Abstract: The present invention provides novel compounds which activate the Kv7 potassium channels. Exemplary compounds of the invention have the structure of Formula 1. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders responsive to the activation of Kv7 potassium channels.

Abstract: A mold tool generally includes a base, a die assembly, a tightening element, a threaded element, and at least one shaping cap. The base defines a cutout, a first threaded hole opposite to the cutout, and a second threaded hole. The die assembly, composed of a first module and a second module, can be inserted into a receiving space of the base. The tightening element can be screwed into the second threaded hole of the base to fix the die assembly in place. The threaded element can be screwed into the first threaded hole of the base. The shaping cap can be fitted at one end of the threaded element. The die assembly defines channels of various diameters each for holding a tube of a specific diameter. The shaping cap can urge one end of a tube held in the die assembly to form a specific type of flare.

Abstract: The present invention provides novel compounds which activate the Kv7 potassium channels. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders responsive to the activation of Kv7 potassium channels.

Abstract: A lock package is provided. The package holder is suitable to simultaneously position at least two locks. The package holder includes a plate portion and a partition. The plate portion has two opposite surfaces, at least two positioning portions, and a non-positioning portion. The surfaces are configured to be disposed with the locks. The positioning portions are configured to position plural escutcheons of the locks, and a portion of each of the escutcheons is exposed, in which the non-positioning portion is configured to cover a plurality of handles of the locks.

Abstract: A mold tool generally includes a base, a die assembly, a tightening element, a threaded element, and at least one shaping cap. The base defines a cutout, a first threaded hole opposite to the cutout, and a second threaded hole. The die assembly, composed of a first module and a second module, can be inserted into a receiving space of the base. The tightening element can be screwed into the second threaded hole of the base to fix the die assembly in place. The threaded element can be screwed into the first threaded hole of the base. The shaping cap can be fitted at one end of the threaded element. The die assembly defines channels of various diameters each for holding a tube of a specific diameter. The shaping cap can urge one end of a tube held in the die assembly to form a specific type of flare.

Abstract: A lock package is provided. The package holder is suitable to simultaneously position at least two locks. The package holder includes a plate portion and a partition. The plate portion has two opposite surfaces, at least two positioning portions, and a non-positioning portion. The surfaces are configured to be disposed with the locks. The positioning portions are configured to position plural escutcheons of the locks, and a portion of each of the escutcheons is exposed, in which the non-positioning portion is configured to cover a plurality of handles of the locks.

Abstract: A caliper piston adjuster includes a body defining a passage, a push rod, a resilient member, a holding rod, a positioning stop plate, and a positioning member. The push rod is fixedly connected with a positioning cart, and mounted with the resilient member, and inserted through the passage of the body, such that one end of the resilient member contacts the positioning part fixed at the push rod. The push rod is connected with a connector and an activating disc respectively at two ends thereof. The connector is connected with the holding rod. The positioning member is inserted through an opening of the positioning stop plate to be connected to the body. With the aid of the resilient member, the caliper piston adjuster can adjust the piston of a caliper cylinder more easily by rotating the holding rod.

Abstract: A wheel cylinder adjuster includes a body, a push rod, a resilient member and a positioning member. The push rod extends through the body and the resilient member is mounted to the push rod and located in the body. The push rod has a positioning part connected thereto and the positioning part contacts one end of the resilient member. The push rod has a connector and an activating disc respectively connected to two ends thereof, the connector has a holding rod extending therethrough. The positioning member is connected to the push rod so that the left-sided wheel cylinder and the right-sided wheel cylinder can be adjusted by using the single wheel cylinder adjuster.

Abstract: Provided are compounds of formula I useful for controlling parasites both in animals and agriculture. Further provided are methods for controlling parasite infestations of an animal by administering an effective amount of a compound as described above, or a pharmaceutically acceptable salt thereof, to an animal, as well as formulations for controlling parasite infestations using the compounds described above or an acceptable salt thereof, and an acceptable carrier.

Abstract: A wheel cylinder adjuster includes a rotary unit and a driving unit connected with the rotary unit. The rotary unit includes a rotary disk, a fixing member, two positioning members, a resilient ring, a restriction member and a clip. The rotary disk has a guide groove designed in a shape containing two semi-ovals. Two stepped slots are defined through the fixing member and the positioning members extend through the two stepped slots. Each positioning member has a guide tip which is located in the guide groove. The resilient ring is mounted to the positioning members and the tubular portion. The rotary disk is rotated and the guide tips of the positioning members more in the stepped slots so as to adjust the distance between the positioning members so as to be operated to different sizes of the wheel cylinders.

Abstract: A wheel cylinder adjuster includes a rotary unit and a driving unit connected with the rotary unit. The rotary unit includes a rotary disk, a fixing member, two positioning members, a resilient ring, a restriction member and a clip. The rotary disk has a guide groove designed in a shape containing two semi-ovals. Two stepped slots are defined through the fixing member and the positioning members extend through the two stepped slots. Each positioning member has a guide tip which is located in the guide groove. The resilient ring is mounted to the positioning members and the tubular portion. The rotary disk is rotated and the guide tips of the positioning members more in the stepped slots so as to adjust the distance between the positioning members so as to be operated to different sizes of the wheel cylinders.

Abstract: A brake cylinder adjustment assembly for adjusting brake cylinders of different sizes and includes a rotation unit and a driving unit which is connected with the rotation unit. The rotation unit includes a rotatable disk, a fixed disk, at least two positioning rods and a clip. The rotatable disk has at least two curved slots and the fixed disk has at least two slide slots. The at least two positioning rods are engaged with the at least two slide slots and the at least two curved slots. The brake cylinder adjustment assembly uses a single driving unit and single rotation unit to adjust the left and right brake cylinders of different sizes.

Abstract: A brake cylinder adjustment assembly for adjusting brake cylinders of different sizes and includes a rotation unit and a driving unit which is connected with the rotation unit. The rotation unit includes a rotatable disk, a fixed disk, at least two positioning rods and a clip. The rotatable disk has at least two curved slots and the fixed disk has at least two slide slots. The at least two positioning rods are engaged with the at least two slide slots and the at least two curved slots. The brake cylinder adjustment assembly uses a single driving unit and single rotation unit to adjust the left and right brake cylinders of different sizes.

Abstract: An oil pipe stopper includes an upper clamping body, a lower clamping body, and an elastic member. The upper clamping body has a central portion with an upper post, two downwardly slanting portions, and two clamping portions. The clamping portions of the upper clamping body are provided with a first stopping member and an engagement groove. The lower clamping body has a central portion with a lower post, two upwardly slanting portions, and two clamping portions. The lower post is telescopically connected with the upper post. The clamping portions of the lower clamping body are provided with a second stopping member and a third stopping member. The downwardly and upwardly slanting portions are crossed such that the first stopping member faces the second stopping member while the engagement groove faces the third stopping member. The elastic member is mounted between the upper clamping body and the lower clamping body.

Abstract: The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.

Abstract: A wheel cylinder adjuster includes plural actuating discs able to match different-sized wheel cylinders, and a driving wrench able to be jointed with the actuating disc. The driving wrench has two ends of its shank respectively provided with right-handed threads and left-handed threads on the surface, having a crosswise insert hole respectively bored at an outer side of the right-handed threads and of the left-handed threads, and the shank has two ends respectively protruding outward to form a positioning rod to be inserted in the insert hole of the actuating disc. Two positioning sleeves are respectively combined with the right-handed threads and the left-handed threads at the two ends of the shank. A holding rod is inserted in either one of the two insert holes at two ends of the driving wrench, and a positioning stop plate is provided to fix one of the two positioning sleeves.

Abstract: A wheel cylinder adjuster includes plural actuating discs able to match different-sized wheel cylinders, and a driving wrench able to be jointed with the actuating disc. The driving wrench has two ends of its shank respectively provided with right-handed threads and left-handed threads on the surface, having a crosswise insert hole respectively bored at an outer side of the right-handed threads and of the left-handed threads, and the shank has two ends respectively protruding outward to form a positioning rod to be inserted in the insert hole of the actuating disc. Two positioning sleeves are respectively combined with the right-handed threads and the left-handed threads at the two ends of the shank. A holding rod is inserted in either one of the two insert holes at two ends of the driving wrench, and a positioning stop plate is provided to fix one of the two positioning sleeves.