Abstract: An antibody or a functional fragment thereof that specifically bind to PD-L1 with high affinity, a nucleic acid molecule that encodes said antibody or the functional fragment thereof, an expression vector and a host cell for use in expressing said antibody or the functional fragment thereof, and a method for producing said antibody or the functional fragment thereof. An immunoconjugate and a pharmaceutical composition containing said antibody or the functional fragment thereof, and a method for using said antibody or the functional fragment thereof to enhance the function of a T cell so as to up-regulate a cell-mediated immune response, for use in treating diseases caused by T cell dysfunction.

Abstract: Technologies are described herein for a health monitor that establishes and monitors a set of alive endpoints to be used as substitutes for a dead working window endpoints. The health monitor periodically monitors substitution endpoints. When a request manager determines that a working window endpoint is dead, the request manager sends a request to the health monitor for a substitute endpoint. The health monitor receives the request and identifies an appropriate substitution endpoint from the health monitor endpoints to provide to the request manager to substitute for the dead endpoint. The health monitor releases the identified substitution endpoint to the request manager.

Abstract: A process for preparing aryl ketones is disclosed. The process includes photo-oxidizing a compound of formula (V), (VI), (VII) or (VIII): in the presence of an oxidative system comprising at least one bromide compound to form aryl ketones. X1, X2, R1, R2, R3, L1, L2, L3, L4, t, n, m and p have the meanings as described in the specification and claims.

Abstract: An oxide semiconductor device includes a substrate, a first patterned oxide semiconductor layer, a source electrode, a drain electrode, and a sidewall spacer. The first patterned oxide semiconductor layer is disposed on the substrate. The source electrode and the drain electrode are disposed on the first patterned oxide semiconductor layer. The sidewall spacer is disposed on a sidewall of the first patterned oxide semiconductor layer. The sidewall spacer may be used to improve the performance of blocking impurities from entering the first patterned oxide semiconductor layer via the sidewall, and the electrical performance and the reliability of the oxide semiconductor device may be enhanced accordingly.

Abstract: An oxide semiconductor device includes a substrate, a first patterned oxide semiconductor layer, a source electrode, a drain electrode, and a sidewall spacer. The first patterned oxide semiconductor layer is disposed on the substrate. The source electrode and the drain electrode are disposed on the first patterned oxide semiconductor layer. The sidewall spacer is disposed on a sidewall of the first patterned oxide semiconductor layer. The sidewall spacer may be used to improve the performance of blocking impurities from entering the first patterned oxide semiconductor layer via the sidewall, and the electrical performance and the reliability of the oxide semiconductor device may be enhanced accordingly.

Abstract: A method for producing an indicator light assembly may include selecting a laser power amount based on the thickness of a plastic housing, and drilling multiple conically shaped cutouts in the plastic housing, each creating a respective inner hole with a first diameter and a respective outer hole with a second diameter, the first diameter being larger than the second diameter. The method may include mounting a light source within the plastic housing, positioning the light source near the first holes on the interior side of the plastic housing such that when the light source is enabled, a portion of the emitted light passes through each cutout and is emitted through the second holes on the exterior side of the plastic housing. The second diameter may be small enough that the second holes are not visible to the human eye when the light source is disabled.

Abstract: The present invention provides an antibody or a functional fragment thereof that specifically binds to PCSK9 with high affinity, also provides a nucleic acid molecule encoding the antibody of the invention or the functional fragment thereof, for expressing an expression vector and a host cell of the antibody or the functional fragment thereof, and also provides a method for producing the antibody or the functional fragment thereof. The present invention provides that the antibody or the functional fragment thereof is used for treating diseases such as dyslipidemia.

Abstract: A set of runspaces with active connections are maintained in a pool. A set of timers are set and, based upon the timers, simple commands are submitted through the runspaces, to maintain the connections in an active state. The runspaces with the active connections can then be used from the cache, without having to open a new connection.

Abstract: A method of adaptive weighting adjustment positioning has the following steps: performing an initialization procedure, determining whether a first feature point is detected; when the first feature point is detected, based on multiple positioning methods, multiple positioning information will be generated, and multiple weightings will be set, and then based on the weightings and the positioning information, calculating the positioning information output; by way of adaptive weighting adjustment among the multiple positioning methods, the multiple positioning methods can be integrated. In this way, even if one of the positioning methods is temporarily unavailable, the positioning information can still be calculated by weighting adjustment between the positioning information of the remaining two available methods, and that allows users to continue to obtain accurate positioning information to confirm the current location.

Abstract: An image positioning method and an image positioning device for using the same is disclosed. The method finds the position of a vehicle that is driving on a road, and a plurality of signs is arranged on the road. Firstly, an electronic map having a plurality of paths, a plurality reference images, and characteristic positions of the plurality of paths and the plurality reference images is provided. Next, at least two positioning images of the signs closest to the vehicle are sequentially retrieved. The reference image identical to the positioning images are searched on the electronic map and used as characteristic images. When the order of all the characteristic images corresponds to the order of all the positioning images, the position of the vehicle is estimated according to the path corresponding to all the characteristic images and the characteristic positions of all the characteristic images.

Abstract: The present invention relates to antibodies and their antigen-binding fragments and to other molecules that are capable of immunospecifically binding to the B7-H5 ligand of the B7-H5:CD28H pathway, and to the uses of such molecules in the treatment and diagnosis of autoimmune disease, transplant rejection and other inflammatory diseases.

Abstract: A runtime capability check determines functionality supported by a client application (e.g. a browser) on a computing device. During the runtime capability check, the client application (e.g. the browser) attempts to execute different function tests to determine its capabilities. The result information from the function tests are stored. The stored result information is used by the client application during subsequent connections with the server (e.g. the cookie is passed from the mobile computing device to the server). Based on the supported functionality as determined by the stored result information, the rendering code is adapted for, generated and delivered to the computing device by the server. For example, when the client application supports the tested functionality then the server renders the content using full feature rendering. When the client application does not support all of the tested functionality then the server renders the content using limited feature rendering.

Abstract: A scanner includes an image capturing module, a drive roller assembly, an idle roller assembly, and a guiding structure. The image capturing module is for capturing an image of an object. The drive roller assembly is for driving the object to move along a feeding direction. The idle roller assembly is for preventing a moving direction of the object away from the feeding direction by resiliently pressing the object. A feeding passage is formed between the drive roller assembly and the idle roller assembly. The guiding structure is disposed in front of the feeding passage and for guiding a normal direction of a leading edge of the object to be oblique relative to the feeding direction at an oblique angle. Therefore, the present invention can effectively reduce variation of a resistance force acting on the object as the object moves in the feeding path, which prevents image distortion.

Abstract: Non-limiting examples described herein relate to processing for transcoding textual content into audio signals. In some examples, transcoding services are provided over a distributed network, for example, through an interaction between a client device and a server device. For instance, a client device may transmit a selection of a document to a server device. The server device may access a document source for the document and transcode content from the document source into speech. The server device may transmit the transcoded content to the client device, for example, where the client device may output the transcoded content. For instance, the transcoded content may be an audio file that is streamed by the client device.

Abstract: The present invention provides a standing wave electron linear accelerator comprising a modulator and a magnetron for producing radio frequency microwaves; a plurality of accelerating tubes for accelerating electrons; a microwave transmission system for feeding the microwaves into the plurality of accelerating tubes; a plurality of electron guns for emitting electron beams into the plurality of accelerating tubes; a plurality of targets impinged by the electrons from a plurality of accelerating tubes to form continuous spectrums of X-rays; a plurality of shielding devices for shielding the continuous spectrums of X-rays generated by the targets; and a microwave distributor disposed adjacent to the end of the microwave transmission system, wherein the microwave distributor has a microwave inlet and a plurality of microwave outlets for distributing the microwaves in the microwave transmission system into the accelerating tubes.

Abstract: A sensor system includes a common gas chamber and a reference gas chamber that respectively receive an exhaust gas and a reference gas. A Nernst cell is exposed to the common gas chamber and the reference air chamber and provides a reference signal indicative of an oxygen difference between the common gas chamber and the reference gas chamber. An oxygen electrochemical pump cell is exposed to the common gas chamber to provide an oxygen signal indicative of an oxygen-only concentration. A gas electrochemical cell is exposed to the common gas chamber and the reference gas chamber and provides a gas signal indicative of a gas concentration. A processor includes a pulsation module that provides a positive and a negative excitation voltage to the gas electrochemical cell for a duration and that are each followed by a decay curve indicative of the gas concentration.

Abstract: A sensor system includes a common gas chamber and a reference gas chamber respectively configured to receive an exhaust gas and a reference gas. A Nernst cell is exposed to the common gas chamber and the reference air chamber. The Nernst cell provides a reference signal indicative of an oxygen difference between the common gas chamber and the reference air chamber. An oxygen electrochemical pump cell is exposed to the common gas chamber and exhaust gas and provides an oxygen signal indicative of an oxygen only concentration. A NOx electrochemical cell is exposed to the common gas chamber and provides a NOx signal indicative of a NOx concentration. A processor is in communication with the Nernst cell, the oxygen-only electrochemical pump cell and NOx electrochemical cells. The processor outputs oxygen and NOx signals and provide a NOx concentration and oxygen concentration of the exhaust.

Abstract: A computer system includes a memory storing an UEFI firmware and a processor. The UEFI firmware supports pre-boot initialization of automatic first-time pairing of Bluetooth devices to the computer system. The processor is operatively coupled to the memory and is used to execute the UEFI firmware, wherein the executing the UEFI firmware performs the steps of: initiating a pre-connection routine to discover a default device information list in the computer system; gathering target device information from the wireless device; filtering default device information list and target device information with a filter condition; determining a result device information if the target device information matches the default device information; and recording the result device information to memory.

Abstract: A semiconductor device package comprises a substrate, a first electronic component, first and second conductive pads, a first frame board, an encapsulation layer, and a conductive layer. The substrate has a first surface and a second surface opposite to the first surface. The first electronic component, the first and second conductive pads, and the first frame board are on the first surface of the substrate. The first frame board surrounds the first electronic component and comprises a first conductive via and a second electronic component. The encapsulation layer encapsulates the first electronic component and the first frame board. The conductive layer is on the first frame board and the encapsulation layer. The first conductive via is electrically connected to the second conductive pad and the conductive layer, and the second electronic component is electrically connected to the first conductive pad.

Abstract: A semiconductor device package comprises a substrate, a first electronic component, first and second conductive pads, a first frame board, an encapsulation layer, and a conductive layer. The substrate has a first surface and a second surface opposite to the first surface. The first electronic component, the first and second conductive pads, and the first frame board are on the first surface of the substrate. The first frame board surrounds the first electronic component and comprises a first conductive via and a second electronic component. The encapsulation layer encapsulates the first electronic component and the first frame board. The conductive layer is on the first frame board and the encapsulation layer. The first conductive via is electrically connected to the second conductive pad and the conductive layer, and the second electronic component is electrically connected to the first conductive pad.