Abstract: Disclosed are methods for treating liver failure in a subject comprising transplanting hepatocytes or stem or progenitor cells in an extrahepatic site in the subject in an amount sufficient to provide liver support and/or induce liver regeneration, where the transplanted hepatocytes or stem or progenitor cells are used along with extracellular matrix-coated microcarriers.

Abstract: MicroRNAs have been shown to be critically involved in control of cell survival and cell death decisions. By identifying microRNAs implicated in Endoplasmic Reticulum stress-induced cardiomyocyte apoptosis, it is envisaged that protein targets involved in same can be identified through specifically selected microRNAs. The microRNAs targeted are miR-351, miR-322, miR-125, miR-424 and miR-7a. Furthermore, the potential application of these identified proteins in the treatment of cardiovascular disease, in particular congestive heart failure, is disclosed.

Abstract: A method on a computer for providing critical chain-based project management is disclosed. The method includes generating a list of sequential time periods for a project comprising a plurality of tasks and calculating a number of tasks for each time period. The method further includes generating a graphic that visually indicates the number of tasks for each time period and a priority of each task and providing the graphic to a user.

Abstract: A method and apparatus for activity-based users' interests modeling for determining relevance of the content distributed to the users is provided. Modeling of the user's interests starts by collecting information about the actions that the user performed and about the contents that were associated with the actions. That information may be used to determine how much interest the user has had in the individual subjects up to date, and to determine which subjects became more or less important to the user over time. Further processing of the information about the interests of each of the individual users in a group of users may produce characteristics indicating the interests of the group as a whole. Additional processing may generate the information reflecting relative importance of the interests of an individual user in the group to the interests of other users in the same group.

Abstract: A method on a computer for providing critical chain-based project management is disclosed. The method includes receiving at least one project plan for a project comprising a plurality of tasks and calculating a task priority for each of the plurality of tasks based on the at least one project plan. The method further includes receiving at least one sub-task for a first task of the plurality of tasks and assigning the at least one sub-task a task priority identical to the task priority of the first task. In one alternative, the method further includes receiving a new task priority for the first task, assigning the new task priority to the first task and assigning the new task priority to the at least one sub-task of the first task. The method may also include an interface to allow starting of sub-tasks only when the parent task is started.

Abstract: A method on a computer for providing critical chain-based project management across a plurality of projects is disclosed. The method includes generating a plurality of plans, each of the plurality of plans corresponding to one of the plurality of projects, wherein a project comprises at least one task. The method further includes generating buffers for each of the plurality of projects and reconciling project resources among the plurality of projects. The method further includes executing the plurality of project plans, including allowing a user to manage the buffers across the plurality of projects. The user is further provided with information associated with buffers for the plurality of projects, so as to evaluate the status of the plurality of projects. Additionally, the user is provided with task prioritization for any task of the plurality of projects, wherein task prioritization is calculated across the plurality of projects.

Abstract: The present invention is directed to monophasic pharmaceutical compositions comprising a conjugated estrogen and a hydrophilic or lipophilic excipient. The present invention is also directed to kits and applicators comprising the pharmaceutical compositions. The invention is also directed to methods for treating menopausal conditions in a female comprising administration of the pharmaceutical compositions.

Abstract: This invention describes a process to synthesize water based coating composition having polyurethane and vinyl polymers in the same backbone, which can be used as topcoat in leather. Polyurethane having iniferter groups are synthesized which is then used to incorporate vinyl monomers. The ionic groups are incorporated into PU by selecting vinyl monomers having carboxyl group. The controlled addition of the vinyl monomers is successfully achieved. Finally, it is dispersed in water to obtain the PU dispersion. The suitability of the product for coating application is evaluated on leather. The coating meets desirable protective and aesthetic demands.

Abstract: The present invention is directed to monophasic pharmaceutical compositions comprising a conjugated estrogen and a hydrophilic or lipophilic excipient. The present invention is also directed to kits and applicators comprising the pharmaceutical compositions. The invention is also directed to methods for treating menopausal conditions in a female comprising administration of the pharmaceutical compositions.

Abstract: The present invention relates to coated capsules with increased capsule shell pliability and resilience and methods of making the coated capsules. The present invention relates to methods of making coated capsules, the methods comprising applying a coating solution comprising sodium carboxymethylcellulose or sodium alginate to the exterior of a capsule to form a coating and drying the coating to produce a coated capsule.

Abstract: A compliance/adherence management and automated data collection system uses a plurality of communications modalities implemented over wireless or wired communications systems for redundantly and persistently transmitting messages to and/or receiving messages from an end user for managing compliance/adherence of the end user concerning schedules and medication and treatment protocols. The system also uses wireless or wired communications modalities for automating real time collection of information from the end user concerning, for example, compliance with the schedule and/or protocol. The collected data can be remotely accessed, in real time, to monitor compliance/adherence and an end user's experiences resulting from compliance/adherence. Further, the management messages are so designed as to be highly personalized in order to achieve a more favorable response from the end user.

Abstract: The present invention relates to an oral pharmaceutical dosage form comprising micronized progesterone, an edible oil, a disintegrant, and a hydrophilic excipient. Particularly, the invention relates to a pharmaceutical dosage form wherein the dosage form is in a powder form and is contained in a pharmaceutically acceptable capsule. The present invention is also directed toward methods of making the dosage form, methods of using the dosage form, and kits comprising the dosage form.

Abstract: This invention describes a process to synthesize water based coating composition having polyurethane and vinyl polymers in the same backbone, which can be used as topcoat in leather. Polyurethane having iniferter groups are synthesized which is then used to incorporate vinyl monomers. The ionic groups are incorporated into PU by selecting vinyl monomers having carboxyl group. The controlled addition of the vinyl monomers is successfully achieved. Finally, it is dispersed in water to obtain the PU dispersion. The suitability of the product for coating application is evaluated on leather. The coating meets desirable protective and aesthetic demands.

Abstract: A method on a computer for providing critical chain-based project management is disclosed. The method includes generating a list of sequential time periods for a project comprising a plurality of tasks and calculating a number of tasks for each time period. The method further includes generating a graphic that visually indicates the number of tasks for each time period and a priority of each task and providing the graphic to a user.

Abstract: A method on a computer for providing critical chain-based project management is disclosed. The method includes receiving at least one project plan for a project comprising a plurality of tasks and calculating a task priority for each of the plurality of tasks based on the at least one project plan. The method further includes receiving at least one sub-task for a first task of the plurality of tasks and assigning the at least one sub-task a task priority identical to the task priority of the first task. In one alternative, the method further includes receiving a new task priority for the first task, assigning the new task priority to the first task and assigning the new task priority to the at least one sub-task of the first task. The method may also include an interface to allow starting of sub-tasks only when the parent task is started.

Abstract: A method on a computer for providing critical chain-based project management across a plurality of projects is disclosed. The method includes generating a plurality of plans, each of the plurality of plans corresponding to one of the plurality of projects, wherein a project comprises at least one task. The method further includes generating buffers for each of the plurality of projects and reconciling project resources among the plurality of projects. The method further includes executing the plurality of project plans, including allowing a user to manage the buffers across the plurality of projects. The user is further provided with information associated with buffers for the plurality of projects, so as to evaluate the status of the plurality of projects. Additionally, the user is provided with task prioritization for any task of the plurality of projects, wherein task prioritization is calculated across the plurality of projects.

Abstract: The present invention is directed to a method of preparing a pharmaceutical dosage form, the method comprising (a) encasing a pharmaceutical dosage form comprising an estrogen in a container essentially impervious to oxygen, and (b) purging the container with an inert gas, and pharmaceutical dosages formed by the method thereof. The present invention is also directed to a pharmaceutical kit comprising (a) a container impervious to oxygen, wherein the container contains an atmosphere of essentially inert gas, and (b) a pharmaceutical dosage form, wherein the pharmaceutical dosage form comprises an estrogen and wherein the pharmaceutical dosage form is encased in the container.

Abstract: A method and system for accessing and sharing metadata amongst a number of data marts through the use of object referencing. A global repository is created. Shared folders containing metadata is contained in the global repository. Any number of data marts can be linked to the global repository. Stored within the folders of the linked data marts are references pointing to certain metadata stored in the shared folders of the global repository. Multiple data marts can reference the same metadata in the global repository. Thereby, the same metadata can be accessed, used, and shared by multiple users across different data marts, provided that they have been granted the proper authority. New metadata can be promoted from a linked data mart into the global repository so that it can be shared, and updates to shared metadata can be automatically propagated to all users referencing that metadata.