Patents by Inventor Sanjeev Gangwar

Sanjeev Gangwar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunoconjugates, compositions for making them, and methods of making and use
    Patent number: 8852599
    Abstract: An immunoconjugate in which a phosphate-prodrugged DNA minor groove binding agent of formula (I), where X is a nucleophilically displaceable leaving group, is conjugated to an antibody or an antigen binding fragment of an antibody, and compounds that can be used for making such immunoconjugates, and uses of such immunoconjugates.
    Type: Grant
    Filed: May 22, 2012
    Date of Patent: October 7, 2014
    Assignee: Bristol-Myers Squibb Company
    Inventors: Qian Zhang, Sanjeev Gangwar, Chin Pan, Daniel W. Derwin
  • TUBULYSIN COMPOUNDS, METHODS OF MAKING AND USE
    Publication number: 20140227295
    Abstract: Tubulysin compounds of the formula (I) where R1, R2, R3a, R3b, R4, R5, W, and n are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
    Type: Application
    Filed: February 11, 2014
    Publication date: August 14, 2014
    Inventors: Qiang CONG, Heng Cheng, Sanjeev Gangwar
  • TUBULYSIN COMPOUNDS, METHODS OF MAKING AND USE
    Publication number: 20140227298
    Abstract: Tubulysin compounds of the formula (I) where R1, R2R3a, R3b, R4, R5, W, and n are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
    Type: Application
    Filed: February 11, 2014
    Publication date: August 14, 2014
    Inventors: Qiang CONG, Heng CHENG, Sanjeev GANGWAR
  • Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof
    Patent number: 8802632
    Abstract: Antiproliferative compounds having a structure represented by formula (II), where n, R1, R2, R3, R4, and R5 are as defined herein, can be used to treat tumors, optionally when conjugated to a ligand such as an antibody:
    Type: Grant
    Filed: January 29, 2013
    Date of Patent: August 12, 2014
    Assignee: Medarex, L.L.C.
    Inventors: Heng Cheng, Sanjeev Gangwar, Qiang Cong
  • ENEDIYNE COMPOUNDS, CONJUGATES THEREOF, AND USES AND METHODS THEREFOR
    Publication number: 20140193438
    Abstract: Enediyne compounds having a structure according to formula (I), where R0, R2, R3, R4, R5, R6, and R7 are defined herein, can be used in chemotherapeutic drugs, especially in conjugates, for the treatment of diseases such as cancer.
    Type: Application
    Filed: March 10, 2014
    Publication date: July 10, 2014
    Applicant: Bristol-Myers Squibb Company
    Inventors: Naidu S. Chowdari, Sanjeev Gangwar, Bilal Sufi
  • Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof
    Patent number: 8772543
    Abstract: Antiproliferative compounds having a structure represented by formula (II), where n, R1, R2, R3, R4, and R5 are as defined herein, can be used to treat tumors, optionally when conjugated to a ligand such as an antibody:
    Type: Grant
    Filed: January 29, 2013
    Date of Patent: July 8, 2014
    Assignee: Medarex, L.L.C.
    Inventors: Heng Cheng, Sanjeev Gangwar, Qiang Cong, Qian Zhang
  • Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof
    Patent number: 8772542
    Abstract: Antiproliferative compounds having a structure represented by formula (II), where n, R1, R2, R3, R4, and R5 are as defined herein, can be used to treat tumors, optionally when conjugated to a ligand such as an antibody:
    Type: Grant
    Filed: January 29, 2013
    Date of Patent: July 8, 2014
    Assignee: Medarex, L.L.C.
    Inventors: Heng Cheng, Sanjeev Gangwar, Qiang Cong
  • Enediyne compounds, conjugates thereof, and uses and methods therefor
    Patent number: 8709431
    Abstract: Enediyne compounds having a structure according to formula (I), where R0, R2, R3, R4, R5, R6, and R7 are defined herein, can be used in chemotherapeutic drugs, especially in conjugates, for the treatment of diseases such as cancer.
    Type: Grant
    Filed: February 11, 2013
    Date of Patent: April 29, 2014
    Assignee: Bristol-Myers Squibb Company
    Inventors: Naidu S. Chowdari, Sanjeev Gangwar, Bilal Sufi
  • Chemical linkers with single amino acids and conjugates thereof
    Patent number: 8664407
    Abstract: The present disclosure provides drug-ligand conjugates that are potent cytotoxins and include a linker between the drug and ligand where the linker has a single amino acid. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
    Type: Grant
    Filed: February 20, 2008
    Date of Patent: March 4, 2014
    Assignee: Medarex, LLC
    Inventors: Liang Chen, Sanjeev Gangwar, Vincent Guerlavais, Nils Lonberg, Qian Zhang
  • Chemical linkers and cleavable substrates and conjugates thereof
    Patent number: 8461117
    Abstract: The present disclosure provides drug-ligand conjugates and drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
    Type: Grant
    Filed: December 28, 2007
    Date of Patent: June 11, 2013
    Assignee: Medarex, Inc.
    Inventors: Bilal Sufi, Vincent Guerlavais, Liang Chen, Sanjeev Gangwar, Qian Zhang, David B. Passmore
  • Chemical linkers and conjugates thereof
    Patent number: 8399403
    Abstract: The present disclosure provides drug-ligand conjugates that are potent cytotoxins, wherein the drug is linked to the ligand through either a peptidyl, hydrazine, or disulfide linker. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
    Type: Grant
    Filed: November 2, 2009
    Date of Patent: March 19, 2013
    Assignee: Medarex, Inc.
    Inventors: Sharon E. Boyd, Liang Chen, Sanjeev Gangwar, Vincent Guerlavais, Kilian Horgan, Zhi-Hong Li, Bilal Sufi
  • Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof
    Patent number: 8394922
    Abstract: Antiproliferative compounds having a structure represented by formula (II), where n, R1, R2, R3, R4, and R5 are as defined herein, can be used to treat tumors, optionally when conjugated to a ligand such as an antibody:
    Type: Grant
    Filed: July 29, 2010
    Date of Patent: March 12, 2013
    Assignee: Medarex, Inc.
    Inventors: Heng Cheng, Qiang Cong, Sanjeev Gangwar
  • IMMUNOCONJUGATES, COMPOSITIONS FOR MAKING THEM, AND METHODS OF MAKING AND USE
    Publication number: 20120301490
    Abstract: An immunoconjugate in which a phosphate-prodrugged DNA minor groove binding agent of formula (I), where X is a nucleophilically displaceable leaving group, is conjugated to an antibody or an antigen binding fragment of an antibody, and compounds that can be used for making such immunoconjugates, and uses of such immunoconjugates.
    Type: Application
    Filed: May 22, 2012
    Publication date: November 29, 2012
    Inventors: QIAN ZHANG, SANJEEV GANGWAR, CHIN PAN, DANIEL W. DERWIN
  • Enzyme-cleavable prodrug compounds
    Patent number: 8034787
    Abstract: The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the enzyme Thimet oligopeptidase, or TOP. Also disclosed are methods of designing prodrugs by utilizing TOP-cleavable sequences within the conjugate and methods of treating patients with prodrugs of the invention.
    Type: Grant
    Filed: August 14, 2008
    Date of Patent: October 11, 2011
    Assignee: Medarex, Inc.
    Inventors: Vincent Dubois, Ann Marie Fernandez, Sanjeev Gangwar, Evan Lewis, Thomas J. Lobl, Matthew H. Nieder, Lesley B. Pickford, Andre Trouet, Geoffrey T. Yarranton
  • Peptidyl prodrugs and linkers and stabilizers useful therefor
    Patent number: 7977465
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Grant
    Filed: March 4, 2009
    Date of Patent: July 12, 2011
    Assignee: Medarex, Inc.
    Inventors: Howard P. Ng, Danny P. C. McGee, Guoxian Wu, Jimmie Moore, Zhi-Hong Li, Sanjeev Gangwar, Oliver L. Saunders, Irina Astafieva
  • Cytotoxic compounds and conjugates
    Patent number: 7968586
    Abstract: The present disclosure provides cytoxic compounds useful as drugs or prodrugs and to drug-cleavable substrate conjugates where the drug and cleavable substrate are optionally linked through a self-immolative linker.
    Type: Grant
    Filed: November 9, 2006
    Date of Patent: June 28, 2011
    Assignee: Medarex, Inc.
    Inventors: Sanjeev Gangwar, Bilal Sufi
  • ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF
    Publication number: 20110027274
    Abstract: Antiproliferative compounds having a structure represented by formula (II), where n, R1, R2, R3, R4, and R5 are as defined herein, can be used to treat tumors, optionally when conjugated to a ligand such as an antibody:
    Type: Application
    Filed: July 29, 2010
    Publication date: February 3, 2011
    Applicant: Medarex, Inc.
    Inventors: Heng Cheng, Qiang Cong, Sanjeev Gangwar, Qian Zhang
  • CONJUGATES OF ANTI-RG-1 ANTIBODIES
    Publication number: 20110020329
    Abstract: Anti-RG-1 antibodies, antibody fragments, or antibody mimetics conjugated to partner molecules, such as drugs, radioisotopes, and cytotoxins, wherein the partner molecule exerts its effect regardless of whether the RG-1 bound conjugate is internalized within a targeted cell, are useful for treating cancers.
    Type: Application
    Filed: November 26, 2008
    Publication date: January 27, 2011
    Inventors: David J. King, Jonathan A. Terrett, Sanjeev Gangwar, Josephine M. Cardarelli, Chetana Rao-Naik, Chin Pan
  • Methods and compounds for preparing CC-1065 analogs
    Patent number: 7847105
    Abstract: A method of forming a CBI CC-1065 analog utilizes NH2 as a starting material, where R3 is H or alkyl and R6 is H, substituted or unsubstituted lower alkyl, cyano, or alkoxy. Intermediates (I) are used and are claimed.
    Type: Grant
    Filed: October 18, 2006
    Date of Patent: December 7, 2010
    Assignee: Medarex, Inc.
    Inventors: Sanjeev Gangwar, Qian Zhang
  • Tripeptide prodrug compounds
    Patent number: 7816317
    Abstract: The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide of three amino acids, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by a trouase enzyme such as Thimet oligopeptidase. Also disclosed are methods of making and using the prodrug compounds.
    Type: Grant
    Filed: March 27, 2007
    Date of Patent: October 19, 2010
    Assignee: Medarex, Inc.
    Inventors: Christopher R. Bebbington, Vincent Dubois, Sanjeev Gangwar, Thomas J. Lobl, Matthew H. Nieder, Lesley B. Pickford, Andre Trouet, Geoffrey T. Yarranton