Abstract: The present invention relates to a method for producing a transparent or semi-transparent liquid glycerin derivative-modified silicone composition that comprises a hydration step of adding water to a liquid glycerin derivative-modified silicone or composition thereof. The present invention can provide a liquid glycerin derivative-modified silicone composition having a transparent or semi-transparent appearance can be provided.

Abstract: The present invention relates to a production method for a liquid high-purity organosilicon compound, the method comprising the steps of: adding, to a mixture containing an organosilicon compound selected from a group consisting of organomodified silcones and organomodified silanes and impurities, an organic wax having affinity with the impurities and having a higher melting point than the organosilicon compound, melting and mixing while heating, and introducing the impurities into the melted organic wax; obtaining a solidified product of the organic wax by cooling the organic wax; and performing solid/liquid phase separation on the organosilicon compound and the solidified product of the organic wax. With the present invention, it is possible to provide a useful method for producing a high-purity organosilicon compound stably and on a commercial scale.

Abstract: The present invention provides agents effective to treat eye diseases, pharmaceutical compositions comprising them, methods for preparing pharmaceuticals for treatment of eye diseases comprising using the agents, use of the agents in manufacture of pharmaceuticals for treatment of eye diseases and methods for treating eye diseases comprising administering the agents or the pharmaceutical compositions. The eye diseases treated by the present invention include particularly glaucoma, especially normal tension glaucoma, or retinitis pigmentosa. The present invention provides the compound of formula (I) wherein R is as defined in the description.

Abstract: A surface treatment agent or a powder treatment agent comprising a co-modified organopolysiloxane is disclosed. The co-modified organopolysiloxane is represented by the general formula: R1aR2bQcSiO(4-a-b-c)/2. The co-modified organopolysiloxane has a number average molecular weight of less than 4500 and includes a long-chain alkyl group and a polyoxyalkylene group in the molecule.

Abstract: A copolymer in which from 45 to 60% by mass of all monomer units are unsaturated monomers having a specific carbosiloxane dendrimer structure is disclosed, along with a composition, a cosmetic raw material, and a cosmetic containing the copolymer. The copolymer has excellent physical properties, including compatibility with other cosmetic raw materials, e.g. hardly soluble ultraviolet absorbers, and is capable of improving the compounding stability of cosmetics. The copolymer imparts cosmetics with good water resistance, sebum resistance, luster, tactile sensation, and adhesiveness to the hair or skin.

Abstract: Provided is an oil-in-water silicone emulsion composition that has a low silicone oligomer content, and that can form, even without the use of an organotin compound as a curing catalyst, a cured film that exhibits satisfactory strength and satisfactory adherence to a substrate, through the removal of water fraction. An oil-in-water silicone emulsion composition comprising (A) 100 mass parts of a polyorganosiloxane that contains in each molecule at least two groups selected from the group consisting of a silicon-bonded hydroxyl group, alkoxy group, and alkoxyalkoxy group, (B) 0.1 to 200 mass parts of a colloidal silica, (C) 0.1 to 100 mass parts of an aminoxy group-containing organosilicon compound that has in each molecule an average of two silicon-bonded aminoxy groups, (D) 1 to 100 mass parts of an ionic emulsifying agent, (E) 0.1 to 50 mass parts of a non-ionic emulsifying agent, and (F) 10 to 500 mass parts of water.

Abstract: The present disclosure concerns at least one entity chosen from compounds of Formula (I) and pharmaceutically acceptable salts thereof: (I) wherein the variable groups X, R1, R2, R3 m, n and p are as defined herein. The present disclosure also relates to methods for the preparation of at least one such entity, and intermediates useful in the preparation thereof, to pharmaceutical compositions containing at least one such entity, to the use of at least one such entity in the preparation of medicaments, and to the use of at least one such entity in the treatment of conditions such as, for example, allergic diseases, autoimmune diseases, viral diseases, and cancer.

Abstract: A method of producing a glycerin derivative-modified silicone or a composition comprising the same, including a process that treats the glycerin derivative-modified silicone or the composition comprising the same with one or more type of acidic inorganic salt, which is solid at 25° C. and water soluble, and which is such that a pH at 25° C. of an aqueous solution prepared by dissolving 50 g of the acidic inorganic salt in 1 L of ion exchanged water is 4 or lower; and an external use preparation, cosmetic composition, or raw materials thereof that contain the low odor glycerin derivative-modified silicone obtained by the production method.

Abstract: [Problem to be Solved] To provide a non-curable coating composition which is used for preventing or reducing the adhesion of various sticky substances to the surfaces of substrates and is stable at elevated temperature, by using modified silicones having functional groups. [Means to Solve the Problem] A non-curable coating composition characterized by containing a carboxy-modified silicone with a carboxy group at a side chain thereof, and an epoxy/oxyalkylene-modified silicone with an epoxy group and an oxyalkylene group at a side chain thereof in a weight ratio ranging from 1:2 to 1:30, and further comprising an oxyalkylene-modified silicone having an HLB of 10 or more with an oxyalkylene group at a side chain thereof.

Abstract: To provide a release modifier which provides a heavy release force to a cured release layer of silicone coating composition. The release modifier comprises an organopolysiloxane resin-organopolysiloxane condensation reaction product that is obtained by the condensation reaction of (a1) 100 weight parts of MQ-type organopolysiloxane resin in which the molar ratio of the M unit to the Q unit is 0.6 to 1.0 and the content of the hydroxyl group or alkoxy group is 0.3 to 2.0 weight % with (a2) 20 to 150 weight parts of chain-form diorganopolysiloxane that has an average degree of polymerization of 100 to 1000 and at least one hydroxyl group or alkoxy group; this organopolysiloxane resin-organopolysiloxane condensation reaction product preferably has a prescribed hydroxyl group content.

Abstract: A co-modified organopolysiloxane represented by General Formula (1): R2R12SiO(R12SiO)nSiR12Q, and a surfactant/dispersing agent, emulsifier for a water-in-oil emulsion, external use preparation and cosmetic composition comprising the same. In the formula, the R1 groups are monovalent hydrocarbon group having 1 to 12 carbon atoms, R2 is a monovalent hydrocarbon group having 13 to 30 carbon atoms, and Q is a sugar alcohol group-containing organic group or a diglycerin derivative group having an average number of repetitions of a glycerin unit of 1.1 to 2.9, n is a number in a range of 0 to 100.

Abstract: A diglycerin derivative-modified silicone, wherein the diglycerin derivative-modified silicone contains a long chain alkyl group as a lipophilic group in a molecule, does not have an oxyalkylene structure wherein an average value of the number of repetitions of the oxyalkylene unit is two or more, has only a glycerin derivative group with an average value of the number of repetitions of glycerin units of 1.1 to 2.9 as a hydrophilic group, and does not have other hydrophilic group in the molecule; a surfactant and dispersing agent, an emulsifier for a water-in-oil emulsion, an external use preparation, and a cosmetic composition containing the same.

Abstract: A liquid organopolysiloxane having fluidity at least 100° C., a silicon-bonded glycerin derivative group, and a crosslinked structure comprising a carbon-silicon bond at the crosslinking portion.

Abstract: The present invention relates to a use of an acid in a manufacture of an organopolysiloxane through a condensation reaction of a silicon-containing compound containing a silicon-bonded hydroxyl group and a silicon-containing compound containing a silicon-bonded aminoxy group. Particularly, the present invention relates to a low-odor composition including such an organopolysiloxane. The composition according to the present invention can have little odor caused by a by-product produced via the condensation reaction described above.

Abstract: The present invention relates to a manufacturing method for an organopolysiloxane-polyoxyalkylene block copolymer obtained by condensation reaction of a polyoxyalkylene compound having a particular chemical structure and an organopolysiloxane having a particular chemical structure. The manufacturing method according to the present invention can enable an easy manufacturing of a high molecular weight organopolysiloxane-polyoxyalkylene block copolymer and provide an organopolysiloxane-polyoxyalkylene block copolymer where an amount of volatile cyclic polysiloxane produced as a by-product is small.

Abstract: A tongue for a seat belt device is provided with a tongue main body that is insertable within a buckle, and a train-around portion through which an intermediate portion of a webbing is inserted. The train-around portion includes a first shaft is fixedly mounted between a pair of opposing walls, and a second shaft that is movably mounted between the walls. The webbing is slidably bent 180° around the first fixed shaft. When tension of the webbing exceeds a predetermined magnitude or greater, the movable second shaft engages the webbing and increases a bending angle of the webbing around the first shaft to an angle greater than 180° thereby increasing frictional resistance between the webbing and the train-around portion.

Abstract: The present invention relates to a glycerin derivative-modified organopolysiloxane elastomer comprising: as a hydrophilic group, a glycerin derivative group in which an average number of repetitions of glycerin units is in a range of 1.0 to 2.4, being free of an oxyalkylene structure having an average number of repetitions of an oxyalkylene unit of 2 or higher; and a crosslinked three-dimensional net-like structure having a carbon-silicon bond in a crosslinking part.

Abstract: The present invention relates to an organopolysiloxane elastomer having a silicon-bonded sugar alcohol-modified group and having a crosslinked three-dimensional network structure comprising a carbon-silicon bond in the crosslinking portion. The organomodified organopolysiloxane elastomer of the present invention has, for example, affinity with various oil agents, has excellent viscosity-improving characteristics, gelification characteristics, and emulsification characteristics, imparts excellent tactile sensation—in particular, an excellent tactile sensation characterized by smoothness with a velvet-like thickness—and imparts an excellent sensation during use.

Abstract: The present invention relates to a liquid organopolysiloxane having fluidity at a temperature of at least 100° C., having a silicon-bonded sugar alcohol-modified group, and having a crosslinked structure comprising a carbon-silicon bond in the crosslinking portion. The liquid organopolysiloxane of the present invention has excellent emulsion characteristics, imparts excellent tactile sensation, and, in particular, when compounded in an external use preparation or a cosmetic composition containing water and oil, takes advantage of the effects of water to suppress oiliness and provide a smooth, thick feeling when applied, a natural feeling to the skin with good compatibility with the skin, excellent moisturizing effects, and an excellent sensation during use without any oily stickiness.

Abstract: The present invention relates to an organopolysiloxane elastomer having a group having a siloxane dendron structure bonded to a silicon atom, and having a crosslinked structure that includes a carbon-silicon bond in the crosslinking portion, and relates to a glycerin derivative-modified organopolysiloxane elastomer having a siloxane dendron structure bonded to a silicon atom and a hydrophilic group bonded to a different silicon atom from the silicon atom, and having a crosslinked structure that includes a carbon-silicon bond in the crosslinking portion.