Abstract: An image sensor may be formed from stacked first and second substrates. An array of imaging pixels and verification circuitry may be formed in the first substrate. Row control circuitry may be formed in the second substrate. The row control circuitry may provide row control signals to the array of imaging pixels. The verification circuitry may also receive the row control signals from the row control circuitry. The first substrate may include a plurality of n-channel metal-oxide semiconductor transistors and may not include any p-channel metal-oxide semiconductor transistors. The verification circuitry may include an SR latch circuit with an S node coupled to a pull-up line and an R node coupled to a pull-down transistor to ensure the SR latch circuit starts up in a set state. The verification circuitry may include a level shifter that shifts a control signal voltage when the control signal is at a low level.

Abstract: The present invention relates to an optimized chimeric antigen receptor (CAR), and genetically modified cells expressing the same, that can target a diverse range of cancer types. More specifically, the CAR has an optimized linker length that facilitates the targeting and lyse of a wide range of cancer cell types by CAR expressing T cells.

Abstract: A method of producing graphene or other two-dimensional material such as graphene including heating the substrate held within a reaction chamber to a temperature that is within a decomposition range of a precursor, and that allows two-dimensional crystalline material formation from a species released from the decomposed precursor; establishing a steep temperature gradient (preferably >1000° C. per meter) that extends away from the substrate surface towards an inlet for the precursor; and introducing precursor through the relatively cool inlet and across the temperature gradient towards the substrate surface. The steep temperature gradient ensures that the precursor remains substantially cool until it is proximate the substrate surface thus minimizing decomposition or other reaction of the precursor before it is proximate the substrate surface. The separation between the precursor inlet and the substrate is less than 100 mm.

Abstract: A method of producing graphene or other two-dimensional material such as graphene including heating the substrate held within a reaction chamber to a temperature that is within a decomposition range of a precursor, and that allows two-dimensional crystalline material formation from a species released from the decomposed precursor; establishing a steep temperature gradient (preferably >1000° C. per meter) that extends away from the substrate surface towards an inlet for the precursor; and introducing precursor through the relatively cool inlet and across the temperature gradient towards the substrate surface. The steep temperature gradient ensures that the precursor remains substantially cool until it is proximate the substrate surface thus minimizing decomposition or other reaction of the precursor before it is proximate the substrate surface. The separation between the precursor inlet and the substrate is less than 100 mm.

Abstract: Binding members, e.g. human antibody molecules, which bind interleukin-6 (IL-6) and neutralise its biological effects. Use of binding members for IL-6 in medical treatment e.g. for treating inflammatory diseases and tumours associated with IL-6.

Abstract: A wireless power transfer secondary or pick-up has a resonant circuit and a switch connected to the resonant circuit operable to produce a phase shift in an oscillating voltage or current in the resonant circuit. A controller is configured to operate the switch to introduce one or more controlled phase shifts in the oscillating voltage or current in the resonant circuit which encode data for detection by a coupled circuit.

Abstract: A uranium oxide fuel pellet having an inner region and an outer rim region about the inner region, and that the fuel pellet is cylindrical and the inner region and outer rim region are coaxial cylindrical regions. The outer rim region has an excess of oxygen in comparison to the inner region , wherein high burnup structure (HBS) formation will be suppressed or delayed. Preferably, the excess oxygen is obtained by a chemical treatment by immersing the pellet in hydrogen peroxide (H2O2) or potassium permanganate (KMnO4) in solution.

Abstract: An artificial reality system is described that renders, presents, and controls user interface elements within an artificial reality environment, and performs actions in response to one or more detected gestures of the user. The artificial reality system includes an image capture device configured to capture image data representative of a physical environment, a head-mounted display (HMD) configured to output artificial reality content, a gesture detector configured to identify, from the image data, a gesture comprising a configuration of a hand that is substantially stationary for at least a threshold period of time and positioned such that a thumb of the hand and at least one other finger form approximately a circle or approximately a circular segment, a user interface (UI) engine to generate a UI element in response to the identified gesture, and a rendering engine to render the UI element as an overlay to the artificial reality content.

Abstract: Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: An artificial reality system is described that renders, presents, and controls user interface elements within an artificial reality environment, and performs actions in response to one or more detected gestures of the user. The artificial reality system includes an image capture device, a head-mounted display (HMD), a gesture detector, a user interface (UI) engine, and a rendering engine. The image capture device captures image data representative of a physical environment. The HMD outputs artificial reality content. The gesture detector identifies, from the image data, a gesture including a configuration of a hand that is substantially stationary for at least a threshold period of time and positioned such that an index finger and a thumb of the hand form approximately a right angle. The UI engine generates a UI element in response to the identified gesture. The rendering engine renders the UI element as an overlay to the artificial reality content.

Abstract: Compounds of Formula (I): and salts thereof, and methods of use as Janus kinase inhibitors are described herein.

Abstract: An artificial reality system is described that renders, presents, and controls user interface elements within an artificial reality environment, and performs actions in response to one or more detected gestures of the user. The artificial reality system includes an image capture device, a head-mounted display (HMD), a user interface (UI) engine, and a rendering engine. The image capture device is configured to capture image data representative of a physical environment. The HMD is configured to output artificial reality content including a representation of a wrist. The rendering engine configured to render a user interface (UI) element. The gesture detector configured to identify a gesture that includes a gripping motion of two or more digits of a hand to form a gripping configuration at the location of the UI element, and a pulling motion away from the wrist while in the gripping configuration.

Abstract: A photo-selective light spectrum-modifying net for use in citrus fruit production, the net comprising a woven array of parallel and mutually spaced first threads and an array of parallel and mutually spaced second threads, the second threads being inclined to the first threads to define an array of openings between the first and second threads, wherein the first threads are uncolored and composed of a first polymer which is selected from a polymer incorporating a white pigment or dye, a transparent polymer or a translucent polymer, and the second threads are colored red and composed of a second polymer which incorporates a red pigment or dye, the second threads being adapted to transmit, scatter and reflect electromagnetic radiation in the wavelength range of from 640 to 680 nm. Also disclosed is a method of producing citrus fruit using the net.

Abstract: An artificial reality system is described that renders, presents, and controls user interface elements within an artificial reality environment, and performs actions in response to one or more detected gestures of the user. The artificial reality system captures image data representative of a physical environment and outputs artificial reality content. The artificial reality system renders a container that includes application content items as an overlay to the artificial reality content. The artificial reality system identifies, from the image data, a selection gesture comprising a configuration of a hand that is substantially stationary for a threshold period of time at a first location corresponding to a first application content item within the container, and a subsequent movement of the hand from the first location to a second location outside the container. The artificial reality system renders the first application content item at the second location in response.

Abstract: A system including an additive management system configured to oversee hydrate formation in a hydrocarbon extraction system, the additive management system including a flow meter configured to measure a fluid flow rate, a first sensor configured to measure at least one of a fluid property and an environmental condition, and a chemical injection device configured to inject a hydrate inhibitor into a fluid flow.

Abstract: Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: An artificial reality system is described that renders, presents, and controls user interface elements within an artificial reality environment, and performs actions in response to one or more detected gestures of the user. The artificial reality system captures image data representative of a physical environment and outputs the artificial reality content. The artificial reality system identifies, from the image data, a gesture comprising a motion of a first digit of a hand and a second digit of the hand to form a pinching configuration a particular number of times within a threshold amount of time. The artificial reality system assigns one or more input characters to one or more of a plurality of digits of the hand and processes a selection of a first input character of the one or more input characters assigned to the second digit of the hand in response to the identified gesture.

Abstract: An artificial reality system is described that renders, presents, and controls user interface elements within an artificial reality environment, and performs actions in response to one or more detected gestures of the user. The artificial reality system includes an image capture device, a head-mounted display (HMD), a user interface (UI) engine, and a rendering engine. The image capture device captures image data representative of a physical environment. The HMD outputs artificial reality content, the artificial reality content including an assistant element. The gesture detector identifies, from the image data, a gesture that includes a gripping motion of two or more digits of a hand to form a gripping configuration at a location that corresponds to the assistant element, and subsequent to the gripping motion, a throwing motion of the hand with respect to the assistant element. The UI engine generates a UI element in response to identifying the gesture.

Abstract: A system determines the transmission strength of the magnetic field signal. The magnetic field signal is transmitted from a first magnetic-sensor device to a second magnetic-sensor device. The system then determines a first projected distance between the first magnetic-sensor device and the second magnetic-sensor device. Based at least in part on the first projected distance, the system calculates an adjusted transmission strength for the magnetic field signal. The system then causes the first magnetic-sensor device to transmit an adjusted magnetic field signal. The adjusted magnetic field signal comprises the adjusted transmission strength. The system receives, from the second magnetic-field device, the adjusted magnetic field signal. Based at least in part upon the received adjusted magnetic field signal, the system, computes a first pose of the first magnetic-sensor device in relation to the second magnetic-sensor device.

Abstract: An artificial reality system is described that renders, presents, and controls user interface elements within an artificial reality environment, and performs actions in response to one or more detected gestures of the user. The artificial reality system can include a menu that can be activated and interacted with using one hand. In response to detecting a menu activation gesture performed using one hand, the artificial reality system can cause a menu to be rendered. A menu sliding gesture (e.g., horizontal motion) of the hand can be used to cause a slidably engageable user interface (UI) element to move along a horizontal dimension of the menu while horizontal positioning of the UI menu is held constant. Motion of the hand orthogonal to the menu sliding gesture (e.g., non-horizontal motion) can cause the menu to be repositioned. The implementation of the artificial reality system does require use of both hands or use of other input devices in order to interact with the artificial reality system.