Abstract: An siRNA which inhibits kininogen (KNG) gene expression, a pharmaceutical composition containing the siRNA, and an siRNA conjugate. Each nucleotide in the siRNA is independently a modified or unmodified nucleotide. The siRNA contains a sense strand and an antisense strand. The sense strand contains nucleotide sequence I, nucleotide sequence I having the same length as the nucleotide sequence shown in SEQ ID NO: 1, with no more than three nucleotide differences. The antisense strand contains nucleotide sequence II, nucleotide sequence II having the same length as the nucleotide sequence shown in SEQ ID NO: 2, with no more than three nucleotide differences. The siRNA, the pharmaceutical composition thereof and the siRNA conjugate can effectively treat and/or prevent septicemia.

Abstract: Provided are an siRNA which inhibits purine nucleoside phosphorylase (PNP) gene expression, a pharmaceutical composition comprising the siRNA, and an siRNA conjugate, capable of effectively treating and/or preventing abnormal uric acid metabolism, or diseases or physiological conditions caused by abnormal uric acid metabolism. Each nucleotide in the siRNA is independently a modified or unmodified nucleotide.

Abstract: Embodiments of the present invention disclose a magnetic resonance system, a magnetic resonance image correction method, and a magnetic resonance imaging method.

Abstract: An autonomous cleaning device and a noise reduction air duct device are provided for autonomous cleaning device. The autonomous cleaning device includes a body and a motor arranged on the body, and the noise reduction air duct device is mounted on the body. The noise reduction air duct device includes an upper housing, a lower housing and a support noise reduction structure made of elastic material. The lower housing and the upper housing enclose to form an air duct, an air inlet is arranged at a position of the air duct corresponding to the motor, and an air outlet is arranged on a side of the air duct away from the air inlet; the support noise reduction structure has a first end fixed on the lower housing, and a second end abutting against a lower surface of the upper housing.

Abstract: Provided is a siRNA for inhibiting HBV gene expression, including a sense strand and an antisense strand. The sense strand includes a nucleotide sequence 1, and the antisense strand includes a nucleotide sequence 2; the nucleotide sequence 1 and the nucleotide sequence 2 are at least partially reversely complementary to form a double-stranded region; the nucleotide sequence 1 and the nucleotide sequence shown in SEQ ID NO: 1 are equal in length, and no more than 3 nucleotide differences are generated; the nucleotide sequence 2 and the nucleotide sequence shown in SEQ ID NO: 2 are equal in length, and no more than 3 nucleotide differences are generated; nucleotides of the 7th, 8th, and 9th bits of the nucleotide sequence 1 and the 2nd, 6th, 14th, and 16th of the nucleotide sequence 2 are fluoro-modified nucleotides. Also provided are a pharmaceutical composition and a conjugate containing the siRNA.

Abstract: An siRNA conjugate having a structure as represented by formula (1) for inhibiting hepatitis B vims gene expression, comprising siRNA and a conjugated group, wherein the sense strand of the siRNA comprises a nucleotide sequence 1, and the antisense strand comprises a nucleotide sequence 2; the nucleotide sequence 1 and the nucleotide sequence 2 are, at least in part, reversely complementary to form a double-stranded region; the nucleotide sequence 1 and SEQ ID NO: 1 are equal in length and differ by no more than three nucleotides; the nucleotide sequence 2 and SEQ ID NO: 2 are equal in length and differ by no more than three nucleotides. The siRNA conjugate can specifically target liver cells and effectively solve the problem of siRNA delivery in vivo, and shows excellent activity and low toxicity to inhibit HBV gene expression while maintaining high stability of siRNA.

Abstract: A hollowed-out earpick head and an earpick, belonging to the field of ear canal cleaning, includes a connecting rod and a cleaning end on an end surface at one end of the connecting rod, an outer wall of the cleaning end is an outwardly convex arc-shaped wall, the cleaning end is hollowed out with a pre-storage cavity, a transportation cavity in communication with the pre-storage cavity extends through the connecting rod, an end of the cleaning end away from the connecting rod is configured with a collecting tank in communication with the pre-storage cavity, the cleaning end is hollowed out with a lateral groove. The cleaning end is hollowed out and in communication with the pre-storage cavity.

Abstract: The present invention relates to the field of video image processing, and provides a filtering method and an apparatus, to resolve a problem that subjective quality and objective quality of an image deteriorate because filtering processing cannot be performed on internal blocks of a non-translational motion prediction unit.

Abstract: An anti-glare apparatus (100), includes a lens assembly (120) having an incident side and a reflective layer (110) on the side of the lens assembly opposite from the incident side. The lens assembly includes a layer of liquid crystal molecules, a first driving electrode (132) and a second driving electrode (131) respectively on both sides of the layer of the liquid crystal molecules; at least one of the first driving electrode or the second driving electrode comprises a plurality of sub-electrodes. The lens assembly is configured to change an optical axis direction of the lens assembly by adjusting a driving voltage of at least one of the plurality of sub-electrodes.

Abstract: An automatic cleaning apparatus includes: a chassis; a front housing arranged at a front end of the chassis; and a sensing device capable sensing movement of the front housing and sending a signal to a control mainboard of the automatic cleaning apparatus when the front housing touches an obstacle and moves relative to the chassis. The sensing device includes a dust blocking member and a rocker arm that triggers the sensing device to send the signal. The rocker arm has a first end rotatably arranged inside the sensing device, and a second end passing through the dust blocking member and extending out of the sensing device. A front housing reset device is arranged on the chassis and capable of biasing the front housing toward an initial position of the front housing.

Abstract: The invention provides a chip stacking structure, including: a first chip, a second chip stacked with the first chip, a first redistribution layer, a second redistribution layer, a third redistribution layer, a first conductive channel, and a second conductive channel;; the first redistribution layer is disposed on a surface of the first chip facing the second chip; the second redistribution layer is disposed on a passive surface of the second chip, and the third redistribution layer is disposed on an active surface of the second chip; the first conductive channel passes through the second chip and the third redistribution layer, connecting the first redistribution layer and the second redistribution layer; and the second conductive channel passes through the second chip, connecting the second redistribution layer and the third redistribution layer.

Abstract: A chip stacking structure includes a plurality of chips that are sequentially stacked and a first redistribution layer arranged on an active side of each chip. The plurality of chips include a first chip and a second chip that are located on an outermost side. Passive sides of the first chip and the second chip both face an outer side, and the chip stacking structure further includes a second redistribution layer arranged on the passive side of the first chip or the second chip. The second redistribution layer is electrically connected to at least one first redistribution layer through a first via hole.

Abstract: The present disclosure provides a siRNA for inhibiting the expression of apolipoprotein C3 (ApoC3) gene, and a pharmaceutical composition and a conjugate comprising the siRNA; wherein each nucleotide in the siRNA is independently a modified nucleotide, and the siRNA comprises a sense strand and an antisense strand; the sense strand comprises a nucleotide sequence A, the nucleotide sequence A having the same length as the nucleotide sequence as represented by SEQ ID NO:1 with no more than 3 nucleotide differences; the antisense strand comprises a nucleotide sequence B, the nucleotide sequence B having the same length as the nucleotide sequence as represented by SEQ ID NO:2 with no more than 3 nucleotide differences.

Abstract: A four-shaft panoramic scanning temperature measuring device with a circulating water-cooling device is provided, which not only improves the working reliability of the probe, but also increases the overall flexibility and scanning measurement efficiency. The circulating water-cooling device is self-cooled. Compared with the conventional single-circulation water-cooling way, the design of five cooling cavities can achieve higher circulating water-cooling efficiency. The four-shaft structure includes a shaft structure for translation, a shaft structure for rotation, a shaft structure for swinging, and a shaft structure with coaxial sight pipe and light pipe. The design of the four-shaft structure is able to panoramically scan the high-temperature components inside the turbine. The temperature measuring device integrates functions of cooling, swinging, translating and rotating together, which solves problems of large size and complex control of the conventional temperature measuring device.

Abstract: An siRNA which inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9) gene expression, a pharmaceutical composition containing the siRNA, and a conjugate. Each nucleotide in the siRNA is independently a modified or unmodified nucleotide. The siRNA contains a sense strand and an antisense strand. The sense strand contains nucleotide sequence I; nucleotide sequence I having the same length as the nucleotide sequence shown in SEQ ID NO: 1, with no more than three nucleotides differences. The antisense strand contains nucleotide sequence II, nucleotide sequence II having the same length as the nucleotide sequence shown in SEQ ID NO: 2, with no more than three nucleotides differences. The siRNA, pharmaceutical composition thereof and the conjugate can effectively treat and/or prevent hypercholesterolemia.

Abstract: This application provides a pixel collection circuit comprising an optical-to-electrical converter circuit configured to convert a collected optical signal into an analog signal; an analog-to-digital converter circuit configured to: receive the analog signal from the optical-to-electrical converter circuit; and perform analog-to-digital conversion on the analog signal to obtain a digital signal; a differential circuit configured to: receive the digital signal from the analog-to-digital converter circuit; and obtain a difference signal between a digital signal of a previous triggering moment and the digital signal of a current triggering moment; the previous triggering moment and the current triggering moment are determined by at least a digital clock signal; a comparison circuit configured to receive the difference signal from the differential circuit, and output a pulse signal.

Abstract: The disclosure discloses a channel combining and time-division processing circuit of a dual-plane pulse Doppler radar seeker. The circuit includes a time-division control circuit configured to receive a time-division control signal, control input of an elevation difference channel signal and an azimuth difference channel signal, combine the elevation difference channel signal and the azimuth difference channel signal and output a combined difference channel signal, and a hybrid bridge circuit configured to receive a sum channel signal, combine channels for the sum channel signal and the combined difference channel signal and output signals on a combined channel. With the circuit of the disclosure, signals received from a sum channel, an azimuth difference channel and an elevation difference channel can be combined into received signals from two channels for processing with one received signal processing channel hardware omitted.

Abstract: Embodiments of the present invention relate to an apparatus for detecting ozone in ambient air, including an absorption cell with a bounded chamber for receiving air sample for analysis, a light source positioned to transmit light through absorption cell, a detector positioned to measure the attenuation of light passing through absorption cell, a pumping system for transporting ambient air into chamber and then reversing direction to transport ozone-free air into the absorption cell for purging the chamber, a scrubber positioned downstream from outlet port of the absorption cell to remove ozone from sample air exiting the absorption cell, a relative humidity (RH) equalizer for controlling humidity of sample air exiting absorption cell such that the sample entering scrubber has relatively the same humidity as ambient air, and a data system for digitizing and processing output from detector.

Abstract: A picture prediction method is provided, which includes: obtaining initial motion information of a current picture block; determining, based on a matching cost criterion, that positions of a pair of reference blocks are a position of a target forward reference block of the current picture block and a position of a target backward reference block of the current picture block, where positions of each pair of reference blocks include a position of a forward reference block and a position of a backward reference block; and for the positions of each pair of reference blocks, a first position offset and a second position offset are in a mirror relationship; and obtaining a predicted value of a pixel value of the current picture block based on a pixel value of the target forward reference block and a pixel value of the target backward reference block.

Abstract: Disclosed are a pressure control method and a pressure control device for a braking cylinder of a rail vehicle, and the rail vehicle. The method includes the following steps: acquiring the air charge-release volume of the braking cylinder of the rail vehicle and the air flowrate of the braking cylinder; determining the charge-release duration according to the air charge-release volume of the braking cylinder and the air flowrate of the braking cylinder, and controlling the charge-release working duration of the air charge-release solenoid valve according to the air charge-release duration; when the working duration of the air charge-release solenoid valve reaches the charge-release duration, acquiring the predictive pressure of the braking cylinder, and controlling the working state of the air charge-release solenoid valve according to the predictive pressure.