Patents by Inventor Sanjeev Gangwar

Sanjeev Gangwar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING
    Publication number: 20170073357
    Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
    Type: Application
    Filed: November 15, 2016
    Publication date: March 16, 2017
    Inventors: Yong ZHANG, Ivar M. MCDONALD, Naidu S. CHOWDARI, Tram N. HUYNH, Robert M. BORZILLERI, Sanjeev GANGWAR
  • HETEROARYLENE-BRIDGED BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING
    Publication number: 20170057959
    Abstract: Benzodiazepine dimers having a structure represented by wherein X comprises a heteroaromatic moiety and is as further defined in the application; R1 is and the other variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
    Type: Application
    Filed: November 15, 2016
    Publication date: March 2, 2017
    Inventors: Ivar M. MCDONALD, Naidu S. CHOWDARI, Walter Lewis JOHNSON, Yong ZHANG, Robert M. BORZILLERI, Sanjeev GANGWAR
  • Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof
    Patent number: 9580467
    Abstract: Antiproliferative compounds having a structure represented by formula (II), where n, R1, R2, R3, R4, and R5 are as defined herein, can be used to treat tumors, optionally when conjugated to a ligand such as an antibody:
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: February 28, 2017
    Assignee: E. R. SQUIBB & SONS, L.L.C.
    Inventors: Heng Cheng, Sanjeev Gangwar, Qiang Cong
  • Benzodiazepine dimers, conjugates thereof, and methods of making and using
    Patent number: 9527871
    Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: December 27, 2016
    Assignee: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Yong Zhang, Ivar M. McDonald, Naidu S. Chowdari, Tram N. Huynh, Robert M. Borzilleri, Sanjeev Gangwar
  • Heteroarylene-bridged benzodiazepine dimers, conjugates thereof, and methods of making and using
    Patent number: 9526801
    Abstract: Benzodiazepine dimers having a structure represented by wherein X comprises a heteroaromatic moiety and is as further defined in the application; R1 is and the other variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: December 27, 2016
    Assignee: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Ivar M. McDonald, Naidu S. Chowdari, Walter Lewis Johnson, Yong Zhang, Robert M. Borzilleri, Sanjeev Gangwar
  • TUBULYSIN COMPOUNDS, METHODS OF MAKING AND USE
    Publication number: 20160264624
    Abstract: Tubulysin compounds of the formula (I) where R1, R2 R3a, R3b, R4, R5, W, and n are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
    Type: Application
    Filed: June 2, 2016
    Publication date: September 15, 2016
    Inventors: Qiang CONG, Heng Cheng, Sanjeev Gangwar
  • BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING
    Publication number: 20160200742
    Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
    Type: Application
    Filed: January 13, 2016
    Publication date: July 14, 2016
    Inventors: Yong Zhang, Ivar M. McDonald, Naidu S. Chowdari, Tram N. Huynh, Robert M. Borzilleri, Sanjeev Gangwar
  • HETEROARYLENE-BRIDGED BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING
    Publication number: 20160199510
    Abstract: Benzodiazepine dimers having a structure represented by wherein X comprises a heteroaromatic moiety and is as further defined in the application; R1 is and the other variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
    Type: Application
    Filed: January 13, 2016
    Publication date: July 14, 2016
    Inventors: Ivar M. MCDONALD, Naidu S. CHOWDARI, Walter Lewis Johnson, Yong Zhang, Robert M. BORZILLERI, Sanjeev Gangwar
  • Tubulysin compounds, methods of making and use
    Patent number: 9382289
    Abstract: Tubulysin compounds of the formula (I) where R1, R2, R3a, R3b, R4, R5, W, and n are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: July 5, 2016
    Assignee: Bristol-Myers Squibb Company
    Inventors: Qiang Cong, Heng Cheng, Sanjeev Gangwar
  • DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS
    Publication number: 20160185791
    Abstract: In one aspect, the present disclosure provides new analogs of uncialamycin of formulae (I) and (II). The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates comprising the compounds of formulae (I) and (II).
    Type: Application
    Filed: August 14, 2014
    Publication date: June 30, 2016
    Applicants: WILLIAM MARSH RICE UNIVERSITY, BRISTOL-MYERS SQUIBB COMPANY, THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Kyriacos C. NICOLAOU, Min LU, Debashis MANDAL, Sanjeev GANGWAR, Naidu S. CHOWDARI, Yam B. POUDEL
  • TUBULYSIN ANALOGS AND METHODS OF MAKING AND USE
    Publication number: 20160130299
    Abstract: Tubulysin analogs of the formula (I) where R1, R2 R3, R4, R5, R6, R7, and Y are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
    Type: Application
    Filed: August 24, 2015
    Publication date: May 12, 2016
    Inventors: Heidi L. PEREZ, Donna WEI, Robert M. BORZILLERI, Sanjeev GANGWAR, Gretchen M. SCHROEDER, Heng CHENG, Robert J. SCHMIDT
  • ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF
    Publication number: 20160060294
    Abstract: Antiproliferative compounds having a structure represented by formula (II), where n, R1, R2, R3, R4, and R5 are as defined herein, can be used to treat tumors, optionally when conjugated to a ligand such as an antibody:
    Type: Application
    Filed: November 12, 2015
    Publication date: March 3, 2016
    Inventors: Heng CHENG, Sanjeev GANGWAR, Qiang CONG
  • Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof
    Patent number: 9226974
    Abstract: Antiproliferative compounds having a structure represented by formula (II), where n, R1, R2, R3, R4, and R5 are as defined herein, can be used to treat tumors, optionally when conjugated to a ligand such as an antibody:
    Type: Grant
    Filed: July 7, 2014
    Date of Patent: January 5, 2016
    Assignee: E. R. SQUIBB & SONS, L.L.C.
    Inventors: Heng Cheng, Sanjeev Gangwar, Qiang Cong
  • Immunoconjugates, compositions for making them, and methods of making and use
    Patent number: 9186416
    Abstract: An immunoconjugate in which a phosphate-prodrugged DNA minor groove binding agent of formula (I), where X is a nucleophilically displaceable leaving group, is conjugated to an antibody or an antigen binding fragment of an antibody, and compounds that can be used for making such immunoconjugates, and uses of such immunoconjugates.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: November 17, 2015
    Assignee: Bristol-Myers Squibb Company
    Inventors: Qian Zhang, Sanjeev Gangwar, Chin Pan, Daniel W. Derwin
  • Enediyne compounds, conjugates thereof, and uses and methods therefor
    Patent number: 9156850
    Abstract: Enediyne compounds having a structure according to formula (I), where R0, R2, R3, R4, R5, R6, and R7 are defined herein, can be used in chemotherapeutic drugs, especially in conjugates, for the treatment of diseases such as cancer.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: October 13, 2015
    Assignee: Bristol-Myers Squibb Company
    Inventors: Naidu S. Chowdari, Sanjeev Gangwar, Bilal Sufi
  • Tubulysin compounds, methods of making and use
    Patent number: 9109008
    Abstract: Tubulysin compounds of the formula (I) where R1, R2R3a, R3b, R4, R5, W, and n are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: August 18, 2015
    Assignee: Bristol-Myers Squibb Company
    Inventors: Qiang Cong, Heng Cheng, Sanjeev Gangwar
  • TUBULYSIN COMPOUNDS, METHODS OF MAKING AND USE
    Publication number: 20150132324
    Abstract: Tubulysin compounds of the formula (I) where R1, R2, R3a, R3b, R4, R5, W, and n are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
    Type: Application
    Filed: January 26, 2015
    Publication date: May 14, 2015
    Inventors: Qiang CONG, Heng Cheng, Sanjeev Gangwar
  • Tubulysin compounds, methods of making and use
    Patent number: 8980824
    Abstract: Tubulysin compounds of the formula (I) where R1, R2, R3a, R3b, R4, R5, W, and n are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: March 17, 2015
    Assignee: Bristol-Myers Squibb Company
    Inventors: Qiang Cong, Heng Cheng, Sanjeev Gangwar
  • IMMUNOCONJUGATES, COMPOSITIONS FOR MAKING THEM, AND METHODS OF MAKING AND USE
    Publication number: 20140364585
    Abstract: An immunoconjugate in which a phosphate-prodrugged DNA minor groove binding agent of formula (I), where X is a nucleophilically displaceable leaving group, is conjugated to an antibody or an antigen binding fragment of an antibody, and compounds that can be used for making such immunoconjugates, and uses of such immunoconjugates.
    Type: Application
    Filed: August 28, 2014
    Publication date: December 11, 2014
    Inventors: Qian ZHANG, Sanjeev Gangwar, Chin Pan, Daniel W. Derwin
  • ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF
    Publication number: 20140323690
    Abstract: Antiproliferative compounds having a structure represented by formula (II), where n, R1, R2, R3, R4, and R5 are as defined herein, can be used to treat tumors, optionally when conjugated to a ligand such as an antibody:
    Type: Application
    Filed: July 7, 2014
    Publication date: October 30, 2014
    Inventors: Heng Cheng, Sanjeev Gangwar, Qiang Cong