Patents by Inventor Sakari Kauppinen
Sakari Kauppinen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20080145912Abstract: The present invention relates to enzyme preparations consisting essentially of an enzyme which has cellulytic activity and comprises a first amino acid sequence having the following sequence (SEQ ID NO: 79) Thr Arg Xaa Xaa Asp Cys Cys Xaa Xaa Xaa Cys Xaa 1???2???3???4???5???6???7???8???9???10??11??12 Trp Xaa 13??14 and a second amino acid sequence having the following sequence Trp Cys Cys Xaa Cys (SEQ ID NO: 80) 1???2???3???4???5 wherein, at position 3 of the first sequence, the amino acid is Trp, Tyr or Phe; at position 4 of the first sequence, the amino acid is Trp, Tyr or Phe; at position 8 of the first sequence, the amino acid is Arg, Lys or His; at positions 9, 10, 12 and 14, respectively, of the first sequence, and at position 4 of the second sequence, the amino acid is any of the 20 naturally occurring amino acid residues with the provisos that, in the first amino acid sequence, (i) when the amino residue at position 12 is Ser, then the amino acidType: ApplicationFiled: April 25, 2007Publication date: June 19, 2008Applicant: Novozymes A/SInventors: Martin Schulein, Torben Henriksen, Lene Nonboe Andersen, Soren Flensted Lassen, Markus Sakari Kauppinen, Lene Lange, Ruby Ilum Nielsen, Shinobu Takagi, Michiko Ihara
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Publication number: 20080096191Abstract: A method for isolating nucleic acid molecules having a repeating nucleotide sequence or a homopolymeric nucleotide sequence, e.g. a poly A stretch, is described. In particular, the method uses oligomeric capture probes spiked with various amounts of locked nucleic acid (LNA). The invention further describes methods for the isolation of RNA molecules, for example polyadenylated mRNA molecules, which overcome the problems of rapid RNA degradation during isolation and analysis of such nucleic acid molecules. This is of major clinical and diagnostic importance, especially when dealing with RNA viruses, such as retroviruses or when analyzing rare or low-abundant mRNAs or mRNAs from biopsies or tissues enriched with RNases.Type: ApplicationFiled: August 14, 2007Publication date: April 24, 2008Applicant: ExiQon A/SInventors: Sakari Kauppinen, Nana Jacobsen
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Publication number: 20070299030Abstract: The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.Type: ApplicationFiled: April 2, 2007Publication date: December 27, 2007Applicants: Koebenhavns Universitet (University of Copenhagen), Trustees of Dartmouth CollegeInventors: Ethan Dmitrovsky, Xi Liu, Sarah Freemantle, Lorenzo Sempere, Charles Cole, Sakari Kauppinen, Mads Bak
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Patent number: 7273745Abstract: The present invention relates to pectate lyases comprising the amino acid sequence Asn Leu Asn Ser Arg Val Pro (NLNSRVP) (amino acids 236-242 of SEQ ID NO: 2) belonging to Family 1 of polysaccharide lyases have good performance in industrial processes under neutral or alkaline conditions such as laundering and textile processing. The pectate lyase may be derivable from Bacillus species.Type: GrantFiled: November 28, 2006Date of Patent: September 25, 2007Assignee: Novozymes A/SInventors: Lene Nonboe Andersen, Hanne Dela, legal representative, Niels Erik Krebs Lange, Mads Eskelund Bjørnvad, Søren Møller, Sanne O. Schrøder Glad, Markus Sakari Kauppinen, Kirk Schnorr, Lars Kongsbak, Martin Schülein, deceased
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Patent number: 7226773Abstract: The present invention relates to enzyme preparations consisting essentially of an enzyme which has cellulytic activity and comprises a first amino acid sequence having the following sequence (SEQ ID NO: 79) Thr Arg Xaa Xaa Asp Cys Cys Xaa Xaa Xaa Cys Xaa Trp Xaa 1 2 3 4 5 6 7 8 9 10 11 12 13 14 and a second amino acid sequence having the following sequence Trp Cys Cys Xaa Cys (SEQ ID NO: 80) 1 2 3 4 5 wherein, at position 3 of the first sequence, the amino acid is Trp, Tyr or Phe; at position 4 of the first sequence, the amino acid is Trp, Tyr or Phe; at position 8 of the first sequence, the amino acid is Arg, Lys or His; at positions 9, 10, 12 and 14, respectively, of the first sequence, and at position 4 of the second sequence, the amino acid is any of the 20 naturally occurring amino acid residues with the provisos that, in the first amino acid sequence, (i) when the amino residue at position 12 is Ser, then the amino acid residue at positionType: GrantFiled: October 14, 2004Date of Patent: June 5, 2007Assignee: Novozymes A/SInventors: Martin Schulein, deceased, Torben Henriksen, legal representative, Lene Nonboe Andersen, Soren Flensted Lassen, Markus Sakari Kauppinen, Lene Lange, Ruby Ilum Nielsen, Shinobu Takagi, Michiko Ihara
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Publication number: 20070117144Abstract: The invention features improved nucleic acids and methods for expression profiling of mRNAs, identifying and profiling of particular mRNA splice variants, and detecting mutations, deletions, or duplications of particular exons or other splice variants, e.g., alterations associated with a disease such as cancer, in a nucleic acid sample, e.g., a biological sample or a patient sample.Type: ApplicationFiled: December 21, 2006Publication date: May 24, 2007Inventors: Sakari Kauppinen, Carsten Alsbo, Peter Nielsen, Daniel Jeffares, Tobias Mourier, Soren Mork, Peter Arctander, Niels Tommerup, Niels Tolstrup, Henrik Vissing
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Publication number: 20070099196Abstract: The invention relates relates to ribonucleic acids and oligonucleotide probes useful for detection and analysis of microRNAs and their target mRNAs, as well as small interfering RNAs (siRNAs).Type: ApplicationFiled: December 29, 2005Publication date: May 3, 2007Inventors: Sakari Kauppinen, Ronald Plasterk, Erno Wienholds, Wigard Kloosterman
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Patent number: 7186513Abstract: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing filamentous fungal expressed sequenced tags. The present invention also relates to filamentous fungal expressed sequenced tags and to computer readable media and substrates containing such expressed sequenced tags for monitoring expression of a plurality of genes in filamentous fungal cells.Type: GrantFiled: August 29, 2003Date of Patent: March 6, 2007Assignee: Novozymes, Inc.Inventors: Randy M. Berka, Michael W. Rey, Jeffrey R. Shuster, Sakari Kauppinen, Ib Groth Clausen, Peter Bjarke Olsen
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Patent number: 7183093Abstract: The present invention relates to mannanases comprising e.g., a sequence of amino acids 32–330 of SEQ ID NO: 2 or their homologues may be derived from e.g., Bacillus sp. I633, or may be encoded by polynucleotide molecules comprising a sequence of nucleotides 94–990 of SEQ ID NO: 1 from, polynucleotide molecules that encode a polypeptide that is at least 65% identical to the sequence of amino acids 32–330 of SEQ ID NO: 2, or degenerate nucleotide sequences thereof. The mannanases are alkaline and are useful e.g. in cleaning compositions, in a fracturing fluid useful to fracture a subterranean formation, for modifying plant material, and for treatment of cellulosic fibers.Type: GrantFiled: February 20, 2003Date of Patent: February 27, 2007Assignee: Novozymes A/SInventors: Markus Sakari Kauppinen, Martin Schulein, Kirk Schnorr, Lene Nonboe Andersen, Mads Eskelund Bjornvad
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Patent number: 7144722Abstract: The present invention relates to pectate lyases comprising the amino acid sequence Asn Leu Asn Ser Arg Val Pro (NLNSRVP) (amino acids 236–242 of SEQ ID NO: 2) belonging to Family 1 of polysaccharide lyases have good performance in industrial processes under neutral or alkaline conditions such as laundering and textile processing. The pectate lyase may be derivable from Bacillus species.Type: GrantFiled: September 4, 2003Date of Patent: December 5, 2006Assignee: Novozymes A/SInventors: Lene Nonboe Andersen, Hanne Dela, legal representative, Niels Erik Krebs Lange, Mads Eskelund Bjornvad, Soren Moller, Sanne O Schroder Glad, Markus Sakari Kauppinen, Kirk Schnorr, Lars Kongsbak, Martin Schulein, deceased
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Patent number: 7094586Abstract: The present invention relates to transglutaminases and transglutaminase preparations obtained from lower fungi belonging to the class Oomycetes and unprecedented high-level expression is achievable by growing these coenocytium forming organisms, especially the strains Pythium sp., Pythium irregulare, Pythium dissotocum, Pythium periilum (or P. periplocum), Pythium torulosum, Pythium ultimum, Pythium aphanidermatum, Phytophthora cactorum, Phytophthora palmivora, Phytophthora porri, Phytophthora infestans, Phytophthora megasperma, Phytophthora cinnamomi and Phytophthora cryptogea; and a recombinant transglutaminase has been cloned and expressed, the enzyme and enzyme preparations being useful for cross-linking proteins, e.g. in flour, baked products, meat products, fish products, cosmetics, cheese, milk products, gelled food products and leather finishing, or as a glutaminase, e.g. in bread and other baked glutein-containing food products.Type: GrantFiled: June 7, 2002Date of Patent: August 22, 2006Assignee: Novozymes A/SInventors: Lisbeth Bech, Grethe Rasmussen, Torben Halkier, Mariko Okada, Lene Nonboe Andersen, Markus Sakari Kauppinen, Thomas Sandal
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Patent number: 7060809Abstract: Modified LNA units are provided that comprises unique base groups. Desirable nucleobase and nucleosidic base substitutions can mediate universal hybridization when incorporated into nucleic acid strands. The novel LNA compounds may be used in a wide variety of applications, such as PCR primers, sequencing, synthesis of antisense oligonucleotides, diagnostics and the like.Type: GrantFiled: September 4, 2002Date of Patent: June 13, 2006Assignee: Exiqon A/SInventors: Jesper Wengel, Sakari Kauppinen
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Patent number: 7001485Abstract: An arrangement for measuring properties of a moving paper web. The arrangement comprises measuring means for measuring paper properties, in connection with which a plane-like support surface is arranged. The plane-like support surface supports the paper web and extends substantially over the whole width of the paper web in the cross-direction relative to the direction of travel of the paper web. An opening arrangement formed by at least one opening is arranged on the support surface for measuring properties of the paper web.Type: GrantFiled: January 14, 2002Date of Patent: February 21, 2006Assignee: Metso Automation OyInventors: Pekka Koivukunnas, Helena Leppäkoski, Matti Kukkurainen, Sakari Kauppinen
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Publication number: 20050272075Abstract: The invention relates to ribonucleic acids, probes and methods for detection, quantification as well as monitoring the expression of mature microRNAs and small interfering RNAs (siRNAs). The invention furthermore relates to methods for monitoring the expression of other non-coding RNAs, mRNA splice variants, as well as detecting and quantifying RNA editing, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease such as cancer. The invention furthermore relates to methods for detection, quantification as well as monitoring the expression of deoxy nucleic acids.Type: ApplicationFiled: April 7, 2005Publication date: December 8, 2005Inventors: Nana Jacobsen, Lars Kongsbak, Sakari Kauppinen, Soren Echwald, Peter Mouritzen, Peter Nielsen, Mikkel Norholm
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Patent number: 6902887Abstract: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing filamentous fungal expressed sequenced tags. The present invention also relates to filamentous fungal expressed sequenced tags and to computer readable media and substrates containing such expressed sequenced tags for monitoring expression of a plurality of genes in filamentous fungal cells.Type: GrantFiled: March 22, 2000Date of Patent: June 7, 2005Assignees: Novozymes Biotech, Inc., Novozymes A/SInventors: Randy M. Berka, Michael W. Rey, Jeffrey R. Shuster, Sakari Kauppinen, Ib Groth Clausen, Peter Bjarke Olsen
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Publication number: 20050053942Abstract: A method for isolating nucleic acid molecules having a repeating nucleotide sequence or a homopolymeric nucleotide sequence, e.g. a poly A stretch, is described. In particular, the method uses oligomeric capture probes spiked with various amounts of locked nucleic acid (LNA). The invention further describes methods for the isolation of RNA molecules, for example polyadenylated mRNA molecules, which overcome the problems of rapid RNA degradation during isolation and analysis of such nucleic acid molecules. This is of major clinical and diagnostic importance, especially when dealing with RNA viruses, such as retroviruses or when analyzing rare or low-abundant mRNAs or mRNAs from biopsies or tissues enriched with RNases.Type: ApplicationFiled: June 20, 2003Publication date: March 10, 2005Inventors: Sakari Kauppinen, Nana Jacobsen
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Patent number: 6855531Abstract: The present invention relates to enzyme preparations consisting essentially of an enzyme which has cellulytic activity and comprises a first amino acid sequence having the following sequence (SEQ ID NO:79) Thr Arg Xaa Xaa Asp Cys Cys Xaa Xaa 1???2???3???4???5???6???7???8???9 Xaa Cys Xaa Trp Xaa 10??11??12??13??14 and a second amino acid sequence having the following sequence Trp Cys Cys Xaa Cys (SEQ ID NO:80) 1???2???3???4???5 wherein, at position 3 of the first sequence, the amino acid is Trp, Tyr or Phe; at position 4 of the first sequence, the amino acid is Trp, Tyr or Phe; at position 8 of the first sequence, the amino acid is Arg, Lys or His; at positions 9, 10, 12 and 14, respectively, of the first sequence, and at position 4 of the second sequence, the amino acid is any of the 20 naturally occurring amino acid residues with the provisos that, in the first amino acid sequence, (i) when the amino residue at position 12 is Ser, then the amino acid residue at poType: GrantFiled: December 10, 2001Date of Patent: February 15, 2005Assignee: Novozymes A/SInventors: Torben Henriksen, Søren Flensted Lassen, Markus Sakari Kauppinen, Martin Shulein
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Publication number: 20040229367Abstract: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing filamentous fungal expressed sequenced tags. The present invention also relates to filamentous fungal expressed sequenced tags and to computer readable media and substrates containing such expressed sequenced tags for monitoring expression of a plurality of genes in filamentous fungal cells.Type: ApplicationFiled: August 29, 2003Publication date: November 18, 2004Applicants: Novozymes Biotech, Inc., Novozymes A/S, Inc.Inventors: Randy M. Berka, Michael W. Rey, Jeffrey R. Shuster, Sakari Kauppinen, Ib Groth Clausen, Peter Bjarke Olsen
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Publication number: 20040219565Abstract: The invention features improved nucleic acids and methods for expression profiling of mRNAs, identifying and profiling of particular mRNA splice variants, and detecting mutations, deletions, or duplications of particular exons or other splice variants, e.g., alterations associated with a disease such as cancer, in a nucleic acid sample, e.g., a biological sample or a patient sample.Type: ApplicationFiled: October 21, 2003Publication date: November 4, 2004Inventors: Sakari Kauppinen, Carsten Alsbo, Peter S. Nielsen, Daniel C. Jeffares, Tobias Mourier, Soren Mork, Peter Arctander, Niels Tommerup, Niels Tolstrup, Henrik Vissing
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Patent number: 6759225Abstract: The inventors have isolated lysophospholipases from Aspergillus (A. niger and A. oryzae) having molecular masses of about 68 kDa and amino acid sequences of 600-604 amino acid residues. The novel lysophospholipases have only a limited homology to known amino acid sequences. The inventors also isolated genes encoding the novel enzymes and cloned them into E. coli strains.Type: GrantFiled: December 4, 2002Date of Patent: July 6, 2004Assignee: Novozymes A/SInventors: Hiroaki Udagawa, Torben Peter Frandsen, Tom Anton Busk Nielsen, Markus Sakari Kauppinen, Soren Christensen