Abstract: The present disclosure relates to hIL2 orthogonal ligands (“IL2 orthologs”) that specifically and selectively bind to the extracellular domain (ECD) a transmembrane polypeptide comprising of a modified hCD122 polypeptide. The binding of the hIL2 ortholog to the modified hCD122 polypeptide participates in the transduction pathway of intracellular signaling resulting in a biological activity of the native intracellular signaling patterns associated with hIL2 binding to either the intermediate or high affinity hIL2 receptor but which exhibits selectivity to an engineered cell expressing an hCD122 orthogonal receptor. The hIL2 orthologs of the present invention exhibit significantly reduced binding relative to their binding to the extracellular domain of wild type hCD122, either alone or when hCD122 is present in the form of an endogenous high or intermediate affinity hIL2 receptors.

Abstract: The embodiments of present invention provide processes and an intermediate for the large-scale preparation of 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide hemisuccinate, and formulations and product forms, such as tablets, made by these processes. Additionally, embodiments of the present invention provide tablets including 25 mg, 50 mg, 100 mg, or 200 mg free base equivalent of 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide hemisuccinate.

Abstract: A gas turbine engine is provided. The gas turbine engine includes a fan; a turbomachine operably coupled to the fan for driving the fan, the turbomachine comprising a compressor section, a combustion section, and a turbine section in serial flow order and together defining a core air flowpath; a static fluid passageway in thermal communication with a portion of the turbomachine; and one or more graphene layers coupled to a portion of the static fluid passageway.

Abstract: A turbine engine includes a pressurized fluid source, a duct system comprising a plurality of ducts in fluid communication with the pressurized fluid source, and a duct failure detection system. The duct failure detection system includes a plurality of pressure sensors. Each of the plurality of pressure sensors is in operable communication with two ducts of the plurality of ducts. Each of the plurality of ducts has at least two pressure sensors of the plurality of pressure sensors in operable communication therewith.

Abstract: Examples of methods for object packings are described herein. In some examples, a method includes generating chromosomes in a genetic procedure. In some examples, each chromosome indicates a packing of objects in a volume. In some examples, the method also includes determining uniformity scores corresponding to the chromosomes. In some examples, each uniformity score is based on object orientation similarity. In some examples, the method further includes selecting a chromosome based on the uniformity scores.

Abstract: In a jet engine having a core that sources a first flow of fluid and a component (such as a fan, a pump, and/or a bleed line) that sources a second flow of fluid, and where the first flow of fluid will typically have, at least during ordinary operation, a higher temperature than the second flow of fluid, at least one flow aperture formed by a first passageway to receive at least a portion of the aforementioned second flow of fluid, wherein that first passageway is comprised of at least one material that (by design and intent) deflects as a function of temperature such that a flow of the second flow of fluid through the at least one flow aperture is thereby desirably modulated.

Abstract: A method of making a heat exchanger with a net shape moldable highly thermally conductive polymer composite includes mixing a polymer and a thermally conductive filler material and molding the polymer composite into heat exchanger components. The heat exchanger can be tailored to varying heating and cooling needs with moldable geometries.

Abstract: An illustrative example assembly for making an elevator load bearing member includes a fabric having a plurality of fibers arranged with some of the fibers transverse to others of the fibers. A plurality of cords are configured to support a load associated with an elevator car. The cords are included in the fabric and have respective coatings. The coatings include a first coating material and a second coating material, or include different coating thicknesses such that some of the coatings have a different coating thickness than others of the coatings, or the coatings include the first coating material and the second coating material and some of the coatings have a different coating thickness than others of the coatings.

Abstract: An example non-transitory computer-readable medium includes instructions that, when executed by a processor, cause the processor to retrieve a plurality of parts to be three-dimensionally (3D) printed and an output rate indicative of a rate at which previous 3D printed parts have been output, select a packing parameter that results in a packing time corresponding to the output rate, and compute a part packing of the plurality of parts for a print bed according to the packing parameter.

Abstract: A system and method of monitoring a powder-bed additive manufacturing process is provided where a layer of additive powder is fused using an energy source and electromagnetic emission signals are measured by a melt pool monitoring system to monitor the print process. The measured emission signals are analyzed to identify outlier emissions and clusters of outliers are identified by assessing the spatial proximity of the outlier emissions, e.g., using clustering algorithms, spatial control charts, etc. An alert may be provided or a process adjustment may be made when a cluster is identified or when a magnitude of a cluster exceeds a predetermined cluster threshold.

Abstract: A turbofan engine is provided. The turbofan engine includes a fan; a turbomachine operably coupled to the fan for driving the fan, wherein the turbomachine, the fan, or both include an engine component; a heat source; and a heat transfer system configured to reduce ice buildup or ice formation in the engine component, the heat transfer system in communication with the heat source, the heat transfer system comprising: a first heat transfer component in communication with the heat source; and a second heat transfer component that extends from the first heat transfer component to or through the engine component, wherein the first heat transfer component comprises one of a heat pipe or a graphene rod, and wherein the second heat transfer component comprises the other of the heat pipe or the graphene rod.

Abstract: A turbine engine includes a pressurized fluid source, a duct system comprising a plurality of ducts in fluid communication with the pressurized fluid source, and a duct failure detection system. The duct failure detection system includes a plurality of pressure sensors. Each of the plurality of pressure sensors is in operable communication with two ducts of the plurality of ducts. Each of the plurality of ducts has at least two pressure sensors of the plurality of pressure sensors in operable communication therewith.

Abstract: The invention relates to systems and methods of revealing portions of outcomes of real-world wagers through interactive media by storing reserve wagers, receiving an indication a first token has been acquired by a user, determining a tracking wager associated with the first token, matching a stored reserve wager with the tracking wager, associating the matched reserve wager with the first token, and revealing at least a portion of the outcome of the matched reserve wager to the user by the user's interaction with the interactive media. By integrating real-world wager outcomes with user interactions, the system may provide an engaging user experience with interactive media. For example, a game may reveal an outcome of a real-world wager (which has already occurred), in response to in-game actions such as user actions in the game, other players' actions, game events, and/or other events.

Abstract: A system and method for performing root cause analysis for enforcement events is presented. The system can enable accurate detection of an enforcement event and identifies the root cause of such events. The system can enable accurate detection of the enforcement event and identifies the root cause of such events using an automation workflow engine. The system can perform root cause analysis based on at least one analysis model. The system can provide a user with an interface to monitor the enforcement event by collecting a list of data points characterizing the enforcement event, as well as analyze the data points to evaluate what is the root cause of the enforcement event.

Abstract: A system and method for automating workflow and performing root cause analysis for enforcement events is presented. The system can enable accurate detection of an enforcement event and identifies the root cause of such events. The system can provide a user with an interface to monitor the enforcement event by collecting a list of data characterizing the enforcement event, as well as analyze the data to evaluate what is the root cause of the enforcement event. The system can extract critical information from train system logs of the train using an extraction model to generate a window of activity providing an analysis model with a comprehensive scope to analyze the enforcement event. The system can give the user robust and accurate information of the root cause of the enforcement event.

Abstract: A method of regulating pressure in a thermal transport bus of a gas turbine engine, the method including: operating the gas turbine engine with the thermal transport bus having an intermediary heat exchange fluid flowing therethrough, the thermal transport bus including one or more heat source heat exchangers and one or more heat sink heat exchangers in thermal communication through the intermediary heat exchanger fluid; and adjusting a flow volume of the thermal transport bus using a variable volume device in fluid communication with the thermal transport bus in response to a pressure change associated with the thermal transport bus.

Abstract: A gas turbine engine including: a first turbine rotor assembly including a plurality of first turbine rotor blades extended within a gas flowpath; and a casing surrounding the first turbine rotor assembly, wherein the casing comprises an outer casing wall extended around the first turbine rotor assembly; a plurality of vanes extended from the outer casing wall and within the gas flowpath at a location aft of the first turbine rotor assembly; and a thermal control ring positioned outward along a radial direction from the outer casing wall, and wherein the thermal control ring comprises a body and a plurality of pins, and wherein the plurality of pins extend between the outer casing wall and the body.

Abstract: A gas turbine engine comprises a turbomachine defining a core flow therethrough during operation. A flow tap is provided in fluid communication with the turbomachine, wherein the flow tap is configured to receive a portion of the core flow therethrough as a bleed flow. A bleed assembly includes a machine load, a bleed flow machine, and a bleed regulator. The bleed flow machine is disposed in fluid communication with the turbomachine through the flow tap, and is configured to drive the machine load. The bleed regulator is configured to regulate a bleed output provided to the bleed flow machine by controlling a capture rate of the bleed flow by the bleed flow machine.

Abstract: Disclosed is an electrically powered, reaction-drive type rotorcraft. Thrust generators on the outer portion of each rotor blade cause the rotors to spin and generate lift, and additionally, may be controlled to produce variable amounts of thrust as the rotor blades rotate through different sectors around a generally non-rotating fuselage such that net lateral forces are produced to control the position and velocity of the vehicle. The rotorcraft may also employ aerodynamic surfaces on each rotor blade whose parts or entire structure can be moved to produce net lateral and vertical forces for control of position and velocity of the vehicle. The rotorcraft, which may be operationally carbon-neutral, stores its electrical energy in batteries and other optional energy storage methods, and may harvest solar energy using arrays of photovoltaic cells disposed on its upper surfaces. Vehicle sizes may range from small Uncrewed Air vehicle Systems to large crewed aircraft.

Abstract: Examples of methods for determining chromosome expiration are described herein. In some examples, a method includes generating, in a genetic procedure, chromosomes indicating object packing positions. In some examples, the method includes determining whether a chromosome of the chromosomes is expired. In some examples, the method includes excluding the chromosome from a subsequent generation in response to determining that the chromosome is expired.