Abstract: A device for administering a fluid to a patient anatomy includes a flexible catheter. The catheter includes a lumen extending therethrough. The catheter is sized and shaped to extend from a proximal end outside a human body to a distal end that can be guided to a target location. A distal portion of the catheter includes one or more exit ports communicating with a first lumen for administering the fluid. A deformable portion of the catheter is formed so that, in a first state, the deformable portion assumes a first shape suitable for guiding the catheter to the target location and, in a second state, the deformable portion assumes a second shape in which the deformable portion curves to extend in at least one radial direction for engaging an inner wall of the target location to anchor the catheter in the target location while administering the fluid.

Abstract: Provided herein is an isolated polynucleotide, which encodes alphavirus non-structural proteins nsp1, nsp2, nsp3 and nsp4 and a polypeptide comprising a coronavirus protein fused to a signal sequence and/or transmembrane domain. The coronavirus protein may be the receptor binding domain of the S1 subunit of coronavirus spike (S) protein. The polynucleotide such as RNA is useful for as a vaccine against coronavirus infection, especially, COVID-19 infection.

Abstract: An apparatus and method for high-order modeling of a system is disclosed. The apparatus comprises at least a computing device to receive a plurality of system data, determine at least a current rate of growth for a plurality of categories of system data, generate at least a second-order model of the projected growth, identify at least a decrease in the second-order model for projected growth, identify a pattern associating the decrease in the second-order model to at least a single system datum, and configure a remote display to export a summary of the identified decrease in second-order model, identified pattern, and the recommended user actions to optimize the system growth rate. The method comprises a machine-learning model to execute the process described above.

Abstract: An apparatus and method for multiple stage process modeling is provided. The apparatus includes a processor and a memory connected to the processor. The memory containing instructions configuring the a processor to receive process data sets, each process data set representing a progression stage that describes a sequence of activities performed by an entity device, generate, using the process data sets and a machine learning algorithm, a progression outlook profile including progression stage profiles, each progression stage profile representative of a respective progression stage and may generate progression actions describing progression from a first progression stage to a second progression stage based on input data, and a progression stage profile classifier that may use input data and identify a progression stage currently occupied by a process based on input data. The processor may receive process data describing a process to classify received process data to a progression stage profile.

Abstract: Provided herein are compositions and methods for the design of synthetic regulatory sequences and for subsequent modulation of neural pathways.

Abstract: Aspects of the subject disclosure may include, for example, a method in which a processing system determines that performance of a service is required at a first location in a smart community; identifies a robot to be transported, and determines whether physical transport or virtual transport is to be performed for the robot. If physical transport is to be performed, the system initiates communication with a robot transport controller to schedule the physical transport to the first location from a different second location. If virtual transport is to be performed, the processing system initiates communication with a radio access network (RAN) to schedule the virtual transport; the virtual transport includes configuring the robot at the first location. Other embodiments are disclosed.

Abstract: A locking clip for retaining a fastener in a bone fixation plate, the locking clip comprising a flexure member and a body member coupled to the flexure member, the body member comprising a locking tab, the locking tab configured to provide an axial limitation to motion of the fastener in a non-rotationally-ratcheting manner, the flexure member resiliently flexible to permit displacement of the locking tab to allow passage of a fastener head of the fastener, the locking tab configured to translate a downward force of the fastener head into a lateral spreading force to effect the displacement, the body member defining a clip tool engagement cavity for translational displacement of the locking tab.

Abstract: An antenna assembly can include a case, a first ground plane, and a multi-band multi-element antenna. The case can include a body portion and a door pivotably coupled to the body portion. The first ground plane can be coupled to the body portion and can divide the case into a first internal volume and a second internal volume. The multi-band multi-element antenna can include at least one multi-band radiating element coupled to a top side of the first ground plane. The antenna assembly can include a tablet computer and/or a display screen.

Abstract: Data is received that comprises or characterizes an executable and dynamic linked library (DLL). Features are then extracted from the executable and DLL. The extracted features are input into at least one machine learning model to generate a suspiciousness score. The machine learning model can be trained to determine whether the executable file comprises ransomware. An execution chain of trust score for the executable and DLL can later be determined based on the extracted features and the suspiciousness score. This execution chain of trust score for the executable and DLL characterizes one or more associated parent processes. This suspiciousness score and the execution chain of trust score can be used to determine whether or not to initiate one or more ransomware countermeasures. Related apparatus, systems, techniques and articles are also described.

Abstract: Various embodiments relate to systems and devices including self-healing functionality. A system may include a mobile surveillance unit. The mobile surveillance unit may include a power source and a relay coupled to the power source. The mobile surveillance may further include a network including at least one network device coupled to the relay. Moreover, the mobile surveillance unit may include a controller coupled to the network. The controller may be configured to determine whether a network device of the at least one network device is in a non-operative state. The controller may also be configured to, responsive to determining that the network device is in the non-operative state, cause the relay to decouple the network device from the power source for a predetermined time period. Associated methods and mobile units, and swappable units, are also disclosed.

Abstract: A device includes a flexible catheter and a material. The catheter includes at least a first channel extending therethrough and is sized and shaped to extend from a proximal end outside a human body to a distal end that can be guided to a target location within a gastrointestinal (GI) system. A first distal portion of the catheter includes at least one exit port communicating with the first channel for administering a fluid to a patient anatomy. The material is fixed to an exterior of the catheter or ejectable from an interior of the catheter into the location that, in a first state or shape, is suitable for guiding the catheter to the location and, in a second state or shape, is suitable for engaging an inner wall of the location to anchor the catheter in the location while administering the fluid via the first channel.

Abstract: An antenna assembly may include at least two PCB bases. Each PCB base may include a first multi-band antenna element, and a second multi-band antenna element, formed on each PCB base. The first multi-band antenna element and the second multi-band antenna elements can include one or more low-band radiating elements, one or more mid-band radiating elements; and one or more high-band radiating elements.

Abstract: Disclosed are engineered meganucleases that bind and cleave a recognition sequence within a serine peptidase inhibitor, Clade A, Member 1 (SERPINA1) gene, which encodes alpha-1 antitrypsin (AAT). Further disclosed are donor polynucleotides that encode functional AAT proteins. The present disclosure also encompasses methods of using such engineered meganucleases and donor polynucleotides to make genetically-modified cells and use of such compositions for treatment of AAT deficiency.

Abstract: Provided herein are methods and compositions of a surrogate mRNA drug product. The surrogate mRNA drug product is made up of a physical property surrogate, a visual property surrogate, and a chemical property surrogate. The surrogate mRNA drug product has at least one quantitative or qualitative property such as viscosity, turbidity, density, and surface tension that is comparable to and matches the same property of a mRNA drug product comprised of mRNA in a lipid nanoparticle (LNP). The surrogate mRNA drug product, however, does not comprise mRNA or LNP.

Abstract: An apparatus for determining system model comparison including a processor and a memory, wherein the processor is configured to receive a first plurality of system data, wherein the first plurality of system data represents a first state of a system, and a second plurality of system data representing a second of the system, output a first model output using a first model of the system and the second plurality of system data; calculate at least a perturbation function; modify the second plurality of system data using the at least a perturbation function; output a second model output using the second model of the system and the at least a perturbation function; compare the first model output to the second model output using an optimization function; and generate a state change output corresponding to the system using the comparison.

Abstract: The present disclosure relates to a computer-readable medium, a method, an apparatus, and a computer program for an attester computer system, to a attester computer system comprising such an apparatus, to a computer-readable medium, a methods, an apparatus, and a computer program for a verifier computer system, to a verifier computer system comprising such an apparatus, and to a system comprising an attester computer system and a verifier computer system or two combined attester and verifier computer systems.

Abstract: A method for meta-model optimization may include receiving an entity and engagement profile, classify each entity and engagement profile to one or more descriptors, compiling a digital model for each entity and engagement profile, identifying an optimal compatibility allocation of entities to engagements; and generating a user display summarizing the optimal meta-model to the user.

Abstract: A device includes a flexible catheter and at least one wirefrom. The catheter includes a first lumen extending therethrough and is sized and shaped to extend to a target location within a gastrointestinal (GI) system. A first distal portion of the catheter includes one or more exit ports communicating with the first lumen for administering a fluid to the location. The wireform is attached around the catheter or deployable from within the catheter, the wireform being formed so that, in a first state, the wireform assumes a first shape suitable for guiding the catheter to the location and, in a second state, the wireform assumes a second shape in which the wire extends away from the catheter in at least one radial direction for contacting a wall of the location to anchor the catheter in the location while administering the fluid via the first lumen.

Abstract: A storage, retrieval and processing system for processing objects is disclosed.

Abstract: Disclosed are flexible fluid reservoirs including a front sheet and a back sheet, each comprising a four-layer insulated wall. The four-layer insulated wall includes an interior layer and an exterior layer, and a metallic film layer and an insulation layer disposed between the interior layer and the exterior layer where the metallic film layer is oriented toward the exterior layer and the insulation layer is oriented toward the interior layer. One or more of the interior or exterior layers can be a metallocene modified polyethylene film. The metallic film layer can be aluminum coated polyethylene terephthalate resin. The insulation layer can be a foam layer comprising closed cell polyethylene resin. The four-layer insulated wall can resist or limit temperature changes of a fluid disposed within the reservoir for a period of time. The insulated fluid reservoirs can include closure mechanisms for sealing an upper opening of the reservoir.