Patents by Inventor Sriram Natarajan
Sriram Natarajan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8969648Abstract: A blood clotting substrate and device which has a plurality of oxygen plasma-treated polypropylene pillars extending from the surface of a polypropylene film.Type: GrantFiled: April 6, 2012Date of Patent: March 3, 2015Assignee: Ethicon, Inc.Inventors: Emma Kim Luong-Van, Isabel Rodriguez, Hong Yee Low, Audrey Yoke Yee Ho, Sriram Natarajan, Noha Elmouelhi, Kevin Cooper, Murty Vyakarnam, Chee Tiong Lim
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Patent number: 8926881Abstract: Synthetic polymer substrates comprising a hierarchical surface structure of multiple domes and multiple pillars on said domes, wherein said substrate is a synthetic polymer film, said domes have diameters in the range from about 5 ?m to about 400 ?m, heights in the range from about 2.5 ?m and about 500 ?m, and said pillars have diameters in the range from about 20 nm to about 5 ?m and aspect ratios of from about 2 to about 50, and methods of making and using them.Type: GrantFiled: April 6, 2012Date of Patent: January 6, 2015Assignees: Depuy Synthes Products, LLC, Agency for Science, Technology and ResearchInventors: Audrey Yoke Yee Ho, Isabel Rodriguez, Hong Yee Low, Emma Kim Luong-Van, Sriram Natarajan, Noha Elmouelhi, Kevin Cooper, Chee Tiong Lim
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Patent number: 8914502Abstract: Described herein are systems and methods for use with a load balancer or traffic director, and administration thereof, wherein the traffic director is provided as a software-based load balancer that can be used to deliver a fast, reliable, scalable, and secure platform for load-balancing Internet and other traffic to back-end origin servers, such as web servers, application servers, or other resource servers. In accordance with an embodiment, the system comprises a traffic director having one or more traffic director instances, which is configured to receive and communicate requests, from clients, to origin servers having one or more pools of servers. A health check subsystem periodically checks the health of its configured resource servers, and also attempts to detect changes in the one or more pools, by sending requests to any new server instances configured as origin servers within the pool, receiving appropriate responses, and updating the configuration accordingly.Type: GrantFiled: August 31, 2012Date of Patent: December 16, 2014Assignee: Oracle International CorporationInventors: Arvind Srinivasan, Sriram Natarajan
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Publication number: 20140235510Abstract: Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter may be used to deposit highly concentrated spots of protein or other materials on a microarray slide, wafer, or other surface. It may also be used to perform various chemistry steps on the same spots. The spotter increases the surface density of substances at each spot by directing a flow the desired substance (or a solution thereof) over the spot area until surface saturation is accomplished. The spotter may be loaded by well plate handling equipment. The spotter uses wells, microfluidic conduits, and orifices to deposit proteins, other biomolecules, or chemicals on a spot on, a separate surface. Each orifice is connected to two wells via microconduits. When the spotter contacts a surface, a seal is formed between the orifices and the surface. The same or different substances may be flowed across each orifice. Any number of orifices may be incorporated into a spotter.Type: ApplicationFiled: February 25, 2013Publication date: August 21, 2014Applicant: University of Utah Research FoundationInventors: David A. Chang-Yen, Sriram Natarajan, Josh Eckman, Bruce K. Gale, David Myszka
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Publication number: 20140208426Abstract: A cloud-based method, a behavioral analysis system, and a cloud-based security system can include a plurality of nodes communicatively coupled to one or more users, wherein the plurality of nodes each perform inline monitoring for one of the one or more users for security comprising malware detection and preclusion; and a behavioral analysis system communicatively coupled to the plurality of nodes, wherein the behavioral analysis system performs offline analysis for any suspicious content from the one or more users which is flagged by the plurality of nodes; wherein the plurality of nodes each comprise a set of known malware signatures for the inline monitoring that is periodically updated by the behavioral analysis system based on the offline analysis for the suspicious content.Type: ApplicationFiled: March 26, 2014Publication date: July 24, 2014Applicant: ZSCALER, INC.Inventors: Sriram NATARAJAN, Narinder PAUL, Julien SOBRIER, Karthikeyan THAMILARASU, Balakrishna BAYAR, Michael Andrew William SUTTON
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Publication number: 20140171342Abstract: The present disclosure provides apparatuses, systems, and methods involving a spotter for depositing a substance on a submerged surface. The spotter comprises an outlet cavity defined at least in part by a spotting orifice, a first opening, and a second opening. The spotter also comprises a first conduit fluidly coupled to the first opening and a second conduit fluidly coupled to the second opening. The spotter is adapted so that fluid flowing through the first conduit and the second conduit is communicated among the first opening, the second opening, and a submerged deposition surface when the sealing orifice is sealed against the submerged deposition surface to form a deposition spot on the submerged deposition surface. The submerged deposition surface is within a liquid such that the liquid covers the deposition spot upon removal of the orifice from the deposition surface.Type: ApplicationFiled: September 13, 2013Publication date: June 19, 2014Inventors: Bruce K. Gale, Joshua W. Eckman, Adam Miles, Christopher Morrow, James Smith, Sriram Natarajan, Mark Eddings
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Publication number: 20140120314Abstract: Synthetic polymer substrates comprising a hierarchical surface structure of multiple domes and multiple pillars on said domes, wherein said substrate is a synthetic polymer film, said domes have diameters in the range from about 5 ?m to about 400 ?m, heights in the range from about 2.5 ?m and about 500 ?m, and said pillars have diameters in the range from about 20 nm to about 5 ?m and aspect ratios of from about 2 to about 50, and methods of making and using them.Type: ApplicationFiled: December 23, 2013Publication date: May 1, 2014Applicants: Agency for Science Technology and Research, Depuy Synthes Products, LLCInventors: Audrey Yoke Yee Ho, Isabel Rodriguez, Hong Yee Low, Emma Kim Luong-Van, Sriram Natarajan, Noha Elmouelhi, Kevin Cooper, Chee Tiong Lim
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Publication number: 20130288225Abstract: A method of separating blood by providing a horizontal substrate having a plurality of oxygen plasma-treated polypropylene pillars extending from the surface of a polypropylene film, depositing a whole blood sample on an upper surface of the substrate, collecting red blood cells on the upper surface of the pillars and permitting remaining components of said whole blood sample to flow downward and through the pillars.Type: ApplicationFiled: April 27, 2012Publication date: October 31, 2013Applicants: AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH, ADVANCED TECHNOLOGIES & REGENERATIVE MEDICINE, LLCInventors: Noha Elmouelhi, Sriram Natarajan, Kevin Cooper, Murty Vyakarnam, Chee Tiong Lim, Emma Kim Luong-Van, Isabel Rodriguez, Hong Yee Low, Audrey Yoke Yee Ho
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Publication number: 20130266761Abstract: Synthetic polymer substrates comprising a hierarchical surface structure of multiple domes and multiple pillars on said domes, wherein said substrate is a synthetic polymer film, said domes have diameters in the range from about 5 ?m to about 400 ?m, heights in the range from about 2.5 ?m and about 500 ?m, and said pillars have diameters in the range from about 20 nm to about 5 ?m and aspect ratios of from about 2 to about 50, and methods of making and using them.Type: ApplicationFiled: April 6, 2012Publication date: October 10, 2013Applicants: Agency for Science Technology and Research, Advanced Technologies & Regenerative Medicine, LLCInventors: Audrey Yoke Yee Ho, Isabel Rodriguez, Hong Yee Low, Emma Kim Luong-Van, Sriram Natarajan, Noha Elmouelhi, Kevin Cooper, Chee Tiong Lim
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Publication number: 20130267880Abstract: A blood clotting substrate and device which has a plurality of oxygen plasma-treated polypropylene pillars extending from the surface of a polypropylene film.Type: ApplicationFiled: April 6, 2012Publication date: October 10, 2013Applicants: Agency for Science Technology and Research, Advanced Technologies & Regenerative Medicine, LLCInventors: Emma Kim Luong-Van, Isabel Rodriguez, Hong Yee Low, Audrey Yoke Yee Ho, Sriram Natarajan, Noha Elmouelhi, Kevin Cooper, Murty Vyakarnam, Chee Tiong Lim
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Publication number: 20130080628Abstract: Described herein are systems and methods for use with a load balancer or traffic director, and administration thereof, wherein the traffic director is provided as a software-based load balancer that can be used to deliver a fast, reliable, scalable, and secure platform for load-balancing Internet and other traffic to back-end origin servers, such as web servers, application servers, or other resource servers. In accordance with an embodiment, the system comprises a traffic director having one or more traffic director instances, which is configured to receive and communicate requests, from clients, to origin servers having one or more pools of servers. A health check subsystem periodically checks the health of its configured resource servers, and also attempts to detect changes in the one or more pools, by sending requests to any new server instances configured as origin servers within the pool, receiving appropriate responses, and updating the configuration accordingly.Type: ApplicationFiled: August 31, 2012Publication date: March 28, 2013Applicant: ORACLE INTERNATIONAL CORPORATIONInventors: Arvind Srinivasan, Sriram Natarajan
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Patent number: 8383059Abstract: Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter may be used to deposit highly concentrated spots of protein or other materials on a microarray slide, wafer, or other surface. It may also be used to perform various chemistry steps on the same spots. The spotter increases the surface density of substances at each spot by directing a flow the desired substance (or a solution thereof) over the spot area until surface saturation is accomplished. The spotter may be loaded by well plate handling equipment. The spotter uses wells, microfluidic conduits, and orifices to deposit proteins, other biomolecules, or chemicals on a spot on a separate surface. Each orifice is connected to two wells via microconduits. When the spotter contacts a surface, a seal is formed between the orifices and the surface. The same or different substances may be flowed across each orifice. Any number of orifices may be incorporated into a spotter.Type: GrantFiled: September 30, 2005Date of Patent: February 26, 2013Assignee: University of Utah Research FoundationInventors: David A. Chang-Yen, Sriram Natarajan, Josh Eckman, Bruce K. Gale, David Myszka
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Publication number: 20120302465Abstract: A biologic-adsorbent, e.g., protein-adsorbent, material is prepared by forming a polymeric substrate into structures having high surface area topography whose biologic adsorbing properties can be controlled. Biologic adsorption by these structures of optimized high surface area topography is increased by mild treating of the surfaces, e.g., by oxygen plasma, without substantially altering topography. Structures can have tailored geometric features including microstructures, e.g., pillars, with a diameter from 100 nm-50 ?m and height greater than 1 ?m.Type: ApplicationFiled: May 26, 2011Publication date: November 29, 2012Applicants: AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH, ADVANCED TECHNOLOGIES & REGENERATIVE MEDICINE, LLCInventors: Noha ELMOUELHI, Kevin COOPER, Sriram NATARAJAN, Hong Yee LOW, Isabel RODRIGUEZ, Emma Kim LUONG-VAN
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Publication number: 20120302427Abstract: A biologic-adsorbent, e.g., protein-adsorbent, material is prepared by forming a polymeric substrate into structures having high surface area topography whose biologic adsorbing properties can be controlled. Biologic adsorption by these structures of optimized high surface area topography is increased by mild treating of the surfaces, e.g., by oxygen plasma, without substantially altering topography. Structures can have tailored geometric features including microstructures, e.g., pillars, with a diameter from 100 nm-50 ?m and height greater than 1 ?m.Type: ApplicationFiled: December 29, 2011Publication date: November 29, 2012Applicants: ADVANCED TECHNOLOGIES & REGENERATIVE MEDICINE, LLCInventors: Noha Elmouelhi, Kevin Cooper, Sriram Natarajan, Hong Yee Low, Isabel Rodriguez, Emma Kim Luong-Van
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Publication number: 20120251611Abstract: A polydioxanone film comprising substantially cylindrical polydioxanone pillars on at least one side thereof, said pillars having diameters from about 0.2 ?m to about 3 ?m, and heights from about 2 ?m to about 20 ?m from the surface of the film, a process for adsorbing proteins using the film and medical devices incorporating the film.Type: ApplicationFiled: March 30, 2012Publication date: October 4, 2012Applicants: AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH, ADVANCED TECHNOLOGIES & REGENERATIVE MEDICINE, LLCInventors: Emma Kim Luong-Van, Isabel Rodriguez, Hong Yee Low, Noha Elmouelhi, Kevin Cooper, Sriram Natarajan, Murty N. Vyakarnam, Chee Tiong Lim
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Patent number: 8211382Abstract: Specialized microfluidic networks are utilized to deposit substances on sensor surfaces. In particular, a flow-based microfluidic printhead is used as an interface to deliver multiple analytes to a sensor for simultaneous analysis. Furthermore, internal referencing is incorporated into sensor regions for improved sensitivity.Type: GrantFiled: September 22, 2009Date of Patent: July 3, 2012Assignee: Wasatch Microfluidics, LLCInventors: David Myszka, Bruce Kent Gale, Joshua Wayne Eckman, Sriram Natarajan
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Publication number: 20120156780Abstract: A method of surface modification of a biocompatible, biodegradable polymer substrate using RF plasma treatment is disclosed. This method and the resulting surface provide for enhanced adhesion and proliferation of cells, such as hKDCs, and can be used with scaffolds for tissue regeneration and with other delivery vehicles such as medical devices.Type: ApplicationFiled: December 21, 2010Publication date: June 21, 2012Inventors: Kevin L. Cooper, Alisha Martin, Sriram Natarajan, Robert Vetrecin, Changdeng Liu
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Patent number: 8205264Abstract: A method for automated evaluation of a SPAM filter rates a sender-receiver pair based on traffic information related to the sender-receiver pair. A SPAM filter intercepts electronic messages transmitted between the sender-receiver pair and classifies them as either SPAM or HAM. On comparing the rating for the sender-receiver pair and the classification for an electronic message between the sender-receiver pair, the method generates a metric indicating the reliability of the spam filter. Repeating these steps for more than one electronic messages and related sender-receiver pairs, the method produces a set of metrics. One or more of the metrics from the set of metrics are used to calculate an evaluation factor for evaluating the SPAM filter.Type: GrantFiled: September 4, 2009Date of Patent: June 19, 2012Assignee: ZscalerInventors: Kailash Kailash, Jose Raphel, Sriram Natarajan
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Publication number: 20120143228Abstract: A laminate and process of making the laminate is disclosed comprising: a surgical mesh having first and second surfaces; and an adhesive structure having adhesive and non-adhesive surfaces, wherein the non-adhesive surface of the adhesive structure is laminated to at least one of said first and second surfaces of said surgical mesh, and the adhesive surface of said adhesive structure has protrusions extending therefrom comprising a resin having a Young's modulus of greater than 17 MPa, which protrusions are of sufficiently low diameter to promote adhesion by increasing physical attractive forces between the adhesive structure and a target surface, as measured by shear adhesion.Type: ApplicationFiled: December 29, 2011Publication date: June 7, 2012Applicants: AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH, ADVANCED TECHNOLOGIES & REGENERATIVE MEDICINE, LLCInventors: Sriram Natarajan, Joseph J. Hammer, Kevin Cooper, Murty N. Vyakarnam, Hong Yee Low, Isabel Rodriguez, Chee Tiong Lim, Audrey Yoke Yee Ho
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Publication number: 20120052234Abstract: An adhesive structure is provided comprising a surface from which extend substantially cylindrical protrusions comprising a stiff resin having a Young's modulus of greater than 17 MPa. The protrusions are of sufficiently low diameter to promote adhesion by physical attractive forces, e.g., Van der Waals attractive forces, as measured by shear adhesion between the adhesive structure and a target surface. A method for preparing the structure is provided as well as a combination of the adhesive structure and target surface.Type: ApplicationFiled: August 30, 2010Publication date: March 1, 2012Inventors: Sriram NATARAJAN, Kevin COOPER, Noha ELMOUELHI, Murty N. VYAKARNAM, Hong Yee LOw, Isabel RODRIGUEZ, Chee Tiong LIM, Audrey Yoke Yee HO