Patents by Inventor Sean A. Daugherty

Sean A. Daugherty has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10449587
    Abstract: A bender and base assembly according to some embodiments of the disclosure is provided. The bender includes a frame having a pivot shaft extending therefrom, and a shoe shaft extending from the frame for receiving a shoe rotatably mounted thereon, the shoe shaft defining a shoe axis and a shoe plane perpendicular to the shoe axis. The base includes a pivot shaft receptacle, wherein the pivot shaft receptacle defines a pivot axis, wherein the pivot shaft of the bender is received by the pivot shaft receptacle of the base; wherein the pivot shaft rotates relative to the pivot shaft receptacle, to rotate the bender on the pivot axis between a horizontal bending position and a vertical bending position; and wherein the pivot axis intersects with the shoe plane. A lock is provided to lock the position of the bender relative to the base.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: October 22, 2019
    Assignee: GREENLEE TOOLS, INC.
    Inventors: Jeffrey J. Plummer, Sean A. Daugherty
  • Patent number: 10406580
    Abstract: An automated bender and its method of operation according to some embodiments of the disclosure is provided. The automated bender includes a carousel which has all of the necessary components for bending a variety of conduit sizes provided thereon. The carousel can be rotated to a desired bending position to bend a particular type of conduit. A straight workpiece is fed into the automated bender and a bent workpiece, which may have multiple bends therein, is output from the automated bender. This bending process is performed without manual intervention. Software for achieving same is provided.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: September 10, 2019
    Assignee: GREENLEE TOOLS, INC.
    Inventors: Sean Daugherty, Jeffrey Plummer, Ryan Mantell, Gerald Tully, Sumeet Pujari
  • Patent number: 10386373
    Abstract: The present invention provides compositions and methods that can be used to determine a peptide signature for an antibody repertoire in a sample comprising multiple antibodies. The method can be used to characterize a phenotype in a sample, such as providing a diagnosis, prognosis or theranosis of a medical condition.
    Type: Grant
    Filed: May 29, 2018
    Date of Patent: August 20, 2019
    Assignee: Serimmune Inc.
    Inventors: Patrick Sean Daugherty, Kathryn Vinaya Louise Kamath, Jack Ryan Reifert
  • Publication number: 20190211089
    Abstract: Activatable binding polypeptides (ABPs), which contain a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM) are provided. Activatable antibody compositions, which contain a TBM containing an antigen binding domain (ABD), a MM and a CM are provided. Furthermore, ABPs which contain a first TBM, a second TBM and a CM are provided. The ABPs exhibit an “activatable” conformation such that at least one of the TBMs is less accessible to target when uncleaved than after cleavage of the CM in the presence of a cleaving agent capable of cleaving the CM. Further provided are libraries of candidate ABPs, methods of screening to identify such ABPs, and methods of use. Further provided are ABPs having TBMs that bind VEGF, CTLA-4, or VCAM, ABPs having a first TBM that binds VEGF and a second TBM that binds FGF, as well as compositions and methods of use.
    Type: Application
    Filed: August 13, 2018
    Publication date: July 11, 2019
    Inventors: Patrick Sean Daugherty, Nancy Stagliano, Jerry Thomas, Kathryn Kamath, James W. West, Sanjay Khare, Jason Sagert
  • Publication number: 20190032043
    Abstract: The present invention provides compositions including peptide display scaffolds that present at least one candidate peptide and at least one detectable moiety in at least one of the N-terminal and C-terminal candidate peptide presenting domains that when expressed in a cell are accessible at a surface of the cell outermembrane. In addition, the present invention also provides kits and methods for screening a library of cells presenting the candidate peptides in peptide display scaffolds to identify a ligand for an enzyme.
    Type: Application
    Filed: June 11, 2018
    Publication date: January 31, 2019
    Inventors: Patrick Sean Daugherty, Kevin Todd Boulware
  • Publication number: 20180267056
    Abstract: The present invention provides compositions and methods that can be used to determine a peptide signature for an antibody repertoire in a sample comprising multiple antibodies. The method can be used to characterize a phenotype in a sample, such as providing a diagnosis, prognosis or theranosis of a medical condition.
    Type: Application
    Filed: May 29, 2018
    Publication date: September 20, 2018
    Inventors: Patrick Sean Daugherty, Kathryn Vinaya Louise Kamath, Jack Ryan Reifert
  • Patent number: 10077300
    Abstract: Activatable binding polypeptides (ABPs), which contain a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM) are provided. Activatable antibody compositions, which contain a TBM containing an antigen binding domain (ABD), a MM and a CM are provided. Furthermore, ABPs which contain a first TBM, a second TBM and a CM are provided. The ABPs exhibit an “activatable” conformation such that at least one of the TBMs is less accessible to target when uncleaved than after cleavage of the CM in the presence of a cleaving agent capable of cleaving the CM. Further provided are libraries of candidate ABPs, methods of screening to identify such ABPs, and methods of use. Further provided are ABPs having TBMs that bind VEGF, CTLA-4, or VCAM, ABPs having a first TBM that binds VEGF and a second TBM that binds FGF, as well as compositions and methods of use.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: September 18, 2018
    Assignees: The Regents of the University of California, CytomX Therapeutics, Inc.
    Inventors: Patrick Sean Daugherty, Nancy Stagliano, Jerry Thomas, Kathryn Kamath, James W. West, Sanjay Khare, Jason Sagert
  • Patent number: 10017757
    Abstract: The present invention provides compositions including peptide display scaffolds that present at least one candidate peptide and at least one detectable moiety in at least one of the N-terminal and C-terminal candidate peptide presenting domains that when expressed in a cell are accessible at a surface of the cell outermembrane. In addition, the present invention also provides kits and methods for screening a library of cells presenting the candidate peptides in peptide display scaffolds to identify a ligand for an enzyme.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: July 10, 2018
    Assignee: The Regents of the University of California
    Inventors: Patrick Sean Daugherty, Kevin Todd Boulware
  • Publication number: 20180062360
    Abstract: A control device according to some embodiments of the disclosure includes one or more motors directed by the control device to form whip(s) from a length of a cable by causing the cutting of the cable in accordance with specifications based at least in part on whip information. An interface communicates the whip information between the control device and a user device.
    Type: Application
    Filed: August 29, 2017
    Publication date: March 1, 2018
    Inventors: William Frederick Nordlin, Sean A. Daugherty, John Jeremiah Morton, Daniel John Marben, Sumeet Pujari
  • Publication number: 20180056410
    Abstract: A machine configured to form at least one whip from a length of cable according to some embodiments of the disclosure includes an input and an output defining a cable travel space being therebetween; a clamping assembly including a pad, and a first driving assembly configured to move the pad into the cable travel space and out of the cable travel space; and a cutting assembly including a cutting tool having at least one cutting edge, and a second driving assembly configured to move the cutting tool into the cable travel space and out of the cable travel space. In some embodiments, the machine further includes a saw assembly including a notching saw having a cutting edge configured to intersect the cable travel space, and a third driving assembly configured to drive the notching saw.
    Type: Application
    Filed: August 29, 2017
    Publication date: March 1, 2018
    Inventors: William Frederick Nordlin, Dale Ritchie Williams, Sean A. Daugherty, John Jeremiah Morton, Daniel John Marben
  • Publication number: 20180002687
    Abstract: Methods of making and using bacterial display polypeptide libraries using circularly permuted OmpX (CPX) variants are disclosed. The invention further relates to methods for enhancing the display of proteins and peptides at the surface of bacteria by optimizing linkers and incorporating mutations at positions 165 and 166 of CPX.
    Type: Application
    Filed: June 5, 2017
    Publication date: January 4, 2018
    Inventors: Patrick Sean Daugherty, Jeffrey Rice
  • Patent number: 9849494
    Abstract: An automated bender and its method of operation according to some embodiments of the disclosure is provided. The automated bender includes a carousel which has all of the necessary components for bending a variety of conduit sizes provided thereon. The carousel can be rotated to a desired bending position to bend a particular type of conduit. A straight workpiece is fed into the automated bender and a bent workpiece, which may have multiple bends therein, is output from the automated bender. This bending process is performed without manual intervention. Software for achieving same is provided.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: December 26, 2017
    Assignee: TEXTRON INNOVATIONS INC.
    Inventors: Jeffrey Plummer, Sean Daugherty, Ryan Mantell, Gerald Tully
  • Patent number: 9695415
    Abstract: Methods of making and using bacterial display polypeptide libraries using circularly permuted OmpX (CPX) variants are disclosed. The invention further relates to methods for enhancing the display of proteins and peptides at the surface of bacteria by optimizing linkers and incorporating mutations at positions 165 and 166 of CPX.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: July 4, 2017
    Assignee: The Regents of the University of California
    Inventors: Patrick Sean Daugherty, Jeffrey Rice
  • Patent number: 9663304
    Abstract: A rotary chuck includes a clamp assembly, a first drive mechanism for operating the clamp assembly to clamp an associated workpiece, a frame rotationally fixed to the clamp assembly, and a second drive mechanism for rotating the frame and the clamp assembly. The second drive mechanism can rotate the frame and the clamp assembly around 360 degrees. A pair of alignment springs are engaged with a mounting plate upon which the second drive mechanism is mounted. The mounting plate can pivot relative to a stable surface to which it is mounted, and the springs limit the pivotal movement. Each first and second drive mechanism includes a motor, and are connected to a microprocessor for operation of the respective motor.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: May 30, 2017
    Assignee: GREENLEE TEXTRON INC.
    Inventors: Ryan Mantell, Jeffrey Plummer, Gerald Tully, Sean Daugherty
  • Publication number: 20160303632
    Abstract: A conduit bender having a unitary frame is mounted to a wheeled base which provides for transportation of the bender. A braking assembly provides for simplified locking of the wheels to secure the bender in a location. The bender is mounted to the base through a pivoting assembly which allows for bending of conduit in either a horizontal or vertical plane. A circuit is provided for controlling the bending operation. An auto-sensing portion of the circuit receives information regarding the characteristics of the conduit to be bent upon placement of the conduit in the bender. A feedback portion of the circuit is used to provide a precise bending operation.
    Type: Application
    Filed: June 27, 2016
    Publication date: October 20, 2016
    Inventors: Jeffrey J. Plummer, Sean A. Daugherty
  • Publication number: 20160228933
    Abstract: A bender and base assembly according to some embodiments of the disclosure is provided. The bender includes a frame having a pivot shaft extending therefrom, and a shoe shaft extending from the frame for receiving a shoe rotatably mounted thereon, the shoe shaft defining a shoe axis and a shoe plane perpendicular to the shoe axis. The base includes a pivot shaft receptacle, wherein the pivot shaft receptacle defines a pivot axis, wherein the pivot shaft of the bender is received by the pivot shaft receptacle of the base; wherein the pivot shaft rotates relative to the pivot shaft receptacle, to rotate the bender on the pivot axis between a horizontal bending position and a vertical bending position; and wherein the pivot axis intersects with the shoe plane. A lock is provided to lock the position of the bender relative to the base.
    Type: Application
    Filed: February 4, 2016
    Publication date: August 11, 2016
    Inventors: Jeffrey J. Plummer, Sean A. Daugherty
  • Patent number: 9375773
    Abstract: A conduit bender having a unitary frame is mounted to a wheeled base which provides for transportation of the bender. A braking assembly provides for simplified locking of the wheels to secure the bender in a location. The bender is mounted to the base through a pivoting assembly which allows for bending of conduit in either a horizontal or vertical plane. A circuit is provided for controlling the bending operation. An auto-sensing portion of the circuit receives information regarding the characteristics of the conduit to be bent upon placement of the conduit in the bender. A feed back portion of the circuit is used to provide a precise bending operation.
    Type: Grant
    Filed: May 5, 2011
    Date of Patent: June 28, 2016
    Assignee: TEXTRON INNOVATIONS INC.
    Inventors: Jeffrey J. Plummer, Sean A. Daugherty
  • Publication number: 20160122425
    Abstract: Activatable binding polypeptides (ABPs), which contain a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM) are provided. Activatable antibody compositions, which contain a TBM containing an antigen binding domain (ABD), a MM and a CM are provided. Furthermore, ABPs which contain a first TBM, a second TBM and a CM are provided. The ABPs exhibit an “activatable” conformation such that at least one of the TBMs is less accessible to target when uncleaved than after cleavage of the CM in the presence of a cleaving agent capable of cleaving the CM. Further provided are libraries of candidate ABPs, methods of screening to identify such ABPs, and methods of use. Further provided are ABPs having TBMs that bind VEGF, CTLA-4, or VCAM, ABPs having a first TBM that binds VEGF and a second TBM that binds FGF, as well as compositions and methods of use.
    Type: Application
    Filed: September 14, 2015
    Publication date: May 5, 2016
    Inventors: Patrick Sean Daugherty, Nancy Stagliano, Jerry Thomas, Kathryn Kamath, James W. West, Sanjay Khare, Jason Sagert
  • Patent number: 9283605
    Abstract: A conduit bender having a unitary frame is mounted to a wheeled base which provides for transportation of the bender. A braking assembly provides for simplified locking of the wheels to secure the bender in a location. The bender is mounted to the base through a pivoting assembly which allows for bending of conduit in either a horizontal or vertical plane. A circuit is provided for controlling the bending operation. An auto-sensing portion of the circuit receives information regarding the characteristics of the conduit to be bent upon placement of the conduit in the bender. A feed back portion of the circuit is used to provide a precise bending operation.
    Type: Grant
    Filed: May 5, 2011
    Date of Patent: March 15, 2016
    Assignee: GREENLEE TEXTRON INC.
    Inventors: Jeffrey J. Plummer, Sean A. Daugherty
  • Publication number: 20160010084
    Abstract: The present invention provides compositions including peptide display scaffolds that present at least one candidate peptide and at least one detectable moiety in at least one of the N-terminal and C-terminal candidate peptide presenting domains that when expressed in a cell are accessible at a surface of the cell outermembrane. In addition, the present invention also provides kits and methods for screening a library of cells presenting the candidate peptides in peptide display scaffolds to identify a ligand for an enzyme.
    Type: Application
    Filed: July 21, 2015
    Publication date: January 14, 2016
    Inventors: Patrick Sean Daugherty, Kevin Todd Boulware