Abstract: Provided is a light emitting device formed of an indirect transition semiconductor configured from a semiconductor material having high exciton binding energy, wherein an active layer of the indirect transition semiconductor or an active region by a pn junction is formed, the light emitting device has an electrode for injecting current into the active layer or the active region, and the internal quantum efficiency is 10% or more.

Abstract: A flame-retardant resin composition including a resin component containing (A) 30 to 90 parts by weight of a thermoplastic polyurethane elastomer having, as measured according to JIS K 7311, a JIS hardness of A98 or less, (B) 70 to 10 parts by weight of an ethylene-vinyl acetate copolymer having a vinyl acetate unit content of 50 to 90% by weight, (C) 0 to 40 parts by weight of at least one polymer selected from the following copolymers (C1) to (C3), (C1) an acid anhydride-modified ethylene-unsaturated carboxylic acid derivative copolymer, (C2) an epoxy group-having ethylene-olefin copolymer, and (C3) an acid anhydride-modified styrene elastomer, and provided that the total amount of components (A), (B) and (C) is 100 parts by weight, (D) a metal hydroxide in a ratio of 40 to 250 parts by weight with respect to the total amount of 100 parts by weight of the resin component containing (A), (B) and (C).

Abstract: [Object] The present invention provides a method of selectively forming a flat plane on an atomic level on a diamond (001), (110) or (111) surface. [Means for Solving Problems] A method of selectively forming a flat plane on a diamond surface comprising growing diamond on a stepped diamond surface of any of crystal structures (001), (110) and (111) by CVD (Chemical Vapor Deposition) under growth conditions such that step-flow growth of diamond is carried out thereafter.

Abstract: A head cap for an aerosol type atomizer is proposed in which a residual gas that remains in the container after the use of the aerosol type atomizer is ended are discharged easily and safely, and which is so structured that the aerosol type atomizer cannot be falsely operated while it is being used.

Abstract: The present invention provides a decoy nucleic acid for the Synoviolin gene promoter. Also provided is the decoy nucleic acid can inhibit the promoter activity by binding to the transcription factor of the Synoviolin gene promoter. It also provides a decoy nucleic acid as expressed in (a) a decoy nucleic acid consisting of a nucleotide sequence as shown in SEQ ID NO: 11 or 12; and it also provides (b) a decoy nucleic acid consisting of a nucleotide sequence as shown in SEQ ID NO: 11 or 12 having deletion, substitution or addition of one or several nucleotides and has the function of inhibiting Synoviolin gene promoter activity.

Abstract: The present invention relates to an antibody against synoviolin or a fragment thereof for providing a monoclonal antibody capable of recognizing a part of synoviolin, which monoclonal antibody is capable of inhibiting the auto-ubiquitination of synoviolin.

Abstract: Disclosed are a chemical carrier body capable of volatilizing a chemical stably for an extended period of time, a receptacle for retaining the chemical carrier body, an indicator adapted for displaying a degree of consumption of a chemical contained in the chemical carrier body, and a chemical heating, volatilizing apparatus adapted for heating the chemical carrier body. The chemical carrier body retaining receptacle is provided with at least one vent hole and has its inner surface spaced from the carrier body by a distance of 1 to 10 mm. The indicator has a mark gradually disappearing and a mark gradually appearing with a lapse of time of heating. The chemical heating, volatilizing apparatus has a heater element that is lager in size than the bottom surface of the chemical carrier body retaining receptacle and whose heat releasing surface is inclined at an angle of 0 to 70 degrees with respect to the plane on which the apparatus is placed.

Abstract: The present invention relates to an assay method for determining a auto-ubiquitination activity of synoviolin, comprising reacting synoviolin and ubiquitin in a reaction system containing them and determining an amount of ubiquitin binding to synoviolin, to a method of screening a substance capable of regulating such an activity, and to a kit for auto-ubiquitination assay of synoviolin.

Abstract: There is provided an n type (100) oriented single crystal diamond semiconductor film into which phosphorus atoms have been doped and a method of producing the same. The n type (100) oriented single crystal diamond semiconductor film, characterized in that (100) oriented diamond is epitaxially grown on a substrate under such conditions that; the diamond substrate (100) oriented diamond, a means for chemical vapor deposition provides hydrogen, hydrocarbon and a phosphorus compound in the plasma vapor phase, the ratio of phosphorus atoms to carbon atoms in the plasma vapor phase is no less than 0.1%, and the ratio of carbon atoms to hydrogen atoms is no less than 0.05%, and the method of producing the same.

Abstract: Provided is an ionomer resin composition containing an ethylene ionomer resin and organo clay, wherein the content of the organo clay is 2 weight % or more and 60 weight % or less relative to the whole ionomer resin composition. Also provided is a tubular shaped article made by extruding the ionomer resin composition, which tubular shaped article has the following properties: rigidity sufficient for allowing an automatic machine to perform the processes of covering over a lithium-ion battery to be covered therewith and the contraction thereof; the contraction processing can be completed at low temperature of 120° C. or less; and superior resistance to an electrolytic solution.

Abstract: The present invention provides a promoter of the synoviolin gene comprising at least the nucleotide sequence of nucleotides 2120-2130 in the nucleotide sequence represented by SEQ ID: NO 1 or 2, or comprising at least the nucleotide sequence of the region of nucleotides 1-2201, 969-2201, 1142-2201, 1699-2201, 1880-2201, 2002-2201, 2094-2201 or 2118-2201 in the nucleotide sequence represented by SEQ ID: NO 1 or 2;or a method for regulating transcription activity characterized in that the activity of the promoter is inhibited or enhanced.

Abstract: The present invention provides a method for suppressing cancer comprising activating tumor suppressor gene p53 or protein p53 for localizing the protein to the nuclear, and a pharmaceutical composition comprising a substance that promotes activation of tumor suppressor gene p53 or protein p53.

Abstract: The present invention provides a method for inhibiting secretase activity. A method for promoting the sensitivity of a secretase inhibitor, a method for binding synoviolin to Herp (homocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-like domain member 1), or the like is employed to inhibit secretase activity.

Abstract: A blower type chemical diffusing apparatus is disclosed which can be of service for an extended period of time and does not give rise to refuse disposal problems. The blower type chemical diffusing apparatus of the invention has an air blower, a chemical retainer and a fuel cell included in the apparatus body whereby powering the air blower to drive it with the fuel cell causes chemical from the chemical retainer to be emitted into an environmental atmosphere.

Abstract: A fan type chemical dispersion equipment, wherein a chemical container (3) and a power supply storage body (2a) are disposed detachably from an equipment body (1) and so as not to be volumetrically limited with each other, whereby, because the equipment body, chemical container, and power supply storage body can be volumetrically formed independently of each other, the settings of a chemical holding amount relative to a fan air blow amount and long or short service time can be performed easily, the chemical container being capable of preventing a chemical impregnated body from being caught between the end face of a chemical container body (3a) and a cover body (3b), and a clip device being capable of firmly fixing the fan type chemical dispersion equipment to the held materials ranging from thin to thick ones.

Abstract: The present invention provides an apoptosis-inducing agent or a therapeutic agent for autoimmune diseases, comprising a substance that induces ER stress; and a method for inhibiting the proliferation of cells, wherein the cells (for example, synoviocytes) are treated with the inducing agent.

Abstract: The present invention provides a pharmaceutical composition containing a substance which inhibits the proliferation of synovial tissue or synovial cells and the interleukin-6 production. It also provides a pharmaceutical composition for inhibiting the proliferation of synovial tissue or synovial cells and the interleukin-6 production, which is useful for diagnosing and treating at least one selected from the group consisting of rheumatoid arthritis, fibrosis, arthritis, cancers, and cerebral neural diseases. In addition, it provides a method for inhibiting the proliferation of synovial cells and the interleukin-6 production by inhibiting the expression of hsHRD3 in synovial cells.

Abstract: The present invention provides a nerve cell differentiation inducing drug containing a Synoviolin expression inhibitor which is a useful drug for treatments of neural disorders, particularly Alzheimer's disease, Parkinson's disease, peripheral nerve disorders or spinal injury. As Synoviolin expression inhibitors, there are siRNA against gene coding Synoviolin (SEQ ID No. 1 or 2), or shRNA, a decoy nucleic acid that inhibits the promoter activity by binding to the transcription factor of the promoter of the Synoviolin gene or antisense oligonucleotide against gene coding the Synoviolin. The nerve cell differentiation inducing drug of the present invention is used for the treatment of neural disorders including Alzheimer's disease, Parkinson's disease, peripheral nerve disorders or spinal injury.

Abstract: A blower type chemical diffusing apparatus is disclosed that is small in thickness, simple in structure and reduced in cost structurally to allow the chemical and battery to be exchanged readily and to facilitate electrically connecting battery to the motor in the blower. The apparatus casing comprises a first and a second side casing counterpart hinged together to allow its opening and closure, a blower with a motor and fan mounted in the first casing body, a chemical cartridge disposed between the blower and the second casing body and containing a chemical impregnated body that comprises a carrier in the form of a sheet impregnated with chemical. Also provided in the first casing body is a battery accommodating recess in which dry cells may removably be accepted to drive the motor and thereby to rotate the fan. Air is thus forced to flow through the chemical cartridge.

Abstract: The present invention provides methods for evaluating the regulation on prolyl 4-hydroxylase activity. The present invention also provides screening methods using the evaluation methods. Furthermore, the present invention provides methods of screening for compounds that are useful for treating or preventing fibrosis or rheumatoid arthritis. The present invention relates to methods for detecting regulatory activity on the synoviolin ubiquitination of prolyl 4-hydroxylase ? subunit (P4HA1). It also relates to methods of screening for compounds with regulatory effect on the ubiquitination activity of synoviolin on P4HA1 based on these methods. Compounds discovered in the screening are useful for treating and/or preventing diseases caused by abnormalities in the prolyl 4-hydroxylase activity, such as fibrosis and rheumatoid arthritis.