Abstract: Described herein are crystalline forms of (R)-5-(2,5-dichloro-4-(5-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)-1,2,4-oxadiazol-3-yl)phenoxy)piperidin-2-one, or a salt or solvate thereof.

Abstract: A pericritical fluid system for a thermal management system associated with a turbine engine may include one or more sensors configured to generate sensor outputs corresponding to one or more phase properties of a pericritical fluid flowing through a cooling circuit of the thermal management system, and a controller configured to generate control commands configured to control one or more controllable components of the thermal management system based at least in part on the sensor outputs. The one or more sensors may include one or more phase detection sensors, such as an acoustic sensor.

Abstract: A tension member for a lifting and/or hoisting system includes a core including a plurality of load carrying fibers arranged in a matrix material, and an outer layer secured to the core including a plurality of outer fibers arranged around a perimeter of the core. The outer layer includes one or more outer fibers arranged off-axis relative to the load carrying fibers of the core. A method of forming a tension member for an elevator system includes arranging a plurality of load carrying fibers along a length of the tension member, retaining the plurality of load carrying fibers in a matrix material to define a core, and enclosing the core in an outer layer including a plurality of outer fibers arranged around a perimeter of the core. The outer layer includes one or more outer fibers arranged off-axis relative to the load carrying fibers of the core.

Abstract: A self-cleaning conduit for a hydrocarbon fluid. The conduit includes a tube and a mesh. The tube has an interior surface defining a flow passage for the hydrocarbon fluid. The mesh is positioned within the flow passage to abut the interior surface and movable along the interior surface to break-up deposits on the interior surface. The mesh is characterized by a mesh activation parameter (MAP) from one ten thousandths to six tenths.

Abstract: A self-cleaning conduit for a hydrocarbon fluid. The conduit includes a tube and a movable sleeve. The tube has an interior surface defining a flow passage for the hydrocarbon fluid. The movable sleeve is positioned within the flow passage to abut the interior surface and is movable along the interior surface in response to a change in an operating characteristic of the conduit to break-up deposits on the interior surface.

Abstract: A system and method for performing root cause analysis for enforcement events is presented. The system can enable accurate detection of an enforcement event and identifies the root cause of such events. The system can enable accurate detection of the enforcement event and identifies the root cause of such events using an automation workflow engine. The system can perform root cause analysis based on at least one analysis model. The system can provide a user with an interface to monitor the enforcement event by collecting a list of data points characterizing the enforcement event, as well as analyze the data points to evaluate what is the root cause of the enforcement event.

Abstract: A method of operating a gas turbine engine comprising: extracting a flow of air from a compressor section of the gas turbine engine into a first conduit; flowing the extracted flow of air through the first conduit to a first location at a turbine section of the turbine section, wherein a second conduit is in fluid communication with the turbine section at a second location; flowing a heat transfer fluid to a first heat exchanger positioned in thermal communication with the flow of air through the first conduit, the heat transfer fluid in thermal communication with the extracted flow of air through the first conduit via the first heat exchanger; and modulating, via a flow control device, a portion of the flow of air extracted from the first conduit to the second conduit downstream of the first heat exchanger.

Abstract: The present disclosure generally relates to methods and apparatuses for chemical vapor deposition (CVD) during additive manufacturing (AM) processes. Such methods and apparatuses can be used to embed chemical signatures into manufactured objects, and such embedded chemical signatures may find use in anti-counterfeiting operations and in manufacture of objects with multiple materials.

Abstract: A method of operating a gas turbine engine comprising: extracting a flow of air from a compressor section of the gas turbine engine into a first conduit; flowing the extracted flow of air through the first conduit to a first location at a turbine section of the turbine section, wherein a second conduit is in fluid communication with the turbine section at a second location; flowing a heat transfer fluid to a first heat exchanger positioned in thermal communication with the flow of air through the first conduit, the heat transfer fluid in thermal communication with the extracted flow of air through the first conduit via the first heat exchanger; and modulating, via a flow control device, a portion of the flow of air extracted from the first conduit to the second conduit downstream of the first heat exchanger.

Abstract: An insulation assembly for use in a gas turbine engine is provided. The insulation assembly defines a hot side and an insulated side and includes: a heat shield layer positioned proximate the hot side; and a thermal absorption layer positioned proximate the insulated side, the thermal absorption layer comprising a phase change material, the insulation assembly defining an air gap positioned between the heat shield layer and the thermal absorption layer.

Abstract: A rotary machine includes a stator and a rotor configured to rotate with respect to the stator. The rotor is arranged with the stator at a rotor-stator interface and defines a rotor face. Further, the rotary machine includes a seal assembly at the rotor-stator interface. The seal assembly includes at least one seal and a groove formed into the rotor at the rotor-stator interface. In addition, the seal assembly includes a removable insert positioned within the groove of the seal assembly and defining at least a portion of the rotor face. As such, during operation of the rotary machine, if the rotor and the stator make undesirable contact at the rotor-stator interface, the removable insert becomes damaged to prevent damage from occurring to the rotor and the stator.

Abstract: Examples of methods for object packing genetic procedures are described herein. In some examples, a method includes generating chromosomes in a genetic procedure. In some examples, each chromosome indicates a packing of objects in a volume. In some examples, the method includes determining a stagnant generation quantity that indicates an amount of generations subsequent to a leading generation with a leading chromosome score. In some examples, the method includes terminating the genetic procedure based on the stagnant generation quantity.

Abstract: Systems and methods for facilitating the sorting of assets to sort locations. In various embodiments, a sort employee scans an asset indicia using a user device, which stores asset data corresponding to the stored asset. As the sort employee nears a sort location (e.g., a delivery vehicle) with the asset and the user device, the user device automatically communicates wirelessly with a sort location receiver to associate the asset data with data indicative of the sort location where the user deposits the asset. In various embodiments, a device may determine whether the user device is proximate the appropriate sort location for the item, and may generate an alert upon a determination that the user device is proximate an incorrect sort location.

Abstract: A gas turbine engine is provided. The gas turbine engine includes a fan comprising a plurality of fan blades; a turbomachine operably coupled to the fan for driving the fan, the turbomachine comprising a compressor section, a combustion section, and a turbine section in serial flow order and together defining a core air flowpath; and one or more graphene layers coupled to, or integrated into, a portion of the gas turbine engine, wherein the one or more graphene layers are configured to reduce ice buildup or ice formation. The one or more graphene layers include graphene or an allotrope thereof.

Abstract: An air-to-air heat exchanger in flow communication with a gas turbine engine is provided. The air-to-air heat exchanger has an air-to-air heat exchanger potential defined by a product raised to a half power, the product being a heat transfer surface area density associated with the air-to-air heat exchanger multiplied by an airflow conductance factor associated with the gas turbine engine. The air-to-air heat exchanger potential is between about 6.7 and 19.5 for a bypass ratio associated with the gas turbine engine between about 3 and 10 and the heat transfer surface area density being between about 3,000 m2/m3 and 10,000 m2/m3 and is between about 2.9 and 12.2 for a bypass ratio associated with the gas turbine engine between about 10 and 20 and the heat transfer surface area density being between about 1,000 m2/m3 and 10,000 m2/m3.

Abstract: Devices, systems, methods, and kits of parts for monitoring operation of an electron beam additive manufacturing systems are disclosed. A monitoring system includes one or more measuring devices positioned on the at least one wall in the interior of a build chamber of the additive manufacturing system. Each one of the one or more measuring devices includes a piezoelectric crystal. The monitoring system further includes an analysis component communicatively coupled to the one or more measuring devices. The analysis component is programmed to receive information pertaining to a frequency of oscillation of the piezoelectric crystal. A collection of material on the one or more measuring devices during formation of an article within the build chamber causes a change to the frequency of oscillation of the piezoelectric crystal that is detectable by the analysis component and usable to determine a potential build anomaly of the article.

Abstract: The present disclosure relates to hIL2 orthogonal ligands (“IL2 orthologs”) that specifically and selectively bind to the extracellular domain (ECD) a transmembrane polypeptide comprising of a modified hCD122 polypeptide. The binding of the hIL2 ortholog to the modified hCD122 polypeptide participates in the transduction pathway of intracellular signaling resulting in a biological activity of the native intracellular signaling patterns associated with hIL2 binding to either the intermediate or high affinity hIL2 receptor but which exhibits selectivity to an engineered cell expressing an hCD122 orthogonal receptor. The hIL2 orthologs of the present invention exhibit significantly reduced binding relative to their binding to the extracellular domain of wild type hCD122, either alone or when hCD122 is present in the form of an endogenous high or intermediate affinity hIL2 receptors.

Abstract: The embodiments of present invention provide processes and an intermediate for the large-scale preparation of 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide hemisuccinate, and formulations and product forms, such as tablets, made by these processes. Additionally, embodiments of the present invention provide tablets including 25 mg, 50 mg, 100 mg, or 200 mg free base equivalent of 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide hemisuccinate.

Abstract: A gas turbine engine is provided. The gas turbine engine includes a fan; a turbomachine operably coupled to the fan for driving the fan, the turbomachine comprising a compressor section, a combustion section, and a turbine section in serial flow order and together defining a core air flowpath; a static fluid passageway in thermal communication with a portion of the turbomachine; and one or more graphene layers coupled to a portion of the static fluid passageway.

Abstract: A turbine engine includes a pressurized fluid source, a duct system comprising a plurality of ducts in fluid communication with the pressurized fluid source, and a duct failure detection system. The duct failure detection system includes a plurality of pressure sensors. Each of the plurality of pressure sensors is in operable communication with two ducts of the plurality of ducts. Each of the plurality of ducts has at least two pressure sensors of the plurality of pressure sensors in operable communication therewith.