Patents by Inventor Silviu Itescu

Silviu Itescu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF TREATING GRAFT VERSUS HOST DISEASE
    Publication number: 20190030080
    Abstract: A method for preventing the development of or treating GvHD complications in a mammalian patient which comprises administering to the mammal a population of cells enriched for STRO-1bright cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Application
    Filed: September 14, 2018
    Publication date: January 31, 2019
    Applicant: Mesoblast, Inc.
    Inventors: Silviu Itescu, Michael David Schuster
  • Methods for treating obesity and/or metabolic syndrome
    Patent number: 10159696
    Abstract: The present disclosure provides methods of treating or preventing obesity or causing weight loss or treating or preventing metabolic syndrome comprising administering to a subject a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: December 25, 2018
    Assignee: MESOBLAST, INC.
    Inventors: Ravi Krishnan, Silviu Itescu
  • METHODS OF TREATING OR PREVENTING RHEUMATIC DISEASE
    Publication number: 20180303879
    Abstract: The present disclosure provides a method for treating or preventing a rheumatic disease, comprising administering a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Application
    Filed: April 17, 2018
    Publication date: October 25, 2018
    Applicant: MESOBLAST, INC.
    Inventors: Peter Ghosh, Silviu Itescu
  • Method of treating graft versus host disease
    Patent number: 10105394
    Abstract: A method for preventing the development of or treating GvHD complications in a mammalian patient which comprises administering to the mammal a population of cells enriched for STRO-1bright cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: October 23, 2018
    Assignee: MESOBLAST, INC.
    Inventors: Silviu Itescu, Michael David Schuster
  • Methods of treating or preventing respiratory conditions
    Patent number: 10028979
    Abstract: The present disclosure provides methods of treating or preventing respiratory condition and/or for treating an IgE-mediated allergy and/or for reducing an allergic response to an allergen and/or for inducing anergy to an allergen in a subject and/or improving lung function in a subject suffering from an allergy comprising administering to a subject a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: July 24, 2018
    Assignee: MESOBLAST, INC.
    Inventors: Silviu Itescu, Ravi Krishnan, Peter Ghosh
  • Methods of treating or preventing rheumatic disease
    Patent number: 9974812
    Abstract: The present disclosure provides a method for treating or preventing a rheumatic disease, comprising administering a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Grant
    Filed: January 11, 2016
    Date of Patent: May 22, 2018
    Assignee: MESOBLAST, INC
    Inventors: Peter Ghosh, Silviu Itescu
  • Method for treating or preventing a pancreatic dysfunction
    Patent number: 9968640
    Abstract: The present invention provides a method for improving pancreatic function in a subject in need thereof, the method comprising administering to the subject STRO-1+ cells and/or progeny cells thereof and/or soluble factors derived therefrom. The method of the invention is useful for treating and/or preventing and/or delaying the onset or progression of a disorder resulting from or associated with pancreatic dysfunction, e.g., resulting from abnormal endocrine or exocrine function of the pancreas.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: May 15, 2018
    Assignee: MESOBLAST, INC.
    Inventors: Silviu Itescu, Ravi Krishnan
  • PREVENTION OF PROGRESSIVE HEART FAILURE
    Publication number: 20170340674
    Abstract: The present disclosure relates to methods for preventing progressive heart failure in subjects with persistent left ventricular (LV) dysfunction. Such methods may also be used for treating or preventing progressive heart failure in subjects with a proximal left anterior descending (LAD) lesion and persistent left ventricular dysfunction.
    Type: Application
    Filed: December 22, 2015
    Publication date: November 30, 2017
    Applicant: Mesoblast International Sàrl
    Inventors: Silviu Itescu, Lee Golden
  • METHOD FOR TREATING HEART FAILURE
    Publication number: 20170333482
    Abstract: The present disclosure relates to methods for treating or preventing heart failure in subjects with elevated left ventricular end systolic volume (LVESV). In particular, the present disclosure related to methods for treating or preventing heart failure in subjects with a LVESV of greater than 70 ml (>70 ml).
    Type: Application
    Filed: December 22, 2015
    Publication date: November 23, 2017
    Applicant: Mesoblast International Sàrl
    Inventors: Silviu Itescu, Lee Golden
  • METHODS FOR INCREASING OSTEOBLASTIC FUNCTION
    Publication number: 20170274016
    Abstract: The present disclosure provides methods of increasing osteoblastic function in a subject, the method comprising systemically administering to the subject a population of stem cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Application
    Filed: April 12, 2017
    Publication date: September 28, 2017
    Applicant: Mesoblast, Inc.
    Inventors: Silviu Itescu, Ravi Krishnan
  • TREATMENT OF T-CELL MEDIATED IMMUNE DISORDERS
    Publication number: 20170258846
    Abstract: A method for suppressing T cell activation which comprises contacting a cell population comprising T cells in vitro or ex vivo with an effective amount of STRO-1+ cells and/or soluble factors derived therefrom to suppress T cell activation.
    Type: Application
    Filed: May 15, 2017
    Publication date: September 14, 2017
    Applicant: Mesoblast, Inc.
    Inventors: Silviu Itescu, Michael David Schuster
  • Methods for increasing osteoblastic function
    Patent number: 9642878
    Abstract: The present disclosure provides methods of increasing osteoblastic function in a subject, the method comprising systemically administering to the subject a population of stem cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: May 9, 2017
    Assignee: MESOBLAST, INC.
    Inventors: Silviu Itescu, Ravi Krishnan
  • METHODS FOR TREATING OBESITY AND/OR METABOLIC SYNDROME
    Publication number: 20170119822
    Abstract: The present disclosure provides methods of treating or preventing obesity or causing weight loss or treating or preventing metabolic syndrome comprising administering to a subject a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Application
    Filed: June 8, 2016
    Publication date: May 4, 2017
    Inventors: Ravi Krishnan, Silviu Itescu
  • TREATMENT OF IMMUNE DISORDERS
    Publication number: 20170106023
    Abstract: The present disclosure relates to stem cells which express high levels of Angeopoetin-1 (Ang1) and uses thereof in inhibiting M1-type macrophage production and treating inflammatory disease such as diabetes.
    Type: Application
    Filed: June 1, 2015
    Publication date: April 20, 2017
    Applicant: Mesoblast International Sarl
    Inventors: Silviu Itescu, Paul Simmons
  • IMPROVED STEM CELL COMPOSITION
    Publication number: 20170107495
    Abstract: The disclosure provides stem cells which express high levels of Angeopoetin-1 (Ang1) and methods for their production. Such stem cells may be used in a range of therapeutic application.
    Type: Application
    Filed: April 7, 2015
    Publication date: April 20, 2017
    Applicant: Mesoblast International Sarl
    Inventors: Silviu Itescu, Paul Simmons
  • METHOD FOR TREATING OR PREVENTING A PANCREATIC DYSFUNCTION
    Publication number: 20170042945
    Abstract: The present invention provides a method for improving pancreatic function in a subject in need thereof, the method comprising administering to the subject STRO-1+ cells and/or progeny cells thereof and/or soluble factors derived therefrom. The method of the invention is useful for treating and/or preventing and/or delaying the onset or progression of a disorder resulting from or associated with pancreatic dysfunction, e.g., resulting from abnormal endocrine or exocrine function of the pancreas.
    Type: Application
    Filed: October 27, 2016
    Publication date: February 16, 2017
    Applicant: MESOBLAST, INC.
    Inventors: Silviu Itescu, Ravi Krishnan
  • PRODUCTION OF REPROGRAMMED PLURIPOTENT CELLS
    Publication number: 20170037377
    Abstract: The present invention provides a method of producing a reprogrammed cell, said method comprising exposing Stro-1+ multipotential cells and/or progeny cells thereof to one or more potency-determining factors under conditions sufficient to reprogram the cells. The present invention also provides cells produced by such a method and cells differentiated therefrom in addition to various uses of those cells.
    Type: Application
    Filed: October 20, 2016
    Publication date: February 9, 2017
    Inventor: Silviu Itescu
  • METHOD OF TREATING GRAFT VERSUS HOST DISEASE
    Publication number: 20160361363
    Abstract: A method for preventing the development of or treating GvHD complications in a mammalian patient which comprises administering to the mammal a population of cells enriched for STRO-1bright cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Application
    Filed: February 26, 2016
    Publication date: December 15, 2016
    Applicant: Mesoblast, Inc.
    Inventors: Silviu Itescu, Michael David Schuster
  • Production of reprogrammed pluripotent cells
    Patent number: 9487756
    Abstract: The present invention provides a method of producing a reprogrammed cell, said method comprising exposing Stro-1+ multipotential cells and/or progeny cells thereof to one or more potency-determining factors under conditions sufficient to reprogram the cells. The present invention also provides cells produced by such a method and cells differentiated therefrom in addition to various uses of those cells.
    Type: Grant
    Filed: March 22, 2010
    Date of Patent: November 8, 2016
    Assignee: MESOBLAST, INC.
    Inventor: Silviu Itescu
  • Method for treating diabetic renal failure or syndrome X
    Patent number: 9480713
    Abstract: The present invention provides a method for improving pancreatic function in a subject in need thereof, the method comprising administering to the subject STRO-1+ cells and/or progeny cells thereof and/or soluble factors derived therefrom. The method of the invention is useful for treating and/or preventing and/or delaying the onset or progression of a disorder resulting from or associated with pancreatic dysfunction, e.g., resulting from abnormal endocrine or exocrine function of the pancreas.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: November 1, 2016
    Assignee: MESOBLAST, INC.
    Inventors: Silviu Itescu, Ravi Krishnan