Abstract: The present invention provides compositions and methods that can be used to determine a peptide signature for an antibody repertoire in a sample comprising multiple antibodies. The method can be used to characterize a phenotype in a sample, such as providing a diagnosis, prognosis or theranosis of a medical condition.

Abstract: An electronic nicotine delivery systems (“ENDS”) device may include aerosol delivery devices such as smoking articles that produce aerosol. The device may include a cartridge for the aerosol production. The cartridge is assigned a unique identifier that is approved for a user or that user's device such that the cartridge and/or the device only operate when approved. The unique identifiers help with user identification, tracking, and age verification.

Abstract: A charger for an electronic nicotine delivery systems (“ENDS”) device, which may include aerosol delivery devices provides functionality for authentication, including age verification. Such devices may be restricted based on age or other factors that require some form of authentication, verification, and/or identification to satisfy the restriction. The accessory or charger may provide or connect with a verification system for confirming an age of a user. If the authentication or verification is not satisfied, the charger or accessory will not charge the device, rendering it unusable.

Abstract: An aerosol delivery or electronic nicotine delivery systems (“ENDS”) device may include smoking articles that produce aerosol. The device may operate upon authentication. The authentication may first include an age verification before an authentication allows for operation of the device. The authentication may include a control signal communication to the device. The control signal communication may include an audio signal, such as an authentication tone that is detected by a microphone or pressure sensor on the device. The control signal communication may include a visual, optical, or light signal that is detected by a light sensor or photodiode on the device.

Abstract: A bender includes a rotatable bending shoe having a plurality of channels therein configured to receive a workpiece and a follower assembly. The follower assembly includes a mount, a follower bar attached to the mount, the follower bar having a plurality of channels therein configured to receive the workpiece, a roller attached to the mount and engaged against the follower bar, the roller having an eccentric shaft extending therefrom, and a motor for rotating the shaft and roller, wherein rotation of the shaft and roller causes the follower bar to translate toward or away from the bending shoe. A drive member can be provided to move the mount toward or away from the bending shoe.

Abstract: An aerosol delivery device is provided that includes a power source, a heating element, a switch coupled to and between the power source and the heating element, and processing circuitry coupled to the switch. The processing circuitry outputs a PWM signal during a heating time period to cause the switch to switchably connect and disconnect the output voltage to the heating element to power the heating element. The processing circuitry outputs a pulse of known current to the heating element, and measure voltage across the heating element, between adjacent pulses of the PWM signal. And the processing circuitry calculates the resistance of the heating element based on the known current and the voltage, calculates the temperature of the heating element based on the resistance, and adjusts a duty cycle of the PWM signal when the temperature deviates from a predetermined target.

Abstract: The present disclosure provides an aerosol delivery device. The aerosol delivery device comprises one or more rechargeable batteries, charging circuitry including an electrical connector configured to interconnect the one or more rechargeable batteries with a power supply, and a sensor configured to detect an action of using the aerosol delivery device by a user and output a signal. The aerosol delivery device also comprises a microprocessor coupled to the charging circuitry and the sensor, the microprocessor, in response to receiving the signal from the sensor, is configured to control the aerosol delivery device to allow vaping or puffing by a user while the aerosol delivery device is connected to a charger.

Abstract: The present disclosure provides an aerosol delivery device comprising a control device that is connectable with a cartridge and that can include one or more additional elements for improving one or both of visible indications of use to a user and resistance to infiltration of liquid into the control device. More particularly, the control device may include a light guide configured for transmitting to a window from a light source that is off-set from the window and a controller configured to direct a varying level of light from the light source. The control device may include one or more elements that are configured to limit infiltration of liquids into the control device and thus may be consider to be water-resistant or water-proof.

Abstract: The present disclosure relates to aerosol delivery devices comprising a power unit and a cartridge that is configured for engagement with the power unit. In particular, the cartridge can be configured for rotation about a longitudinal axis thereof so as to be insertable into a chamber of the power unit in a plurality of different orientations. Further, the aerosol delivery device can include processing circuitry that can be configured for detection of the cartridge orientation and execution of a control function assigned to the respective orientation.

Abstract: An aerosol delivery device is provided. The aerosol delivery device includes a power source, an aerosol production component, a sensor to produce measurements of atmospheric air pressure in an air flow path through at least one housing, and a switch coupled to and between the power source and the aerosol production component. The aerosol delivery device also includes processing circuitry that determines a difference between the measurements of atmospheric air pressure and a reference atmospheric air pressure. Only when the difference is at least a threshold difference, the processing circuitry outputs a signal to cause the switch to switchably connect and disconnect an output voltage from the power source to the aerosol production component to adjust power provided to the aerosol production component to a power target that is variable according to a predetermined relationship between the difference and the power target.

Abstract: Methods of making and using bacterial display polypeptide libraries using circularly permuted OmpX (CPX) variants are disclosed. The invention further relates to methods for enhancing the display of proteins and peptides at the surface of bacteria by optimizing linkers and incorporating mutations at positions 165 and 166 of CPX.

Abstract: The present disclosure provides an aerosol delivery device and a cartridge for an aerosol delivery device. In various implementations, the aerosol delivery device comprises a control device that includes an outer housing defining a cartridge receiving chamber, and further includes a power source and a control component, and a cartridge that includes a mouthpiece, a tank, a heating assembly, and a bottom cap. The mouthpiece defines an exit portal in an end thereof, and the tank is configured to contain a liquid composition therein. The cartridge is configured to be removably coupled with the receiving chamber of the control device, and the heating assembly defines a vaporization chamber and is configured to heat the liquid composition to generate an aerosol. An inlet airflow is defined by a gap between the cartridge and the control device that originates at an interface between an outer peripheral surface the mouthpiece and control device.

Abstract: The present disclosure provides an aerosol delivery device and a cartridge for an aerosol delivery device. In various implementations, the aerosol delivery device comprises a control device that includes an outer housing defining a cartridge receiving chamber, and further includes a power source and a control component, and a cartridge that includes a mouthpiece, a tank, a heating assembly, and a bottom cap. The mouthpiece defines an exit portal in an end thereof, and the tank is configured to contain a liquid composition therein. The cartridge is configured to be removably coupled with the receiving chamber of the control device, and the heating assembly defines a vaporization chamber and is configured to heat the liquid composition to generate an aerosol. The heating assembly comprises a substantially planar heating member and a liquid transport element, wherein the heating member is installed in a bowed orientation.

Abstract: The present disclosure relates to aerosol delivery devices and cartridges for aerosol delivery devices. The cartridge comprises a mouthpiece having a proximal end and a distal end, the proximal end of the mouthpiece having an exit portal defined therethrough, a tank defining a proximal end and a closed distal end, the tank being configured to contain a liquid composition that includes a distinctive characteristic, and a heater configured to heat the liquid composition. The distal end of the mouthpiece is configured to engage the proximal end of the tank, and when the cartridge is coupled with the aerosol delivery device at least one feature of the cartridge, or at least one feature of the control device, or at least one feature of both the cartridge and the control device, provides a visual indication of a color associated with the distinctive characteristic.

Abstract: A conduit bender having a unitary frame is mounted to a wheeled base which provides for transportation of the bender. A braking assembly provides for simplified locking of the wheels to secure the bender in a location. The bender is mounted to the base through a pivoting assembly which allows for bending of conduit in either a horizontal or vertical plane. A circuit is provided for controlling the bending operation. An auto-sensing portion of the circuit receives information regarding the characteristics of the conduit to be bent upon placement of the conduit in the bender. A feedback portion of the circuit is used to provide a precise bending operation.

Abstract: A bender includes a rotatable bending shoe having a plurality of channels therein configured to receive a workpiece and a follower assembly. The follower assembly includes a mount, a follower bar attached to the mount, the follower bar having a plurality of channels therein configured to receive the workpiece, a roller attached to the mount and engaged against the follower bar, the roller having an eccentric shaft extending therefrom, and a motor for rotating the shaft and roller, wherein rotation of the shaft and roller causes the follower bar to translate toward or away from the bending shoe. A drive member can be provided to move the mount toward or away from the bending shoe.

Abstract: The present invention provides compositions and methods that can be used to determine a peptide signature for an antibody repertoire in a sample comprising multiple antibodies. The method can be used to characterize a phenotype in a sample, such as providing a diagnosis, prognosis or theranosis of a medical condition.

Abstract: A conduit bender having a unitary frame is mounted to a wheeled base which provides for transportation of the bender. A braking assembly provides for simplified locking of the wheels to secure the bender in a location. The bender is mounted to the base through a pivoting assembly which allows for bending of conduit in either a horizontal or vertical plane. A circuit is provided for controlling the bending operation. An auto-sensing portion of the circuit receives information regarding the characteristics of the conduit to be bent upon placement of the conduit in the bender. A feedback portion of the circuit is used to provide a precise bending operation.

Abstract: A bender and base assembly according to some embodiments of the disclosure is provided. The bender includes a frame having a pivot shaft extending therefrom, and a shoe shaft extending from the frame for receiving a shoe rotatably mounted thereon, the shoe shaft defining a shoe axis and a shoe plane perpendicular to the shoe axis. The base includes a pivot shaft receptacle, wherein the pivot shaft receptacle defines a pivot axis, wherein the pivot shaft of the bender is received by the pivot shaft receptacle of the base; wherein the pivot shaft rotates relative to the pivot shaft receptacle, to rotate the bender on the pivot axis between a horizontal bending position and a vertical bending position; and wherein the pivot axis intersects with the shoe plane. A lock is provided to lock the position of the bender relative to the base.

Abstract: An automated bender and its method of operation according to some embodiments of the disclosure is provided. The automated bender includes a carousel which has all of the necessary components for bending a variety of conduit sizes provided thereon. The carousel can be rotated to a desired bending position to bend a particular type of conduit. A straight workpiece is fed into the automated bender and a bent workpiece, which may have multiple bends therein, is output from the automated bender. This bending process is performed without manual intervention. Software for achieving same is provided.