Abstract: A system and method for electrical stimulation of a body tissue. An array of microneedles, formed from an electrically conductive material are adapted for puncturing a surface of the tissue. A processing unit is configured to determine from a signal when the microneedles in the microneedle array are in a predetermined position in the tissue or when tissue surrounding one or more microneedles has been ablated.

Abstract: Disclosed is a process for the preparation of certain intermediates, e.g. the following compound: which intermediate and processes are useful in the preparation of a BTK inhibitor, such as ibrutinib.

Abstract: A clock source outputs a clock signal. A first delay line receives a first clock source signal and produces a first output, the first clock source signal at least partially based on the clock signal. A first clock spine receives the first output and produces a global reference clock signal. A second delay line receives a second clock source signal and produces a second output, the second clock source signal at least partially based on the clock signal. A second clock spine receives the second output and produces a global feedback clock signal. A global phase detector detects a phase difference between the global reference clock signal and the global feedback clock signal to produce a global phase detector output. The second clock source signal is controlled at least partially based on the global phase detector output.

Abstract: An incremental encoder apparatus including: a scale including a series of periodic features defining an optical incremental scale, and at least one magnetic reference mark; and a readhead. The readhead includes at least one incremental sensor configured to detect light from the optical incremental scale and to output at least one signal dependent thereon, and at least two analogue Hall sensors, each including at least two output terminal pairs, and each configured to switch repeatedly between each output terminal pair so as to reduce any inherent offset in the output of the analogue Hall sensor. The apparatus is configured to determine the presence of the reference mark from the outputs of the at least two analogue Hall sensors.

Abstract: The present application relates to current sensing circuitry (100) that comprises a differential amplifier (110) comprising first and second inputs configured to sense a current across a sense resistance, and an output configured to output a current sense signal. The circuitry (100) further comprises a first current source, a second current source and a switch network operable in: a first phase in which the first current source is connected to the first input and disconnected from the output, and the second current source is connected to the output and disconnected from the first input; and a second phase in which the first current source is connected to the output and disconnected from the first input, and the second current source is connected to the first input and disconnected from the output.

Abstract: A tightening device for applying a preload to a fastening element, wherein the fastening element is suitable for fastening a diaphragm pump head part to a drive system for impressing movement on a diaphragm of the diaphragm pump head part in a device for conveying fluid. The tightening device has a support with support surface for supporting a bearing surface of the fastening element, wherein the support has a threaded bore through which a screw element penetrates. The screw element has a contact surface at its front end, wherein the contact surface of the screw element and the support surface of the support face opposite directions, and the distance between the contact surface of the screw element and the support surface of the support can be changed by screwing in or unscrewing the screw element.

Abstract: A reusable shipper container has a container body with a payload chamber for holding goods and a lid operable to access the payload chamber. The reusable shipper container also has one or more sensors in the payload chamber to senses a humidity or temperature of the payload chamber or the goods. The reusable shipper container also has a tablet display screen detachably coupled to the container body that communicates with the sensors in the payload chamber.

Abstract: An assembly for a diaphragm pump includes: a body defining a plurality of diaphragm chambers spaced apart about a body axis, wherein each diaphragm chamber defines a membrane opening, an inlet chamber in fluid communication with each diaphragm chamber, and an outlet chamber in fluid communication with each diaphragm chamber; and a plurality of flexible membranes that each comprise an outer edge, wherein the body is configured to clamp the outer edge of each membrane along a corresponding membrane opening to seal a corresponding one of the diaphragm chambers; wherein the membranes are configured to deflect substantially in parallel to the body axis to suction fluid into each diaphragm chamber from the inlet chamber and discharge fluid from each diaphragm chamber into the outlet chamber; wherein each membrane comprises a coupling section configured to couple the membrane to a pump drive and arranged along a diaphragm axis that extends in parallel to the body axis, and a deflection section arranged radially outw

Abstract: A method for multi-view dataset formation from fleet data is described. The method includes detecting at least a pair of vehicles within a vicinity of one another, and having overlapping viewing frustums of a scene. The method also includes triggering a capture of sensor data from the pair of vehicles. The method further includes synchronizing the sensor data captured by the pair of vehicles. The method also includes registering the sensor data captured by the pair of vehicles within a shared coordinate system to form a multi-view dataset of the scene.

Abstract: The instrumented device comprises a body to be attached to a mixing valve producing a mixed fluid by blending hot and cold fluids. The body defines a main channel and a bypass channel, provided for the outflow of the mixed fluid through the body. The device comprises a turbine arranged in the main channel, being bypassed by the bypass channel, such that, as soon as the flow rate of the mixed fluid flowing through the body is non-zero, all or a portion of the mixed fluid flowing through the body passes through the main channel passing through the turbine and, at the same time, a portion of the mixed fluid flowing through the body is likely to bypass the turbine by flowing in the bypass channel between the upstream and the downstream of the turbine.

Abstract: Disclosed herein is a technique for obtaining information relating to a navigable network from devices (12) that are associated with users travelling within the navigable network. For example, a central server can issue requests to the devices (12) for automatically obtaining sensor data, with a request including a set of instructions for obtaining sensor data from one or more sensor(s) (13) accessible by the device (12). The request also includes a location-specific trigger. Thus, when it is determined that the device (12) has reached the location associated with the trigger, the device is able to automatically action the instructions in order to obtain the requested sensor data, which can then be reported back to the server.

Abstract: The invention relates to a method for accelerating a vehicle with a continuously variable transmission (1050) where a gear ratio of the transmission is at first larger than a gear ratio of a virtual fixed gear. While the vehicle is accelerating, the gear ratio of the transmission is increased to the gear ratio of the virtual fixed gear. The transmission is then operated with the gear ratio of the virtual fixed gear.

Abstract: A cyber security appliance has one or more modules to interact with entities in an operational technology network and potentially in an informational technology network. The operational technology module can reference various machine-learning models trained on a normal pattern of life of users, devices, and/or controllers of the operational technology network. A comparator module cooperates with the operational technology module to compare the received data on the operational technology network to the normal pattern of life of any of the users, devices, and controllers to detect anomalies in the normal pattern of life for these entities in order to detect a cyber threat. An autonomous response module can be programmed to respond to counter the detected cyber threat.

Abstract: The disclosure provides methods of making gene-edited plants that are resistant to downy mildew, such as plants with reduced expression of homoserine kinase (HSK), 2-oxoglutarate-Fe(II) oxygenase (2OGO), or both. The disclosure further provides methods of making gene-edited modified plants that are cold tolerant, such as plants with reduced expression of MYB14. In some examples, CRISPR/Cas methods are used, wherein the plants include a mutated HSK, 2OGO, and/or MYB14 gene resulting in reduced expression and/or gene activity. Plants generated using the methods are provided. Such plants can include other desirable traits. HSK, 2OGO, and/or MYB14 nucleic acid and protein molecules are provided, as are gRNAs specific for HSK, 2OGO, or MYB14 and vectors containing such.

Abstract: The disclosed technology includes a support system for an optical sighting device of a bow. The support system includes a support structure configured to attach to a bow and an elevation assembly configured to move along an elevation direction relative to the support structure. The support structure can include an elevation actuator configured to cause the elevation assembly to move along the elevation direction when the elevation actuator is actuated and a windage assembly configured to move along a windage direction relative to the support structure. The windage direction can be approximately perpendicular to the elevation direction. The support structure can further include a windage actuator configured to cause the windage assembly to move along the windage direction when the windage actuator is actuated. The windage actuator can be disposed at least partially in the elevation actuator.

Abstract: The present invention concerns an electronic device, preferably a thin film electronic device, and a method for producing the device. The device comprises an intermediate structure (301, 401, 501) at the interface between neighboring unit devices connected in series. The intermediate structure is suitable to employ deposition techniques that make it possible to avoid steps of scribing or patterning insulating and/or separating lines between adjacent layers of the device.

Abstract: A portable two-mode probe to be applied against a biological tissue to be examined, the probe including an ultrasonic transducer configured to emit ultrasonic waves into the tissue and to receive ultrasonic waves reflected by the tissue, the transducer extending along a transverse axis; and at least two optodes placed on either side of the transverse axis, such that the transducer extends between the two optodes. Further, each optode includes a casing containing a light emitter configured to emit a light wave toward the tissue, and/or an optical detector configured to detect a light wave scattered by the tissue. The optodes are arranged such that at least one light emitter and at least one optical detector are placed on either side of the transducer, and at least one optical detector has a detection area formed from a semiconductor and connected to a circuit board.

Abstract: Systems, methods, and computer-readable storage media for compliance verification and validation of cyber resilience in a distributed entity or third-party network (DETPN). Some methods can include generating or identifying, by one or more processing circuits, one or more compliance parameters for a plurality of entities or third-parties on the DETPN. Some methods can include determining, by the one or more processing circuits, at least one compliance level. Some methods can include receiving or identifying, by the one or more processing circuits, environmental data of the DETPN. Some methods can include determining, by the one or more processing circuits at a second timing phase, an updated at least one compliance level for at least one of the plurality of entities or third-parties based at least on the environmental data. In some implementations, some methods can include generating and storing, by the one or more processing circuits, one or more tokens.

Abstract: A network element include one or more modules each supporting one or more pluggable modules; and a first manifold and a second manifold each configured to connect to a conduit associated with a coldplate, wherein one of the first manifold and the second manifold is an inlet manifold and the other is an outlet manifold for a cooling fluid that flows through the conduit to cool the one or more pluggable modules. The one or more pluggable modules can be each a pluggable optical module that is one of compliant to any of XFP, SFP, XENPAK, X2, CFP, CFP2, CFP4, CFP8, QSFP, QSFP+, QSFP28, OSFP, and QSFP-DD and have a housing that has dimensions similar to any of XFP, SFP, XENPAK, X2, CFP, CFP2, CFP4, CFP8, QSFP, QSFP+, QSFP28, OSFP, and QSFP-DD.