Patents by Inventor Silviu Itescu

Silviu Itescu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FUNCTIONAL RECOVERY FROM CEREBRAL INFARCTION
    Publication number: 20220226386
    Abstract: The present disclosure provides methods of treating a subject who has suffered a cerebral infarction, the method comprising administering systemically to the subject a population of cells enriched for mesenchymal lineage precursor or stem cells (MLPSCs) such as STRO-1+ cells or progeny thereof to increase stimulus-induced cortical activation or reduce infarct volume.
    Type: Application
    Filed: May 22, 2020
    Publication date: July 21, 2022
    Inventor: Silviu ITESCU
  • METHOD FOR TREATING OR PREVENTING GASTROINTESTINAL BLEEDING
    Publication number: 20220160776
    Abstract: The present disclosure relates to method of treating or preventing gastrointestinal (GI) bleeding in a subject in need thereof, the method comprising administering to the subject a composition comprising mesenchymal lineage precursor or stem cells (MLPSCs).
    Type: Application
    Filed: January 28, 2020
    Publication date: May 26, 2022
    Inventors: Silviu ITESCU, Kenneth M. BOROW
  • METHOD FOR TREATING LOWER BACK PAIN
    Publication number: 20220143097
    Abstract: A method of treating lower back pain in a subject in need thereof, the method comprising administering to the subject a composition comprising mesenchymal lineage precursor or stem cells (MLPSCs), wherein the lower back pain is associated with an intervertebral disc that has a disc height that is not substantially reduced compared to that of an adjacent healthy disc in the subject.
    Type: Application
    Filed: January 2, 2020
    Publication date: May 12, 2022
    Inventors: Silviu ITESCU, Roger BROWN
  • Stem cell composition
    Patent number: 11312941
    Abstract: The disclosure provides stem cells which express high levels of Angeopoetin-1 (Ang1) and methods for their production. Such stem cells may be used in a range of therapeutic applications.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: April 26, 2022
    Assignee: MESOBLAST INTERNATIONAL SARL
    Inventors: Silviu Itescu, Paul Simmons
  • METHOD FOR IMPROVING VISUAL ACUITY
    Publication number: 20220079991
    Abstract: The present disclosure relates to a method of improving visual acuity in a subject suffering from an ocular disease, the method comprising administering to the subject a composition comprising mesenchymal lineage precursor or stem cells (MLPSCs) in an amount sufficient to improve visual acuity.
    Type: Application
    Filed: January 3, 2020
    Publication date: March 17, 2022
    Inventor: Silviu ITESCU
  • EXPANSION OF HEMATOPOIETIC STEM CELLS
    Publication number: 20210388319
    Abstract: The present disclosure relates to methods and compositions for expansion of human hematopoietic stem cells. The present disclosure also relates to methods of treatment involving the use of the expanded HSCs.
    Type: Application
    Filed: October 31, 2019
    Publication date: December 16, 2021
    Applicant: Mesoblast International Sarl
    Inventors: Silviu Itescu, Paul Simmons
  • Methods for increasing osteoblastic function
    Patent number: 11135249
    Abstract: This application provides methods for treating a human subject suffering from a bone fracture by administering to the subject a population of cells enriched from STRO-1+ multipotential cells and/or multipotential progeny of such cells.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: October 5, 2021
    Assignee: MESOBLAST, INC
    Inventors: Silviu Itescu, Ravi Krishnan
  • CELLULAR COMPOSITIONS AND METHODS OF TREATMENT I
    Publication number: 20210163932
    Abstract: The present disclosure relates to cellular compositions that are modified to introduce a nucleic acid or vector expressing the same. Such compositions may be used to deliver nucleic acid to a target cell and treat disease such as cancer.
    Type: Application
    Filed: November 21, 2018
    Publication date: June 3, 2021
    Applicant: Mesoblast International Sárl
    Inventors: Peter BRINK, Ira COHEN, Richard LIN, Sergey DORONIN, Irina POTAPOVA, Virginijus VALIUNAS, Dan DEVINE, Anthony SANDRASAGRA, Nick LOIZOS, Silviu ITESCU
  • METHOD OF TREATING GRAFT VERSUS HOST DISEASE
    Publication number: 20210085723
    Abstract: A method for preventing the development of or treating GvHD complications in a mammalian patient which comprises administering to the mammal a population of cells enriched for STRO-1bright cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Application
    Filed: October 22, 2020
    Publication date: March 25, 2021
    Applicant: Mesoblast, Inc.
    Inventors: Silviu Itescu, Michael David Schuster
  • Method of treating graft versus host disease
    Patent number: 10849932
    Abstract: A method for preventing the development of or treating GvHD complications in a mammalian patient which comprises administering to the mammal a population of cells enriched for STRO-1bright cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: December 1, 2020
    Assignee: MESOBLAST, INC.
    Inventors: Silviu Itescu, Michael David Schuster
  • MESENCHYMAL LINEAGE PRECURSOR OR STEM CELLS WITH ENHANCED IMMUNOSUPPRESSION
    Publication number: 20200325450
    Abstract: The present disclosure relates to cellular therapy products comprising mesenchymal lineage precursor or stem cells and potency assay for these products. The present disclosure also relates to methods for treatment of immune or inflammatory disorders, and treatment or prevention of graft versus host disease (GVHD), or one or more symptoms associated with GVHD, by administration of mesenchymal lineage precursor or stem cells.
    Type: Application
    Filed: May 4, 2018
    Publication date: October 15, 2020
    Inventors: Silviu ITESCU, Paul SIMMONS
  • METHODS OF TREATING OR PREVENTING RESPIRATORY CONDITIONS
    Publication number: 20200289578
    Abstract: The present disclosure provides methods of treating or preventing respiratory condition and/or for treating an IgE-mediated allergy and/or for reducing an allergic response to an allergen and/or for inducing anergy to an allergen in a subject and/or improving lung function in a subject suffering from an allergy comprising administering to a subject a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Application
    Filed: June 1, 2020
    Publication date: September 17, 2020
    Applicant: Mesoblast, Inc.
    Inventors: Silviu Itescu, Ravi Krishnan, Peter Ghosh
  • TREATMENT OF IMMUNE DISORDERS
    Publication number: 20200281984
    Abstract: The present disclosure relates to stem cells which express high levels of Angeopoetin-1 (Ang1) and uses thereof in inhibiting M1-type macrophage production and treating inflammatory disease such as diabetes.
    Type: Application
    Filed: March 24, 2020
    Publication date: September 10, 2020
    Applicant: Mesoblast International Sarl
    Inventors: Silviu Itescu, Paul Simmons
  • Methods of treating or preventing respiratory conditions
    Patent number: 10688134
    Abstract: The present disclosure provides methods of treating or preventing respiratory condition and/or for treating an IgE-mediated allergy and/or for reducing an allergic response to an allergen and/or for inducing anergy to an allergen in a subject and/or improving lung function in a subject suffering from an allergy comprising administering to a subject a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: June 23, 2020
    Assignee: Mesoblast, Inc.
    Inventors: Silviu Itescu, Ravi Krishnan, Peter Ghosh
  • Treatment of immune disorders
    Patent number: 10624930
    Abstract: The present disclosure relates to stem cells which express high levels of Angeopoetin-1 (Ang1) and uses thereof in inhibiting M1-type macrophage production and treating inflammatory disease such as diabetes.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: April 21, 2020
    Assignee: MESOBLAST INTERNATIONAL SARL
    Inventors: Silviu Itescu, Paul Simmons
  • Methods of treating or preventing rheumatic disease
    Patent number: 10596199
    Abstract: The present disclosure provides a method for treating or preventing a rheumatic disease, comprising administering a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Grant
    Filed: April 17, 2018
    Date of Patent: March 24, 2020
    Assignee: MESOBLAST, INC.
    Inventors: Peter Ghosh, Silviu Itescu
  • METHODS FOR INCREASING OSTEOBLASTIC FUNCTION
    Publication number: 20190343887
    Abstract: This application provides methods for treating a human subject suffering from a bone fracture by administering to the subject a population of cells enriched from STRO-1+ multipotential cells and/or multipotential progeny of such cells.
    Type: Application
    Filed: July 2, 2019
    Publication date: November 14, 2019
    Applicant: Mesoblast, Inc.
    Inventors: Silviu Itescu, Ravi Krishnan
  • STEM CELL COMPOSITION
    Publication number: 20190345452
    Abstract: The disclosure provides stem cells which express high levels of Angeopoetin-1 (Ang1) and methods for their production. Such stem cells may be used in a range of therapeutic applications.
    Type: Application
    Filed: June 7, 2019
    Publication date: November 14, 2019
    Applicant: Mesoblast International Sarl
    Inventors: Silviu Itescu, Paul Simmons
  • Stem cell composition
    Patent number: 10400218
    Abstract: The disclosure provides stem cells which express high levels of Angeopoetin-1 (Ang1) and methods for their production. Such stem cells may be used in a range of therapeutic application.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: September 3, 2019
    Assignee: MESOBLAST INTERNATIONAL SARL
    Inventors: Silviu Itescu, Paul Simmons
  • METHODS OF TREATING OR PREVENTING RESPIRATORY CONDITIONS
    Publication number: 20190046575
    Abstract: The present disclosure provides methods of treating or preventing respiratory condition and/or for treating an IgE-mediated allergy and/or for reducing an allergic response to an allergen and/or for inducing anergy to an allergen in a subject and/or improving lung function in a subject suffering from an allergy comprising administering to a subject a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Application
    Filed: July 16, 2018
    Publication date: February 14, 2019
    Applicant: Mesoblast, Inc.
    Inventors: Silviu Itescu, Ravi Krishnan, Peter Ghosh