Abstract: The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: A press comprising: at least one press ram by means of which a press stroke can be carried out when the press is actuated; at least one first working station and a second working station, wherein the first and the second working station each has a tool lower part and a tool upper part, wherein a first forming stage is formed by means of the tool lower part and the tool upper part of the first working station, and a second forming stage is formed by means of the tool lower part and the tool upper part of the second working station; and a mechanical element for transmitting the press stroke to one of the first or second forming stages, wherein the press stroke can be transmitted to the first and the second forming stages independently from one another.

Abstract: A damage resistant glassware apparatus which includes a fluid container having a rim at a top end and a base at a bottom end, the fluid container constructed of a glass material, the rim to define an opening to a storage cavity within the fluid container, a first protective insert coupled to and integrally formed with the rim, and a second protective insert coupled to and integrally formed with the bottom end, wherein the first and second protective inserts are constructed of a non-glass material.

Abstract: Robot cell with a robot cell chamber for loading and unloading single-station machine tools and with a machine chamber, wherein at least one robot is arranged in the robot cell chamber and wherein at least two clamping points and at least one machining spindle of a single-station machine tool are arranged in the machine chamber, and so the clamping points for receiving workpieces in the machine chamber can be reached by the robot, wherein the robot cell chamber can be coupled to the machine chamber such that a machining chamber is formed in the state in which the robot cell chamber is coupled to the machine chamber, and a device for machining, wherein the device has a robot cell and a single-station machine tool.

Abstract: The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: The present invention provides a compound of formula (I): a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses as complement pathway modulators for the treatment of ocular diseases. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses as a factor D inhibitor for the treatment of ophthalmic diseases. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: The present invention provides a compound of formula I a method for manufacturing the compounds of the invention, and its therapeutic uses as inhibitor of the complement alternative pathway and particularly as inhibitor of Factor B for the treatment of e.g. age-related macular degeneration and diabetic retinopathy. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: A turbine blade having an airfoil and a fir tree root is disclosed. The fir tree root has a lengthwise direction, a crosswise direction extending between two lateral sides of the fir tree root, and a span direction extending from a root base towards an airfoil tip. The fir tree root includes a web interposed between each pair of at least two neighboring channels. For each web, a web-to-channel ratio with each of the two neighboring channels is chosen to be larger than or equal to 0.5 and is smaller than or equal to 0.85 at least at a position where the root width is a minimum load bearing root width in a load bearing section of the fir tree root. In another aspect, overall web-to-channel ratio is defined as a ratio between the sum of all web lengths and the sum of all channel lengths.

Abstract: Techniques are disclosed for facilitating the process of undoing and redoing modifications that are made to content using an online content management system (CMS). As a user makes changes to content, such as by editing a webpage using a web-based CMS, a history of the user's modifications is generated and stored locally on the client. When the user invokes an undo command, the modification history can be used to determine a previous state of the content and restore the content to that previous state. Similarly, when the user invokes a redo command, the modification history can be used to return to a state that had previously been undone. In some embodiments, the process of undoing or redoing the user's modifications is selectively performed on either a client side or a server side of the online system, depending on the type of content that is being manipulated.

Abstract: The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention and its therapeutic uses as complement pathway modulators for the treatment of ocular diseases. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: The disclosed embodiments relate to a system and method for secure, uninterrupted operation of a mobile device. The method includes identifying, at repeated intervals, a voice of a device operator. The method also includes determining if the device operator is an authorized user of the mobile device based on the voice. Additionally, the method includes continuing an operation of the mobile device if the device operator is an authorized user. Further, the method includes interrupting operation of the mobile device if the device operator is not an authorized user.

Abstract: A rotating gas turbine blade is disclosed which includes an airfoil with a suction side and a pressure side, the airfoil extending in a radial direction from a blade root to a blade tip. The blade tip includes a tip shroud, the airfoil having internal cooling passages for a cooling medium, which extend through the tip shroud. Outlet ports are provided above a selected internal airfoil cooling passage for the cooling medium to be ejected above the tip shroud in a direction of the blade's pressure side. Dust accumulation is avoided at the tip end of the selected internal cooling passage.

Abstract: A rotating blade for a gas turbine includes an airfoil extending in a longitudinal direction and having a leading edge and a trailing edge, whereby the airfoil is bordered at its outer end by a tip shroud, whereby the airfoil includes two or more internal passages, which run in longitudinal direction and are separated by solid webs, and whereby a plurality of shroud fins is arranged on top of the tip shroud to improve gas sealing against a corresponding stator heat shield. The stability and life time of the blade can be enhanced by selecting a position of each of the shroud fins to be exclusively above one of the webs and/or a leading edge wall.

Abstract: The present invention provides a compound of formula (I), a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: Techniques are disclosed for facilitating the process of undoing and redoing modifications that are made to content using an online content management system (CMS). As a user makes changes to content, such as by editing a webpage using a web-based CMS, a history of the user's modifications is generated and stored locally on the client. When the user invokes an undo command, the modification history can be used to determine a previous state of the content and restore the content to that previous state. Similarly, when the user invokes a redo command, the modification history can be used to return to a state that had previously been undone. In some embodiments, the process of undoing or redoing the user's modifications is selectively performed on either a client side or a server side of the online system, depending on the type of content that is being manipulated.

Abstract: The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses as a factor D inhibitor for the treatment of ophthalmic diseases. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: The present disclosure is directed towards systems and methods for flexible field mapping between disparate systems, which comprises generating a base mapping request comprising a base mapping between a source data object having one or more source data fields and a target data object having one or more target data fields and generating a field mapping request comprising a field mapping between a given source data field and a given target data field. One or more data items are identified from the target data object responsive to the base mapping request and the field mapping request. A combined request is then generated comprising the one or more data items responsive to the base mapping request and the field mapping request. The combined request is transmitted to a target memory. One or more tax values responsive to the combined request are subsequently calculated based on the one or more data items.

Abstract: A method is provided for operating a heat accumulator of a motor vehicle. Accordingly, following a start of the motor vehicle, a length and/or duration of a distance to be driven by the motor vehicle are/is ascertained or estimated. Depending on the length and/or the duration, a decision is made as to whether discharging of the heat accumulator will be carried out.