Patents by Inventor Samuel A. Wickline

Samuel A. Wickline has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20070255117
    Abstract: Methods and devices for enhanced ultrasound detection based upon changing temperature and ultrasound reflectivity of a temperature-dependent contrast agent bound to an ultrasound target are disclosed. The methods and devices can be used for enhanced imaging alone or in conjunction with drug delivery, with therapeutic approaches such as hyperthermia or cryotherapy or with other imaging modalities.
    Type: Application
    Filed: February 20, 2007
    Publication date: November 1, 2007
    Applicant: Barnes-Jewish Hospital
    Inventors: Gregory Lanza, Samuel Wickline, Christopher Hall
  • Publication number: 20070237721
    Abstract: MRI contrast agents that employ paramagnetic agents and chemical exchange saturation transfer (paraCEST) and which are coupled to targeted particulate delivery vehicles provide sufficient concentration of the paraCEST contrast agents to obtain useful images of target tissues or organs. In addition, the image contrast may be switched on or off with a presaturation radio frequency pulse, avoiding the necessity obtaining pre-injection and post-injection images.
    Type: Application
    Filed: March 29, 2007
    Publication date: October 11, 2007
    Inventors: Gregory LANZA, Samuel Wickline, Garry Kiefer, Phillip Athey
  • Patent number: 7279150
    Abstract: Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the particulate components.
    Type: Grant
    Filed: January 26, 2004
    Date of Patent: October 9, 2007
    Assignees: Barnes-Jewish Hospital, The Dow Chemical Corporation
    Inventors: Gregory M. Lanza, Samuel A. Wickline, Phillip S. Athey, Gyongyi Gulyas, Garry E. Kiefer
  • Publication number: 20070232909
    Abstract: Disclosed herein is a technique for performing medical imaging on a region of interest (ROI) wherein information theoretic signal receivers are used to enhance the detection and monitoring of pathologies such as angiogenesis and muscular dystrophy. Examples of information theoretic signal receivers that can be used in the practice of the invention include Shannon entropy signal receivers, continuous limit Shannon entropy signal receivers, Renyi entropy signal receivers, specific heat analog signal receivers, and thermodynamic energy analog signal receivers. The contrast enhancement provided by contrast agents, either targeted contrast agents or bubble-based contrast agents, is enhanced through the use of such information theoretic signal receivers. Further still, the contrast agents can be heated to further enhance visualization with information theoretic signal receivers.
    Type: Application
    Filed: March 28, 2007
    Publication date: October 4, 2007
    Applicant: WASHINGTON UNIVERSITY
    Inventors: Michael S. Hughes, Samuel A. Wickline, Gregory M. Lanza
  • Publication number: 20070202040
    Abstract: Emulsions comprising nanoparticles formed from high boiling perfluorochemical substances, said particles coated with a lipid/surfactant coating are made target-specific by directly coupling said nanoparticles to a targeting ligand. The nanoparticles may further include biologically active agents, radionuclides, and/or other imaging agents.
    Type: Application
    Filed: April 25, 2007
    Publication date: August 30, 2007
    Applicant: Barnes-Jewish Hospital
    Inventors: Gregory Lanza, Samuel Wickline
  • Patent number: 7255875
    Abstract: Emulsions preferably of nanoparticles formed from high boiling liquid perfluorochemical substances, said particles coated with a lipid/surfactant coating are made specific to regions of activated endothelial cells by coupling said nanoparticles to a ligand specific for ?v?3 integrin, other than an antibody. The nanoparticles may further include biologically active agents, radionuclides, or other imaging agents.
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: August 14, 2007
    Assignees: Barnes-Jewish Hospital, Bristol Myers Squibb Medical Imaging, Inc.
    Inventors: Gregory M. Lanza, Samuel A. Wickline, Tom Harris
  • Patent number: 7235227
    Abstract: An improved contrast agent for magnetic resonance imaging comprises particles to each of which is coupled a multiplicity of chelating agents containing paramagnetic ions. In the improved agent, the position of the ion is offset from the surface of the particle so as to improve the relaxivity imparted by the contrast agent. A tether offsetting the chelate from the surface of the particle may optionally contain cleavage sites permitting more facile excretion of the chelated paramagnetic ion.
    Type: Grant
    Filed: March 26, 2003
    Date of Patent: June 26, 2007
    Assignee: Barnes-Jewish Hospital
    Inventors: Gregory M. Lanza, Samuel A. Wickline
  • Publication number: 20070140965
    Abstract: Methods for inhibiting restenosis in blood vessels expanded by angioplasty are described. The method comprises administering blood vessel wall-targeted emulsion containing an anti-restenotic agent.
    Type: Application
    Filed: December 1, 2006
    Publication date: June 21, 2007
    Applicant: Barnes-Jewish Hospital
    Inventors: Gregory Lanza, Samuel Wickline
  • Patent number: 7220401
    Abstract: Emulsions comprising nanoparticles formed from high boiling perfluorochemical substances, said particles coated with a lipid/surfactant coating are made target-specific by directly coupling said nanoparticles to a targeting ligand. The nanoparticles may further include biologically active agents, radionuclides, and/or other imaging agents.
    Type: Grant
    Filed: August 20, 2002
    Date of Patent: May 22, 2007
    Assignee: Barnes-Jewish Hospital
    Inventors: Gregory Lanza, Samuel A. Wickline
  • Patent number: 7186399
    Abstract: A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site specific ligand activated with a biotin activating agent; (b) an avidin activating agent; and (c) lipid encapsulated particles activated with a biotin activating agent, whereby the ligand is conjugated to the particles through an avidin-biotin interaction and the resulting conjugate is bound to the molecular epitopes on such surface. The conjugate is effective for imaging by x-ray, ultrasound, magnetic resonance or positron emission tomography. Compositions for use in ultrasonic imaging of natural or synthetic surfaces and for enhancing the acoustic reflectivity thereof are also disclosed.
    Type: Grant
    Filed: November 22, 2002
    Date of Patent: March 6, 2007
    Assignee: Barnes-Jewish Hospital
    Inventors: Gregory M. Lanza, Samuel A. Wickline
  • Patent number: 7179449
    Abstract: Methods and devices for enhanced ultrasound detection based upon changing temperature and ultrasound reflectivity of a temperature-dependent contrast agent bound to an ultrasound target are disclosed. The methods and devices can be used for enhanced imaging alone or in conjunction with drug delivery, with therapeutic approaches such as hyperthermia or cryotherapy or with other imaging modalities.
    Type: Grant
    Filed: January 30, 2001
    Date of Patent: February 20, 2007
    Assignee: Barnes-Jewish Hospital
    Inventors: Gregory M. Lanza, Samuel A. Wickline, Christopher S. Hall
  • Publication number: 20070010577
    Abstract: This invention relates generally to methods for ameliorating at least one symptom or aspect of atherosclerosis. The methods include administration of targeted carrier compositions comprising a therapeutic agent effective in ameliorating at least one aspect of atherosclerosis coupled to a targeting ligand effective is targeting the therapeutic agent to tissue associated with atherosclerotic plaque.
    Type: Application
    Filed: January 16, 2004
    Publication date: January 11, 2007
    Applicant: BARNES-JEWISH HOSPITAL
    Inventors: Gregory Lanza, Samuel Wickline
  • Publication number: 20060239919
    Abstract: Disclosed herein is a medical imaging technique that uses a fluorinated nanoparticle contrast agent for imaging of an interior portion of a body. The fluorinated nanoparticles preferably comprise nontargeted intravascular fluorocarbon or perfluorocarbon nanoparticles. The interior body portion may be a patient's vasculature, and the medical imaging is preferably noninvasive MR angiography, which may encompass (either for 2D imaging or 3D imaging) MR coronary angiography, MR carotid angiography, MR peripheral angiography, MR cerebral angiography, MR arterial angiography, and MR venous angiography. Coils tuned to match to the 19F signal can be used, or dual tuned coils for 19F and 1H imaging can be used. Clinical field strengths (e.g. 1.5 T) and clinical doses may be used while still providing effective images.
    Type: Application
    Filed: March 3, 2006
    Publication date: October 26, 2006
    Inventors: Samuel Wickline, Gregory Lanza
  • Patent number: 7096057
    Abstract: Disclosed herein is an RF probe for use with a medical imaging apparatus, the probe comprising an intracorporeal self-tuned resonator coil for receiving a signal indicative of an image of an interior portion of a body. The resonator coil is preferably coupled to a transmission medium having a characteristic impedance such that the resonator coil is substantially self-matching with the transmission medium's characteristic impedance. Preferably the resonator coil comprises an open wound conductor having a plurality of turns. The length of the resonator coil can be used to tune the resonator coil to a desired frequency, such as the Larmour frequency. Further, a return lead of the transmission medium is preferably coupled to an end of the conductor, and a signal lead of the transmission medium is preferably coupled to a point on the winding, thereby defining a turns ratio for the resonator coil.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: August 22, 2006
    Assignee: Barnes Jewish Hospital
    Inventors: Frank Hockett, Samuel A. Wickline, Xin Yu
  • Publication number: 20060147380
    Abstract: Emulsions preferably of nanoparticles formed from high boiling liquid perfluorochemical substances, said particles coated with a lipid/surfactant coating are made specific to regions of activated endothelial cells by coupling said nanoparticles to a ligand specific for ?v?3 integrin, other than an antibody. The nanoparticles may further include biologically active agents, radionuclides, or other imaging agents.
    Type: Application
    Filed: December 16, 2005
    Publication date: July 6, 2006
    Inventors: Gregory Lanza, Samuel Wickline, Tom Harris
  • Publication number: 20050175541
    Abstract: The invention is directed to methods for the delivery of a therapeutic agent using lipid-encapsulated particles containing the therapeutic agent and ultrasound energy. For example, it particularly relates to the use of ultrasound with a lipid-encapsulated emulsion comprising an oil where the emulsion is coupled a targeting ligand and comprises a therapeutic agent.
    Type: Application
    Filed: November 19, 2004
    Publication date: August 11, 2005
    Inventors: Gregory Lanza, Samuel Wickline
  • Publication number: 20050079131
    Abstract: Emulsions preferably of nanoparticles formed from oil compounds coupled to a high Z number atom, said particles coated with a lipid/surfactant coating. The nanoparticles are made specific to targeted cells or tissues by coupling said nanoparticles to a ligand specific for the target cells or tissues. The nanoparticles may further include biologically active agents, radionuclides and/or other imaging agents.
    Type: Application
    Filed: August 6, 2004
    Publication date: April 14, 2005
    Inventors: Gregory Lanza, Samuel Wickline
  • Patent number: 6869591
    Abstract: An improved contrast agent for magnetic resonance imaging comprises particles to each of which is coupled a multiplicity of chelating agents containing paramagnetic ions. In the improved agent, the position of the ion is offset from the surface of the particle so as to improve the relaxivity imparted by the contrast agent.
    Type: Grant
    Filed: May 21, 2002
    Date of Patent: March 22, 2005
    Assignee: Barnes-Jewish Hospital
    Inventors: Gregory Lanza, Samuel A. Wickline
  • Publication number: 20040248856
    Abstract: Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the particulate components.
    Type: Application
    Filed: January 26, 2004
    Publication date: December 9, 2004
    Inventors: Gregory M. Lanza, Samuel A. Wickline
  • Patent number: 6821506
    Abstract: A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site specific ligand activated with a biotin activating agent; (b) an avidin activating agent; and (c) lipid encapsulated particles activated with a biotin activating agent, whereby the ligand is conjugated to the particles through an avidin-biotin interaction and the resulting conjugate is bound to the molecular epitopes on such surface. The conjugate is effective for imaging by x-ray, ultrasound, magnetic resonance or positron emission tomography. Compositions for use in ultrasonic imaging of natural or synthetic surfaces and for enhancing the acoustic reflectivity thereof are also disclosed.
    Type: Grant
    Filed: December 28, 2001
    Date of Patent: November 23, 2004
    Assignee: Barnes-Jewish Hospital
    Inventors: Gregory M. Lanza, Samuel A. Wickline