Patents by Inventor Samuel A. Wickline

Samuel A. Wickline has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PEPTIDE-SMALL INTERFERING RNA-HYALURONIC ACID NANOPARTICLES AND METHODS OF USE THEREOF
    Publication number: 20240216520
    Abstract: The present disclosure provides nanoparticle compositions and their use in the treatment of viral infections.
    Type: Application
    Filed: April 6, 2022
    Publication date: July 4, 2024
    Inventors: Samuel WICKLINE, Hua PAN
  • Antithrombotic nanoparticles and methods for treating necrotizing enterocolitis
    Patent number: 11779544
    Abstract: The present disclosure is directed to antithrombotic nanoparticles and methods of treating necrotizing enterocolitis.
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: October 10, 2023
    Assignee: University of South Florida
    Inventors: Akhil Maheshwari, Samuel Wickline, Kopperuncholan Namachivayam, Hua Pan
  • BOOTSTRAPPED SEMANTIC PREPROCESSING FOR MEDICAL DATASETS
    Publication number: 20230274562
    Abstract: Bootstrapped semantic preprocessing techniques for medical datasets such as whole slide histopathology image datasets can be used to more efficiently and effectively train artificial intelligence used for medical purposes. The bootstrapped semantic preprocessing techniques generally include deriving metrics from image features and adjusting images according to the metrics. This process can be repeated iteratively for unknown and unlabeled data using a bootstrapping technique to normalize unknown samples to the training dataset distribution.
    Type: Application
    Filed: February 27, 2023
    Publication date: August 31, 2023
    Inventors: Christopher Collazo, Lawrence Hall, Dmitry Goldgof, Samuel Wickline, Hua Pan
  • PEPTIDE-POLYNUCLEOTIDE-HYALURONIC ACID NANOPARTICLES AND METHODS FOR POLYNUCLEOTIDE TRANSFECTION
    Publication number: 20230263855
    Abstract: The present disclosure relates to nanoparticles and methods for polynucleotide transfection.
    Type: Application
    Filed: November 18, 2022
    Publication date: August 24, 2023
    Inventors: Samuel A. Wickline, Hua Pan, Christine Thien-Nga Pham, Huimin Yan
  • Peptide-polynucleotide-hyaluronic acid nanoparticles and methods for polynucleotide transfection
    Patent number: 11529388
    Abstract: The present disclosure relates to nanoparticles and methods for polynucleotide transfection.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: December 20, 2022
    Inventors: Samuel A. Wickline, Hua Pan, Christine Thien-Nga Pham, Huimin Yan
  • Nanoparticle delivery system for diseases associated with major basement membrane components of blood vessels accessible from blood stream
    Patent number: 11337931
    Abstract: A targeting nanoparticle composition and method of treatment for diseases associated with major basement membrane components of blood vessels accessible from blood stream is presented. The composition includes pegylated perfluorocarbon nanoparticles having a targeting ligand attached that targets the basement membrane components, specifically collagen IV. The targeted nanoparticles may contain at least one pharmaceutically active agent capable of treating a glomerular disease such as lupus nephritis.
    Type: Grant
    Filed: November 17, 2020
    Date of Patent: May 24, 2022
    Assignee: University of South Florida
    Inventors: Ruisheng Liu, Samuel A. Wickline, Jin Wei, Hua Pan, Jie Zhang
  • Antithrombotic nanoparticles and methods for treating necrotizing enterocolitis
    Patent number: 10987315
    Abstract: The present disclosure is directed to antithrombotic nanoparticles and methods of treating necrotizing enterocolitis.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: April 27, 2021
    Assignee: University of South Florida
    Inventors: Akhil Maheshwari, Samuel Wickline, Kopperuncholan Namachivayam, Hua Pan
  • NANOPARTICLE DELIVERY SYSTEM FOR DISEASES ASSOCIATED WITH MAJOR BASEMENT MEMBRANE COMPONENTS OF BLOOD VESSELS ACCESSIBLE FROM BLOOD STREAM
    Publication number: 20210069119
    Abstract: A targeting nanoparticle composition and method of treatment for diseases associated with major basement membrane components of blood vessels accessible from blood stream is presented. The composition includes pegylated perfluorocarbon nanoparticles having a targeting ligand attached that targets the basement membrane components, specifically collagen IV. The targeted nanoparticles may contain at least one pharmaceutically active agent capable of treating a glomerular disease such as lupus nephritis.
    Type: Application
    Filed: November 17, 2020
    Publication date: March 11, 2021
    Inventors: Ruisheng Liu, Samuel A. Wickline, Jin Wei, Hua Pan, Jie Zhang
  • PEPTIDE-POLYNUCLEOTIDE-HYALURONIC ACID NANOPARTICLES AND METHODS FOR POLYNUCLEOTIDE TRANSFECTION
    Publication number: 20200353036
    Abstract: The present disclosure relates to nanoparticles and methods for polynucleotide transfection.
    Type: Application
    Filed: May 8, 2020
    Publication date: November 12, 2020
    Inventors: Samuel A. Wickline, Hua Pan, Christine Thien-Nga Pham, Huimin Yan
  • Peptide-polynucleotide complex for polynucleotide transfection
    Patent number: 10758627
    Abstract: A pharmaceutical composition comprising a peptide-polynucleotide complex, and methods of use thereof.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: September 1, 2020
    Assignee: Washington University
    Inventors: Samuel A. Wickline, Kirk Hou
  • PEPTIDE-POLYNUCLEOTIDE COMPLEX FOR POLYNUCLEOTIDE TRANSFECTION
    Publication number: 20200046844
    Abstract: A pharmaceutical composition comprising a peptide-polynucleotide complex, and methods of use thereof.
    Type: Application
    Filed: July 1, 2016
    Publication date: February 13, 2020
    Inventors: Samuel A. Wickline, Kirk Hou
  • Compositions and methods for polynucleotide transfection
    Patent number: 9987371
    Abstract: A pharmaceutical composition comprising a peptide-polynucleotide complex, and methods of use thereof.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: June 5, 2018
    Assignee: WASHINGTON UNIVERSITY
    Inventors: Samuel A. Wickline, Kirk Hou
  • Antithrombotic nanoparticle
    Patent number: 9808500
    Abstract: The present invention encompasses an antithrombotic nanoparticle and use thereof.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: November 7, 2017
    Assignee: WASHINGTON UNIVERSITY
    Inventors: Samuel A. Wickline, Jacob Myerson, Rohun Palekar, Hua Pan
  • Antithrombotic nanoparticle
    Patent number: 9764043
    Abstract: The present invention encompasses an antithrombotic nanoparticle.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: September 19, 2017
    Assignee: WASHINGTON UNIVERSITY
    Inventors: Jacob Myerson, Samuel A. Wickline
  • ANTITHROMBOTIC NANOPARTICLE
    Publication number: 20170065669
    Abstract: The present invention encompasses an antithrombotic nanoparticle and use thereof.
    Type: Application
    Filed: October 25, 2016
    Publication date: March 9, 2017
    Inventors: Samuel A. Wickline, Jacob Myerson
  • METHODS FOR IMPROVING MUSCLE STRENGTH
    Publication number: 20160324835
    Abstract: The present invention relates to methods for improving muscle strength and treating muscular dystrophy.
    Type: Application
    Filed: July 18, 2016
    Publication date: November 10, 2016
    Inventors: Samuel A. Wickline, Gregory M. Lanza
  • Ligand directed toroidal nanoparticles for therapy and diagnostic imaging
    Patent number: 9468607
    Abstract: The present invention provides nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles to deliver therapeutic agents and/or imaging agents.
    Type: Grant
    Filed: October 9, 2008
    Date of Patent: October 18, 2016
    Assignee: WASHINGTON UNIVERSITY
    Inventors: Gregory M. Lanza, Samuel A. Wickline, Dipanjan Pan
  • NANOPARTICLE DELIVERY SYSTEMS FOR CYTOLYTIC PEPTIDE PRODRUGS
    Publication number: 20160296628
    Abstract: Compositions and methods of treatment using conjugates of pore-forming compounds coupled to blocking segments by protease-cleavable linkers and absorbed onto lipid-based delivery vehicles are described. These compositions and methods permit personalization of treatment.
    Type: Application
    Filed: January 22, 2016
    Publication date: October 13, 2016
    Applicant: Washington University
    Inventors: Samuel A. WICKLINE, Andrew JALLOUK, Paul SCHLESINGER, Hua PAN
  • Multifunctional nanoscopy for imaging cells
    Patent number: 9453809
    Abstract: Disclosed herein is an apparatus comprising a metal shunt and a semiconductor material in electrical contact with the metal shunt, thereby defining a semiconductor/metal interface for passing a flow of current between the semiconductor material and the metal shunt in response to an application of an electrical bias to the apparatus, wherein the semiconductor material and the metal shunt lie in different planes that are substantially parallel planes, the semiconductor/metal interface thereby being parallel to planes in which the semiconductor material and the metal shunt lie, and wherein, when under the electrical bias, the semiconductor/metal interface is configured to exhibit a change in resistance thereof in response to a perturbation. Such an apparatus can be used as a sensor and deployed as an array of sensors.
    Type: Grant
    Filed: January 23, 2014
    Date of Patent: September 27, 2016
    Assignee: Washington University
    Inventors: Stuart A. Solin, Kirk D. Wallace, Samuel A. Wickline, Michael S. Hughes
  • Particles for imaging
    Patent number: 9446150
    Abstract: The invention encompasses particles comprising metal atoms, methods of making the particles, and methods for using the particles. In particular, the particles may be used to image biological tissues or to deliver a bioactive agent.
    Type: Grant
    Filed: October 9, 2008
    Date of Patent: September 20, 2016
    Assignee: WASHINGTON UNIVERSITY
    Inventors: Gregory M. Lanza, Samuel A. Wickline, Dipanjan Pan, Angana Senpan