Abstract: System for producing a nucleic acid construct of interest, said system comprising: a set of n entry DNAs numbered 1 to n, n being an integer of at least 2, each of said n entry DNAs comprising in this order: (i) a type IIs restriction endonuclease recognition site followed by the cleavage site thereof; (ii) a sequence portion linking the cleavage site of said recognition site of item (i) with the cleavage site of the recognition site of the following item (iii), and (iii) a cleavage site of a further type IIs restriction endonuclease recognition site followed by the recognition site of said cleavage site; the cleavage sites of the type IIs restriction endonuclease recognition sites of item (iii) of entry DNAs 1 to n?1 are complementary to the cleavage sites of the type IIs restriction endonuclease recognition sites of item (i) of entry DNAs 2 to n, respectively; the cleavage site of the type IIs restriction endonuclease recognition site of item (iii) of entry DNA n is complementary to the cleavage site of

Abstract: System for producing a nucleic acid construct of interest, said system comprising: a set of n entry DNAs numbered 1 to n, n being an integer of at least 2, each of said n entry DNAs comprising in this order: (i) a type IIs restriction endonuclease recognition site followed by the cleavage site thereof; (ii) a sequence portion linking the cleavage site of said recognition site of item (i) with the cleavage site of the recognition site of the following item (iii), and (iii) a cleavage site of a further type IIs restriction endonuclease recognition site followed by the recognition site of said cleavage site; the cleavage sites of the type IIs restriction endonuclease recognition sites of item (iii) of entry DNAs 1 to n?1 are complementary to the cleavage sites of the type IIs restriction endonuclease recognition sites of item (i) of entry DNAs 2 to n, respectively; the cleavage site of the type IIs restriction endonuclease recognition site of item (iii) of entry DNA n is complementary to the cleavage site of

Abstract: A vehicle system for classifying spoken utterance within a vehicle cabin as one of system-directed and non-system directed may include at least one microphone to detect at least one acoustic utterance from at least one occupant of the vehicle, at least one camera to detect occupant data indicative of occupant behavior within the vehicle corresponding to the acoustic utterance, and a processor programmed to receive the acoustic utterance, receive the occupant data, determine whether the occupant data is indicative of a vehicle feature, classify the acoustic utterance as a system-directed utterance in response to the occupant data being indicative of a vehicle feature, and process the acoustic utterance.

Abstract: Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease.

Abstract: Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease.

Abstract: A method for tracking a component in a production line having a plurality of processing systems includes processing and/or testing, by each of the processing systems, the component, providing a processing signal characterizing the processing and/or testing for a higher-level electronic computing unit, and tracking, by the computing unit based on the received processing signals, the component through the production line. A query signal characterizing a component property of one of the processing systems of the production line is received by the computing unit. The component is ascertained by the computing unit and at least one component information signal characterizing the component property of the ascertained component is provided.

Abstract: A compound of formula (I) or an N-oxide, a salt, a hydrate, a solvate, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer for use in the treatment or prophylaxis of brain ischemia, ischemic brain injury, Ischemic Stroke (IS), haemorrhagic stroke, traumatic brain injury, spinal cord injury.

Abstract: A printed circuit board having essentially a first region, a second region, and a third region. The first region and the third region can be used for the placement of electrical and/or electronic components. The second region located in the middle of the three regions is a bend region. A side edge of the printed circuit board is offset inward in this region in order to narrow the contour of the printed circuit board in the bend region. This region likewise has one or more through holes. Both the narrowing and the through holes facilitate a bending of the printed circuit board, namely a bending of the first region relative to the third region or vice versa.

Abstract: A ceramic absorber for damping, in particular absorbing, vibrations, in particular combustion vibrations, preferably in gas turbines, which has a foam structure. For the ceramic absorber, the sound absorption capacity is set in a defined way and the efficiency is improved. The foam structure is based on a ceramic powder which contains either a component from the class of silicates or a component from the class of oxides, or a combination of a component from the class of silicates and a component from the class of oxides, and the foam structure has a homogeneous pore distribution.

Abstract: Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease.

Abstract: The present invention provides a tomaymycin biosynthetic gene cluster of Streptomyces species FH6421, and its use for producing 11-de-O-methyltomaymycm.

Abstract: A sea water cooling system including a first fluid cooling loop coupled to a first side of a heat exchanger and to a thermal load, a second fluid cooling loop coupled to a second side of the heat exchanger and including a pump for circulating fluid through the second fluid cooling loop, and a controller operatively connected to the pump, wherein the controller is configured to monitor an actual temperature in the first fluid cooling loop and to adjust a speed of the pump based on the monitored temperature to achieve a predetermined temperature in the first fluid cooling loop. The system may be selectively operable in one of a plurality of operating modes, wherein in a first operating mode the pump operates based entirely on cooling demands of the thermal load, and in a second operating mode the pump operates to maintain a fluid pressure above a predefined pressure.

Abstract: A modular rotor assembly for a screw pump including a power rotor and an idler rotor having respective first ends adapted to be disposed in a suction side of the screw pump and respective second ends adapted to be disposed in a discharge side of the screw pump, the power rotor including a balance piston adapted to be disposed within a pump housing of the screw pump with a radial clearance between an entire circumference of the balance piston and the pump housing is in a range between 1 micron and 200 microns, wherein the power rotor is provided with a tapered bearing surface configured to define a wedge-shaped, radial gap axially intermediate the power rotor and the idler rotor.

Abstract: A sea water cooling system including a first fluid cooling loop coupled to a first side of a heat exchanger and to a thermal load, a second fluid cooling loop coupled to a second side of the heat exchanger and including a pump for circulating fluid through the second fluid cooling loop, and a controller operatively connected to the pump, wherein the controller is configured to monitor an actual temperature in the first fluid cooling loop and to adjust a speed of the pump based on the monitored temperature to achieve a predetermined temperature in the first fluid cooling loop. The system may be selectively operable in one of a plurality of operating modes, wherein in a first operating mode the pump operates based entirely on cooling demands of the thermal load, and in a second operating mode the pump operates to maintain a fluid pressure above a predefined pressure.

Abstract: The present invention provides a tomaymycin biosynthetic gene cluster of Streptomyces species FH6421, and its use for producing 11-de-O-methyltomaymycin.

Abstract: A seawater cooling system adapted to mitigate salt crystallization in a seawater cooling loop. The system may include a pump operatively connected to the cooling loop and configured to pump seawater through the cooling loop, a temperature sensor operatively connected to the cooling loop and configured to monitor a temperature of the seawater in the cooling loop, and a controller operatively connected to the temperature sensor and to the pump, the controller configured to issue a warning and to increase a speed of the pump if it is determined that the monitored temperature of the seawater exceeds a predetermined threshold temperature.

Abstract: An intelligent sea water cooling system including a first fluid cooling loop coupled to a first side of a heat exchanger and to a thermal load, a second fluid cooling loop coupled to a second side of the heat exchanger, a pump for circulating fluid through the second fluid cooling loop, and a controller connected to the pump. The controller may monitor a temperature in the first fluid cooling loop and may adjust a speed of the pump to keep the temperature within a preferred operating range. If the speed of the pump is reduced to a predefined minimum pressure pump speed, the controller may start a timer t1 having a predefined duration. If the timer t1 expires and the temperature has not increased relative to when the timer t1 was started, the controller may reduce the speed of the pump below the minimum pressure pump speed.

Abstract: A seawater cooling system adapted to mitigate salt crystallization in a seawater cooling loop. The system may include a pump operatively connected to the cooling loop and configured to pump seawater through the cooling loop, a temperature sensor operatively connected to the cooling loop and configured to monitor a temperature of the seawater in the cooling loop, and a controller operatively connected to the temperature sensor and to the pump, the controller configured to issue a warning and to increase a speed of the pump if it is determined that the monitored temperature of the seawater exceeds a predetermined threshold temperature.

Abstract: In a device for producing and/or processing a workpiece, in particular circuit boards, in a work station, in particular for printing a corresponding blank or for checking finished circuit boards, at least one mark is provided on the workpiece. In this arrangement, at least one reference, which can be brought into alignment with the mark, is provided in the work station.

Abstract: Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease.