Abstract: Cured silicone particles are disclosed. The cured silicone particles are obtained by curing a curable silicone composition comprising at least components (A) through (C), wherein components (A) and (B) are polyorganosiloxanes having certain average formulas, and component (C) is a catalyst. The average particle size of the cured silicone particles is from 0.1 to 500 ?m. Related methods and a cosmetic material comprising the cured silicone particles are also disclosed.

Abstract: A liquid organopolysiloxane having fluidity at least 100° C., a silicon-bonded glycerin derivative group, and a crosslinked structure comprising a carbon-silicon bond at the crosslinking portion.

Abstract: The present invention provides a glycerin-modified silicone which has an excellent emulsification/dispersion performance and thickening effect when used alone, particularly when the oil phase is a continuous phase. The present invention is a specific diglycerin derivative-modified silicone having a long-chain hydrocarbon group at a prescribed ratio in a molecule and having as a hydrophilic group only a diglycerin derivative group not having an oxyalkylene structure with an average value of the number of repetitions of oxyalkylene units of two or more; and a composition containing the diglycerin derivative-modified silicone.

Abstract: A surface treatment agent or a powder treatment agent comprising a co-modified organopolysiloxane is disclosed. The co-modified organopolysiloxane is represented by the general formula: R1aR2bQcSiO(4?a?b?c)/2. The co-modified organopolysiloxane has a number average molecular weight of less than 4500 and includes a long-chain alkyl group and a polyoxyalkylene group in the molecule.

Abstract: The present invention provides a release control agent for producing a release agent composition that has sufficient releasability from a silicone-based adhesive agent and that exhibits excellent releasability even when pressure is applied to a cured product; a silicone release agent composition containing such a release control agent; a release sheet having a cured layer formed from the cured product of the silicone release agent composition; and a laminated body having the release sheet and an adhesive layer. The present invention includes a release control agent containing from 15 to 29 mol % of a fluorine atom-containing organic group in each molecule, and an organopolysiloxane having no hydrosilylation reactive group; a silicone release agent composition containing such a release control agent; a release sheet; and a laminated body.

Abstract: A method of producing a glycerin derivative-modified silicone or a composition comprising the same, including a process that treats the glycerin derivative-modified silicone or the composition comprising the same with one or more type of acidic inorganic salt, which is solid at 25° C. and water soluble, and which is such that a pH at 25° C. of an aqueous solution prepared by dissolving 50 g of the acidic inorganic salt in 1 L of ion exchanged water is 4 or lower; and an external use preparation, cosmetic composition, or raw materials thereof that contain the low odor glycerin derivative-modified silicone obtained by the production method.

Abstract: The present invention relates to a monoalkenyl-containing glycerin derivative with purity of not less than 92% and electrical conductivity of not greater than 50 ?S/cm. The monoalkenyl-containing glycerin derivative can be manufactured by a manufacturing method comprising a step (A): a step of reacting a ketalized glycerin derivative and a monoalkenyl glycidyl ether in the presence of an inorganic base to obtain a ketal of monoalkenyl-containing glycerin derivative; a step (B): a step of purifying the ketal of monoalkenyl-containing glycerin derivative obtained in the step (A) by distillation; and a step (C): a step of hydrolyzing the ketal of monoalkenyl-containing glycerin derivative obtained in the step (B). The present invention is able to provide a high-purity monoalkenyl-containing glycerin derivative that was difficult in the past.

Abstract: The present invention relates to a glycerin derivative-modified organopolysiloxane elastomer comprising: as a hydrophilic group, a glycerin derivative group in which an average number of repetitions of glycerin units is in a range of 1.0 to 2.4, being free of an oxyalkylene structure having an average number of repetitions of an oxyalkylene unit of 2 or higher; and a crosslinked three-dimensional net-like structure having a carbon-silicon bond in a crosslinking part.

Abstract: The present invention provides compounds which can regulate VCP activity. The present invention provides the compound of formula (I) (R is as defined in the description) or oxides, esters, prodrugs, pharmaceutically acceptable salts or solvates thereof. The compounds can regulate VCP activity, and thus are useful for treating VCP-mediated diseases such as neurodegenerative diseases.

Abstract: A novel silicone surfactant comprises a co-modified organopolysiloxane copolymer having a long chain alkyl group, a polyether group, and a specific average polymerization degree of its siloxane back-bone. The silicone surfactant can be used for an emulsifier (especially for a water-in-oil (W/O) type emulsifier), a surface treatment agent, a powder treatment agent, or a dispersant in a cosmetic composition or a medicament. A W/O emulsion composition comprising the silicone surfactant; a powder composition where the surface of the powder is treated using the silicone surfactant as a powder treatment agent; a powder composition further comprising an oil agent and having a form of powder in oil dispersion; and a preparation for external use, particularly a cosmetic composition or medicament, comprising the same; are also disclosed.

Abstract: An aqueous coating composition for reducing friction and/or blocking at a surface, said composition comprising a solid lubricant and a modified or synthetic clay mineral having thickening properties such that a 2% by weight aqueous dispersion of the modified or synthetic clay mineral thickener has a viscosity of at least 1000 mPa·s. Preferred clay minerals used as thickeners are preferably smectite clays such as saponite, hectorite, stevensite, sauconite, bentonite, beidellite, nontronite, or montmorillonite.

Abstract: A co-modified organopolysiloxane represented by General Formula (1): R2R12SiO(R12SiO)nSiR12Q, and a surfactant/dispersing agent, emulsifier for a water-in-oil emulsion, external use preparation and cosmetic composition comprising the same. In the formula, the R1 groups are monovalent hydrocarbon group having 1 to 12 carbon atoms, R2 is a monovalent hydrocarbon group having 13 to 30 carbon atoms, and Q is a sugar alcohol group-containing organic group or a diglycerin derivative group having an average number of repetitions of a glycerin unit of 1.1 to 2.9, n is a number in a range of 0 to 100.

Abstract: The present invention relates to a use of an acid in a manufacture of an organopolysiloxane through a condensation reaction of a silicon-containing compound containing a silicon-bonded hydroxyl group and a silicon-containing compound containing a silicon-bonded aminoxy group. Particularly, the present invention relates to a low-odor composition including such an organopolysiloxane. The composition according to the present invention can have little odor caused by a by-product produced via the condensation reaction described above.

Abstract: The present invention relates to a manufacturing method for an organopolysiloxane-polyoxyalkylene block copolymer obtained by condensation reaction of a polyoxyalkylene compound having a particular chemical structure and an organopolysiloxane having a particular chemical structure. The manufacturing method according to the present invention can enable an easy manufacturing of a high molecular weight organopolysiloxane-polyoxyalkylene block copolymer and provide an organopolysiloxane-polyoxyalkylene block copolymer where an amount of volatile cyclic polysiloxane produced as a by-product is small.

Abstract: The present disclosure concerns at least one entity chosen from compounds of Formula (I) and pharmaceutically acceptable salts thereof: (I) wherein the variable groups X, R1, R2, R3 m, n and p are as defined herein. The present disclosure also relates to methods for the preparation of at least one such entity, and intermediates useful in the preparation thereof, to pharmaceutical compositions containing at least one such entity, to the use of at least one such entity in the preparation of medicaments, and to the use of at least one such entity in the treatment of conditions such as, for example, allergic diseases, autoimmune diseases, viral diseases, and cancer.

Abstract: The present disclosure concerns at least one entity chosen from compounds of Formula (I) and pharmaceutically acceptable salts thereof: (I) wherein the variable groups X, R1, R2, R3 m, n and p are as defined herein. The present disclosure also relates to methods for the preparation of at least one such entity, and intermediates useful in the preparation thereof, to pharmaceutical compositions containing at least one such entity, to the use of at least one such entity in the preparation of medicaments, and to the use of at least one such entity in the treatment of conditions such as, for example, allergic diseases, autoimmune diseases, viral diseases, and cancer.

Abstract: The present invention provides a glycerin-modified silicone which has an excellent emulsification/dispersion performance and thickening effect when used alone, particularly when the oil phase is a continuous phase. The present invention is a specific diglycerin derivative-modified silicone having a long-chain hydrocarbon group at a prescribed ratio in a molecule and having as a hydrophilic group only a diglycerin derivative group not having an oxyalkylene structure with an average value of the number of repetitions of oxyalkylene units of two or more; and a composition containing the diglycerin derivative-modified silicone.

Abstract: The present invention relates to an organopolysiloxane elastomer having a group having a siloxane dendron structure bonded to a silicon atom, and having a crosslinked structure that includes a carbon-silicon bond in the crosslinking portion, and relates to a glycerin derivative-modified organopolysiloxane elastomer having a siloxane dendron structure bonded to a silicon atom and a hydrophilic group bonded to a different silicon atom from the silicon atom, and having a crosslinked structure that includes a carbon-silicon bond in the crosslinking portion.

Abstract: The present invention relates to a manufacturing method for a liquid high-purity glycerin derivative-modified silicone, the method comprising: a step of adding, to a mixture containing a glycerin derivative-modified silicone and impurities, an organic wax having affinity with the impurities and having a higher melting point than the glycerin derivative-modified silicone, melting and mixing while heating, and introducing the impurities into the melted organic wax; a step of obtaining a solidified product of the organic wax by cooling the organic wax; and a step of performing solid-liquid phase separation on the glycerin derivative-modified silicone and the solidified product of the organic wax. With the present invention, it is possible to provide a useful method for stably producing a high-purity glycerin derivative-modified silicone on a commercial scale.

Abstract: The present invention relates to a monoalkenyl-containing glycerin derivative with purity of not less than 92% and electrical conductivity of not greater than 50 ?S/cm. The monoalkenyl-containing glycerin derivative can be manufactured by a manufacturing method comprising a step (A): a step of reacting a ketalized glycerin derivative and a monoalkenyl glycidyl ether in the presence of an inorganic base to obtain a ketal of monoalkenyl-containing glycerin derivative; a step (B): a step of purifying the ketal of monoalkenyl-containing glycerin derivative obtained in the step (A) by distillation; and a step (C): a step of hydrolyzing the ketal of monoalkenyl-containing glycerin derivative obtained in the step (B). The present invention is able to provide a high-purity monoalkenyl-containing glycerin derivative that was difficult in the past.