Abstract: The present invention provides agents effective to treat eye diseases, pharmaceutical compositions comprising them, methods for preparing pharmaceuticals for treatment of eye diseases comprising using the agents, use of the agents in manufacture of pharmaceuticals for treatment of eye diseases and methods for treating eye diseases comprising administering the agents or the pharmaceutical compositions. The eye diseases treated by the present invention include particularly glaucoma, especially normal tension glaucoma, or retinitis pigmentosa. The present invention provides the compound of formula (I) wherein R is as defined in the description.

Abstract: Assembling performance of a torsion bar to a spool is improved. When a webbing take-up device is assembled, the torsion bar is inserted into the spool while catch projections of a serration pillar of the torsion bar are corresponded to insertion grooves of an insertion hole of the spool. Subsequently, in a state where the serration pillar of the torsion bar arrives at an catch hole of the spool, the torsion bar is rotated in a winding direction with respect to the spool, so that the catch projections are caught by catch surfaces of catch grooves of the catch hole, whereby the torsion bar is made non-removable from the spool. Therefore, a direction in which the torsion bar is assembled to the spool is made to be only an axial direction of the spool, and assembling performance of the torsion bar to the spool can be improved.

Abstract: Silicone-based pressure-sensitive adhesive composition comprising 100 parts (A) a branched organopolysiloxane having on molecular terminals at least two alkenyl groups and represented by (R3SiO1/2)4-p(R1R2SiO1/2)p(R2SiO)m(RR1SiO)n(SiO4/2), to 400 parts (B) an organopolysiloxane composed of R3R22SiO1/2 units and SiO4/2 units, (C) an organohydrogenpolysiloxane, and a catalytic quantity of (D) a platinum-type catalyst. Pressure-sensitive adhesive tape or sheet having an adhesive layer in the form of a cured layer of the aforementioned composition.

Abstract: The invention concerns compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein n, R1 and R2 are as defined in the description. The present invention also relates to processes for the preparation of such compounds, novel intermediates useful in the preparation of such compounds, pharmaceutical compositions containing them and their use in the treatment of disease, for example cancer.

Abstract: The present invention provides compounds which can regulate VCP activity. The present invention provides the compound of formula (I) (R is as defined in the description) or oxides, esters, prodrugs, pharmaceutically acceptable salts or solvates thereof. The compounds can regulate VCP activity, and thus are useful for treating VCP-mediated diseases such as neurodegenerative diseases.

Abstract: Provided is an oil-in-water silicone emulsion composition that has a low silicone oligomer content, and that can form, even without the use of an organotin compound as a curing catalyst, a cured film that exhibits satisfactory strength and satisfactory adherence to a substrate, through the removal of water fraction. An oil-in-water silicone emulsion composition comprising (A) 100 mass parts of a polyorganosiloxane that contains in each molecule at least two groups selected from the group consisting of a silicon-bonded hydroxyl group, alkoxy group, and alkoxyalkoxy group, (B) 0.1 to 200 mass parts of a colloidal silica, (C) 0.1 to 100 mass parts of an aminoxy group-containing organosilicon compound that has in each molecule an average of two silicon-bonded aminoxy groups, (D) 1 to 100 mass parts of an ionic emulsifying agent, (E) 0.1 to 50 mass parts of a non-ionic emulsifying agent, and (F) 10 to 500 mass parts of water.

Abstract: Disclosed is a novel biaryl amide derivative represented by formula (1) and having an affinity for the aldosterone receptor; also disclosed is a pharmaceutically acceptable salt thereof. (In the formula, A is any of the groups represented by formula (a); L is —CONH—, etc.; R1 is a substitutable aminosulfonyl group, etc.; R2 is a hydrogen atom, etc.; R3 is a hydrogen atom, etc.; R4 is a hydrogen atom, a halogen atom, hydroxy group, a substitutable amino group, a substitutable C1-6 alkoxy group, a substitutable 4- to 7-membered cyclic amino group, etc.; R5a, R5b and R5c are each independently hydrogen atoms, etc.; R6 is a halogen atom, a cyano group, etc.; R7 and R8 are each independently a hydrogen atom, etc.; and m is an integer such as 0.

Abstract: The present invention relates to a non-curable coating composition which is used for preventing adhesion of various sticky substances to the surfaces of substrates. The non-curable coating composition contains a carboxy-modified silicone represented by the following general formula (1) and an epoxy/oxyalkylene-modified silicone represented by the following general formula (2) in a weight ratio ranging from 1:2 to 1:30, and further comprising an oxyalkylene-modified silicone having an HLB of 10 or more, represented by the following general formula (3): R3SiO (R2SiO)m(RASiO)nSiR3 (1) R3—pXpSiO (R2SiO)x(RX—SiO)y(RYSiO)zSiXqR3—q (2) R3—pYpSiO (R2SiO)a(RYSiO)bSiYqR3-q (3) wherein each R?C1—6 alkyl; A=carboxy-containing group; m=0 to 1,000; n=2 to 100; X=epoxy-containing group; Y=oxyethylene-containing group; p=0 to 1; q=0 to 1; x=0 to 500; y=1 to 100; z=1 to 300; a=0 to 100; b=0 to 50; and p+q+b=1 or more.

Abstract: A tongue for a seat belt device is provided with a tongue main body that is insertable within a buckle, and a train-around portion through which an intermediate portion of a webbing is inserted. The train-around portion includes a first shaft is fixedly mounted between a pair of opposing walls, and a second shaft that is movably mounted between the walls. The webbing is slidably bent 180° around the first fixed shaft. When tension of the webbing exceeds a predetermined magnitude or greater, the movable second shaft engages the webbing and increases a bending angle of the webbing around the first shaft to an angle greater than 180° thereby increasing frictional resistance between the webbing and the train-around portion.

Abstract: The present invention relates to a contamination inhibitor containing at least one polyorganosiloxane that has silicon-bonded functional groups and that has a number average molecular weight of 3,000 to 500,000 in terms of standard polystyrene as determined by gel permeation chromatography and a silicon-bonded functional group equivalent (a number average molecular weight per mol of the silicon-bonded functional groups) of 3,000 to 500,000 on average. The contamination inhibitor of the present invention can effectively prevent or reduce adhesion of adhering substances on the surface of a substrate even under high temperature conditions, and exhibits superior stability, since the modified silicone having functional groups is used.

Abstract: A silicone-type pressure-sensitive adhesive composition comprising (A) 100 weight parts of organopolysiloxane condensation reaction product that has at least two alkenyl groups and that is yielded by a condensation reaction between (a) hydroxyl-functional diorganopolysiloxane and (b) organopolysiloxane resin, (B) organohydrogenpolysiloxane having at least two silicon-bonded hydrogen atoms in the molecule, in an amount sufficient to provide from 1 to 200 silicon-bonded hydrogen atoms with reference to all the alkenyl groups in the composition, (C) an organotitanium compound, at from 0.1 to 20 weight parts, and (D) a platinum catalyst in a catalytic quantity.

Abstract: An aqueous coating composition for reducing friction and/or blocking at a surface, said composition comprising a solid lubricant and a modified or synthetic clay mineral having thickening properties such that a 2% by weight aqueous dispersion of the modified or synthetic clay mineral thickener has a viscosity of at least 1000 mPa·s. Preferred clay minerals used as thickeners are preferably smectite clays such as saponite, hectorite, stevensite, sauconite, bentonite, beidellite, nontronite, or montmorillonite.

Abstract: In the present pretensioner, press contact portions are formed further to a side of an open end of a packing housing section than central portions of opposing faces along a depth direction of the packing housing section. Accordingly, when a packing is being fitted into the packing housing section, no great resistance is imparted to a curved face side of the packing from a press contact wall of a housing section body and the opposing face, and the packing is fitted comparatively smoothly therein. Consequently, even when fitting the packing into the packing housing section, a packing main body is largely resilient-deformed, such that a large collapse in a through hole can be prevented, and the sealing ability of the seal due to deformation of the packing main body can be effectively enhanced.

Abstract: A silicone-based pressure-sensitive adhesive composition comprising (A) a condensation-reaction product obtained by subjecting a diorganopolysiloxane having silanol groups on both molecular terminals and 2 or more silicon-bonded alkenyl groups located in side molecular chains in one molecule (a) and organopolysiloxane resin having one or more hydrolyzable groups in one molecule (b) to a condensation reaction in the presence of catalyst (c), (B) an organohydrogenpolysiloxane, (C) a diorganopolysiloxane having silicon-bonded alkenyl groups on both molecular terminals, (D) an organopolysiloxane resin and (E) a platinum catalyst.

Abstract: A solventless cured release coating-forming organopolysiloxane composition having a viscosity at 25° C. of 50 to 2,000 mPa·s comprising (A) 100 weight parts of an alkenyl-functional diorganopolysiloxane that has a viscosity of 25 to 1,000 mPa·s; (B) 0.5 to 15 weight parts of a diorganopolysiloxane that has a viscosity of at least 10,000 mPa·s and that has an aliphatically unsaturated group content of no more than 0.1 mole %; (C) 0.5 to 5 weight parts of a branched organopolysiloxane that has more than one SiO4/2 unit and that is a polymer product provided by an equilibration polymerization between a branched organosiloxane oligomer represented by the average siloxane unit formula (1) (SiO4/2)(RaRb2SiO1/2)x(1) and a diorganosiloxane oligomer; (D) a specific amount of an organohydrogenpolysiloxane that has a viscosity of 1 to 1,000 mPa·s; and (E) a hydrosilylation reaction catalyst in a catalytic quantity.

Abstract: To provide a release modifier which provides a heavy release force to a cured release layer of silicone coating composition. The release modifier comprises an organopolysiloxane resin-organopolysiloxane condensation reaction product that is obtained by the condensation reaction of (a1) 100 weight parts of MQ-type organopolysiloxane resin in which the molar ratio of the M unit to the Q unit is 0.6 to 1.0 and the content of the hydroxyl group or alkoxy group is 0.3 to 2.0 weight % with (a2) 20 to 150 weight parts of chain-form diorganopolysiloxane that has an average degree of polymerization of 100 to 1000 and at least one hydroxyl group or alkoxy group; this organopolysiloxane resin-organopolysiloxane condensation reaction product preferably has a prescribed hydroxyl group content.

Abstract: Silicone-based pressure-sensitive adhesive composition comprising 100 parts (A) a branched organopolysiloxane having on molecular terminals at least two alkenyl groups and represented by (R3SiO1/2)4-p(R1R2SiO1/2)p(R2,SiO)m(RR1SiO)n(SiO4/2), to 400 parts (B) an organopolysiloxane composed of R3R2SiO1/2 units and SiO4/2 units, (C) an organohydrogenpolysiloxane, and a catalytic quantity of (D) a platinum-type catalyst. Pressure-sensitive adhesive tape or sheet having an adhesive layer in the form of a cured layer of the aforementioned composition.

Abstract: In the present pretensioner, press contact portions are formed further to a side of an open end of a packing housing section than central portions of opposing faces along a depth direction of the packing housing section. Accordingly, when a packing is being fitted into the packing housing section, no great resistance is imparted to a curved face side of the packing from a press contact wall of a housing section body and the opposing face, and the packing is fitted comparatively smoothly therein. Consequently, even when fitting the packing into the packing housing section, a packing main body is largely resilient-deformed, such that a large collapse in a through hole can be prevented, and the sealing ability of the seal due to deformation of the packing main body can be effectively enhanced.

Abstract: Assembling performance of a torsion bar to a spool is improved. When a webbing take-up device is assembled, the torsion bar is inserted into the spool while catch projections of a serration pillar of the torsion bar are corresponded to insertion grooves of an insertion hole of the spool. Subsequently, in a state where the serration pillar of the torsion bar arrives at an catch hole of the spool, the torsion bar is rotated in a winding direction with respect to the spool, so that the catch projections are caught by catch surfaces of catch grooves of the catch hole, whereby the torsion bar is made non-removable from the spool. Therefore, a direction in which the torsion bar is assembled to the spool is made to be only an axial direction of the spool, and assembling performance of the torsion bar to the spool can be improved.

Abstract: A silicone-type pressure-sensitive adhesive composition comprising (A) 100 weight parts of organopolysiloxane condensation reaction product that has at least two alkenyl groups and that is yielded by a condensation reaction between (a) hydroxyl-functional diorganopolysiloxane and (b) organopolysiloxane resin, (B) organohydrogenpolysiloxane having at least two silicon-bonded hydrogen atoms in the molecule, in an amount sufficient to provide from 1 to 200 silicon-bonded hydrogen atoms with reference to all the alkenyl groups in the composition, (C) an organotitanium compound, at from 0.1 to 20 weight parts, and (D) a platinum catalyst in a catalytic quantity.