Abstract: The invention relates to methods for treating prostate cancer by targeting the generation of splice variants of the androgen receptor. In one aspect, this can be achieved by targeting JMJD6 to reduce the production of androgen receptor splice variants. The invention finds particular use in the treatment of prostate cancer that is resistant to conventional androgen therapy.

Abstract: A pharmaceutically nanoemulsion formulation of Compound 1 is disclosed along with methods for making the same. An example embodiment of the nanoemulsion of Compound 1 is comprised of lecithin, medium chain triglycerides (MCT), sucrose, EDTA and water.

Abstract: A storage vessel can include a shell that is formed by fibers wound about an axis and infused with a resin matrix. The resin matrix can include metal nanoparticles coated with a polymer and distributed within a resin. The nanoparticles provide low coefficients of thermal expansion, and the polymer coatings enhance their bonding with the resin. The shells of such storage vessels provide increased tensile strength and modulus at both room and cryogenic temperatures. Such improvements stem from the higher interfacial residual thermal stress at cryogenic temperature due to their low thermal expansion properties, which in turn promotes crack branching that increases the energy dissipation of the matrix.

Abstract: Methods and uses of Rilpivirine and analogues thereof in the treatment and/or prevention of proliferative cell diseases and conditions are disclosed. Among the diseases and conditions that may be treated and/or prevented, are cancers characterised by Aurora A dysregulation.

Abstract: Aspects of the invention include obtaining one or more feature values that define an architecture design of a memory array and implementing a machine learning model to obtain a predicted power, performance, and area (PPA) of the memory array based on the one or more features. The predicted PPA output by the machine leaning model is assessed based on predefined PPA goals. A design of an integrated circuit that includes the memory array is finalized and fabricated based on the predicted PPA meeting the predefined PPA goals.

Abstract: An evaluation unit for a magnetostrictive displacement sensor and a magnetostrictive displacement sensor for determining a position of at least one position encoder having an input for receiving an electrical measurement signal generated by the magnetostrictive displacement sensor are proposed. The electrical measurement signal includes a position signal representing a position of a position encoder movable relative to a magnetostrictive device component and a reference signal representing a reference position, having a first evaluation branch for evaluating the measurement signal. The first evaluation branch is adapted to determine a position signal time of flight of the position signal and a first reference signal time of flight of the reference signal.

Abstract: Aspects of the invention include obtaining one or more feature values that define an architecture design of a memory array and implementing a machine learning model to obtain a predicted power, performance, and area (PPA) of the memory array based on the one or more features. The predicted PPA output by the machine leaning model is assessed based on predefined PPA goals. A design of an integrated circuit that includes the memory array is finalized and fabricated based on the predicted PPA meeting the predefined PPA goals.

Abstract: A storage vessel can include a shell that is formed by fibers wound about an axis and infused with a resin matrix. The resin matrix can include metal nanoparticles coated with a polymer and distributed within a resin. The nanoparticles provide low coefficients of thermal expansion, and the polymer coatings enhance their bonding with the resin The shells of such storage vessels provide increased tensile strength and modulus at both room and cryogenic temperatures. Such improvements stem from the higher interfacial residual thermal stress at cryogenic temperature due to their low thermal expansion properties, which in turn promotes crack branching that increases the energy dissipation of the matrix.

Abstract: A hybrid functionalized lamellar comprises a layered double hydroxide and [Sn2S6]4? anions intercalated with the gallery of the layered double hydroxide to form a [Sn2S6]4? intercalated layered double hydroxide.

Abstract: The system comprises a plurality of sensing nodes for detecting real time health parameters of patients; a user interface having a plurality of entry fields allotted to a plurality of medical practitioners and pharmacy shops for updating an information of treatment, medication, disease, stage of disease, treatment duration, and the like; a 6G transceiver for wirelessly communicating with the plurality of sensing nodes and user interfaces; a blockchain-based memory for storing the real time health parameters and the information of treatment, medication, disease, stage of disease, treatment duration, and the like; and a central processing unit for generating a health record of each patients thereby storing into the blockchain-based memory such that a medical practitioner is allowed to access the stored data to study the health record of a patient before treatment or before suggesting any medication/vaccine to avoid the complications or any side effect.

Abstract: An evaluation unit for a magnetostrictive displacement sensor and a magnetostrictive displacement sensor for determining a position of at least one position encoder having an input for receiving an electrical measurement signal generated by the magnetostrictive displacement sensor are proposed, wherein the electrical measurement signal comprises a position signal representing a position of a position encoder movable relative to a magnetostrictive device component and a reference signal representing a reference position, having a first evaluation branch for evaluating the measurement signal, wherein the first evaluation branch is adapted to determine a position signal time of flight of the position signal and a first reference signal time of flight of the reference signal.

Abstract: An approach is provided in which a system writes a set of data into a register file entry that includes a first memory array and a second memory array. The register file entry also includes a set of first write ports corresponding to the first memory array and a set of second write ports corresponding to the second memory array. The system configures a selection bit based on determining that a selected one of the set of first write ports is utilized to store the set of data in the first memory array. In turn, the system reads the set of data out of the first memory array based on the configured selection bit.

Abstract: The invention relates to a compact thermal reactor for rapid growth of high quality carbon nanotubes (CNT2) produced by chemical process with low power consumption comprising: a processing chamber having a vacuum vessel, the vacuum vessel having a side cover formed of a first side wall and a second side wall, a top cover, a bottom cover connected to a support stand; feed through housing provided with a substrate; a heating system consisting of a heating element and back means; and at least one each inlet and outlet for gas injection into the process chamber for growing high quality carbon nanotubes over the substrate.

Abstract: Systems and methods are provided for determining the security risk associated with one or more users of a computer network. Users are monitored over time to build security related profiles which are employed to assess the risk they impose on the network. The user profiles, which may be computed as online and network user profiles for each user, are processed to classify users according to user groups. A composite risk measure is generated, for a given user, based on a first measure that is obtained by processing the user profile data, and a second security risk measure, that is obtained by comparing the present user group to which the user has classified and a prior user group that was associated with the given user. Action may be taken by an administrator to mitigate the risk posed by that user based on the computed composite risk score.

Abstract: An electronic device which can easily access information associated with an item displayed in a notification bar and a method for operating a notification bar thereof are provided. The electronic device includes a touch screen for detecting a selection of an item displayed in the notification bar, and a controller for controlling the touch screen so as to display an information providing window which provides information associated with the selected item, in response to selection of the item.

Abstract: An approach is provided in which a system writes a set of data into a register file entry that includes a first memory array and a second memory array. The register file entry also includes a set of first write ports corresponding to the first memory array and a set of second write ports corresponding to the second memory array. The system configures a selection bit based on determining that a selected one of the set of first write ports is utilized to store the set of data in the first memory array. In turn, the system reads the set of data out of the first memory array based on the configured selection bit.

Abstract: Reducing power consumption in a multi-slice computer processor that includes a re-order buffer and an architected register file, including: designating an entry in the re-order buffer as being invalid and unwritten; assigning a pending instruction to the entry in the re-order buffer; responsive to assigning the pending instruction to the entry in the re-order buffer, designating the entry as being valid; writing data generated by executing the pending instruction into the re-order buffer; and responsive to writing data generated by executing the pending instruction into the re-order buffer, designating the entry as being written.

Abstract: A position sensor comprises a waveguide of a magnetostrictive material, which extends along a measurement path and which is configured for conducting mechanical pulses triggered by magnetostriction, and a housing for the waveguide. A positioning element is provided which is elastic at least regionally; which is held in the housing while being deformed; and which has a recess which extends along the measurement path and forms a receiver for the waveguide. In the position sensor in accordance with the invention, the recess has a slit which extends along the measurement path; which, viewed in a cross-sectional plane, reaches from a reception section up to a boundary of the positioning element; and which enables a lateral insertion of the waveguide into the reception section. The invention furthermore comprises a method of manufacturing a position sensor in accordance with the invention.

Abstract: A position sensor comprises a waveguide of magnetostrictive material which extends along a measurement path and which is configured for conducting mechanical pulses triggered by magnetostriction. A transducer at a first end of the waveguide serves for coupling a current pulse into the waveguide and for detecting a mechanical pulse conducted by the waveguide in the direction of the transducer. A damping element of an elastomer material is provided at a second end of the waveguide for damping a mechanical pulse propagating in the direction of the second end, wherein the hardness of the elastomer material increases as the distance from the transducer increases. The invention furthermore relates to a method of manufacturing a damping element of such a position sensor.

Abstract: Methods and apparatus for preventing premature reads from a general purpose register (GPR) including receiving an instruction comprising a source operand identifying a source GPR entry; setting a read-enabled flag based on a value in a particular entry of a source ready vector; if the read-enabled flag indicates data in the source GPR entry is ready for reading, dispatching the received instruction, including performing a read operation of the data in the source GPR entry; and if the read-enabled flag indicates data in the source GPR entry is not ready for reading, dispatching the received instruction without performing a read operation of the data in the source GPR entry.