Patents by Inventor Shan Gao

Shan Gao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220356474
    Abstract: Provided are a siRNA for inhibiting the expression of an angiopoietin-like protein 3 (ANGPTL3) gene, and a pharmaceutical composition and a conjugate comprising the siRNA; wherein each nucleotide in the siRNA is independently a modified or unmodified nucleotide, and the siRNA comprises a sense strand and an antisense strand; the sense strand comprises a nucleotide sequence A, the nucleotide sequence A having the same length as the nucleotide sequence as represented by SEQ ID NO:1 with no more than 3 nucleotide differences; the antisense strand comprises a nucleotide sequence B, the nucleotide sequence B having the same length as the nucleotide sequence as represented by SEQ ID NO:2 with no more than 3 nucleotide differences.
    Type: Application
    Filed: June 23, 2022
    Publication date: November 10, 2022
    Applicant: SUZHOU RIBO LIFE SCIENCE CO., LTD.
    Inventors: Hongyan ZHANG, Shan GAO, Daiwu KANG, Lina KONG
  • Patent number: 11492620
    Abstract: Provided is a modified double-stranded oligonucleotide, in which the sense strand comprises a nucleotide sequence 1, the anti-sense strand comprises a nucleotide sequence 2, the nucleotide sequences 1 and 2 are both 19 nucleotides in length, and in the direction from 5? end to 3? end, nucleotides at positions 7, 8 and 9 of the nucleotide sequence 1 and nucleotides at positions 2, 6, 14 and 16 of the nucleotide sequence 2 are all fluoro-modified nucleotides, and each nucleotide at other positions is independently one of non-fluoro-modified nucleotides. Further provided are a pharmaceutical composition and a conjugate comprising the oligonucleotide, and pharmaceutical use thereof.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: November 8, 2022
    Assignee: SUZHOU RIBO LIFE SCIENCE CO., LTD.
    Inventors: Hongyan Zhang, Shan Gao, Daiwu Kang
  • Patent number: 11466979
    Abstract: The present invention discloses a method of measuring longitude deformation of blades. The radiation and rotation speed of the blade are collected by an optical probe and a synchronized rotation sensor. The stretch of the blade is able to be determined by the obvious change in the light intensity detected by the optical probe. The precision servo motor keeps driving the optical probe to move upward. The collected radiation is compared with the radiation collected on the previous point. The stretch of the blade is calculated based on position of the blade tip which is determined by the time when the high level radiation from the blade is disappeared. The longitude deformation of the blade is calculated by plugging the stretch into the deformation equation. Mapping the calculated deformation with the number of the blade calculated with rotation speed synchronizing signals to achieve the deformation of all the blades.
    Type: Grant
    Filed: January 19, 2021
    Date of Patent: October 11, 2022
    Assignee: University of Electronic Science and Technology of China
    Inventors: Chao Wang, Zezhan Zhang, Peifeng Yu, Yi Niu, Ying Duan, Xueke Gou, Yekui Zhong, Anmei Qiu, Pei Huang, Yuehai Zhang, Shan Gao, Jing Jiang
  • Publication number: 20220315929
    Abstract: Provided are an siRNA for inhibiting gene expression of plasma prekallikrein (PKK), a pharmaceutical composition containing the siRNA and an siRNA conjugate. Also provided is the use of the siRNA or the pharmaceutical composition thereof or the siRNA conjugate in the preparation of drugs for treating and/or preventing inflammatory diseases or thromboembolic diseases.
    Type: Application
    Filed: May 21, 2020
    Publication date: October 6, 2022
    Applicant: SUZHOU RIBO LIFE SCIENCE CO., LTD.
    Inventors: Hongyan ZHANG, Shan GAO, Daiwu KANG
  • Publication number: 20220315011
    Abstract: An information collection unit collects information indicating a driving operation of a vehicle by a driver and a state of the vehicle changed by the driving operation, and outputs, among the collected information, information in a period from a start point at which a driving operation contributing to stop of the vehicle is performed to a stop start point in a stop state where a stop time of the vehicle continues for a predetermined time or more, as driving operation information. A state estimation unit acquires driver state information indicating a state of the driver from a learned learner on which machine learning has been performed so as to output the driver state information when the driving operation information is input, by inputting the driving operation information output from the information collection unit to the learner and performing arithmetic processing of the learner.
    Type: Application
    Filed: June 18, 2019
    Publication date: October 6, 2022
    Applicant: Mitsubishi Electric Corporation
    Inventors: Kimika IKEGAMI, Takuji MORIMOTO, Genta YOSHIMURA, Shan GAO
  • Patent number: 11426713
    Abstract: The present application discloses a monolithic catalyst with the function of selective adsorption-catalytic oxidation of organic waste gas and a preparation method and application thereof. The present application adopts a double coating design. A first coating is a molecular sieve primer coating. A second coating is an active component coating, which uses a neutral silica sol, so as to protect the activity and effectiveness of a noble metal and a catalytic promoter on the molecular sieve.
    Type: Grant
    Filed: December 31, 2021
    Date of Patent: August 30, 2022
    Assignee: Zhejiang Tianlan Environmental Protection Technology Co., Ltd.
    Inventors: Shan Gao, Zhongbiao Wu, Yuejun Wang, Haibo Ni, Dongjie Ge, Ziwei Zhou
  • Publication number: 20220271370
    Abstract: An intelligent thermoelectric-battery integrated structure, which belongs to the field of new energy device, is provided. The structure intelligently controls the temperature of the single cells inside the battery pack by means of direct contact, so as to reduce the temperature and cut off the occurrence of thermal runaway from the root cause. In addition, the Seebeck voltage generated based on the temperature difference can directly store energy inside the battery when charging, and can increase the overall output voltage when discharging. The advantage of this structure solves the contradiction between the difficulty of achieving high energy density and high safety performance for traditional batteries at the same time, and provides a practical solution for the development and utilization of a new generation of high-performance batteries.
    Type: Application
    Filed: May 10, 2022
    Publication date: August 25, 2022
    Inventors: Chao Wang, Jing Jiang, Yi Niu, Xinrui He, Zhipeng Li, Fu Li, Pei Huang, Yuehai Zhang, Shan Gao
  • Patent number: 11420602
    Abstract: A rail train brake control system, comprising: a single vehicle brake control unit, a train brake control unit, a traction control unit and a communication control unit; the single vehicle brake control unit is provided in each vehicle of the rail train, the train brake control unit and the communication control unit are provided in the vehicles at both ends of the rail train, and the traction control unit is disposed in motor vehicles of a plurality of vehicles; and the single vehicle brake control unit, the train brake control unit, the traction control unit and the communication control unit implement communication by means of the gateway. The system can realize flexible marshalling of a train. Further disclosed is a train comprising the train brake control system.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: August 23, 2022
    Assignee: CRRC TANGSHAN CO., LTD.
    Inventors: Zhonghua Liu, Lei Chen, Chunjie Xie, Hongmei Xu, Bo Zhou, Keyu Cao, Peilei Fang, Qingdong Meng, Zhenshan Ji, Shan Gao, Liyun Shao
  • Publication number: 20220260423
    Abstract: An optical probe with high stability for measurement of radiation information of a turbine disk of an aeroengine includes a one-piece outer casing, a pressing ring, a sapphire window piece, an inner spacer, an outer spacer, a lens, first fixing nuts, second fixing nuts, fixing ropes and fixing screws. The one-piece outer casing is made from GH3044 solid solution strengthened nickel-based antioxidant alloy. An interior of the probe is divided into eight parts, which are as follows from a proximal hot end to a right end of the probe in sequence: a pressing ring chamber, a cold air vent, a sapphire window piece chamber, an outer spacer fixing chamber, a lens chamber, a beam chamber, a beam focusing chamber, and an optical fiber chamber.
    Type: Application
    Filed: May 2, 2022
    Publication date: August 18, 2022
    Inventors: Chao Wang, Jing Jiang, Yi Niu, Hongzu Li, Zezhan Zhang, Lihao Yang, Peifeng Yu, Shan Gao
  • Patent number: 11414665
    Abstract: Provided are an siRNA for inhibiting expression of a Hepatitis B virus gene, and a pharmaceutical composition and conjugate containing the siRNA. Each nucleotide in the siRNA is an independently modified or unmodified nucleotide; the siRNA comprises a sense strand and an antisense strand; the sense strand comprises a nucleotide sequence A; the length of the nucleotide sequence A is the same as that of a nucleotide sequence as shown in SEQ ID NO: 1, and the number of the nucleotide differences is not more than three; the antisense strand comprises a nucleotide sequence B; and the length of the nucleotide sequence B is the same as that of a nucleotide sequence as shown in SEQ ID NO: 2, and number of nucleotide differences is not more than three.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: August 16, 2022
    Assignee: SUZHOU RIBO LIFE SCIENCE CO., LTD.
    Inventors: Hongyan Zhang, Shan Gao, Daiwu Kang
  • Patent number: 11414661
    Abstract: Provided are a siRNA for inhibiting the expression of an angiopoietin-like protein 3 (ANGPTL3) gene, and a pharmaceutical composition and a conjugate comprising the siRNA; wherein each nucleotide in the siRNA is independently a modified or unmodified nucleotide, and the siRNA comprises a sense strand and an antisense strand; the sense strand comprises a nucleotide sequence A, the nucleotide sequence A having the same length as the nucleotide sequence as represented by SEQ ID NO:1 with no more than 3 nucleotide differences; the antisense strand comprises a nucleotide sequence B, the nucleotide sequence B having the same length as the nucleotide sequence as represented by SEQ ID NO:2 with no more than 3 nucleotide differences.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: August 16, 2022
    Assignee: SUZHOU RIBO LIFE SCIENCE CO., LTD.
    Inventors: Hongyan Zhang, Shan Gao, Daiwu Kang, Lina Kong
  • Publication number: 20220237766
    Abstract: A measurement and reconstruction method for a turbine blade strain field of with integrates an imaging technology and an infrared photoelectric measurement technology. The imaging technology is mainly responsible for the measurement of the strain field on a target blade surface, so as to use a digital image processing technology to obtain blade strain field data. The infrared photoelectric measurement technology is mainly aimed at the strain at blade edges, which uses temperature difference between the blade edges and blade gaps to perform strain measurement. Measurement results of the two modes are finally converted into blade strain parameters, thereby reconstructing the target blade strain field based on host computer software.
    Type: Application
    Filed: April 13, 2022
    Publication date: July 28, 2022
    Inventors: Jing Jiang, Yi Niu, Chao Wang, Peifeng Yu, Zezhan Zhang, Shan Gao
  • Publication number: 20220235359
    Abstract: An siRNA inhibiting xanthine oxidase (XO) gene expression, a pharmaceutical composition containing the siRNA, a siRNA conjugate, and an application of the siRNA in the preparation of drugs for treating and/or preventing uric acid metabolism disorder or diseases or physical conditions caused by uric acid metabolism disorder. Each nucleotide in the siRNA is an independent modified or unmodified nucleotide, and the siRNA contains a sense strand and an antisense strand.
    Type: Application
    Filed: May 21, 2020
    Publication date: July 28, 2022
    Applicant: SUZHOU RIBO LIFE SCIENCE CO., LTD.
    Inventors: Hongyan ZHANG, Shan GAO, Daiwu KANG
  • Publication number: 20220223979
    Abstract: The present application relates to a secondary battery, a battery module and an apparatus. The secondary battery includes an electrode assembly and a casing. The electrode assembly includes a main body portion and a tab portion, the tab portion extending out from the main body portion along an end of the main body portion and including an outer peripheral surface. The casing includes an accommodating hole for accommodating the electrode assembly. The casing includes a limiting protrusion. The outer peripheral surface extends around an axis of the accommodating hole. The limiting protrusion protrudes toward the tab portion and presses against the outer peripheral surface of the tab portion. The limiting protrusion is adapted to limit a position of the tab portion. The secondary battery provided by the present application can reduce the possibility of fatigue fracture of the adapting piece.
    Type: Application
    Filed: April 2, 2022
    Publication date: July 14, 2022
    Applicant: Contemporary Amperex Technology Co., Limited
    Inventors: Qinglin BAI, Zhiyang WU, Shan GAO, Chunyang PENG, Lingyan JIANG
  • Publication number: 20220186221
    Abstract: The present disclosure provides an siRNA capable of inhibiting expression of a complement protein 5(C5) gene, and a pharmaceutical composition and conjugate containing the siRNA. Each nucleotide in the siRNA is an independent modified or unmodified nucleotide. The siRNA comprises a sense strand and an antisense strand. The sense strand comprises a nucleotide sequence I, and the nucleotide sequence I has the same length and no more than three nucleotide differences from a nucleotide sequence shown in SEQ ID NO: 1. The antisense strand comprises a nucleotide sequence II, and the nucleotide sequence II has the same length and no more than three nucleotide differences from a nucleotide sequence shown in SEQ ID NO: 2. The siRNA, the pharmaceutical composition and the conjugate thereof provided by the present disclosure can effectively treat and/or prevent complement-mediated related diseases, such as myasthenia gravis (MG).
    Type: Application
    Filed: May 21, 2020
    Publication date: June 16, 2022
    Applicant: SUZHOU RIBO LIFE SCIENCE CO., LTD.
    Inventors: Hongyan ZHANG, Shan GAO, Daiwu KANG
  • Patent number: 11363274
    Abstract: A video data inter prediction method is provided, which includes: determining a candidate motion information list of a current picture block, where the candidate motion information list includes at least one first candidate motion information group, at least one second candidate motion information group, the first candidate motion information group is a motion information group determined based on motion information of preset locations on a first neighboring picture block of the current picture block and a motion model of the first neighboring picture block, the second candidate motion information group is a set of motion information of at least two sample locations that are respectively neighboring to at least two preset locations on the current picture block; determining target motion information from the candidate motion information list; and performing inter prediction on the current picture block based on the target motion information.
    Type: Grant
    Filed: June 11, 2020
    Date of Patent: June 14, 2022
    Assignee: HUAWEI TECHNOLOGIES CO., LTD.
    Inventors: Huanbang Chen, Shan Gao, Haitao Yang
  • Publication number: 20220159292
    Abstract: The present invention relates to the field of video image processing, and provides a filtering method and an apparatus, to resolve a problem that subjective quality and objective quality of an image deteriorate because filtering processing cannot be performed on internal blocks of a non-translational motion prediction unit.
    Type: Application
    Filed: February 1, 2022
    Publication date: May 19, 2022
    Inventors: Huanbang CHEN, Sixin LIN, Haitao YANG, Shan GAO
  • Publication number: 20220150433
    Abstract: This application provides a pixel collection circuit comprising an optical-to-electrical converter circuit configured to convert a collected optical signal into an analog signal; an analog-to-digital converter circuit configured to: receive the analog signal from the optical-to- electrical converter circuit; and perform analog-to-digital conversion on the analog signal to obtain a digital signal; a differential circuit configured to: receive the digital signal from the analog-to-digital converter circuit; and obtain a difference signal between a digital signal of a previous triggering moment and the digital signal of a current triggering moment; the previous triggering moment and the current triggering moment are determined by at least a digital clock signal; a comparison circuit configured to receive the difference signal from the differential circuit, and output a pulse signal.
    Type: Application
    Filed: January 24, 2022
    Publication date: May 12, 2022
    Inventors: Yifan FU, Shan GAO, Jiantong ZHOU, Jing XIAO
  • Publication number: 20220138265
    Abstract: The present disclosure relates to systems, non-transitory computer-readable media, and methods for efficiently providing a graphical user interface for visualizing large amounts of data on a single interface. In particular, in one or more embodiments, the disclosed systems utilize topic hierarchies and multidata display elements to intuitively present many types of data for many topics on a single interface. The system also uses an activatable timeline to visualize changes to large amounts of data over time.
    Type: Application
    Filed: October 4, 2021
    Publication date: May 5, 2022
    Inventors: Jamie Morningstar, Daan Lindhout, Shan Gao, Ryan Debenham
  • Publication number: 20220126725
    Abstract: A method for scheduling EV battery swap based on IoV, in which the roadside units regard battery-swap station clusters with a high degree of potential cooperation as a whole, and gather them into a single battery swap area; taking a service rate of a cluster of swap stations as an assessment target, and mainly examining a service capability, a service quality, and location information of each of swap station nodes themselves, and a current state of those electric vehicles that require to swap battery; providing a solution of the best joint actions for the overall electric vehicles to maintain the overall service balance of every swap station and improve a long-term performance of Internet of Vehicles. According to the invention, a battery of the electric vehicles can be swapped as soon as possible, and every battery swap station can maintain business balance.
    Type: Application
    Filed: January 23, 2021
    Publication date: April 28, 2022
    Inventors: Tong Wang, Guangxin Yang, Yu Wang, Shan Gao, Liwei Chen