In one embodiment, the common ?-chain receptor cytokines in the multivalent biomolecule are expressed as Fc fusion proteins with an IgG1 Fc. The multivalent biomolecule presented herein can be used to activate or suppress immune responses in a subject.

Abstract: A stream of events is received at a local security agent running on an endpoint at an enterprise network. The local security agent may detect an event of a first event type and may generate an aggregate event with subsequent events of the first event type in the stream. The local security agent may then transmit the aggregate event to a security resource for detecting security threats.

Abstract: A golf shoe with an upper and a sole assembly connected to the upper. The sole assembly comprises an outsole comprising an outsole zone with a wave-like configuration. The outsole zone includes a plurality of directional traction elements with sidewalls extending from a lower surface of the outsole. The directional traction elements may be arranged along different sections of the outsole zone according to an angular orientation of the sidewalls of the directional traction elements. The directional traction elements may include (i) a first set of directional traction elements arranged along a first section of the outsole zone and (ii) a second set of directional traction elements arranged along a second section of the outsole zone. The first and/or second set(s) of directional traction elements may include a plurality of directionally aligned traction elements with sidewalls that are oriented in a same direction.

Abstract: A surgical instrument includes a supply chamber, a handle assembly, a sleeve extending from the handle assembly, a distal ring, a plurality of needle tines, and a deflector. The plurality of needle tines extends through a lumen of the sleeve, is movable through the lumen of the sleeve via the handle assembly, and is configured to dispense a therapeutic agent from the supply chamber. The deflector extends through the lumen and is movable through the lumen via the handle assembly. Retraction of the deflector relative to the sleeve and the plurality of needle tines causes the needle tines to deflect away from a central longitudinal axis of the sleeve against the distal ring to change an angle between a trajectory of the plurality of needle tines and the central longitudinal axis.

Abstract: A cutter including a cutting head and an adjustable handle pivotally coupled to the cutting head. The adjustable handle includes a first adjustment assembly to change a length the adjustable handle extends from the cutting head. The adjustable handle also includes a second adjustment assembly to change the position of the adjustable handle with respect to the cutting head.

Abstract: Devices and methods for articulating a distal end of a surgical device are provided. In one exemplary embodiment, the device includes an articulation joint that includes both an inner guide and an outer sleeve. The inner guide includes one channel extending therethrough that receives both a cutting mechanism and a closure band. Further, an outer surface of the inner guide, in conjunction with the outer sleeve, can define two additional channels that each receive an articulation band for articulating an end effector coupled to the articulation joint. The outer surface of the inner guide can include a plurality of ribs that also help define the two additional channels. Further, the outer sleeve can include a plurality of slots formed in it to improve flexibility and stability. Additional configurations of articulation joints, and configurations of components of a surgical device, are also provided, as are methods for using the same.

Abstract: Systems and methods for customizing medical tapes from a roll stock at customer use sites are provided. The system includes a tape converting machine where an adhesion modification mechanism is configured to modify adhesion properties of the tape from the roll stock, automatically or based on received customization instructions.