Abstract: A charging device for charging an energy storage device is described. The charging device includes a memory for storing a plurality of state machines and a processing device coupled to the memory. The processing device is configured to select a state machine of the plurality of state machines and to operate the charging device in accordance with the selected state machine.

Abstract: The invention provides murine, chimeric, and humanized antibodies that specifically bind to CD33. The antibodies are useful for treatment and diagnoses of various cancers as well as detecting CD33.

Abstract: A system according to the principles of the present disclosure includes an error count module and a sensor diagnostic module. The error count module increases an error count when an actual air/fuel ratio generated by an oxygen sensor monitoring an exhaust system of an engine is different than a desired air/fuel ratio. The error count module selectively adjusts a rate at which the error count is increased based on an ambient temperature. The sensor diagnostic module diagnoses a fault in the oxygen sensor when the error count is greater than a first predetermined count.

Abstract: Power distribution systems and methods are described. In one example, a method of testing a power distribution zone select interlocking system including a first circuit protection device and a second circuit protection device coupled to the first circuit protection device downstream of the first circuit protection device is described. The method includes receiving, by the second circuit protection device, an input instructing the second circuit protection device to test communication between the first circuit protection device and the second circuit protection device, and outputting, by the second circuit protection device, a blocking signal in response to the input. The first circuit protection display an indication of reception of the blocking signal to confirm proper interconnection of the zone select interlocking signals.

Abstract: A system according to the principles of the present disclosure includes a storage capability module and at least one of an engine speed control module and a spark control module. The storage capability module determines a capability of a catalytic converter to store oxygen. The engine speed control module controls a speed of an engine based on the oxygen storage capability of the catalytic converter. The spark control module controls a spark timing of the engine based on the oxygen storage capability of the catalytic converter.

Abstract: Provided is a data storage drive for encrypting data, comprising a microprocessor and circuitry coupled to the microprocessor and adapted to receive a session encrypted data key and to decrypt the session encrypted data key using a session key, wherein a result is a data key that is capable of being used to encrypt clear text and to decrypt cipher text written to a storage medium. Also provided is a system, comprising a microprocessor and circuitry coupled to the microprocessor and adapted to receive a session encrypted data key and to decrypt the session encrypted data key using a private key, wherein a result is a secret key that is capable of being used to encrypt clear text and to decrypt cipher text written to a storage medium.

Abstract: A fuel control system for a vehicle includes a pressure compensation module that compensates an intake oxygen signal based on an intake pressure signal and that generates a compensated intake oxygen signal. A blow-by estimation module generates an estimated blow-by flow. A purge flow estimation module estimates the purge flow based on the compensated intake oxygen signal and the estimated blow-by flow. A fuel control estimation module reduces fueling to injectors of an engine of the vehicle based on the purge flow.

Abstract: Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) having a carboxylic acid equivalent at the C-terminal phenylalanine were prepared and attached to ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand-drug conjugates were active in vitro and in vivo in inhibiting cell proliferation and are represented by the general structure of Lv-[(LU)0-1-(D)1-4]p wherein L- is Ligand unit; LU is a Linker unit (LU); v is 1; p is an number ranging from about 1 to about 20; and D is a drug moiety having the formula: wherein the moiety —N(R9)Z1 is a phenylalanine bioisostere, wherein Z1 is —CH(R10)Z2 so that the phenylalanine bioisostere has the structure of Formula A: and wherein the substituents R2-R10, X1 and Z2 are as defined.

Abstract: A system according to the principles of the present disclosure includes an error period module and a sensor diagnostic module. The error period module determines an error period based on an amount of time that a first air/fuel ratio and a desired air/fuel ratio are different. A first oxygen sensor generates a first signal indicating the first air/fuel ratio. The sensor diagnostic module diagnoses a fault in the first oxygen sensor when the error period is greater than a predetermined period.

Abstract: An isolating clip for holding tubes, fluid lines and the like is provided with a rigid outer shell and a flexible insert. The insert includes an outer body and a tube seat suspended from the outer body by flexible connectors. Bumpers can be provided in the space between the outer body and tube seat to limit deflection of the tube seat.

Abstract: A method and apparatus for a software tool that interfaces with a Field Operations software tool and incorporates Voter Score, Voter Scorecard, Post-Election Voter History, Household Visualization, Voter Support Visualization, Household Mailing Labels, E-Mail Voter Footer, and Voter List of Friends and Family.

Abstract: The present invention provides the capability to quickly and easily determine the online reputation a target, and to quickly and easily take steps to improve the online reputation of the target. For example, a method of monitoring and affecting online reputation may comprise gathering information potentially related to an online reputation of a target, filtering the gathered information to eliminate information not related to the target, computing a reputation score for the filtered information based on both positive and negative information related to the target, generating positive information relating to the target, and distributing the generated positive information relating to the target to a plurality of online locations.

Abstract: Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) having a carboxylic acid equivalent at the C-terminal phenylalanine were prepared and attached to ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.

Abstract: This invention relates to pyrrolobenzodiazepines (PBDs), in particular pyrrolobenzodiazepine dimers having a C2-C3 double bond and an aryl group at the C2 position in each monomer unit, and their inclusion in targeted conjugates. The differing substituent groups may offer advantages in the preparation and use of the compounds, particularly in their biological properties and the synthesis of conjugates, and the biological properties of these conjugates.

Abstract: A machine is provided for preparing a desired product from a capsule containing desired ingredients. The machine includes a brew chamber that is adapted to hold the capsule at a downward angle relative to a horizontal plane. A cover for the brew chamber is adapted to move between an open position and a closed position. A loading mechanism is provided for extending and retracting the brew chamber. An injection system is provided for injecting a fluid into the capsule. A fluid transfer system is provided for transferring a desired fluid from a fluid source to the injection system. A dispensing system is provided for dispensing product to a receptacle. A reusable capsule is also provided for use with the machine.

Abstract: A charging device for a power storage device includes a power conduit configured to deliver current to the power storage device and a detection system configured to be coupled to the power conduit. The detection system includes a current control device coupled to the power conduit and configured to control the current delivered to the power storage device. The detection system also includes a test conductor, a current sensor coupled to the test conductor, and a controller coupled to the current sensor by the test conductor. The current sensor is arranged to detect an amount of current within the test conductor and configured to generate a current measurement signal representative of the current detected. The controller is configured to generate a test signal, transmit the test signal through the test conductor, receive the current measurement signal, and determine a status of the detection system based on the current measurement signal.

Abstract: A compound, or a pharmaceutically acceptable salt or solvate thereof, or conjugates thereof, selected from the group consisting of formula wherein: (a) R10 is H, and R11 is OH, ORA, where RA is saturated C1-4 alkyl; (b) R10 and R11 form a nitrogen-carbon double bond between the nitrogen and carbon atoms to which they are bound; or (c) R10 is H and R11 is S02M, where z is 2 or 3 and M is a monovalent pharmaceutically acceptable cation, or both M together are a divalent pharmaceutically acceptable cation.

Abstract: A system according to the principles of the present disclosure includes an engine speed module and a valve control module. The engine speed module determines a speed of an engine based on a position of a crankshaft. The valve control module selectively adjusts an operating frequency of a purge valve based on the engine speed.

Abstract: A compound with the formula (I), wherein: R2 is of formula (II), where X is selected from the group comprising: OH, SH, CO2H, COH, N?C?O, NHNH2, CONHNH2, formula (A), formula (B), NHRN, wherein RN is selected from the group comprising H and C1-4 alkyl; RC1, RC2 and RC3 are independently selected from H and unsubstituted C1-2 alkyl; and either: R12 is selected from the group consisting of: (ia) C5-10 aryl group, optionally substituted by one or more substituents selected from the group comprising: halo, nitro, cyano, ether, C1-7 alkyl, C3-7 heterocyclyl and bis-oxy-C1-3 alkylene; (ib) C1-5 saturated aliphatic alkyl; (ic) C3-6 saturated cycloalkyl; (id) formula (C), wherein each of R21, R22 and R23 are independently selected from H, C1-3 saturated alkyl, C2-3 alkenyl, C2-3 alkynyl and cyclopropyl, where the total number of carbon atoms in the R12 group is no more than 5; (ie) formula (D), wherein one of R25a and R25b is H and the other is selected from: phenyl, which phenyl is optionally substituted by a group

Abstract: Ligand Drug conjugate compounds comprising a ?-glucuronide-based linker and methods of using such compounds are provided.