Abstract: Electrically controlled hybridization is used to selectively assemble oligonucleotides on the surface of a microelectrode array. Controlled activation of individual electrodes in the microelectrode array attracts oligonucleotides in solution to specific regions of the array where they hybridize to other oligonucleotides anchored on the array. The oligonucleotides that hybridize may provide locations for subsequent oligonucleotides to hybridize. The active electrodes and the oligonucleotides in solution may be varied during each round of synthesis. This allows for multiple oligonucleotides each with different and specific sequences to be created in parallel. This is accomplished without the use of phosphoramidite chemical synthesis or template-independent DNA polymerase enzymatic synthesis. Oligonucleotides created with these techniques may be used to encode digital data. Fully assembled oligonucleotides may be separated from the array and sequenced, stored, or otherwise processed.

Abstract: A glass substrate formed from a glass composition is disclosed. In embodiments, the composition comprises: from 60 mol. % to 75 mol. % SiO2; from 2 mol. % to 15 mol. % Li2O; from 1.9 mol. % to 15 mol. % Y2O3; and at least one of B2O3 and Na2O. B2O3+Na2O is from 2 mol. % to 13 mol. %. Y2O3+Al2O3 is from 10 mol. % to 24 mol. %. A ratio R2O/Al2O3 is from 0.5 to 4, where R2O is a total concentration of Li2O, Na2O, K2O, Rb2O, and Cs2O. (R2O+RO)/Al2O3 is from 0.5 to 4.5, where RO is a total concentration of BeO, MgO, CaO, SrO, and BaO. The glass substrate has a Young's modulus from 75 gigapascals (GPa) to 110 GPa. The glass substrate is ion exchangeable to form a strengthened glass article.

Abstract: Exemplary embodiments may enable synchronization of a display of a mobile computing device with a display of an ATM. The displays first may be synched when a user positions the mobile computing device in proximity to the ATM. Near field communication (NFC) initially may be used when the mobile phone is in proximity with the ATM. Once the communication connection has been realized, the displays may be synchronized to reflect the connection. After the NFC connection has been realized, a cellular connection between a user's mobile computing device with a server having a secure connection with the ATM may be established. One or more financial transactions may be initiated with the ATM from the mobile computing device via the cellular connection. The display of the mobile computing device and the ATM may remain synched during the one or more financial transactions.

Abstract: A method for capturing material extracted from biochar is provided comprising the steps of: (i) providing a biochar; (ii) contacting the biochar with an extraction media, where the extraction media causes the removal of residual compounds from the pores and surface of the biochar, creating a resulting extract comprised of the extraction media and removed compounds; and (iii) collecting the resulting extract. The method also can include other steps of extraction and purification. The method further comprises the step of applying the resulting extract to seeds, plants, soil, other agricultural products, or for use in other applications. A biochar having high levels of soluble signaling compounds is also provided, where the biochar is derived from a biomass source that together with predefined pyrolysis parameters produces resulting biochar having increased levels of soluble signaling compounds that are known to increase seed germination rates and early plant growth.

Abstract: A glass-based article of a composition comprising: from 48 mol. % to 75 mol. % SiO2; from 8 mol. % to 40 mol. % Al2O3; from 9 mol. % to 40 mol. % Li2O; from 0 mol. % to 3.5 mol. % Na2O; from 9 mol. % to 28 mol. % R2O, wherein R is an alkali metal and R2O comprises at least Li2O and Na2O; from 0 mol. % to 10 mol. % Ta2O5; from 0 mol. % to 4 mol. % ZrO2; from 0 mol. % to 4 mol. % TiO2; from 0 mol. % to 3.5 mol. % R?O, R? being a metal selected from Ca, Mg, Sr, Ba, Zn, and combinations thereof; and from 0 mol. % to 8 mol. % RE2O3, RE being a rare earth metal selected from Sc, Y, La, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, and combinations thereof. The glass is ion exchangeable. R2O+R?O?Al2O3?Ta2O5+1.5*RE2O3?ZrO2?TiO2 is in a range from ?8 mol. % to 5 mol. %. ZrO2+TiO2+SnO2 is in a range from greater than or equal to 0 mol % to less than or equal to 2 mole %. The composition is free of As2O3, Sb2O3, and PbO.

Abstract: A system for producing fragmented video content is provided. The system includes a processing device, a non-transitory data store, and a memory storage device having at least a Manifest Processing Service (MPS) unit stored therein. The MPS unit is configured to generate at least one master manifest and store the master manifest in the non-transitory data store, the master manifest comprising a timing reference for a video fragment of the fragmented video content, wherein the timing reference indicates a temporal boundary of processing for the video fragment.

Abstract: A device and method for delivering a synthetic mesh or graft for anatomical repair at a defect site. A plurality of flexible arms is connected to the synthetic mesh or graft. Grasping jaws are individually controlled at or near a proximal end of the device for connection of the graft and release of the graft at the surgical site. The flexible arms, with graft attached are positioned through a surgical incision to the defect site. An actuator positions the flexible arms to assume a radial array at the surgical site, unfolding and spreading the graft for attachment. The length of each flexible arm is individually adjustable to adapt to the size and shape of the graft selected for installation at the defect site to repair the defect.

Abstract: Compounds, conjugates and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed compounds may be useful, among other things, in treating of cancer and inhibiting ALKS. Compounds incorporated into a conjugate with an antibody construct are also described herein.

Abstract: A method is provided for categorizing a problem report in a repository of a problem reporting system as an enhancement request or as a defect. Based on the problem report being the defect and having a high severity level, determining a score indicating a probability that a text portion of the problem report includes problem reproduction steps. In response to the score indicating the probability of problem reproduction steps, flagging the problem report to automate. For each problem report to automate, copying the text portion of the problem report to an automated test script, whereby the test script runs in a continuous pipeline.

Abstract: The knitted textiles include a knitted structure including a plurality of hollow yarns. Each hollow yarn includes a yarn body and defines a yarn hole extending through the yarn body to allow expansion of the yarn body upon inflation of each hollow yarn through the yarn hole. The knitted structure is configured to transition from an unexpanded state to an expanded state in response to the inflation of the hollow yarns through the yarn hole. The knitted structure has a first porosity in the unexpanded state, and the knitted structure has a second porosity in the expanded state. The second porosity is less than the first porosity such that a visibility through the knitted structure is greater when the knitted structure is in the unexpanded state than when the knitted structure is in the expanded state.

Abstract: A control system for a fuel cutoff system of a motor vehicle includes a fuel cutoff module that generates a fuel cutoff signal for disabling a supply of fuel to an engine, in response to the fuel cutoff module detecting a deceleration fuel cutoff (DFCO) event. The control system further includes an oxygen storage module determining an amount of oxygen accumulated in a catalyst and comparing this amount to an oxygen storage capacity (OSC) of the catalyst, in response to the fuel cutoff module determining the DFCO event. The control system further includes an intake valve timing module generating a phasing signal to actuate a plurality of cam phasers to reduce a flow rate of oxygen to the catalyst, in response to the fuel cutoff module determining the DFCO event and the oxygen storage module determining that the amount of oxygen stored in the catalyst is less than the OSC.

Abstract: Embodiments described herein include a method of making a tobacco extract comprising; (a) contacting tobacco with an extraction solvent at a first temperature and first pressure which are selected such that the extraction solvent is supercritical, such that tobacco flavor and/or aroma components are extracted from the tobacco into the solvent; (b) separating the residual tobacco solids from the supercritical extraction solvent containing tobacco components; (c) exposing the extraction solvent containing tobacco components to conditions in a vessel at which the extraction solvent is subcritical, thereby releasing the tobacco components from the extraction solvent, (d) contacting the residual tobacco solids with an extraction solvent at a second temperature and second pressure which are selected such that the extraction solvent is supercritical, such that nicotine are extracted from the tobacco into the extraction solvent; and wherein the second temperature and/or second pressure is higher than the respective f

Abstract: Various compositions are disclosed for the treatment of viral infections. The compositions of conjugates comprise antibody constructs attached to myeloid cell agonists via a linker are also provided. Additionally provided are the methods of preparation and use of the conjugates. This includes methods for treating viral infections, such as viral liver diseases.

Abstract: High quality Boron Nitride Nanotubes (BNNTs) may be synthesized by heating a boron melt target via one or more laser diodes, including laser diode stacks. The use of a diode stack and beam shaping optics to irradiate the boron melt eliminates the need for a conventional laser cavity as has been employed with previous embodiments. The diode arrangements facilitate managing power distribution on the born melt(s), nitrogen gas flows, and blackbody radiation that drive the BNNT self-assembly process. These parameters may be used for controlling the proportions and characteristics of boron species, a-BN particles, h-BN nanocages, and h-BN nano sheets in the as-synthesized BNNT material while enhancing the quality of the BNNTs.

Abstract: A system for preventing material accumulation relative to an agricultural implement may include a ground engaging tool supported on an agricultural implement and a controller configured to determine a presence of excessive residue across a forward portion of the field forward of the ground engaging tool based at least in part residue data associated with an amount of residue across a forward portion of the field. The controller may initiate a control action associated with adjusting an operating parameter of the ground engaging tool such that the amount of residue incorporated into the field by the ground engaging tool is reduced across a section of the field having excessive residue to reduce a likelihood of material accumulation relative to the ground engaging tool as it passes across the section of the field.

Abstract: A glass or glass-ceramic carrier substrate, the substrate having undergone at least one complete cycle of a semiconductor fabrication process and having also undergone a reclamation process following the end of the semiconductor fabrication process; the glass or glass-ceramic carrier substrate comprising at least one of the following properties: (i) a coefficient of thermal expansion of less than 13 ppm/° C.; (ii) a Young's Modulus of 70 GPa to 150 GPa; (iii) an IR transmission of greater than 80% at a wavelength of 1064 nm; (iv) a UV transmission of greater than 20% at a wavelength of 255 nm to 360 nm; (v) a thickness tolerance within the same range as the thickness tolerance of the carrier substrate before undergoing at least one complete cycle of the semiconductor fabrication process; (vi) a total thickness variation of less than 2.5 ?m; (vii) a failure strength of greater than 80 MPa using a 4-point-bending test; (viii) a pre-shape of 50 ?m to 300 ?m.

Abstract: An electrical connector for high speed signals. The connector has multiple conductive elements that may serve as signal or ground conductors. A member formed with lossy material and conductive compliant members may be inserted in the connector. The conductive compliant members may be aligned with conductive elements of the connector configured as ground conductors. For a connector configured to carry differential signals, the ground conductors may separate pairs of signal conductors. The member may further include a conductive web, embedded within the lossy material, that interconnects the conductive compliant members. For a receptacle connector, the conductive elements may have mating contact portions aligned along opposing surfaces of a cavity. The conductive elements may have contact tails for attachment to a printed circuit board and intermediate portions connecting the mating contact portions and the contact tails. The conductive compliant members may press against the intermediate portions.

Abstract: An apparatus of an edge gateway disclosed herein includes an access evaluator to determine whether a data access attempt, if permitted, will cause data specified in the data access attempt to cross a data boundary, the data boundary associated with at least one condition to be met before the data specified in the data access attempt will be permitted to cross the boundary. The apparatus further includes an operations determiner to determine an operation to be applied to the data for which access is being attempted, in response to determining the data access attempt will cause the data to cross the data boundary, and an operation applier to apply the operation to the data. The application of the operation to the data causes the condition to be met, so that the data access occurs in conformance with the condition.

Abstract: The invention provides compounds of formula (I): where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds and methods of using such compounds to treat respiratory diseases.

Abstract: An inertia bullet remover and associated methods for removing a bullet from an ammunition casing. The inertia bullet remover includes a carriage for carrying the ammunition casing. The carriage is movable with respect to a base between a first position and a second position. Movement of the carriage is guided by a guide. Movement of the carriage is stopped by a stop, which causes the bullet to exit the ammunition casing via inertia.