Abstract: An aerosol delivery or electronic nicotine delivery systems (“ENDS”) device may include smoking articles that produce aerosol. The device may operate upon authentication. The authentication may first include an age verification before an authentication allows for operation of the device. The authentication may include a control signal communication to the device. The control signal communication may include an audio signal, such as an authentication tone that is detected by a microphone or pressure sensor on the device. The control signal communication may include a visual, optical, or light signal that is detected by a light sensor or photodiode on the device.

Abstract: The present invention provides compositions and methods that can be used to determine a peptide signature for an antibody repertoire in a sample comprising multiple antibodies. The method can be used to characterize a phenotype in a sample, such as providing a diagnosis, prognosis or theranosis of a medical condition.

Abstract: A test fixture for testing aerosol provision devices includes a housing, a plurality of testing modules disposed at the housing where each of the testing modules includes a cavity configured to receive a portion of an aerosol provision device, and processing circuitry operably coupled to the testing modules. Each of the testing modules is configured to interface with an assembly of a respective one of the aerosol provision devices to transition the assembly between an initial state and a transitioned state during a functional test controlled by the processing circuitry. The processing circuitry is configured to conduct the functional test of at least two of the testing modules simultaneously.

Abstract: An aerosol delivery device may include a rechargeable power source configured to provide power to generate an aerosol, device electronics configured to generate the aerosol responsive to application of the power from the power source, and a lock assembly configured to perform either one or both of preventing recharging the power source and preventing the application of the power from the power source to the device electronics in a locked state, and to enable recharging the power source and the application of power from the power source to the device electronics in an unlocked state. The lock assembly may be configured to detect a wake event while the lock assembly is in the locked state, wake the lock assembly in response to the wake event, perform an authentication process, and, in response to completing the authentication process, transition the lock assembly between the locked state and the unlocked state.

Abstract: The present disclosure relates to aerosol delivery devices and cartridges for aerosol delivery devices. The cartridge comprises a mouthpiece having a proximal end and a distal end, the proximal end of the mouthpiece having an exit portal defined therethrough, a tank defining a proximal end and a closed distal end, the tank being configured to contain a liquid composition that includes a distinctive characteristic, and a heater configured to heat the liquid composition. The distal end of the mouthpiece is configured to engage the proximal end of the tank, and when the cartridge is coupled with the aerosol delivery device at least one feature of the cartridge, or at least one feature of the control device, or at least one feature of both the cartridge and the control device, provides a visual indication of a color associated with the distinctive characteristic.

Abstract: An aerosol provision system (1) for generating an aerosol from an aerosol-generating material (43) during a session of use, the aerosol provision system comprising: the aerosol-generating material (43); at least one heater (48) configured to aerosolise the aerosol-generating material (43); a plurality of substances (60, 70) disposed within the aerosol provision system (1) and arranged to be released at different times during the session of use; wherein a first substance (60) of the plurality of substances is encapsulated by a first shell (61), and a second substance (70) of the plurality of substances is encapsulated by a second shell (71).

Abstract: An electronic nicotine delivery systems (“ENDS”) device may include aerosol delivery devices such as smoking articles that produce aerosol. The device may include a cartridge for the aerosol production. The cartridge is assigned a unique identifier that is approved for a user or that user's device such that the cartridge and/or the device only operate when approved. The unique identifiers help with user identification, tracking, and age verification.

Abstract: A method of preventing unauthorized use of an aerosol provision device may include receiving a wireless signal including an unlock code for unlocking the aerosol provision device, processing the wireless signal to determine host device characterization information or environmental context information, tuning processing circuitry to process the unlock code based on the host device characterization information or environmental context information, and transitioning the aerosol provision device from a locked state to an unlocked state responsive to processing the unlock code.

Abstract: The present disclosure provides activatable binding polypeptides (ABPs), which contain a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM). The present disclosure provides activatable antibody compositions, which contain a TBM containing an antigen binding domain (ABD), a MM and a CM. Furthermore the present disclosure also provides ABPs which contain a first TBM, a second TBM and a CM. The ABPs exhibit an “activatable” conformation such that at least one of the TBMs is less accessible to target when uncleaved than after cleavage of the CM in the presence of a cleaving agent capable of cleaving the CM. The disclosure further provides libraries of candidate ABPs, methods of screening to identify such ABPs, and methods of use. The disclosure further provides ABPs having TBMs that bind VEGF, CTLA-4, or VCAM, ABPs having a first TBM that binds VEGF and a second TBM that binds FGF, as well as compositions and methods of use.

Abstract: An aerosol delivery device may include a rechargeable power source configured to provide power to generate an aerosol, device electronics configured to generate the aerosol responsive to application of the power from the power source, and a lock assembly configured to perform either one or both of preventing recharging the power source and preventing the application of the power from the power source to the device electronics in a locked state, and to enable recharging the power source and the application of power from the power source to the device electronics in an unlocked state. The lock assembly may be configured to detect a wake event while the lock assembly is in the locked state, wake the lock assembly in response to the wake event, perform an authentication process, and, in response to completing the authentication process, transition the lock assembly between the locked state and the unlocked state.

Abstract: The present invention provides compositions and methods that can be used to determine a peptide signature for an antibody repertoire in a sample comprising multiple antibodies. The method can be used to characterize a phenotype in a sample, such as providing a diagnosis, prognosis or theranosis of a medical condition.

Abstract: The present invention provides compositions and methods that can be used to determine a peptide signature for an antibody repertoire in a sample comprising multiple antibodies. The method can be used to characterize a phenotype in a sample, such as providing a diagnosis, prognosis or theranosis of a medical condition.

Abstract: A method of preventing unauthorized use of an aerosol provision device may include receiving a wireless signal including an unlock code for unlocking the aerosol provision device, processing the wireless signal to determine host device characterization information or environmental context information, tuning processing circuitry to process the unlock code based on the host device characterization information or environmental context information, and transitioning the aerosol provision device from a locked state to an unlocked state responsive to processing the unlock code.

Abstract: The present disclosure provides an aerosol delivery device. The aerosol delivery device comprises one or more rechargeable batteries, charging circuitry including an electrical connector configured to interconnect the one or more rechargeable batteries with a power supply, and a sensor configured to detect an action of using the aerosol delivery device by a user and output a signal. The aerosol delivery device also comprises a microprocessor coupled to the charging circuitry and the sensor, the microprocessor, in response to receiving the signal from the sensor, is configured to control the aerosol delivery device to allow vaping or puffing by a user while the aerosol delivery device is connected to a charger.

Abstract: An aerosol delivery device may include a rechargeable power source configured to provide power to generate an aerosol, device electronics configured to generate the aerosol responsive to application of the power from the power source, and an authentication module. The authentication module may include a separate chip or circuit board relative to the device electronics. The authentication module may be inserted into the aerosol delivery device between the power source and the device electronics to control provision of the power to the device electronics for generation of the aerosol or between the power source and a charge port of the aerosol delivery device to control charging of the power source.

Abstract: The present disclosure provides an aerosol delivery device comprising a control device that is connectable with a cartridge and that can include one or more additional elements for improving one or both of visible indications of use to a user and resistance to infiltration of liquid into the control device. More particularly, the control device may include a light guide configured for transmitting to a window from a light source that is off-set from the window and a controller configured to direct a varying level of light from the light source. The control device may include one or more elements that are configured to limit infiltration of liquids into the control device and thus may be consider to be water-resistant or water-proof.

Abstract: A charger for an electronic nicotine delivery systems (“ENDS”) device, which may include aerosol delivery devices provides functionality for authentication, including age verification. Such devices may be restricted based on age or other factors that require some form of authentication, verification, and/or identification to satisfy the restriction. The accessory or charger may provide or connect with a verification system for confirming an age of a user. If the authentication or verification is not satisfied, the charger or accessory will not charge the device, rendering it unusable.

Abstract: An aerosol provision device is provided that includes an aerosol generator powered to generate an aerosol from an aerosol-generating material for delivery to a user. The aerosol provision device includes a sensor to detect a process variable other than temperature that indicates use of the aerosol provision device, and the sensor includes an on-chip temperature sensor to measure the temperature. The aerosol provision device also includes processing circuitry to control power to the aerosol generator, responsive to the process variable detected by the sensor. The processing circuitry is further configured to receive a signal from the sensor that indicates the temperature as measured by the sensor, and suspend power to the aerosol generator based on the temperature and a threshold temperature.

Abstract: An aerosol provision device is provided having a power source including a first temperature sensor, processing circuitry including a second temperature sensor, and a use sensor including a third temperature sensor. A temperature of the aerosol provision device may be determined based on at least two of: the temperature measured by the first temperature sensor, the temperature measured by the second temperature sensor, and the temperature measures by the third temperature sensor, and at least one device function may be controlled based on the determined temperature of the aerosol provision device, and at least one threshold temperature.

Abstract: An aerosol delivery or electronic nicotine delivery systems (“ENDS”) device may include smoking articles that produce aerosol. The device may operate upon authentication. The authentication may first include an age verification before an authentication allows for operation of the device. The authentication may include a control signal communication to the device. The control signal communication may include an audio signal, such as an authentication tone that is detected by a microphone or pressure sensor on the device. The control signal communication may include a visual, optical, or light signal that is detected by a light sensor or photodiode on the device.