Patents by Inventor Sanjeev Gangwar

Sanjeev Gangwar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING A PYRIDINE OR PYRAZINE MOIETY, CONJUGATES THEREOF, AND METHODS AND USES THEREFOR
    Publication number: 20190055245
    Abstract: Compounds having a structure according to formula (I) where R1 and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
    Type: Application
    Filed: August 14, 2018
    Publication date: February 21, 2019
    Inventors: Yam B. POUDEL, Liqi He, Sanjeev Gangwar, Shoshana L. Posy, Prasanna Sivaprakasam
  • TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING A HETEROBIARYL MOIETY, CONJUGATES THEREOF, AND METHODS AND USES THEREFOR
    Publication number: 20190055246
    Abstract: Compounds having a structure according to formula (I) or (II) where R1, R2, and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
    Type: Application
    Filed: August 14, 2018
    Publication date: February 21, 2019
    Inventors: Liqi HE, Sanjeev Gangwar, Shoshana L. Posy, Yam B. Poudel, Prasanna Sivaprakasam
  • Benzodiazepine dimers, conjugates thereof, and methods of making and using
    Patent number: 10112975
    Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: October 30, 2018
    Assignee: Briston-Myers Squibb Company
    Inventors: Yong Zhang, Ivar M. McDonald, Naidu S. Chowdari, Tram N. Huynh, Robert M. Borzilleri, Sanjeev Gangwar
  • Tubulysin analogs and methods of making and use
    Patent number: 10077287
    Abstract: Tubulysin analogs of the formula (I) where R1, R2 R3, R4, R5, R6, R7, and Y are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: September 18, 2018
    Assignee: Bristol-Myers Squibb Company
    Inventors: Heidi L. Perez, Donna Wei, Robert M. Borzilleri, Sanjeev Gangwar, Gretchen M. Schroeder, Heng Cheng, Robert J. Schmidt
  • ANTIPROLIFERATIVE COMPOUNDS AND CONJUGATES MADE THEREFROM
    Publication number: 20180110873
    Abstract: A compound capable of inhibiting cell proliferation, having a structure according to formula (I) wherein the variables in formula (I) are as defined in the specification. Such compounds are useful as anti-cancer agents, especially in antibody-drug conjugates.
    Type: Application
    Filed: October 20, 2017
    Publication date: April 26, 2018
    Inventors: Ivar M. MCDONALD, Prasanna SIVAPRAKASAM, Christiana I. IWUAGWU, Kevin M. Peese, Heng CHENG, Naidu S. CHOWDARI, Sanjeev GANGWAR
  • BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING
    Publication number: 20180079781
    Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
    Type: Application
    Filed: October 17, 2017
    Publication date: March 22, 2018
    Inventors: Yong ZHANG, Ivar M. MCDONALD, Naidu S. CHOWDARI, Tram N. HUYNH, Robert M. BORZILLERI, Sanjeev GANGWAR
  • DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS
    Publication number: 20180065976
    Abstract: In one aspect, the present disclosure provides new analogs of uncialamycin. The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates which may be used to treat cancer or another disease or disorder.
    Type: Application
    Filed: August 15, 2017
    Publication date: March 8, 2018
    Applicants: WILLIAM MARSH RICE UNIVERSITY, BRISTOL-MYERS SQUIBB COMPANY, THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Kyriacos C. NICOLAOU, Min LU, Debashis MANDAL, Sanjeev GANGWAR, Naidu S. CHOWDARI, Yam B. POUDEL
  • SECO-CYCLOPROPAPYRROLOINDOLE COMPOUNDS, ANTIBODY-DRUG CONJUGATES THEREOF, AND METHODS OF MAKING AND USE
    Publication number: 20180051031
    Abstract: seco-Cyclopropapyrroloindole compounds of formula (I) where Hal, R1, R2, and R3 are as defined in the application, are potent anti-cancer agents that can be used in antibody-drug conjugates.
    Type: Application
    Filed: August 18, 2017
    Publication date: February 22, 2018
    Inventors: Fukang YANG, Qian ZHANG, Lawrence B. SNYDER, Sanjeev GANGWAR, Dale L. BOGER
  • HETEROARYLENE-BRIDGED BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING
    Publication number: 20180037581
    Abstract: Benzodiazepine dimers having a structure represented by wherein X comprises a heteroaromatic moiety and is as further defined in the application; R1 is and the other variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
    Type: Application
    Filed: October 17, 2017
    Publication date: February 8, 2018
    Inventors: Ivar M. MCDONALD, Naidu S. CHOWDARI, Walter Lewis JOHNSON, Yong ZHANG, Robert M. BORZILLERI, Sanjeev GANGWAR
  • Heteroarylene-bridged benzodiazepine dimers, conjugates thereof, and methods of making and using
    Patent number: 9822112
    Abstract: Benzodiazepine dimers having a structure represented by wherein X comprises a heteroaromatic moiety and is as further defined in the application; R1 is and the other variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: November 21, 2017
    Assignee: Bristol-Meyers Squibb Company
    Inventors: Ivar M. McDonald, Naidu S. Chowdari, Walter Lewis Johnson, Yong Zhang, Robert M. Borzilleri, Sanjeev Gangwar
  • Benzodiazepine dimers, conjugates thereof, and methods of making and using
    Patent number: 9822144
    Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: November 21, 2017
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yong Zhang, Ivar M. McDonald, Naidu S. Chowdari, Tram N. Huynh, Robert M. Borzilleri, Sanjeev Gangwar
  • ANTIBODY-DRUG CONJUGATE OF AN ANTI-GLYPICAN-3 ANTIBODY AND A TUBULYSIN ANALOG, PREPARATION AND USES
    Publication number: 20170326249
    Abstract: An antibody-drug conjugate having a structure represented by formula (I) wherein m is 1, 2, 3, or 4 and Ab is an anti-glypican-3 antibody having heavy and light chain CDRs as disclosed herein.
    Type: Application
    Filed: May 5, 2017
    Publication date: November 16, 2017
    Inventors: Chin PAN, Josephine M. CARDARELLI, Haichun HUANG, Sanjeev GANGWAR, Qiang CONG, Karla A. HENNING, Chetana RAO-NAIK, Mohan SRINIVASAN, Vangipuram S. RANGAN, Francis Y. LEE, Ginger C. RAKESTRAW
  • ANTIBODY-DRUG CONJUGATES OF TUBULYSIN ANALOGS WITH ENHANCED STABILITY
    Publication number: 20170326247
    Abstract: The drug component of an antibody-drug conjugate having a structure according to formula (II), where Ab, m, n, R1, R2, R3, R4, and R5 are as defined in the application, exhibits unexpectedly improved stability.
    Type: Application
    Filed: May 5, 2017
    Publication date: November 16, 2017
    Inventors: Qiang CONG, Sanjeev GANGWAR, Vangipuram S. RANGAN, Mei-Chen SUNG
  • Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents
    Patent number: 9777013
    Abstract: In one aspect, the present disclosure provides new analogs of uncialamycin of formulae (I) and (II). The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates comprising the compounds of formulae (I) and (II).
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: October 3, 2017
    Assignees: WILLIAM MARSH RICE UNIVERSITY, THE SCRIPPS RESEARCH INSTITUTE, BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Kyriacos C. Nicolaou, Min Lu, Debashis Mandal, Sanjeev Gangwar, Naidu S. Chowdari, Yam B. Poudel
  • TUBULYSIN COMPOUNDS, METHODS OF MAKING AND USE
    Publication number: 20170260232
    Abstract: Tubulysin compounds of the formula (I) where R1, R2 R3a, R3b, R4, R5, W, and n are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
    Type: Application
    Filed: May 23, 2017
    Publication date: September 14, 2017
    Inventors: Qiang CONG, Heng CHENG, Sanjeev GANGWAR
  • HETEROARYLENE-BRIDGED BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING
    Publication number: 20170233392
    Abstract: Benzodiazepine dimers having a structure represented by wherein X comprises a heteroaromatic moiety and is as further defined in the application; R1 is and the other variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
    Type: Application
    Filed: May 5, 2017
    Publication date: August 17, 2017
    Inventors: Ivar M. MCDONALD, Naidu S. Chowdari, Walter Lewis Johnson, Yong Zhang, Robert M. Borzilleri, Sanjeev Gangwar
  • BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING
    Publication number: 20170233436
    Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
    Type: Application
    Filed: May 5, 2017
    Publication date: August 17, 2017
    Inventors: Yong ZHANG, Ivar M. MCDONALD, Naidu S. CHOWDARI, Tram N. HUYNH, Robert M. BORZILLERI, Sanjeev GANGWAR
  • Tubulysin compounds, methods of making and use
    Patent number: 9688721
    Abstract: Tubulysin compounds of the formula (I) where R1, R2 R3a, R3b, R4, R5, W, and n are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: June 27, 2017
    Assignee: Bristol-Myers Squibb Company
    Inventors: Qiang Cong, Heng Cheng, Sanjeev Gangwar
  • Heteroarylene-bridged benzodiazepine dimers, conjugates thereof, and methods of making and using
    Patent number: 9676775
    Abstract: Benzodiazepine dimers having a structure represented by wherein X comprises a heteroaromatic moiety and is as further defined in the application; R1 is and the other variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: June 13, 2017
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ivar M. McDonald, Naidu S. Chowdari, Walter Lewis Johnson, Yong Zhang, Robert M. Borzilleri, Sanjeev Gangwar
  • Benzodiazepine dimers, conjugates thereof, and methods of making and using
    Patent number: 9676794
    Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: June 13, 2017
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yong Zhang, Ivar M. McDonald, Naidu S. Chowdari, Tram N. Huynh, Robert M. Borzilleri, Sanjeev Gangwar