Patents by Inventor Stefan Werner

Stefan Werner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8193410
    Abstract: A process of producing a transgenic multi-cellular plants or parts thereof expressing a trait of interest, said trait having a controlled distribution of said trait to progeny, wherein said process comprises (i) producing a first plant or a cell thereof having in a first locus of a nuclear chromosome a first heterologous nucleotide sequence comprising a first fragment of a nucleotide sequence encoding said trait of interest, (ii) producing a second plant or a cell thereof having in a second locus of a nuclear chromosome homologous to said nuclear chromosome of step (i), a second heterologous nucleotide sequence comprising a second fragment of the nucleotide sequence encoding said trait of interest, and (iii) hybridising said first and said second plant or cells thereof to generate progeny exhibiting said functional trait of interest due to binding between a protein or polypeptide encoded by said first heterologous nucleotide sequence and a protein or polypeptide encoded by said second heterologous nucleotide
    Type: Grant
    Filed: November 19, 2009
    Date of Patent: June 5, 2012
    Assignee: Icon Genetics GmbH
    Inventors: Stefan Werner, Anatoly Giritch, Serik Eliby, Sylvestre Marillonnet, Victor Klimyuk, Yuri Gleba
  • Patent number: 8183433
    Abstract: A method of controlling a genetically-modified plant or plant cells, said method comprising the following steps: (a) providing a genetically-modified plant or plant cells, said plant or plant cells containing a heterologous nucleic add encoding a first polypeptide containing or consisting of a first fragment of a protein, (b) introducing a second polypeptide into cells of said genetically-modified plant or plant cells, said second polypeptide containing (i) a second fragment of said protein and (ii) a peptide sequence enabling the introduction of said second polypeptide into cells of said genetically-modified plant or plant cells, whereby said first fragment and said second fragment jointly generate a predetermined function of said protein only when jointly present.
    Type: Grant
    Filed: November 20, 2003
    Date of Patent: May 22, 2012
    Assignee: Icon Genetics GmbH
    Inventors: Stefan Werner, Sylvestre Marillonnet, Victor Klimyuk, Yuri Gleba
  • Patent number: 8101823
    Abstract: A method of controlling a genetically-modified multi-cellular organism or a part thereof, comprising the following steps: (a) providing a multi-cellular organism or a part thereof, whereby cells of said multi-cellular organism or said part contain a heterologous nucleic acid, (b) causing expression of a I protein from said heterologous nucleic acid in at least some of said cells, wherein said protein is capable of (i) leaving a cell and entering other cells of said multi-cellular organism or a part thereof, (ii) causing expression of said protein in cells containing said heterologous nucleic acid, and optionally (iii) controlling a cellular process of interest.
    Type: Grant
    Filed: November 20, 2003
    Date of Patent: January 24, 2012
    Assignee: Icon Genetics GmbH
    Inventors: Stefan Werner, Sylvestre Marillonnet, Yurii Dorokhov, Victor Klimyuk, Yuri Gleba
  • Patent number: 8093458
    Abstract: A process of producing a protein of interest by expression of said protein of interest from a sequence of interest in a plant or in plant leaves, comprising: (a) transfecting said plant or said plant leaves by infiltrating said plant or said plant leaves with an Agrobacterium strain in the presence of a complementing factor, said Agrobacterium strain containing in T-DNA a heterologous DNA sequence having a sequence portion encoding a replicon, wherein said sequence encoding a replicon contains sequences necessary for replicon function of said replicon, said sequences being derived from a plant virus, and said sequence of interest to be expressed from said replicon, (b) optionally isolating said protein of interest from said plant or said plant leaves infiltrated in step (a), wherein said Agrobacterium strain is provided with a first genetic modification rendering said Agrobacterium strain defective for transfecting organisms with said T-DNA in the absence of said complementing factor.
    Type: Grant
    Filed: July 7, 2005
    Date of Patent: January 10, 2012
    Assignee: Icon Genetics GmbH
    Inventors: Sylvestre Marillonnet, Carola Engler, Stefan Mühlbauer, Stefan Herz, Stefan Werner, Victor Klimyuk, Yuri Gleba
  • Patent number: 8053632
    Abstract: A method of controlling a genetically-modified plant, comprising (a) providing a genetically-modified plant, whereby cells of said genetically-modified plant contain a heterologous nucleic acid and whereby said genetically-modified plant is inactive with regard to a cellular process of interest, (b) switching on said cellular process of interest by directly introducing a polypeptide from a cell-free composition into cells containing said heterologous nucleic acid wherein said polypeptide and said heterologous nucleic acid are mutually adapted such that said polypeptide is capable of switching on said cellular process of interest.
    Type: Grant
    Filed: November 20, 2003
    Date of Patent: November 8, 2011
    Assignee: Icon Genetics GmbH
    Inventors: Stefan Werner, Sylvestre Marillonnet, Victor Klimyuk, Yuri Gleba
  • Publication number: 20110263024
    Abstract: A process of inserting a nucleic acid sequence of interest into an acceptor nucleic acid, comprising the following steps: amplifying by PCR a DNA comprising in the following order a sequence segment U, a nucleic acid sequence segment of known nucleotide sequence K2 and a nucleic acid sequence segment of known sequence K3 using a forward primer defining a first end of the amplified DNA and a reverse primer defining a second end of the amplified DNA, said reverse primer terminating at its 3?-end in a nucleotide sequence of nucleic acid sequence segment K3; treating the linear double-stranded DNA molecules contained in the PCR product obtained in the previous step with an exonuclease to obtain a single-stranded overhang at the first end of the DNA and a single-stranded overhang comprising nucleic acid segments K2 and K3 at the second end of the DNA; and annealing the product of the previous step to a linearized double-stranded acceptor nucleic acid having at a first end thereof a single-stranded overhang comp
    Type: Application
    Filed: October 8, 2009
    Publication date: October 27, 2011
    Applicant: ICON GENETICS GmbH
    Inventors: Sylvestre Marillonnet, Stefan Werner, Carola Engler, Romy Kandzia, Frank Thieme, Ernst Weber
  • Publication number: 20110190365
    Abstract: The present invention relates to novel 4-phenyl-1H-pyrazoles and their use as insecticides and/or parasiticides and also to processes for their preparation and to compositions comprising such phenylpyrazoles.
    Type: Application
    Filed: August 1, 2009
    Publication date: August 4, 2011
    Applicant: Bayer Crop Science AG
    Inventors: Stefan Werner, Klaus-Helmut Müller, Hans-Georg Schwarz, Tetsuya Murata, Klaus Raming, Ulrich Görgens, Angela Becker, Eva-Maria Franken, Elichi Shimojo, Katsuhiko Shibuya, Ulrich Ebbinghaus-Kintscher, Teruyuki Chihara, Masashi Ataka, Olga Malsam, Arnd Voerste
  • Publication number: 20110124647
    Abstract: The present invention relates to novel derivatives of substituted benzylamines, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in particular insects.
    Type: Application
    Filed: March 28, 2008
    Publication date: May 26, 2011
    Applicant: Bayer CropScience AG
    Inventors: Christian Arnold, Ulrich Görgens, Hans-Georg Schwarz, Graham Holmwood, Roland Andree, Olga Malsam, Otto Schallner, Eva-Marie Franken, Horst-Peter Antonicek, Stefan Werner
  • Publication number: 20110124660
    Abstract: The present invention relates to diazinylpyrazolyl compounds of the formula (I) where R1 to R3, X and Q are as defined in the description, and to their use in crop protection, in particular as insecticides, and also to processes for their preparation and compositions comprising such diazinylpyrazolylimines and -imidoates.
    Type: Application
    Filed: November 11, 2010
    Publication date: May 26, 2011
    Applicant: Bayer CropScience AG
    Inventors: Hans-Georg Schwarz, Robert Velten, Achim Hense, Simon Maechling, Stefan Werner, Bernd Alig, Eva-Maria Franken, Arnd Voerste, Ulrich Görgens
  • Publication number: 20110021539
    Abstract: Pyrazin-2-ylpyrazoles are described, as is the use thereof as insecticides and/or parasiticides. Additionally described are processes for preparation thereof, and compositions which comprise such pyrazin-2-ylpyrazoles.
    Type: Application
    Filed: May 28, 2010
    Publication date: January 27, 2011
    Applicant: Bayer CropScience AG
    Inventors: Hans-Georg Schwarz, Jens Frackenpohl, Achim Hense, Simon Maechling, Stefan Schnatterer, Robert Velten, Stefan Werner, Angela Becker, Olga Malsam, Eva-Maria Franken, Arnd Voerste, Ulrich Görgens, Peter Lümmen
  • Publication number: 20100144672
    Abstract: The present invention relates to pyrimidinylpyrazoles and their use as insecticides, and also to processes for their preparation and to compositions comprising such arylpyrazoles.
    Type: Application
    Filed: December 12, 2007
    Publication date: June 10, 2010
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Jens Frackenpohl, Olaf Gebauer, Silvia Cerezo-Galvez, Mazen Es-Sayed, Ulrich Görgens, Eva-Maria Franken, Olga Malsam, Stefan Schnatterer, Christian Arnold, Peter Lümmen, Hans-Georg Schwarz, Achim Hense, Stefan Werner
  • Publication number: 20100138948
    Abstract: A process of producing a transgenic multi-cellular plants or parts thereof expressing a trait of interest, said trait having a controlled distribution of said trait to progeny, wherein said process comprises (i) producing a first plant or a cell thereof having in a first locus of a nuclear chromosome a first heterologous nucleotide sequence comprising a first fragment of a nucleotide sequence encoding said trait of interest, (ii) producing a second plant or a cell thereof having in a second locus of a nuclear chromosome homologous to said nuclear chromosome of step (i), a second heterologous nucleotide sequence comprising a second fragment of the nucleotide sequence encoding said trait of interest, and (iii) hybridising said first and said second plant or cells thereof to generate progeny exhibiting said functional trait of interest due to binding between a protein or polypeptide encoded by said first heterologous nucleotide sequence and a protein or polypeptide encoded by said second heterologous nucleotide
    Type: Application
    Filed: November 19, 2009
    Publication date: June 3, 2010
    Applicant: Icon Genetics GmbH
    Inventors: Stefan Werner, Anatoly Giritch, Serik Eliby, Sylvestre Marillonnet, Victor Klimyuk, Yuri Gleba
  • Patent number: 7718848
    Abstract: A process of the production of a product of interest in an F1 seed obtained by a hybridization of a first and a second transgenic parental plant, said hybridization generating a genetic endowment in said F1 seed for said production by combining in said F1 seed first and second partial genetic endowments of said first and second transgenic parental plants, followed by isolating said product of interest from said F1 seed or a seedling thereof.
    Type: Grant
    Filed: June 4, 2004
    Date of Patent: May 18, 2010
    Assignee: Icon Genetics GmbH
    Inventors: Stefan Werner, Romy Kandzia, Serik Eliby, Sylvestre Marillonnet, Victor Klimyuk, Yuri Gleba
  • Patent number: 7674089
    Abstract: A device which is used to guide at least two flow media having different pressures with a shaft or similar force-transmitting element, and a pressure insulating element such as a housing surrounding the shaft or similar. Areas arranged next to each other in the direction of the axis are determined between the force-transmitting element and the pressure-insulating element by sealing elements; at least one of the preferably magnetofluidic sealing elements is leakage-free, and two areas for fluids (A, B) having different pressures flank an area for an auxiliary liquid (H), whereby said area is subdivided by a device into two partial areas for two different pressure areas. A conveying medium is allocated to the area at high pressure and ambient air is allocated to the area at low pressure. The auxiliary liquid (H) is a carrier oil of the magnetofluid, optionally a silicon oil, allocated to the sealing element.
    Type: Grant
    Filed: October 6, 2004
    Date of Patent: March 9, 2010
    Assignee: Allweiler AG
    Inventor: Stefan Werner
  • Patent number: 7642404
    Abstract: A process of producing a transgenic multi-cellular plants or parts thereof expressing a trait of interest, said trait having a controlled distribution of said trait to progeny, wherein said process comprises (i) producing a first plant or a cell thereof having in a first locus of a nuclear chromosome a first heterologous nucleotide sequence comprising a first fragment of a nucleotide sequence encoding said trait of interest, (ii) producing a second plant or a cell thereof having in a second locus of a nuclear chromosome homologous to said nuclear chromosome of step (i), a second heterologous nucleotide sequence comprising a second fragment of the nucleotide sequence encoding said trait of interest, and (iii) hybridising said first and said second plant or cells thereof to generate progeny exhibiting said functional trait of interest due to binding between a protein or polypeptide encoded by said first heterologous nucleotide sequence and a protein or polypeptide encoded by said second heterologous nucleotide
    Type: Grant
    Filed: March 21, 2003
    Date of Patent: January 5, 2010
    Assignee: ICON Genetics GmbH
    Inventors: Stefan Werner, Anatoly Giritch, Serik Eliby, Sylvestre Marillonnet, Victor Klimyuk, Yuri Gleba
  • Publication number: 20090324421
    Abstract: A turbine blade is provided. The turbine blade includes a support structure and a shell which surrounds the support structure and which is connected to and at a distance from the support structure by at least one spacing element. For example the spacing element can be a solder globule in order to form a space through which a cooling medium can flow between the support structure and the shell. A method for the production of a turbine blade having a support structure and a shell which surrounds the support structure and which is connected to and at a distance from the support structure is also provided. The shell is soldered to the support structure in at least at one place of the support structure in order to connect the shell to and at a distance from the support structure.
    Type: Application
    Filed: January 14, 2008
    Publication date: December 31, 2009
    Inventors: Fathi Ahmad, Scarlett Fajardo-Reina, Markus Gill, Stefan Werner Kiliani, Silvio-Ulrich Martin, Ralf Müsgen, Oliver Schneider
  • Patent number: 7632981
    Abstract: A process of producing a transgenic multi-cellular plant or animal organism expressing a trait of interest and having a controlled distribution of said trait to progeny, wherein said process comprises hybridising a first multi-cellular organism or a cell thereof having a first heterologous DNA sequence comprising a first fragment of a nucleotide sequence encoding said trait of interest and a second multi-cellular organism or a cell thereof having a second heterologous DNA sequence comprising a second fragment of the nucleotide sequence encoding said trait of interest, whereby said first and said second heterologous sequences are designed such that said trait of interest arises due to RNA trans-splicing after said hybridation.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: December 15, 2009
    Assignee: Icon Genetics GmbH
    Inventors: Stefan Werner, Sylvestre Marillonnet, Victor Klimyuk, Yuri Gleba
  • Publication number: 20090282579
    Abstract: A process of producing one or more than one protein of interest, comprising: (a) providing a plant or plant cells comprising a first heterologous nucleotide sequence comprising a nucleotide sequence encoding an RNA replicon, and a first inducible promoter operably linked to said nucleotide sequence encoding said RNA replicon; said RNA replicon not encoding a protein providing for cell-to-cell movement of said RNA replicon in said plant; said RNA replicon encoding a polymerase and said one or more than one protein of interest, said polymerase being adapted for replicating said RNA replicon; and (b) inducing, in said plant or plant cells of step (a), said inducible promoter, thereby producing said one or more than one protein of interest in said plant or plant cells.
    Type: Application
    Filed: May 25, 2007
    Publication date: November 12, 2009
    Applicant: Icon Genetics GmbH
    Inventors: Stefan Werner, Sylvestre Marillonnet, Victor Klimyuk, Yuri Gleba
  • Publication number: 20090062514
    Abstract: A process of purifying a protein of interest using viral particles or virus-like particles comprising a plurality of fusion protein molecules, said fusion protein comprising the following fusion protein domains: (i) a plant viral coat protein, (ii) a recombinant protein, and (iii) optionally a peptide linker linking said plant viral coat protein and said recombinant protein, wherein formation of said viral particle does not require free viral coat protein.
    Type: Application
    Filed: September 15, 2006
    Publication date: March 5, 2009
    Applicant: Icon Genetics GmbH
    Inventors: Stefan Werner, Sylvestre Marillonnet, Victor Klimyuk, Yuri Gleba
  • Publication number: 20080083296
    Abstract: A shifting arm for transmitting shifting movements is a formed part which is formed without cutting from a thin sheet. It includes a mouth recess in from an edge of the sheet, and stop faces are formed along the edges of the recess and out of the plane of the sheet.
    Type: Application
    Filed: December 5, 2007
    Publication date: April 10, 2008
    Applicant: SCHAEFFLER KG
    Inventors: Stephan SEUFERLING, Horst DOPPLING, Stefan WERNER, Rainer SCHUBEL