Patents by Inventor Samuel A. Wickline

Samuel A. Wickline has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150357503
    Abstract: The inventors disclose a new high performance optical sensor, preferably of nanoscale dimensions, that functions at room temperature based on an extraordinary optoconductance (EOC) phenomenon, and preferably an inverse EOC (I-EOC) phenomenon, in a metal-semiconductor hybrid (MSH) structure having a semiconductor/metal interface. Such a design shows efficient photon sensing not exhibited by bare semiconductors. In experimentation with an exemplary embodiment, ultrahigh spatial resolution 4-point optoconductance measurements using Helium-Neon laser radiation reveal a strikingly large optoconductance property, an observed maximum measurement of 9460% EOC, for a 250 nm device. Such an exemplary EOC device also demonstrates specific detectivity higher than 5.06×1011 cm?Hz/W for 632 nm illumination and a high dynamic response of 40 dB making such sensors technologically competitive for a wide range of practical applications.
    Type: Application
    Filed: August 17, 2015
    Publication date: December 10, 2015
    Inventors: Stuart A. Solin, Samuel A. Wickline, AKM Shah Newaz, Kirk D. Wallace
  • Publication number: 20150335623
    Abstract: The present invention relates to methods for improving muscle strength and treating muscular dystrophy.
    Type: Application
    Filed: August 3, 2015
    Publication date: November 26, 2015
    Inventors: Samuel A. Wickline, Gregory M. Lanza
  • Publication number: 20150314013
    Abstract: A pharmaceutical composition comprising a peptide-polynucleotide complex, and methods of use thereof.
    Type: Application
    Filed: July 2, 2015
    Publication date: November 5, 2015
    Inventors: Samuel A. Wickline, Kirk Hou
  • Patent number: 9111838
    Abstract: The inventors disclose a new high performance optical sensor, preferably of nanoscale dimensions, that functions at room temperature based on an extraordinary optoconductance (EOC) phenomenon, and preferably an inverse EOC (I-EOC) phenomenon, in a metal-semiconductor hybrid (MSH) structure having a semiconductor/metal interface. Such a design shows efficient photon sensing not exhibited by bare semiconductors. In experimentation with an exemplary embodiment, ultrahigh spatial resolution 4-point optoconductance measurements using Helium-Neon laser radiation reveal a strikingly large optoconductance property, an observed maximum measurement of 9460% EOC, for a 250 nm device. Such an exemplary EOC device also demonstrates specific detectivity higher than 5.06×1011 cm?Hz/W for 632 nm illumination and a high dynamic response of 40 dB making such sensors technologically competitive for a wide range of practical applications.
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: August 18, 2015
    Assignee: Washington University
    Inventors: Stuart A. Solin, Samuel A. Wickline, AKM Shah Newaz, Kirk D. Wallace
  • Patent number: 9095521
    Abstract: The present invention relates to methods for improving muscle strength and treating muscular dystrophy.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: August 4, 2015
    Assignee: Washington University
    Inventors: Samuel A. Wickline, Gregory M. Lanza
  • Publication number: 20150011578
    Abstract: The present invention relates to methods for improving muscle strength and treating muscular dystrophy.
    Type: Application
    Filed: February 1, 2013
    Publication date: January 8, 2015
    Inventors: Samuel A. Wickline, Gregory M. Lanza
  • Publication number: 20140197855
    Abstract: Disclosed herein is an apparatus comprising a metal shunt and a semiconductor material in electrical contact with the metal shunt, thereby defining a semiconductor/metal interface for passing a flow of current between the semiconductor material and the metal shunt in response to an application of an electrical bias to the apparatus, wherein the semiconductor material and the metal shunt lie in different planes that are substantially parallel planes, the semiconductor/metal interface thereby being parallel to planes in which the semiconductor material and the metal shunt lie, and wherein, when under the electrical bias, the semiconductor/metal interface is configured to exhibit a change in resistance thereof in response to a perturbation. Such an apparatus can be used as a sensor and deployed as an array of sensors.
    Type: Application
    Filed: January 23, 2014
    Publication date: July 17, 2014
    Inventors: Stuart A. Solin, Kirk D. Wallace, Samuel A. Wickline, Michael S. Hughes
  • Patent number: 8637944
    Abstract: Disclosed herein is an apparatus comprising a metal shunt and a planar semiconductor material in electrical contact with the metal shunt, the metal shunt located on a surface of the semiconductor material, thereby defining a semiconductor/metal interface for passing a flow of current between the semiconductor material and the metal shunt in response to an application of an electrical bias to the apparatus, wherein a portion of that semiconductor material surface is not covered by the metal shunt, wherein the semiconductor material and the metal shunt lie in different planes that are substantially parallel planes, the semiconductor/metal interface thereby being parallel to the plane of semiconductor material, and wherein, when under the electrical bias, the semiconductor/metal interface is configured to exhibit a change in resistance thereof in response to a perturbation. Such an apparatus can be used as a sensor and deployed as an array of sensors.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: January 28, 2014
    Assignee: Washington University
    Inventors: Stuart A. Solin, Kirk D. Wallace, Samuel A. Wickline, Michael S. Hughes
  • Patent number: 8617516
    Abstract: The present invention provides a substantially non-lytic, non-cytotoxic anchor peptide that is capable of stably inserting into lipid membranes. In particular, the invention provides nanoparticles comprising stably inserted anchor peptides, which may be conjugated to a variety of different cargo complexes.
    Type: Grant
    Filed: October 22, 2010
    Date of Patent: December 31, 2013
    Assignee: Washington University
    Inventors: Samuel A. Wickline, Hua Pan, Neelesh R. Soman, Gregory M. Lanza, Paul H. Schlesinger
  • Publication number: 20130278806
    Abstract: The inventors disclose a new high performance optical sensor, preferably of nanoscale dimensions, that functions at room temperature based on an extraordinary optoconductance (EOC) phenomenon, and preferably an inverse EOC (I-EOC) phenomenon, in a metal-semiconductor hybrid (MSH) structure having a semiconductor/metal interface. Such a design shows efficient photon sensing not exhibited by bare semiconductors. In experimentation with an exemplary embodiment, ultrahigh spatial resolution 4-point optoconductance measurements using Helium-Neon laser radiation reveal a strikingly large optoconductance property, an observed maximum measurement of 9460% EOC, for a 250 nm device. Such an exemplary EOC device also demonstrates specific detectivity higher than 5.06×1011 cm?Hz/W for 632 nm illumination and a high dynamic response of 40 dB making such sensors technologically competitive for a wide range of practical applications.
    Type: Application
    Filed: June 18, 2013
    Publication date: October 24, 2013
    Inventors: Stuart A. Solin, Samuel A. Wickline, AKM Shah Newaz, Kirk D. Wallace
  • Publication number: 20130234740
    Abstract: Disclosed herein is an apparatus comprising a metal shunt and a planar semiconductor material in electrical contact with the metal shunt, the metal shunt located on a surface of the semiconductor material, thereby defining a semiconductor/metal interface for passing a flow of current between the semiconductor material and the metal shunt in response to an application of an electrical bias to the apparatus, wherein a portion of that semiconductor material surface is not covered by the metal shunt, wherein the semiconductor material and the metal shunt lie in different planes that are substantially parallel planes, the semiconductor/metal interface thereby being parallel to the plane of semiconductor material, and wherein, when under the electrical bias, the semiconductor/metal interface is configured to exhibit a change in resistance thereof in response to a perturbation. Such an apparatus can be used as a sensor and deployed as an array of sensors.
    Type: Application
    Filed: May 6, 2013
    Publication date: September 12, 2013
    Inventors: Stuart A. Solin, Kirk D. Wallace, Samuel A. Wickline, Michael S. Hughes
  • Patent number: 8500644
    Abstract: A method for imaging a region of interest (ROI) within a body. The method includes applying ultrasound energy to the ROI, receiving ultrasound data for the ROI in response to the applied ultrasound energy, executing a moving window analysis on the received ultrasound data to generate a plurality of windows of information, applying a Renyi entropy signal receiver to each of the generated windows to generate Renyi entropy data, and presenting an image of the ROI based on the Renyi entropy data.
    Type: Grant
    Filed: October 28, 2009
    Date of Patent: August 6, 2013
    Assignee: Washington University
    Inventors: Michael S. Hughes, John McCarthy, Gregory Lanza, Mladen Victor Wickerhauser, Samuel Wickline
  • Patent number: 8496945
    Abstract: Compositions which comprise emulsions of nanoparticles for delivery of membrane-integrating peptides are described. The nanoparticles comprise a liquid hydrophobic core coated with a lipid/surfactant layer which contains the membrane-integrating peptides. Methods to use such compositions are also described.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: July 30, 2013
    Assignee: Washington University
    Inventors: Paul Schlesinger, Neelesh Soman, Gregory Lanza, Samuel A. Wickline
  • Patent number: 8497459
    Abstract: The inventors disclose a new high performance optical sensor, preferably of nanoscale dimensions, that functions at room temperature based on an extraordinary optoconductance (EOC) phenomenon, and preferably an inverse EOC (I-EOC) phenomenon, in a metal-semiconductor hybrid (MSH) structure having a semiconductor/metal interface. Such a design shows efficient photon sensing not exhibited by bare semiconductors. In experimentation with an exemplary embodiment, ultrahigh spatial resolution 4-point optoconductance measurements using Helium-Neon laser radiation reveal a strikingly large optoconductance property, an observed maximum measurement of 9460% EOC, for a 250 nm device. Such an exemplary EOC device also demonstrates specific detectivity higher than 5.06×1011 cm?Hz/W for 632 nm illumination and a high dynamic response of 40 dB making such sensors technologically competitive for a wide range of practical applications.
    Type: Grant
    Filed: January 7, 2011
    Date of Patent: July 30, 2013
    Assignee: Washington University
    Inventors: Stuart A. Solin, Samuel A. Wickline, Akm Shah Newaz, Kirk D. Wallace
  • Patent number: 8436436
    Abstract: Disclosed herein is an apparatus for sensing characteristics of an object. In a preferred embodiment, the apparatus comprises an array, wherein the array comprises a plurality of nanoscale hybrid semiconductor/metal devices which are in proximity to an object, each hybrid semiconductor/metal device being configured to produce a voltage in response to a perturbation, wherein the produced voltage is indicative of a characteristic of the object. Any of a variety of nanoscale EXX sensors can be selected as the hybrid semiconductor/metal devices in the array. With such an array, ultra high resolution images of nanoscopic resolution can be generated of objects such as living cells, wherein the images are indicative of a variety of cell biologic processes.
    Type: Grant
    Filed: July 31, 2007
    Date of Patent: May 7, 2013
    Assignee: Washington University
    Inventors: Stuart A. Solin, Kirk D. Wallace, Samuel A. Wickline, Michael S. Hughes
  • Publication number: 20130064765
    Abstract: The present invention encompasses an antithrombotic nanoparticle.
    Type: Application
    Filed: December 17, 2010
    Publication date: March 14, 2013
    Applicant: THE WASHINGTON UNIVERSITY
    Inventors: Jacob Myerson, Samuel A. Wickline
  • Publication number: 20120128590
    Abstract: Compositions which comprise emulsions of nanoparticles for delivery of membrane-integrating peptides are described. The nanoparticles comprise a liquid hydrophobic core coated with a lipid/surfactant layer which contains the membrane-integrating peptides. Methods to use such compositions are also described.
    Type: Application
    Filed: May 17, 2011
    Publication date: May 24, 2012
    Applicant: Washington University
    Inventors: Paul Schlesinger, Neelesh Soman, Gregory Lanza, Samuel A. Wickline
  • Publication number: 20120100186
    Abstract: Nanoparticulate compositions which employ membrane-integrating peptides to effect contraception and/or protection against infection by sexually transmitted virus are described.
    Type: Application
    Filed: October 20, 2011
    Publication date: April 26, 2012
    Applicant: Washington University
    Inventors: Samuel A. WICKLINE, Gregory LANZA, Joshua HOOD
  • Publication number: 20110233382
    Abstract: The inventors disclose a new high performance optical sensor, preferably of nanoscale dimensions, that functions at room temperature based on an extraordinary optoconductance (EOC) phenomenon, and preferably an inverse EOC (I-EOC) phenomenon, in a metal-semiconductor hybrid (MSH) structure having a semiconductor/metal interface. Such a design shows efficient photon sensing not exhibited by bare semiconductors. In experimentation with an exemplary embodiment, ultrahigh spatial resolution 4-point optoconductance measurements using Helium-Neon laser radiation reveal a strikingly large optoconductance property, an observed maximum measurement of 9460% EOC, for a 250 nm device. Such an exemplary EOC device also demonstrates specific detectivity higher than 5.06×1011 cm?Hz/W for 632 nm illumination and a high dynamic response of 40 dB making such sensors technologically competitive for a wide range of practical applications.
    Type: Application
    Filed: January 7, 2011
    Publication date: September 29, 2011
    Inventors: Stuart A. Solin, Samuel A. Wickline, AKM Shah Newaz, Kirk D. Wallace
  • Publication number: 20110208058
    Abstract: A method for imaging a region of interest (ROI) within a body. The method includes applying ultrasound energy to the ROI, receiving ultrasound data for the ROI in response to the applied ultrasound energy, executing a moving window analysis on the received ultrasound data to generate a plurality of windows of information, applying a Renyi entropy signal receiver to each of the generated windows to generate Renyi entropy data, and presenting an image of the ROI based on the Renyi entropy data.
    Type: Application
    Filed: October 28, 2009
    Publication date: August 25, 2011
    Applicant: WASHINGTON UNIVERSITY IN ST. LOUIS
    Inventors: Michael S. Hughes, John McCarthy, Gregory Lanza, Mladen Victor Wickerhauser, Samuel Wickline