Abstract: The present disclosure provides novel nucleic acid-guided nucleases and methods of using the nucleases for genome editing. The present disclosure further provides a system for editing a target region in a genome comprising a nucleic acid-guided nuclease, a heterologous guide nucleic acid for complexing with the nucleic acid-guided nuclease, and an editing polynucleotide configured to bind to the target region.

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R2a, R3, Ra2, Ra4, Ra5, Ra6, Ra7, X1, X1a, A1 and A2 have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating and preventing of one or more diseases or disorders associated with integrated stress response.

Abstract: Disclosed herein are system, method, and computer program product embodiments for providing a security model to customizable live applications in a cloud collaboration platform. The security approach may dedicate a frame to each live application, serving the frame from a different domain than a document in which the live application is embedded. This approach ensures that more stringent security requirements may be required of the live application and allows the data presented to the live application to be narrowly tailored. The security model may further leverage sandbox attributes and content-security policies to restrict the behavior of sandboxed and non-sandboxed live applications in accordance with best security practices.

Abstract: Implants for the fusion or fixation of two bone segments are described. For example, the implants can be used for the fusion or fixation of the sacroiliac joint. The implants can have a matrix structure, have a rectilinear cross-sectional area, and have a curvature.

Abstract: The apparatuses and methods described herein refer generally to equipment that may be used for exercise. In one embodiment, a pad for user exercise is disclosed. The pad may comprise a base plate; a dome disposed above the base plate; and a center plate disposed beneath at least a portion of the dome and coupled to the base plate via at least one spring affixed to the base plate; wherein the center plate is configured to provide resiliency and bounce to the dome.

Abstract: A charger base station includes at least one of a security system, home automation system, life safety system, a PER system and a tele-health system, the charger base station including a housing having a charger port for charging an electronic device with the housing having a compartment for a microprocessor, a memory, a firmware, a transceiver, a cellular communicator, Wi-Fi, and hardware, and software producing a security system supporting IP video, at least one peripheral device taken from the group of 319 MHz, 345 MHz, 433 MHz, 868 MHz and 900 MHz wireless peripherals, a home automation system serving as controller of z-wave or zigbee devices, life safety devices, a PERs device and tele-health device capable of measuring, recording and wirelessly transmitting physiological data of a connected tele-health product, life safety device and a PERs via at least one of a backend device, a central station device and local and remote user devices.

Abstract: A T-post hanger plate for mounting to a T-post forms an opening passing through the plate. The opening is shaped to allow the T-post to pass through the opening when the plate is orientated perpendicular to the T-post, and the opening engages the protrusions on the flange of the T-post when the T-post hanger plate is angled relative to the T-post. A hook at an end of the T-post hanger plate allows a target to be hung from the hanger plate when it is mounted to a T-post. The hook has a smooth inner surface and an angular outer surface. Striking the target causes the target to pivot on the hook, but the angular outer surface causes the target to bind on the hook preventing the target from swinging off of the hook due to the movement created by striking the target with a projectile, such as a bullet.

Abstract: Techniques are described for reducing false alarms related to security and automation systems. One method includes receiving a request to activate a security function associated with a automation system, initiating a first security duration after a predetermined time associated with the received request, detecting an occurrence of an event associated with the automation system during the first security duration, initiating a second security duration based on the detecting, and broadcasting a message requesting authentication credentials at a location of the automation system during the second security duration.

Abstract: An armrest for a vehicle includes an armrest element and a floating support assembly configured for selectively pivoting the armrest element in a vehicle-fore and -aft motion. The floating support assembly includes at least one vertically translatable support arm pivotally attached to the armrest element. The at least one vertically translatable support arm may be operatively supported by a resilient member.

Abstract: An assembly for mounting a door with a vehicle compartment includes an arm coupled with the compartment and with the door and a constant-force spring having a coil coupled with one of the door and the compartment and an end coupled with the other of the door and the compartment such that a contraction of the spring causes the door to move with rotation of the arm.

Abstract: Techniques are described for reducing false alarms related to security and automation systems. One method includes receiving a request to activate a security function associated with a automation system, initiating a first security duration after a predetermined time associated with the received request, detecting an occurrence of an event associated with the automation system during the first security duration, initiating a second security duration based on the detecting, and broadcasting a message requesting authentication credentials at a location of the automation system during the second security duration.

Abstract: A T-post hanger plate for mounting to a T-post forms an opening passing through the plate. The opening is shaped to allow the T-post to pass through the opening when the plate is orientated perpendicular to the T-post, and the opening engages the protrusions on the flange of the T-post when the T-post hanger plate is angled relative to the T-post. A hook at an end of the T-post hanger plate allows a target to be hung from the hanger plate when it is mounted to a T-post. The hook has a smooth inner surface and an angular outer surface. Striking the target causes the target to pivot on the hook, but the angular outer surface causes the target to bind on the hook preventing the target from swinging off of the hook due to the movement created by striking the target with a projectile, such as a bullet.

Abstract: A diagnostic system for assessing cardiovascular health is provided that incorporates a microfluidic platform and sensors that capture inflammatory monocytes. The portable microfluidic platform shears activated monocytes in a small volume of blood (˜50 ?L) over a glass substrate that mimics the stress and molecular constituents of an inflamed artery. The sensor utilizes CD11c antibodies and/or VLA-4 ligands to capture cells. The device captures a subset of inflammatory subset of activated white blood cells that play a critical role in the progression of cardiovascular disease and whose numbers in the blood and the efficiency of capture directly correlate with risk and pathogenesis of cardiovascular disease. The risk of future cardiac events can be assessed. The system can facilitate early detection of cardiovascular disease and can guide risk factor modification and therapy following treatment.

Abstract: An air bag chute assembly attaches an air bag module to an automotive instrument panel. An outer collar attaches the assembly to the instrument panel. A tubular chute extends interiorly from the collar to a lower end defining a deployment path for the air bag. A door flap is disposed in an upper end of the chute rotatable from the collar to emerge from the instrument panel. A hinge attaching the door flap to the collar comprises a plurality of S-shaped extendable hinge straps laterally spaced along one edge of the door flap. A first hinge strap proximate one lateral end of the hinge has a first length shorter than a second length of a second hinge strap proximate an opposite lateral end of the hinge, thereby restricting rotation of the door flap at the one lateral end in order to avoid contacting a windshield during deployment.

Abstract: Techniques are described for reducing false alarms related to security and automation systems. One method includes receiving a request to activate a security function associated with a automation system, initiating a first security duration after a predetermined time associated with the received request, detecting an occurrence of an event associated with the automation system during the first security duration, initiating a second security duration based on the detecting, and broadcasting a message requesting authentication credentials at a location of the automation system during the second security duration.

Abstract: Techniques are described for reducing false alarms related to security and automation systems. One method includes receiving a request to activate a security function associated with a automation system, initiating a first security duration after a predetermined time associated with the received request, detecting an occurrence of an event associated with the automation system during the first security duration, initiating a second security duration based on the detecting, and broadcasting a message requesting authentication credentials at a location of the automation system during the second security duration.

Abstract: A cup holder assembly includes a door configured for translation between an open and a closed configuration, at least one receiver sidewall, and at least one first cup holder surface provided by a bottom surface of the door and configured to upwardly extend at least a portion of the receiver sidewall when the door is disposed in an open configuration. A retention system for a container is provided, including at least one container biasing member and at least one container supporting member. The container biasing member may be door-mounted or receiver sidewall-mounted.

Abstract: An assembly for mounting a door with a vehicle compartment includes an arm coupled with the compartment and with the door, a track fixed with the compartment, and a carrier pivotably coupled with the door and slidable along the track. The assembly further includes a spring coupled between the door and the compartment such that a contraction of the spring alone causes the door to move with rotation of the arm and movement of the carrier along the track. A track cover engages the carrier to prevent disengagement of the carrier from the track.

Abstract: An armrest for a vehicle includes an armrest element and a floating support assembly configured for selectively pivoting the armrest element in a vehicle-fore and -aft motion. The floating support assembly includes at least one vertically translatable support arm pivotally attached to the armrest element. The at least one vertically translatable support arm may be operatively supported by a resilient member.

Abstract: An assembly for mounting a door with a vehicle compartment includes an arm coupled with the compartment and with the door, a track fixed with the compartment, and a carrier pivotably coupled with the door and slidable along the track. The assembly further includes a spring coupled between the door and the compartment such that a contraction of the spring alone causes the door to move with rotation of the arm and movement of the carrier along the track. A track cover engages the carrier to prevent disengagement of the carrier from the track.