Abstract: Methods for the preparation of sidechain-bearing taxanes, comprising the preparation of an oxazoline compound, coupling the oxazoline compound with a taxane having a hydroxyl group directly bonded at C-13 thereof to form an oxazoline sidechain-bearing taxane, and opening the oxazoline ring of the oxazoline sidechain-bearing taxane so formed. Compounds prepared by the methods of the present invention are also disclosed.

Abstract: A pseudomycin prodrug represented by structure (A) where R1 is a phosphate benzyloxycarbamate or phosphate methyleneoxycarbamate linkage is described. The phosphate prodrug demonstrates antifungal activity with less adverse side effects than the parent pseudomycin compound.

Abstract: A solder ball allocation on a chip, and a method of the same are provided. The chip has a substrate, first solder balls and second solder balls. The first solder balls are located in a periphery of the substrate and arranged outwardly. The second solder balls are located in a central part of the substrate and arranged with several first geometric patterns that construct a second geometric pattern. The first geometric patterns are also arranged to divide the chip into several power source blocks. The conflict between the second solder balls and the power source blocks are analyzed to remove the second solder balls with conflicts. The power line can go through the middle directly to avoid the power source bypass, or other reasons that cause the chip unable to work stable. The invention divides the chip into several power source blocks without increase the chip volume and cost.

Abstract: A circuit sub-board for regulating constant power source and strengthening ground connections. The circuit sub-board is a double-layered printed circuit board having a large surface power-source layer and a ground-connection layer. The circuit sub-board is utilized to cover the insufficiently ground-covered main board signaling lines as well as insufficiently ground-connected power and ground signaling lines on the main board. With the installation of the circuit sub-board, signals can be transmitted more reliably and with less interference.

Abstract: A circuit sub-board for regulating constant power source and strengthening ground connections. The circuit sub-board is a double-layered printed circuit board having a large surface power-source layer and a ground-connection layer. The circuit sub-board is utilized to cover the insufficiently ground-covered main board signaling lines as well as insufficiently ground-connected power and ground signaling lines on the main board. With the installation of the circuit sub-board, signals can be transmitted more reliably and with less interference.

Abstract: A trace layout of a printed circuit board (PCB) is provided with a north bridge, at least a peripheral component interconnect (PCI) slot, and an accelerate graphics port (AGP) slot. The PCB includes at least a first trace layer and a second trace layer under the first trace layer. The AGP slot is mounted between the north bridge and the PCI slot. The PCB further includes a number of first traces, and a number of second traces. The first traces are used for connecting the north bridge to the PCI slot while the second traces are used to connect the north bridge to the AGP slot. Some of the first traces are on the second trace layer under the AGP slot, while the other of the first traces are on the first trace layer or the second trace layer and trace aside the AGP slot. Most of the second traces are on the first trace layer and the other of the second traces are on the second trace layer.

Abstract: A memory control system for controlling write-enable signals. The memory control system has a first memory slot having a write-enable pin thereon, a second memory slot having a first write-enable pin and a second write-enable pin thereon and a control chipset having a write-enable pin and a dual-purpose write-enable/memory-parity-data pin thereon. The write-enable pin of the control chipset is connected to the write-enable pin of the first memory slot and the first write-enable pin of the second memory slot. The write-enable/memory-parity-data pin of the control chipset is connected to the second write-enable pin of the second memory slot. In this invention, since the design of the write-enable system is more flexible, length of trace line on a computer board can be greatly reduced. In addition, the system permits the incorporation of one cycle (1T) timing into design of memory access commands.

Abstract: A computer main board having a plurality of 184-lead memory module slots and a plurality of 168-lead memory module slots, a computer system, a terminal circuit module and memory modules that can be used in the main board and computer system. A control chipset on the main board can be preset so that any particular memory module on a memory module slot can be selected to operate in a special write mode. In other words, whether the write data has 64-bit length or not, a complete 64-bit data according to 64-bit (QW) block division is first read out and modified before writing the complete 64-bit data, In this invention, the wiring layout of the main board does not have to follow the signal line bit sequence. Al that is required is to connect each independent data line of the 168-pin slot with each independent data line of the 184-pin memory module slot.

Abstract: A memory control system for controlling write-enable signals. The memory control system has a first memory slot having a write-enable pin thereon, a second memory slot having a first write-enable pin and a second write-enable pin thereon and a control chipset having a write-enable pin and a dual-purpose write-enable/memory-parity-data pin thereon. The write-enable pin of the control chipset is connected to the write-enable pin of the first memory slot and the first write-enable pin of the second memory slot. The write-enable/memory-parity-data pin of the control chipset is connected to the second write-enable pin of the second memory slot. In this invention, since the design of the write-enable system is more flexible, length of trace line on a computer board can be greatly reduced. In addition, the system permits the incorporation of one cycle (1T) timing into design of memory access commands.

Abstract: An integrated circuit (IC) mounting board is provided for use to mount an IC module and as least one bypass capacitor thereon. The IC mounting board allows the layout of the wiring between the IC module and the circuit lines on the IC mounting board to be more convenient to carry out. Moreover, the IC mounting board allows the bypass capacitor to provide the bypass effect more effectively.

Abstract: The present invention provides a computer motherboard having an Intel P54C compatible processor socket and a control chip having specifically arranged data pins and address pins which allows a short signal path arrangement from the processor socket to a cache tap RAM and a cache data RAM. The computer motherboard comprises a four-layer printed circuit board, a processor socket, a cache data RAM, a cache tag RAM, and a control chip. All these components are connected by using a high-order-bit data bus, a low-order-bit data bus, and an address bus through the top and bottom layers of the circuit board. The cache data RAM is positioned on the right side of the processor socket. The control chip is positioned on the top side of the cache data RAM and on the top-right side of the processor socket.

Abstract: Novel methods for the preparation of sidechain-bearing taxanes, comprising the preparation of an oxazoline compound, coupling the oxazoline compound with a taxane having a hydroxyl group directly bonded at C-13 thereof to form an oxazoline sidechain-bearing taxane, and opening the oxazoline ring of the oxazoline sidechain-bearing taxane so formed. Novel compounds prepared by the methods of the present invention are also provided.

Abstract: A method of recovering adipic acid and 6-hydroxycaproic acid from the waste solution of alkali metal salts of organic acids coming from the process of cyclohexane oxidation, which comprises:(i) basifying the reaction mixture coming from cyclohexane oxidation with an aqueous solution of an alkali-metal base so that the organic acids essentially comprising adipic acid and 6-hydroxycaproic acid therein, are saponified, extracting the formed alkali metal salts of organic acids from the mixture with water, then acidifying the aqueous extract comprising the alkali metal salts of organic acids to a pH value of 3 or lower with an aqueous solution of a protic inorganic acid, as a result, said aqueous extract is separated into an oily layer and an aqueous layer;(ii) extracting the organic acid from said oily layer obtained from the step (i) with an aqueous solution of a protic inorganic acid, to obtain an aqueous extract;(iii) extracting the organic acid from the aqueous layer obtained from the step (i) with an organic

Abstract: The present invention relates to a compound of the formula wherein R.sup.1 and R.sup.2 are selected from lower alkyl groups having 1-6 carbon atoms, substituted or unsubstituted aryl groups, and unsaturated alkyl groups having 1-6 carbon atoms; R.sup.3 is a substituted or unsubstituted lower alkyl group having 1-6 carbons; and R.sup.4 is selected from substituted or unsubstituted lower alkyl groups having 1-6 carbon atoms, substituted or unsubstituted aryl groups, and unsaturated alkyl groups having 1-6 carbon atoms. The present invention also relates to a pharmaceutical composition comprising the above compound, as well as a method of treating tumor cells with the compound.

Abstract: The present invention relates to methods for substantially enhancing the stereoselective synthesis of .beta.-anomeric nucleoside analogs. In methods according to the present invention, the introduction of a phenylseleno group onto a blocked lactone sugar precursor may be selected so that the desirable phenylseleno substituent is introduced on the side of the blocked lactone away from the blocking group. This stereospecific introduction of the phenylseleno group in sugar precursor allows the synthesis of nucleoside analogs and in particular, 2',3',-dideoxy- and 2',3'-dideoxy-2',3'-didehydronucleoside analogs in very high yield. In certain preferred embodiments, the preferred phenylseleno blocked lactone is obtained in an amount representing approximately 90% or more of the total amount of the stereoisomers obtained. In even more preferred embodiments, the amount of the preferred stereoisomer is at least 95%, even more preferably at least about 97% of the total amount of phenylseleno blocked lactone produced.

Abstract: Novel methods for the preparation of sidechain-bearing taxanes, comprising the preparation of an oxazoline compound, coupling the oxazoline compound with a taxane having a hydroxyl group directly bonded at C-13 thereof to form an oxazoline sidechain-bearing taxane, and opening the oxazoline ring of the oxazoline sidechain-bearing taxane so formed. Novel compounds prepared by the methods of the present invention are also provided.

Abstract: The present invention relates to improved, efficient chemical syntheses of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) and 3-amino-4-methylpyridine-2-carboxaldehyde thiosemicarbazone (3-AMP).

Abstract: The present invention concerns novel paclitaxel derivatives, their use as antitumor agents, and pharmaceutical formulations.

Abstract: Novel methods for the preparation of sidechain-bearing taxanes, comprising the preparation of an oxazoline compound, coupling the oxazoline compound with a taxane having a hydroxyl group directly bonded at C-13 thereof to form an oxazoline sidechain-bearing taxane, and opening the oxazoline ring of the oxazoline sidechain-bearing taxane so formed. Novel compounds prepared by the methods of the present invention are also provided.

Abstract: The present invention relates to novel prodrug forms of ribonucleoside diphosphate reductase inhibitors 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) 3-amino-4-methylpyridine-2-carboxaldehyde thiosemicarbazone (3-AMP) which have increased water solubility, bioavailablity and resistance to in vivo acetylation of their amino functions. Novel compounds according to the present invention relate to those of the formula: ##STR1## where R.sup.4 is H or CH.sub.3 andR.sup.5 is CHR, benzyl or ortho or para substituted benzyl;R is H, CH.sub.3, CH.sub.2 CH.sub.3, CH.sub.2 CH.sub.2 CH.sub.3 or ##STR2## R' is a free acid phosphate, phosphate salt or an --S--S--R" group; R" is CH.sub.2 CH.sub.2 NHR.sup.6, CH.sub.2 CH.sub.2 OH, CH.sub.2 COOR.sup.7, an ortho or para substituted alkylphenyl and ortho or para substituted nitro-phenyl;R.sup.6 is H, C.sub.1 -C.sub.4 acyl group, trifluoroacetyl, benzoyl or substituted benzoyl group, andR.sup.7 is H, C.sub.1 -C.sub.4 alkyl or a benzyl or substituted benzyl.