Abstract: A model eye for evaluating a retinal imaging system includes a retinal cup and a resolution target. The retinal cup includes an interior surface having a bowl-like shape to represent a fundus of a human eye. The resolution target is disposed on the interior surface for assessing a spatial resolution of the retinal imaging system. The resolution target includes light and dark contrasting regions with straight edges separating the light and dark contrasting regions. At least two of the straight edges are orthogonal. An array of dark color microfeatures may be disposed in the light contrasting region and an array of light color microfeatures may be disposed in the dark contrasting region. The light and dark color microfeatures are variably sized for assessing the spatial resolution of the retinal imaging system.

Abstract: A technique for imaging a retina with a retinal camera includes illuminating the retina with a plurality of distinct illumination bands that are substantially exclusive of green visible light while substantially not illuminating the retina with the green visible light. A first retinal image is acquired while illuminating the retina with the distinct illumination bands and substantially not illuminating the retina with the green visible light.

Abstract: A technique for imaging a retina with a retinal camera includes illuminating the retina with a plurality of distinct illumination bands that are substantially exclusive of green visible light while substantially not illuminating the retina with the green visible light. A first retinal image is acquired while illuminating the retina with the distinct illumination bands and substantially not illuminating the retina with the green visible light.

Abstract: Introduced here are retinal cameras having optical stops whose size and/or position can be modified to increase the size of the space in which an eye can move while being imaged. In some embodiments, an optical stop is mechanically moved to recover retinal image quality as the subject shifts their eye. In some embodiments, an optical stop is digitally created using a pixelated liquid crystal display (LCD) layer having multiple pixels that are individually controllably. In some embodiments, multiple non-pixelated LCD layers are connected to one another to form a variable transmission stack, and each LCD layer within the variable transmission stack may be offset from the other LCD layers. In such embodiments, the optical stop can be moved by changing which LCD layer is active at a given point in time.

Abstract: Introduced here are retinal cameras having optical stops whose size and/or position can be modified to increase the size of the space in which an eye can move while being imaged. In some embodiments, an optical stop is mechanically moved to recover retinal image quality as the subject shifts their eye. In some embodiments, an optical stop is digitally created using a pixelated liquid crystal display (LCD) layer having multiple pixels that are individually controllably. In some embodiments, multiple non-pixelated LCD layers are connected to one another to form a variable transmission stack, and each LCD layer within the variable transmission stack may be offset from the other LCD layers. In such embodiments, the optical stop can be moved by changing which LCD layer is active at a given point in time.

Abstract: A model eye for evaluating a retinal imaging system includes a retinal cup, a corneal plate, and a dummy retina. The retinal cup includes an interior concave surface. The corneal plate mates to the retinal cup to define an interior cavity with the interior concave surface of the retinal cup. The dummy retina is formed from a flexible material layer attached to the interior concave surface. The dummy retina mimics a human retina and the flexible material layer includes a plurality of peripheral notches in a perimeter of the flexible material layer to aid the flexible material layer to conform to the interior concave surface.

Abstract: A retinal imaging system includes an eyepiece lens assembly, an image sensor adapted to acquire a retinal image of an eye through the eyepiece lens assembly, and a controller communicatively coupled to the image sensor. The controller including logic that when executed causes the retinal imaging system to perform operations including: obtaining an indication of a pathology of interest (POI) related to the eye or an eye sidedness, selecting an eyebox location for an eyebox of the retinal imaging system based at least in part on the POI or an eye sidedness, and acquiring the retinal image of the eye when the eye is determined to be positioned within the eyebox. The eyebox corresponds to a bound region in space defined relative to the eyepiece lens assembly.

Abstract: The technology described herein is directed to a fundus camera and, more specifically, to a fundus camera having a display that projects active visual alignment stimuli onto an eye of an examinee via one or more components of an optimal assembly. The active visual alignment stimuli are dynamically adjusted to guide an examinee toward optical alignment for fundus imaging.

Abstract: Introduced here are approaches to assessing digital images generated during image capture sessions using a machine learning model so as to stratify patients for examination. By applying the machine learning model to the digital images, the patients that are most in need of further examination can be identified to graders. For example, outputs produced by the diagnostic model may trigger the generation and transmission of notifications for patients that are deemed to warrant further examination.

Abstract: A system for imaging a retina of an eye includes a first lens for positioning proximate to the eye; a light source positioned to illuminate the eye when the system is aligned with the eye; an image sensor adapted to capture a retinal image of the retina through the first lens; an aperture disposed along an optical path extending from the image sensor and passing through the first lens; and a processing apparatus communicatively coupled to the image sensor and the light source, wherein the processing apparatus includes logic that when executed by the processing apparatus causes the system to perform operations including: illuminating the eye with the light source and capturing the retinal image with the image sensor.

Abstract: Eye cups and retinal imaging systems including an eye cup are described. In an embodiment, the eye cup is shaped to couple with an eyepiece lens assembly. In an embodiment, the eye cup includes a concave socket shaped to couple to a periorbital region of an eye, the concave socket defining a viewing aperture positioned to align with a pupil of the eye along a longitudinal axis of the viewing aperture when the concave socket is coupled to the periorbital region; and a flange extending from the concave socket away from the longitudinal axis and shaped to couple with a lateral margin of the periorbital region when the concave socket is coupled to the periorbital region. In an embodiment, an outer edge of the flange extends farther from the longitudinal axis than an outer edge of portion of the concave socket.

Abstract: Introduced here are diagnostic platforms able to optimize computer-aided diagnostic (CADx) models by simulating the optical performance of an imaging device based on its mechanical components. For example, a diagnostic platform may acquire a source image associated with a confirmed diagnosis of a medical condition, simulate optical performance based on design data corresponding to a virtual prototype of the imaging device, generate a training image by altering the source image based on the optical performance, apply a diagnostic model to the training image, and then determine whether the performance of the diagnostic model meets a specified performance threshold. If the diagnostic model fails to meet the specified performance threshold, the diagnostic platform can automatically optimize the diagnostic model for the imaging device by altering its underlying algorithm(s).

Abstract: Device for use in a biosensor comprising a multisite array of test sites, the device being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest from a biological by modulating the pH or ionic gradient near the electrodes in such biosensor. The device provides a biosensor which is more accurate, reliable and the results of which are more reproducible. Analytic methods for more accurately measuring an analyte of interest in a biological sample are also provided.

Abstract: Described herein are systems and methods for delivery of a drug to an eye using a head mounted drug delivery system (e.g., smart eyeglasses). The head mounted drug delivery system can include an iris detection and tracking module to detect an iris of an eye and blinking of the eye; a drug delivery module to receive at least one signal from the iris detection and tracking module and to release a drug onto the eye; and a transmitter to communicate data wirelessly from the iris detection and tracking module and/or the drug delivery module. The drug delivery module includes: a reservoir to store the drug, a pump to propel the drug from the reservoir to at least one nozzle, and at least one nozzle to spray the drug onto the eye. A mobile device can wirelessly receive data from the iris detection and tracking module and/or the drug delivery module.

Abstract: Virtual reality, VR, headset-based and open-display based electronic systems that can be used to perform color vision tests. The systems may improve the sensitivity, consistency, and ease of application of the tests. Other aspects are also described.

Abstract: Disclosed is a headset for monitoring periocular humidity, the headset including a housing configured to be positioned on a user's face and defining a periocular air space. The headset includes a humidity sensor configured to measure a humidity of air within the periocular air space, and an ophthalmic testing unit configured to measure a physiological parameter of an eye of the user. The headset further includes a processor coupled to the humidity sensor and the ophthalmic testing unit. The processor is configured to receive the measured humidity and the measured physiological parameter, and determine an ophthalmic condition based on the measured humidity and the measured physiological parameter.

Abstract: The technology described herein is directed to a fundus camera and, more specifically, to a fundus camera having a display that projects active visual alignment stimuli onto an eye of an examinee via one or more components of an optimal assembly. The active visual alignment stimuli are dynamically adjusted to guide an examinee toward optical alignment for fundus imaging.

Abstract: Introduced here are retinal cameras having optical stops whose size and/or position can be modified to increase the size of the space in which an eye can move while being imaged. In some embodiments, an optical stop is mechanically moved to recover retinal image quality as the subject shifts their eye. In some embodiments, an optical stop is digitally created using a pixelated liquid crystal display (LCD) layer having multiple pixels that are individually controllably. In some embodiments, multiple non-pixelated LCD layers are connected to one another to form a variable transmission stack, and each LCD layer within the variable transmission stack may be offset from the other LCD layers. In such embodiments, the optical stop can be moved by changing which LCD layer is active at a given point in time.

Abstract: A dynamic illuminator includes a central aperture, a ring of inner light sources, a plurality of primary illumination arrays, and a plurality of secondary illumination arrays. The ring of inner light sources is arranged around the central aperture. The plurality of primary illumination arrays extends along radial axes from the central aperture outside of the ring of inner light sources, wherein the primary illumination arrays each includes a plurality of primary light sources. The plurality of secondary illumination arrays is disposed along secondary axes extending from the central aperture outside of the ring of inner light sources. The secondary illumination arrays each includes a plurality of secondary light sources. The secondary axes of the secondary illumination arrays are disposed angularly between adjacent ones of the primary illumination arrays.

Abstract: Introduced here are approaches to assessing whether digital features (or simply “features”) detected in digital images by detection models are representative of artifacts that can obscure actual pathologies. A diagnostic platform may characterize each digital feature detected in a digital image based on its likelihood of being an artifact. For instance, a digital feature could be characterized as being representative of an artifact caused by improper illumination, an artifact caused by a physical element that is adhered to the lens through which light is collected by an imaging device, or a pathological feature indicative of a disease.