Abstract: Provided is an effective and safe method for treating or preventing a cancer using aAVC. The present invention finds suitable ranges of the dose of ?-GalCer loaded on aAVC cell surface, and the amount of ?-GalCer loaded on aAVC cell surface in a pharmaceutical composition comprising aAVC, which are preferred in terms of securing effectiveness and safety in the treatment and prevention of a cancer using aAVC, and provides an effective and safe method for treating or preventing a cancer using aAVC, aAVC for effective and safe treatment or prevention of a cancer, and a pharmaceutical composition comprising the same, etc.

Abstract: To provide: an atomizer that allows a sample liquid to be made into minute droplets stably and that inhibits clogging of an aerosol gas outlet by salting out or the like when atomizing a sample containing a high density matrix; a sample introduction unit that includes the atomizer; and an analysis device. An atomizer includes: a liquid supply tube that has a first channel in which a liquid can circulate and that has, on one end, an outlet to spray the liquid; and a gas supply tube that encloses the liquid supply tube with a gap therebetween, that has a second channel in which a gas can circulate, and that has, on one end, an outlet to spray the gas. The second channel is defined by the outer circumferential face of the liquid supply tube and the inner circumferential face of the gas supply tube and has a narrow portion upstream of the outlet.

Abstract: An object of the present invention is to provide clinically applicable aAVC-NY-ESO-1 cells stably expressing NY-ESO-1 in order to use aAVC-NY-ESO-1 cells in treating patients having a NY-ESO-1-expressing cancer. The present invention provides, for example, a human-derived cell comprising a polynucleotide encoding CD1d and a polynucleotide encoding NY-ESO-1 or a fragment thereof, wherein the polynucleotide encoding NY-ESO-1 or a fragment thereof is operably linked to an inducible promoter.

Abstract: This disclosure relates to a peptide inducing immunity to SARS-CoV-2. Also, the disclosure relates to a composition containing the peptide and inducing immunity to SARS-CoV-2.

Abstract: A surrounding information collection system requests a vehicle to transmit surrounding information, and stores the surrounding information transmitted from the vehicle in response to the request. The surrounding information collection system requests a vehicle to transmit surrounding information, the vehicle acquiring the surrounding information having accuracy greater than a threshold calculated based on accuracy of the stored surrounding information.

Abstract: An object of the present invention is to provide clinically applicable aAVC-NY-ESO-1 cells stably expressing NY-ESO-1 in order to use aAVC-NY-ESO-1 cells in treating patients having a NY-ESO-1-expressing cancer. The present invention provides, for example, a human-derived cell comprising a polynucleotide encoding CD1d and a polynucleotide encoding NY-ESO-1 or a fragment thereof, wherein the polynucleotide encoding NY-ESO-1 or a fragment thereof is operably linked to an inducible promoter.

Abstract: [Problem to be Solved] Provided is an effective and safe method for treating or preventing a cancer using aAVC. [Solution] The present invention finds suitable ranges of the dose of ?-GalCer loaded on aAVC cell surface, and the amount of ?-GalCer loaded on aAVC cell surface in a pharmaceutical composition comprising aAVC, which are preferred in terms of securing effectiveness and safety in the treatment and prevention of a cancer using aAVC, and provides an effective and safe method for treating or preventing a cancer using aAVC, aAVC for effective and safe treatment or prevention of a cancer, and a pharmaceutical composition comprising the same, etc.

Abstract: A vehicle allocation service system includes an acquisition unit configured to acquire biological information and positional information of a user, a selection unit configured to select a moving object to be provided to the user based on the biological information, a decision unit configured to acquire priority added to a satisfied condition of the biological information of the user and decide an order of vehicle allocation for the selected moving object according to the priority, and an instruction unit configured to instruct the selected moving object to move according to the positional information.

Abstract: A spray ionization device comprising: a first tube that has a first flow path through which a liquid can flow and a first outlet on one end thereof from which the liquid is sprayed; a second tube that surrounds the first tube with a gap therebetween, has a second flow path through which a gas can flow, and has a second outlet on the one end thereof; and an electrode that extends through the interior of the first flow path of the first tube, from the other end thereof to the one end, said electrode being arranged such that the tip thereof is at the same position as the first outlet or is further on the other end side than the first outlet, and said electrode being able to apply a voltage to the liquid by means of a power source connected to the electrode.

Abstract: A spray ionization device comprising: a first pipe body that has a first flow path which allows a liquid to flow therethrough, and has, at one end thereof, a first outlet through which the liquid is sprayed out; a second pipe body that surrounds the first pipe body; and a third pipe body that surrounds the second pipe body with a space interposed therebetween, that has a second flow path allowing a gas to flow therethrough, and that has a second outlet at the one end. At least the leading end part of the third pipe body including the second outlet is made of an electrically conductive material so as to serve as an electrode. Charged droplets can be sprayed from the second outlet by applying an electric field to droplets sprayed from the first outlet using a power supply connected to the electrode.

Abstract: The sample introduction device includes a nebulizer that atomizes a sample liquid; a spray chamber that has one end into which a spray port part of the nebulizer is inserted and the other end from which at least a part of liquid droplets of the sample liquid sprayed from the spray port part is discharged to an outside; and a heating electromagnetic wave radiation unit that is arranged outside the spray chamber, wherein the heating electromagnetic wave radiation unit performs radiation of heating electromagnetic waves from the outside of the spray chamber toward at least a part of the spray chamber other than a part into which the spray port part of the nebulizer is inserted.

Abstract: An object of the present invention is to provide clinically applicable aAVC-NY-ESO-1 cells stably expressing NY-ESO-1 in order to use aAVC-NY-ESO-1 cells in treating patients having a NY-ESO-1-expressing cancer. The present invention provides, for example, a human-derived cell comprising a polynucleotide encoding CD1d and a polynucleotide encoding NY-ESO-1 or a fragment thereof, wherein the polynucleotide encoding NY-ESO-1 or a fragment thereof is operably linked to an inducible promoter.

Abstract: A server apparatus as a management apparatus in a system includes a controller configured to execute acquiring commodity-or-the-like purchase information of a user in a first mobile store from a store device of the first mobile store, selecting a commodity or a service predicted to be purchased next by the user based on commodities or services in the acquired commodity-or-the-like purchase information, and transmitting information regarding the user to a store device of a second mobile store dealing in the selected commodity or service.

Abstract: Provided in the present disclosure is a spray ionization device comprising: a first tube that has a first flow path in which a liquid can flow, the first tube having a first outlet on one end thereof from which the liquid is sprayed; a second tube that surrounds the first tube with a gap therebetween and has a second flow path in which a gas can flow, the second tube having a second outlet on the one end thereof and the second flow path being defined by the outer peripheral surface of the first tube and the inner peripheral surface of the second tube; and an electrode contacting the liquid flowing through the first flow path, the electrode being able to apply a voltage to the liquid by means of a power source connected to the electrode, wherein charged droplets of the liquid can be sprayed from the second outlet.

Abstract: The present invention provides a composition for use in activating innate immunity, comprising an immunostimulant. The present invention also provides a combination use of an immunostimulant and an artificial adjuvant vector cell.

Abstract: A surrounding information collection system requests a vehicle to transmit surrounding information, and stores the surrounding information transmitted from the vehicle in response to the request. The surrounding information collection system requests a vehicle to transmit surrounding information, the vehicle acquiring the surrounding information having accuracy greater than a threshold calculated based on accuracy of the stored surrounding information.

Abstract: The present invention provides a cell activating the immune system and a pharmaceutical composition containing the cell. According to the present invention, there is provided a mammalian cell having at least one protein selected from the group consisting of E6 protein and E7 protein for early genes of human papillomavirus and a fusion protein of E6 protein and E7 protein, and CD1d protein, wherein the mammalian cell is pulsed with a CD1d ligand. According to the present invention, there are also provided a fusion protein having E7 protein, E6 protein and E7 protein in this order, a nucleic acid encoding the protein and a gene expression vector therefor.

Abstract: A spray ionization device is provided with: a first tube body having a first flow channel through which a first fluid can flow, and having, at one end thereof, a first outlet for spraying the first liquid; a second tube body having a second flow channel through which a second fluid can flow, and having, at one end thereof, a second outlet for spraying the second liquid; an outer tube that has a gas flow channel through which a gas can flow, the outer tube having, at one end thereof, a spray port that is covered with a porous member; and an electrode that is provided between the first flow channel, the second channel, and the first outlet or the second outlet and the porous member, the electrode allowing for a voltage to be applied to the first liquid and/or the second liquid by a power source.

Abstract: The present invention provides an adjuvant that can cause immune activation or particularly T cell immune activation. The present invention provides an adjuvant that can cause particularly antigen-specific immune activation or particularly T cell immune activation.

Abstract: An information processing device includes a control unit configured to perform: acquiring a degree of congestion of persons that are located in a predetermined range including a plurality of vehicles which is parked at predetermined positions and is able to travel autonomously; determining a positional relationship between the plurality of vehicles based on the degree of congestion; and transmitting a movement command to a first vehicle which is a vehicle which is requested to move out of the plurality of vehicles such that the determined positional relationship is satisfied.