Abstract: A rapid detection method for ricin toxin is provided. The rapid detection method for ricin toxin comprises reacting an adenine-containing oligonucleotide chain substrate labeled with a fluorescent group and a quenching group, a buffer solution, a BSA solution, a to-be-detected sample and sterile water, incubating at a constant temperature, detecting a fluorescence signal value, and determining whether the ricin toxin exists based on a difference between an average value of final fluorescence signal values and an average value of final fluorescence signal values of a negative control; wherein the sample is judged as a positive sample when the average value of the detected final fluorescence signal values is greater than the average value of the final fluorescence signal values of the negative control by +3 times standard deviation.

Abstract: The present disclosure provides a siRNA for inhibiting the expression of apolipoprotein C3 (ApoC3) gene, and a pharmaceutical composition and a conjugate comprising the siRNA; wherein each nucleotide in the siRNA is independently a modified nucleotide, and the siRNA comprises a sense strand and an antisense strand; the sense strand comprises a nucleotide sequence A, the nucleotide sequence A having the same length as the nucleotide sequence as represented by SEQ ID NO:1 with no more than 3 nucleotide differences; the antisense strand comprises a nucleotide sequence B, the nucleotide sequence B having the same length as the nucleotide sequence as represented by SEQ ID NO:2 with no more than 3 nucleotide differences.

Abstract: A method for a system backup, includes: backing up a system mapping table before a system file is updated, wherein the system mapping table includes at least one first storage address, and each first storage address corresponds to an address where first system file data is currently stored in a memory; retaining, in response to that the system file is updated, the first system file data in the memory; and storing updated second system file data in the memory and determining an updated system mapping table.

Abstract: A device for simulating high-frequency current propagation of partial discharge of a GIL/GIS is disclosed. The device comprises a casing, a busbar cavity, an adjustable impedor, a first metal support, a second metal support, a third metal support, and a high-frequency current sensor. The first metal support and the second metal support are separated by an insulating support, the third metal support has an end connected to the second metal support, as well as an end connected to a grounding grid, and the adjustable impedor is formed by an adjustable resistor and an adjustable inductor which are connected in series, and is connected in series between the first metal support and the second metal support through a wire.

Abstract: Provided are siRNA for inhibiting an expression level of a RPTOR gene and regulating and controlling the activity of mTORC1, and a pharmaceutical composition and conjugate containing the siRNA. The siRNA includes a sense strand and an antisense strand; each nucleotide in the siRNA is independently a modified or unmodified nucleotide. The sense strand includes a nucleotide sequence I, the length of the nucleotide sequence I is equal to the length of a nucleotide sequence as shown in SEQ ID NO: 1, with no more than three nucleotide differences; the antisense strand includes a nucleotide sequence II, the length of the nucleotide sequence II is equal to the length of a nucleotide sequence as shown in SEQ ID NO: 2, with no more than three nucleotide differences.

Abstract: A pixel circuit, a driving method thereof, and a display device. The pixel circuit includes a light emission time control circuit, a current control circuit, and a light emission circuit. The light emission time control circuit includes a first drive circuit, a coupling circuit, and a first voltage write circuit. The first voltage write circuit is configured to transmit a fixed voltage to a control terminal of the first drive circuit. The coupling circuit is connected to the control terminal of the first drive circuit. A first terminal of the first drive circuit outputs a control voltage to a control terminal of the current control circuit. An output of the current control circuit is connected to the light emission circuit.

Abstract: The present application relates to a secondary battery, a battery module and an apparatus. The secondary battery includes an electrode assembly and a casing. The electrode assembly includes a main body portion and a tab portion, the tab portion extending out from the main body portion along an end of the main body portion and including an outer peripheral surface. The casing includes an accommodating hole for accommodating the electrode assembly. The casing includes a limiting protrusion. The outer peripheral surface extends around an axis of the accommodating hole. The limiting protrusion protrudes toward the tab portion and presses against the outer peripheral surface of the tab portion. The limiting protrusion is adapted to limit a position of the tab portion. The secondary battery provided by the present application can reduce the possibility of fatigue fracture of the adapting piece.

Abstract: A picture prediction method is provided, which includes: obtaining initial motion information of a current picture block; determining, based on a matching cost criterion, that positions of a pair of reference blocks are a position of a target forward reference block of the current picture block and a position of a target backward reference block of the current picture block, where positions of each pair of reference blocks include a position of a forward reference block and a position of a backward reference block; and for the positions of each pair of reference blocks, a first position offset and a second position offset are in a mirror relationship; and obtaining a predicted value of a pixel value of the current picture block based on a pixel value of the target forward reference block and a pixel value of the target backward reference block.

Abstract: Antibodies against the CD3 complex are being tested in bispecific and trispecific antibody formats that further recognize a tumor-associated antigen. Such antibodies are commonly associated with on-target toxicities, however. It is discovered herein that the toxicities can be reduced or avoided if the bispecific and trispecific antibody adopts a suitable structure and uses an anti-CD3 unit having a suitably balanced T cell activation activity level. Provided are such bispecific and trispecific antibody structures. Also provided is a broad spectrum of anti-CD3 antibodies having different levels of T cell activation activities that can be readily used in different scenarios.

Abstract: Provided are single domain anti-4-1BB antibodies and polypeptides, such as bispecific antibodies and chimeric antigen receptors, that include these single domain antibodies. Methods of using the antibodies or polypeptides for treating and diagnosing diseases such as cancer are also provided.

Abstract: Systems and methods for predicting a delivery time are provided. An example method includes: receiving one or more configurations for a merchant account associated with a merchant; providing to a machine-learning model parcel data corresponding to one or more products purchased from the merchant and the one or more configurations. The machine-learning model is trained based on historical parcel data, configurations, and delivery times to predict an estimated delivery time of one or more products. The method further includes receiving from the machine-learning model an estimated delivery time of the one or more products purchased from the merchant; obtaining updated parcel data corresponding to the one or more products; providing to the machine-learning model the updated parcel data to receive an updated estimated delivery time; and returning the updated estimated delivery time.

Abstract: The present application relates to a secondary battery, a battery module and an apparatus. The secondary battery includes an electrode assembly and a casing. The electrode assembly includes a main body portion and a tab portion, the tab portion extending out from the main body portion along an end of the main body portion and including an outer peripheral surface. The casing includes an accommodating hole for accommodating the electrode assembly. The casing includes a limiting protrusion. The outer peripheral surface extends around an axis of the accommodating hole. The limiting protrusion protrudes toward the tab portion and presses against the outer peripheral surface of the tab portion. The limiting protrusion is adapted to limit a position of the tab portion. The secondary battery provided by the present application can reduce the possibility of fatigue fracture of the adapting piece.

Abstract: Provided are a siRNA for inhibiting the expression of hepatitis B virus gene, and a pharmaceutical composition and conjugate containing the siRNA. Each nucleotide in the siRNA is independently a modified nucleotide. The siRNA includes a sense strand and an antisense strand. The sense strand of the siRNA includes a nucleotide sequence 1 having the same length and no more than three nucleotides different from the nucleotide sequence shown in SEQ ID NO: 155, and the antisense strand of the siRNA includes a nucleotide sequence 2 having the same length and no more than three nucleotides different from the nucleotide sequence shown in SEQ ID NO: 156.

Abstract: Provided by the present disclosure are a nanoemulsion and method for its preparation, and a high-temperature-resistant, high-density, oil-based well completion fluid and the application thereof. The nanoemulsion comprises a lipophilic alkenyl monomer, a hydrophilic alkenyl monomer, an emulsifier, a cross-linking agent, and water. The high-temperature-resistant, high-density, oil-based completion fluid comprises a base oil, a main emulsifier, an auxiliary emulsifier, an aqueous solution of salt, organic soil, an alkalinity regulator, a filtrate loss reducer, a stabilizer, and a weighting material. The stabilizer comprises the described nanoemulsion.

Abstract: An information collection unit collects information indicating a driving operation of a vehicle by a driver and a state of the vehicle changed by the driving operation, and outputs, among the collected information, information in a period from a start point at which a driving operation contributing to stop of the vehicle is performed to a stop start point in a stop state where a stop time of the vehicle continues for a predetermined time or more, as driving operation information. A state estimation unit acquires driver state information indicating a state of the driver from a learned learner on which machine learning has been performed so as to output the driver state information when the driving operation information is input, by inputting the driving operation information output from the information collection unit to the learner and performing arithmetic processing of the learner.

Abstract: A multi-branch fixed offshore photovoltaic (PV) structure with automatic pitch adjustment includes a fixed base, a multi-branch integrated tower, and a PV device. The fixed base includes an upper section, a middle section and a lower section arranged in the seabed. The upper section is above the sea level and connected to the multi-branch integrated tower. The multi-branch integrated tower includes a main tower body and multiple pitch-regulating frames rotatably connected to the main tower body. The main tower body is provided with a control and energy storage system to drive the pitch-regulating frames to rotate. The PV device is fixed to the pitch-regulating frames. The main body is provided with a sunlight monitoring system to monitor solar orientation and inclination angle of a sunlight relative to the PV device. The sunlight monitoring system is connected to the control and energy storage system.

Abstract: A measurement and reconstruction method for a turbine blade strain field of with integrates an imaging technology and an infrared photoelectric measurement technology. The imaging technology is mainly responsible for the measurement of the strain field on a target blade surface, so as to use a digital image processing technology to obtain blade strain field data. The infrared photoelectric measurement technology is mainly aimed at the strain at blade edges, which uses temperature difference between the blade edges and blade gaps to perform strain measurement. Measurement results of the two modes are finally converted into blade strain parameters, thereby reconstructing the target blade strain field based on host computer software.

Abstract: An siRNA capable of inhibiting expression of apolipoprotein C3(APOC3) gene, comprising a sense strand and an antisense strand; the sense strand and the antisense strand respectively comprise a nucleotide sequence I and a nucleotide sequence II consisting of 19 modified or unmodified nucleotides, the nucleotide sequence I and the nucleotide sequence II are at least partially reversely complementary to form a double-stranded region, and the nucleotide sequence II is at least partially reversely complementary to a nucleotide sequence in an mRNA expressed by APOC3 gene; in a direction from 5? end to 3? end, at least one of the 3rd to 6th nucleotides of the nucleotide sequence II is a stabilizing modified nucleotide. The siRNA and a pharmaceutical composition and an siRNA conjugate containing same can effectively treat and/or prevent diseases or disorders related to expression of APOC3 gene, and have a significantly reduced off-target effect.

Abstract: A double-stranded oligonucleotide capable of regulating the expression level of a target gene includes a sense strand and an antisense strand. The sense strand and the antisense strand each includes nucleotide sequence I or nucleotide sequence II consisting of 19 modified or unmodified nucleotides, the nucleotide sequence I and the nucleotide sequence II are at least partially reverse complementary to form a double-stranded region, and the nucleotide sequence II is at least partially reverse complementary to a nucleotide sequence in an mRNA expressed by the target gene; and according to the direction from the 5? end to the 3? end, at least one of the 3rd to 6th nucleotides of the nucleotide sequence II is a stabilizing modified nucleotide, and none of the nucleotides other than the 3rd to 9th nucleotides in the nucleotide sequence II are stabilizing modified nucleotides.

Abstract: Provided are a siRNA for inhibiting the expression of hepatitis B virus gene, and a pharmaceutical composition and conjugate containing the siRNA. Each nucleotide in the siRNA is independently a modified nucleotide. The siRNA comprises a sense strand and an antisense strand. The sense strand of the siRNA comprises a nucleotide sequence 1 having the same length and no more than three nucleotides different from the nucleotide sequence shown in SEQ ID NO: 155, and the antisense strand of the siRNA comprises a nucleotide sequence 2 having the same length and no more than three nucleotides different from the nucleotide sequence shown in SEQ ID NO: 156.