Abstract: Systems and methods for performing DNSSEC signing are described in which digital signature operations may be performed by a network accessible signing server that is configured to interact with a separate client application. Exemplary methods may include receiving a signing request at the signing server from the client application to sign first data. The signing server may determine an active KSK and/or an active ZSK for the first data. The first data may then be transmitted by the signing server to a digital signature modules, which may include, for example, a hardware support module, or software signing applications. The signing server may receive a digitally signed version of the first data from the digital signature module, and provide the signed first data to the client application.

Abstract: Processes for forming a vulcanizable elastomeric formulation are disclosed. The processes include the steps of mixing an elastomer with a vulcanizing agent to form a vulcanizable elastomeric formulation that includes the vulcanizing agent dispersed in the elastomeric compound, wherein the vulcanizing agent includes a cyclododecasulfur compound. A process for forming a vulcanized elastomeric article is also described.

Abstract: A probe seal for a female hydraulic coupling member has both internal and external pressure-energized seals. The outer wall or opposing ends of the seal have one or more pressure-energized seals for sealing between the body of the probe seal and the body of a coupling member in which the probe seal is installed. Annular, L-shaped, T-shaped or angled grooves in the inner wall of the seal form cavities and sealing projections that can be urged in an inward, radial direction by fluid pressure within an associated cavity to increase the sealing effectiveness between the body of the seal and the probe of a male hydraulic coupling member inserted in the receiving chamber of the female coupling member.

Abstract: An exercise machine may include a tower enclosing, at least in part, a cable and pulley system, a base supporting the tower on a surface, and a plurality of handles operatively coupled to the cable and pulley system and configured to extend from the tower. The exercise machine may include a resistance motor operatively coupled to the cable and pulley system. The resistance motor may include a fan and a flywheel connected to a common shaft. The exercise machine may be operatively associated with a user interface which includes an exercise display area configured to activate one or more exercise indicators in a predetermined sequence and a control area including at least one mode control operable to change the sequence of activation of the one or more exercise indicators. The user interface may be provided on a console of the exercise machine.

Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1a, R1b, R1c, R1d, R2, R2a, and A are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

Abstract: Devices are provided to automatically access blood from beneath or within skin. These devices include an injector configured to drive a needle into the skin and subsequently to retract the needle from the skin. These devices additionally include a seal to which suction is applied. To drive the needle into the skin, the needle is first driven through the seal, creating at least one hole in the seal. The suction applied to the seal acts to draw blood from the puncture formed in the skin by the needle, through the at least one hole in the seal, and to a sensor, blood storage element, or other payload. These devices can be wearable and configured to automatically access blood from skin, for example, to access blood from the skin at one or more points in time while a wearer of a device is sleeping.

Abstract: Pyrazole derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the serotonin 5HT2A receptor. Formula (Ia). Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of insomnia and related sleep disorders, platelet aggregation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, reducing the risk of blood clot formation, asthma or symptoms thereof, agitation or symptoms thereof, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de la Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic disorders, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizophrenia and related disorders, diabetic-related disorders, progressive multifocal leukoencephalopathy and the like.

Abstract: A flex spline torque transfer device using force applied at multiple positions for each area of contact between the flex spline and outer ring. The positions of at which force is applied may be outside the areas of contact. This design may also be used in conjunction with a magnetic method of applying force to the flex spline, mechanical force acting as a constraint to prevent the flex spline from fully disengaging from the outer ring.

Abstract: Installation of a bushing into the shift cable end of an automatic transmission, without replacing the entire shift cable end, is accomplished via methods and specialized tools that do not divert the force applied by compressive tools away from the non-load-bearing surfaces of the bushing and shift cable end, and maintain the axial alignment of the bushing with the shift cable end during installation, thus preventing deformation of the shift cable end and bushing during installation, and ensuring the proper coupling of the shift cable end and shift lever. In particular embodiments, a shift cable end protective member is secured to the shift cable end, a bushing installation member is inserted into the bushing, through the shift cable end and into the protective member, and a compressive force is applied simultaneously to the protective member and installation member, thus pressing the bushing into place within the shift cable end.

Abstract: The present invention provides antibodies that bind to CD3 and methods of using the same. According to certain embodiments, the antibodies of the invention bind human CD3 with high affinity and induce human T cell proliferation. The invention includes antibodies that bind CD3 and induce T cell-mediated killing of tumor cells. According to certain embodiments, the present invention provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds human CD3, and a second antigen-binding molecule that specifically binds human CD20. In certain embodiments, the bispecific antigen-binding molecules of the present invention are capable of inhibiting the growth of B-cell tumors expressing CD20. The antibodies and bispecific antigen-binding molecules of the invention are useful for the treatment of diseases and disorders in which an upregulated or induced targeted immune response is desired and/or therapeutically beneficial.

Abstract: A toothbrush is provided, including an elongated handle and a brush head supported by the handle. The brush head has a base and a plurality of bristles that extend from the base to form a contact surface elevated from the base. The handle includes a thumb press section that include ridges and flat sections. The toothbrush may include a skeletal structure with an overmoulding encasing the skeletal structure. The overmoulding may form the outer surface of portions of the toothbrush, including the thumb press section.

Abstract: The present invention relates to a refrigerant composition, including difluoromethane (HFC-32), pentafluoroethane (HFC-125), and trifluoroiodomethane (CF3I) for use in a heat exchange system, including air conditioning and refrigeration applications and in particular aspects to the use of such compositions as a replacement of the refrigerant R-410A for heating and cooling applications and to retrofitting heat exchange systems, including systems designed for use with R-410A.

Abstract: Systems and methods for allocating electrical current among battery sets connected in a substantially parallel configuration. A respective state of health is determined for each respective battery set in a plurality of battery sets. The respective state of health reflects a respective present amount of total energy able to be stored by each respective battery set relative to a specification of the respective battery set. A respective allocation of electrical current for each battery set in the plurality of battery sets is determined based on the respective state of health for each respective battery set. A current flow through each respective battery set is configured to its respective allocation of electrical current based on determining the respective allocation.

Abstract: Methods and systems for exchanging various forms of value, including coins, currency, credit, debit, and/or bank account funds, for prepaid cash cards, credit cards, phone cards, and the like. In one embodiment, a value exchange machine includes a coin input region, a coin sorting/counting apparatus, a card reader, and a communications facility configured to communicate with a remote computer network. In another embodiment, a value exchange system includes one or more of the value exchange machines connected to one or more remote computers via a communications link. A user wishing to purchase, for example, a prepaid cash card can visit one of the value exchange machines, select the desired transaction, and pay for the card with coins, currency, a credit card, a debit card, and/or bank account funds. After confirming payment, the value exchange machine dispenses the card to the user.

Abstract: Systems, methods, and non-transitory computer-readable media taught herein process a subset of a three-dimensional array of voxels to form an image of a region of interest in an object. Images thus formed are clear, comprehensible, and contextual. The systems, methods, and non-transitory computer-readable media taught herein select the subset of voxels that represent the region of interest along a direction perpendicular to a view direction defined by the region of interest. The subset of voxels represents one or more portions of a plurality of image slices of the object.

Abstract: The present invention relates to the use of the compound 1-(2-(4-fluorophenyl)thiazol-5-yl)-1-(pyridin-4-yl)ethanol (“ASNOO1”) in treatments without concomitant use of a steroid and/or in the form of a racemic mixture, e.g. in prostate cancer treatment. It also relates to its use in methods that are food indifferent.

Abstract: A multilayer interlayer containing a specified ionomer skin layer and an acoustic damping intermediate layer, and laminate containing such interlayer are provided, wherein the laminate has a desirable combination of sound insulating, flexural strength and optical properties suitable for use in transportation and architectural end uses.

Abstract: In the synthesis of boron nitride nanotubes (BNNTs) via high temperature, high pressure methods, a boron feedstock may be elevated above its melting point in a nitrogen environment at an elevated pressure. Methods and apparatus for supporting the boron feedstock and subsequent boron melt are described that enhance BNNT synthesis. A target holder having a boron nitride interface layer thermally insulates the target holder from the boron melt. Using one or more lasers as a heat source, mirrors may be positioned to reflect and control the distribution of heat in the chamber. The flow of nitrogen gas in the chamber may be heated and controlled through heating elements and flow control baffles to enhance BNNT formation. Cooling systems and baffle elements may provide additional control of the BNNT production process.

Abstract: A predator simulation apparatus for repelling animals may include a housing. A speaker may be disposed on the housing. The speaker may also be configured to emit an animal repellant sound. A scent dispenser may be disposed on the housing. The scent dispenser may be configured to release an animal repellant odor. A motion sensor may be electrically coupled to the speaker. A control switch may also be electrically coupled to the speaker.

Abstract: The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection.