Patents by Inventor Shumin Wang

Shumin Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12576163
    Abstract: The present disclosure provides a fluorescent contrast agent with a targeting function, and a preparation method and a use thereof, and belongs to the technical fields of nanomaterials and biomedical materials. The fluorescent contrast agent (MR780 NPs) of the present disclosure can specifically bind to CD206 on a surface of tumor-associated macrophages (TAMs). MR780 NPs accumulate in lymph nodes invaded by tumor cells and undergo an oxidation-reduction reaction with reduced glutathione in a tumor microenvironment, which triggers a fluorescence signal of MR780 NPs; and MR780 NPs do not accumulate and do not show fluorescence in normal lymph nodes. Therefore, the fluorescent contrast agent of the present disclosure can be used to diagnose lymph node metastasis (LNM) of breast cancer, realize the preoperative evaluation of LNM, assist in the clinical determination of tumor staging and the formulation of a surgical plan, and achieve the accurate resection under intraoperative fluorescence navigation.
    Type: Grant
    Filed: April 29, 2022
    Date of Patent: March 17, 2026
    Assignees: Peking University Third Hospital, Ordos Clinical Medical College of Inner Mongolia. Medical University
    Inventors: Shumin Wang, Xiaolong Liang, Duo Zhao, Shiyuan Yang, Menghong Xu, Huiwen Li
  • Publication number: 20260022334
    Abstract: The present disclosure discloses a composition, method and application thereof for improving the quality of in vitro maturation of oocytes and the pregnancy rate after in vitro produced embryos transfer. The present disclosure aims at the problems of low maturation rate and poor subsequent embryo development potential caused by metabolic disorders during in vitro maturation of oocytes, and provides a composition including two or more regulators in vitamin C, L-carnitine and thrombopoietin to regulate the metabolism of oocytes, thereby greatly improving the in vitro maturation rate of oocytes and the subsequent embryo development potential. The present disclosure not only improves the efficiency of in vitro embryo production of livestock, but also provides a reference for improving the efficiency of human assisted reproductive technology. The method is simple, safe and efficient, and has great application value and broad application prospects.
    Type: Application
    Filed: February 19, 2025
    Publication date: January 22, 2026
    Inventors: Jianhui TIAN, Guangyin XI, Jia HAO, Yuan YUE, Shumin WANG, Lei AN, Min GUO
  • Publication number: 20250332222
    Abstract: The disclosure relates to a batch management method for improving the farrowing rate or the number born alive in swine. It includes the following steps: synchronization of estrus in swine are used an exogenous gonadotropin(s) to synchronize follicular development, and then fed with 1-[bis(4-cyanophenyl)alkyl]-1,2,4-triazole after 6-12 hours. Next the gilts or sows are bred in batches after treated with ovulation-inducing drug(s). The disclosure can effectively alleviate decreased farrowing rate and number of piglets born alive in the batch gilts or sows used the fixed-time artificial insemination, without influencing the serum estrogen level, estrus and ovulation time in mated gilts or sows. Therefore, a novel method for improving the reproductive efficiency of gilts or sows will be established, which is valuable for popularizing batch farrowing in swine including with fixed-time artificial insemination.
    Type: Application
    Filed: August 8, 2024
    Publication date: October 30, 2025
    Inventors: Jianhui TIAN, Shumin WANG, Lei AN, Yue WANG, Wei ZHAO, Linghua CHENG, Jiage DAI, Zhicheng SHI
  • Patent number: 12364671
    Abstract: The present disclosure relates to the field of livestock farming, and specifically provides a feeding method for gilts in batch for promoting onset of puberty and alleviating estrus disorder of gilts, which is aiming at an industrial problem that a large number of gilts are culled due to delayed puberty onset or estrus disorder. The method includes: feeding, prior to onset of puberty for gilts with vitamin A combined with lactic acid; and performing, subsequent to the puberty onset of gilts, estrus synchronization treatment and insemination treatment on the gilts. By applying vitamin A combined with lactic acid, the present disclosure alleviates the delayed puberty onset or estrus disorder of the gilts, reduces the feeding duration and feeding cost of the gilts, facilitates synchronous estrus treatment of the gilts.
    Type: Grant
    Filed: November 22, 2024
    Date of Patent: July 22, 2025
    Assignee: CHINA AGRICULTURAL UNIVERSITY
    Inventors: Jianhui Tian, Shumin Wang, Lei An, Guo Sun, Fupeng Wang, Qianying Yang
  • Patent number: 12343321
    Abstract: The disclosure relates to the field of biology and provides a breeding method for ameliorating or avoiding the adverse effects of exogenous gonadotropins on reproductive performance, which comprises administrating N-acetylcysteine and vitamin A prior to the exogenous gonadotropin treatment. The disclosure can effectively improve the reproductive performance, including improving the uterine receptivity and pregnancy outcome after exogenous gonadotropins treatment, such as embryo implantation rate, the status of embryo development after implantation, pregnancy rate, live birth, health condition of born offspring, and other effects, by using a combination of N-acetylcysteine and vitamin A.
    Type: Grant
    Filed: September 27, 2024
    Date of Patent: July 1, 2025
    Assignee: CHINA AGRICULTURAL UNIVERSITY
    Inventors: Jianhui Tian, Shumin Wang, Lei An, Yue Wang, Yusheng Qin, Wei Zhao
  • Patent number: 12190495
    Abstract: The present disclosure discloses a microscopic non-destructive measurement method of a microstructure linewidth based on a translation difference, based on a conventional microscopic imaging method, a high-precision displacement platform is used to move a to-be-measured sample, one microscopic image of the sample is acquired before and after the displacement separately, subtraction is performed on the two image to obtain a differential image, a light intensity distribution function of the differential image is derived, data fitting is performed on the differential image, and a high-precision sample linewidth measurement result is obtained by using the characteristic of a high differential pulse positioning resolution.
    Type: Grant
    Filed: September 22, 2023
    Date of Patent: January 7, 2025
    Assignee: NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Zhishan Gao, Jianqiu Ma, Qun Yuan, Yifeng Sun, Xiao Huo, Shumin Wang, Jiale Zhang, Xiaoxin Fan
  • Publication number: 20240265520
    Abstract: The present disclosure discloses a microscopic non-destructive measurement method of a microstructure linewidth based on a translation difference, based on a conventional microscopic imaging method, a high-precision displacement platform is used to move a to-be-measured sample, one microscopic image of the sample is acquired before and after the displacement separately, subtraction is performed on the two image to obtain a differential image, a light intensity distribution function of the differential image is derived, data fitting is performed on the differential image, and a high-precision sample linewidth measurement result is obtained by using the characteristic of a high differential pulse positioning resolution.
    Type: Application
    Filed: September 22, 2023
    Publication date: August 8, 2024
    Inventors: Zhishan GAO, Jianqiu MA, Qun YUAN, Yifeng SUN, Xiao HUO, Shumin WANG, Jiale ZHANG, Xiaoxin FAN
  • Patent number: 12002546
    Abstract: This disclosure pertains to markers and methods useful in identifying Cannabis plants that have a day length neutral phenotype, and methods of breeding plants having a day length neutral phenotype.
    Type: Grant
    Filed: April 13, 2022
    Date of Patent: June 4, 2024
    Assignee: Aurora Cannabis Enterprises Inc.
    Inventors: Gregory Baute, Shumin Wang, Jason Sawler, Jose Celedon
  • Publication number: 20230346982
    Abstract: The present disclosure provides a fluorescent contrast agent with a targeting function, and a preparation method and a use thereof, and belongs to the technical fields of nanomaterials and biomedical materials. The fluorescent contrast agent (MR780 NPs) of the present disclosure can specifically bind to CD206 on a surface of tumor-associated macrophages (TAMs). MR780 NPs accumulate in lymph nodes invaded by tumor cells and undergo an oxidation-reduction reaction with reduced glutathione in a tumor microenvironment, which triggers a fluorescence signal of MR780 NPs; and MR780 NPs do not accumulate and do not show fluorescence in normal lymph nodes. Therefore, the fluorescent contrast agent of the present disclosure can be used to diagnose lymph node metastasis (LNM) of breast cancer, realize the preoperative evaluation of LNM, assist in the clinical determination of tumor staging and the formulation of a surgical plan, and achieve the accurate resection under intraoperative fluorescence navigation.
    Type: Application
    Filed: April 29, 2022
    Publication date: November 2, 2023
    Inventors: Shumin WANG, Xiaolong LIANG, Duo ZHAO, Shiyuan YANG, Menghong XU, Huiwen LI
  • Publication number: 20220333214
    Abstract: This disclosure pertains to markers and methods useful in identifying Cannabis plants that have a day length neutral phenotype, and methods of breeding plants having a day length neutral phenotype.
    Type: Application
    Filed: March 31, 2021
    Publication date: October 20, 2022
    Applicant: 1769474 ALBERTA LTD.
    Inventors: Gregory Baute, Shumin Wang, Jason Sawler, Jose Celedon
  • Publication number: 20220235425
    Abstract: This disclosure pertains to markers and methods useful in identifying Cannabis plants that have a day length neutral phenotype, and methods of breeding plants having a day length neutral phenotype.
    Type: Application
    Filed: April 13, 2022
    Publication date: July 28, 2022
    Applicant: 1769474 ALBERTA LTD.
    Inventors: Gregory Baute, Shumin Wang, Jason Sawler, Jose Celedon
  • Patent number: 10989065
    Abstract: Provided is a steam turbine overspeed protection system, includes a drive gear arranged to match a rotation speed of a rotor of a steam turbine; a rotating shaft parallel to an axis of the drive gear and capable of rotating at a critical rotation speed; a protective gear arranged on the rotating shaft and forming a lead screw nut mechanism with the rotating shaft, and arranged to be capable of engaging with the drive gear when the rotation speed of the drive gear exceeds the critical rotation speed; and an operating rod connected to the protective gear; wherein, when the drive gear engages with the protective gear, the protective gear can move in the axial direction of the rotating shaft and thereby drive the operating rod to move and produce an action that activates a protection device for preventing steam turbine overspeed.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: April 27, 2021
    Assignee: CHINA SHENHUA ENERGY COMPANY LIMITED
    Inventors: Shumin Wang, Yanchao Li, Zhijiang Liu, Xing Wei, Wei Wang, Lihua Cao, Zhijia Lv
  • Publication number: 20210090955
    Abstract: The present disclosure provides a method for preparing heterostructure, which includes providing a donor substrate and forming a sacrificial layer on a surface of the donor substrate; forming a thin film cover layer on a surface of the sacrificial layer, wherein a top surface of the thin film cover layer is an implantation surface; performing ion implantation from the implantation surface, such that a defect layer is formed in the sacrificial layer; providing an acceptor substrate, and bonding the acceptor substrate to the implantation surface of the thin film cover layer; removing the sacrificial layer along the defect layer. The method for preparing the heterostructure of the present disclosure can successfully transfer the thin film cover layer to the acceptor substrate. The present disclosure can provide a compliant substrate, while the semiconductor donor substrate material can be reused, therefore is energy-efficient and environmental-friendly.
    Type: Application
    Filed: December 7, 2017
    Publication date: March 25, 2021
    Applicant: SHANGHAI INSTITUTE OF MICROSYSTEM AND INFORMATION TECHNOLOGY, CHINESE ACADEMY OF SCIENCES
    Inventors: Xin OU, Shumin WANG, Chang WANG, Tiangui YOU, Yanchao ZHANG, Kai HUANG, Lijuan WANG, Jiajie LIN, Wenwu PAN
  • Patent number: 10742330
    Abstract: A measurement device may include a bias source to provide a bias, a photodiode to provide a linear current based on an input optical power and the bias, a log amplifier to receive the linear current and to provide a voltage, and one or more processors to receive the voltage and to determine a measurement of the input optical power at an observed temperature. The measurement may be determined based on a photodiode current corresponding to the voltage, a dark current, and a calibration current. The calibration current may be determined, for a threshold power range, based on a first plurality of current measurements at a first temperature and at a plurality of optical powers, a second current measurement at a second temperature and at a first optical power, and a third current measurement at the second temperature and at a second optical power.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: August 11, 2020
    Assignee: Lumentum Operations LLC
    Inventor: Shumin Wang
  • Publication number: 20190288779
    Abstract: A measurement device may include a bias source to provide a bias, a photodiode to provide a linear current based on an input optical power and the bias, a log amplifier to receive the linear current and to provide a voltage, and one or more processors to receive the voltage and to determine a measurement of the input optical power at an observed temperature. The measurement may be determined based on a photodiode current corresponding to the voltage, a dark current, and a calibration current. The calibration current may be determined, for a threshold power range, based on a first plurality of current measurements at a first temperature and at a plurality of optical powers, a second current measurement at a second temperature and at a first optical power, and a third current measurement at the second temperature and at a second optical power.
    Type: Application
    Filed: March 15, 2018
    Publication date: September 19, 2019
    Inventor: Shumin WANG
  • Publication number: 20190257212
    Abstract: Provided is a steam turbine overspeed protection system, includes a drive gear arranged to match a rotation speed of a rotor of a steam turbine; a rotating shaft parallel to an axis of the drive gear and capable of rotating at a critical rotation speed; a protective gear arranged on the rotating shaft and forming a lead screw nut mechanism with the rotating shaft, and arranged to be capable of engaging with the drive gear when the rotation speed of the drive gear exceeds the critical rotation speed; and an operating rod connected to the protective gear; wherein, when the drive gear engages with the protective gear, the protective gear can move in the axial direction of the rotating shaft and thereby drive the operating rod to move and produce an action that activates a protection device for preventing steam turbine overspeed.
    Type: Application
    Filed: October 20, 2017
    Publication date: August 22, 2019
    Inventors: Yanchao LI, Shumin WANG, Zhijiang LIU, Xing WEI, Wei WANG, Zhijia LV, Lihua CAO
  • Publication number: 20190219648
    Abstract: This specification describes RF coils using an elastic substrate that can be stretched and/or wrapped around the target anatomy. In some examples, a system includes an RF coil array including at least one elastic and conductive loop, the elastic and conductive loop having a length and being elastic in that, in response to a stress, the length stretches from a first length to a second length greater than the first length and returns to the first length after removal of the stress. The elastic and conductive loop is configurable to surround at least a portion of a magnetic resonance imaging subject's body for magnetic resonance imaging of the portion of the subject's body. The system includes an RF circuit coupled to the RF coil array and configured to cause a voltage to be induced through the elastic and conductive loop.
    Type: Application
    Filed: August 30, 2017
    Publication date: July 18, 2019
    Inventors: Weili Lin, Shumin Wang
  • Patent number: 10059306
    Abstract: A defroster and a vehicle are provided. The defroster includes: a housing defining an air outlet; a heating device disposed in the housing; an air blower defining a blowing outlet and disposed in the housing; and an air duct defining a duct inlet and a duct outlet, the air duct being disposed between the blowing outlet and the heating device so that air blown out from the blower outlet enters the air duct via the duct inlet and goes out of the air duct via the duct outlet, then passes through the heating device to exchange heat with the heating device, and is discharged out of the housing via the air outlet, wherein an area of the duct inlet is different from that of the duct outlet.
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: August 28, 2018
    Assignee: BYD Company Limited
    Inventors: Qing Gong, Xinping Lin, Shuming Zhao, Zhihai Li, Shumin Wang, Changcai Zhang, Maolin Ren, Liuping Tang, Guocong Chen, Xiaofang Li
  • Patent number: 9952297
    Abstract: A parallel plate waveguide forms a volume coil used for magnetic resonance imaging and spectroscopy. The waveguide includes a first conductor arranged on a first side of the waveguide and a second conductor arranged on a second side of the waveguide. Excitation of the first conductor and the second conductor creates a transverse electromagnetic field between the first conductor and the second conductor which causes a target within the volume coil to emit radio frequency signals used for producing an image of the target.
    Type: Grant
    Filed: May 7, 2015
    Date of Patent: April 24, 2018
    Assignee: AUBURN UNIVERSITY
    Inventor: Shumin Wang
  • Patent number: 9927147
    Abstract: A PTC electric heating assembly, an electric heating device and an electric vehicle are provided. The PTC electric heating assembly (2) comprises two electrode plates (23) and a PTC heating module (20) disposed between the two electrode plates (23), and comprising an insulation fixing frame (22) and a plurality of PTC heating elements (21), the insulation fixing frame (22) defining a plurality of fixing units (220) and the PTC heating elements (21) being disposed into the fixing units (220) respectively.
    Type: Grant
    Filed: June 27, 2013
    Date of Patent: March 27, 2018
    Assignee: BYD COMPANY LIMITED
    Inventors: Mengxiang Wu, Maolin Ren, Tianyou Deng, Shumin Wang, Xiaofang Li, Hongmei Qiu, Xinping Lin