Abstract: A seawater cooling system adapted to mitigate salt crystallization in a seawater cooling loop. The system may include a pump operatively connected to the cooling loop and configured to pump seawater through the cooling loop, a temperature sensor operatively connected to the cooling loop and configured to monitor a temperature of the seawater in the cooling loop, and a controller operatively connected to the temperature sensor and to the pump, the controller configured to issue a warning and to increase a speed of the pump if it is determined that the monitored temperature of the seawater exceeds a predetermined threshold temperature.

Abstract: In a device for producing and/or processing a workpiece, in particular circuit boards, in a work station, in particular for printing a corresponding blank or for checking finished circuit boards, at least one mark is provided on the workpiece. In this arrangement, at least one reference, which can be brought into alignment with the mark, is provided in the work station.

Abstract: Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease.

Abstract: Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease.

Abstract: Disclosed herein are systems and methods for embedding database procedures in data-driven software applications written in a language different from the database-procedure language. For example, in some embodiments, the hosting application may be written in ABAP whereas the database procedure may be written in SQLScript. In various embodiments, the database procedures are encapsulated in specially marked methods of the host application, which, when called at runtime, cause the database procedures to be created in a database catalog and executed on a database server.

Abstract: A sea water cooling system including a first fluid cooling loop coupled to a first side of a heat exchanger and to a thermal load, a second fluid cooling loop coupled to a second side of the heat exchanger and including a pump for circulating fluid through the second fluid cooling loop, and a controller operatively connected to the pump, wherein the controller is configured to monitor an actual temperature in the first fluid cooling loop and to adjust a speed of the pump based on the monitored temperature to achieve a predetermined temperature in the first fluid cooling loop. The system may be selectively operable in one of a plurality of operating modes, wherein in a first operating mode the pump operates based entirely on cooling demands of the thermal load, and in a second operating mode the pump operates to maintain a fluid pressure above a predefined pressure.

Abstract: A new, reliable, easily scalable and reproducible method for the production of recombinant butyrylcholinesterase (rBuChE) is provided. Through the utilization of a plant transfection procedure, various plant strains have been shown to generate effective and scalable amounts of rBuChE under acceptable manufacturing processes to permit reliable levels of such enzymes for desired nerve agent protection requirements (including tetrameric products). As well, such methods in engineered plant lines have shown suitable production of these enzymes in tetramer form with glycan formation and sialylation (for terminal groups) to allow for optimal potency against organophosphorus agent exposure as well as proper immunogenic response within the plant sources. The overall production method, including the transfection and production within mammalian cells, as well as the process steps involved for such a reliable sourcing platform from plants is thus encompassed within the invention.

Abstract: A sea water cooling system including a first fluid cooling loop coupled to a first side of a heat exchanger and to a thermal load, a second fluid cooling loop coupled to a second side of the heat exchanger and including a pump for circulating fluid through the second fluid cooling loop, and a controller operatively connected to the pump, wherein the controller is configured to monitor an actual temperature in the first fluid cooling loop and to adjust a speed of the pump based on the monitored temperature to achieve a predetermined temperature in the first fluid cooling loop. The system may be selectively operable in one of a plurality of operating modes, wherein in a first operating mode the pump operates based entirely on cooling demands of the thermal load, and in a second operating mode the pump operates to maintain a fluid pressure above a predefined pressure.

Abstract: A modular rotor assembly for a screw pump including a power rotor and an idler rotor having respective first ends adapted to be disposed in a suction side of the screw pump and respective second ends adapted to be disposed in a discharge side of the screw pump, the power rotor including a balance piston adapted to be disposed within a pump housing of the screw pump with a radial clearance between an entire circumference of the balance piston and the pump housing is in a range between 1 micron and 200 microns, wherein the power rotor is provided with a tapered bearing surface configured to define a wedge-shaped, radial gap axially intermediate the power rotor and the idler rotor.

Abstract: A sea water cooling system including a first fluid cooling loop coupled to a first side of a heat exchanger and to a thermal load, a second fluid cooling loop coupled to a second side of the heat exchanger and including a pump for circulating fluid through the second fluid cooling loop, and a controller operatively connected to the pump, wherein the controller is configured to monitor an actual temperature in the first fluid cooling loop and to adjust a speed of the pump based on the monitored temperature to achieve a predetermined temperature in the first fluid cooling loop. The system may be selectively operable in one of a plurality of operating modes accordance, wherein in a first operating mode the pump is operated based entirely on cooling demands of the thermal load, and in a second operating mode the pump is operated to maintain a fluid pressure above a predefined pressure.

Abstract: Disclosed herein are systems and methods facilitating extensions to software applications that access a database, and in particular to applications with embedded database procedures. In various embodiments, an extension anchor embedded in the application as well as one or more extensions implemented as database procedures are encapsulated in specially marked database-procedure methods.

Abstract: An intelligent sea water cooling system including a first fluid cooling loop coupled to a first side of a heat exchanger and to a thermal load, a second fluid cooling loop coupled to a second side of the heat exchanger, a pump for circulating fluid through the second fluid cooling loop, and a controller connected to the pump. The controller may monitor a temperature in the first fluid cooling loop and may adjust a speed of the pump to keep the temperature within a preferred operating range. If the speed of the pump is reduced to a predefined minimum pressure pump speed, the controller may start a timer t1 having a predefined duration. If the timer t1 expires and the temperature has not increased relative to when the timer t1 was started, the controller may reduce the speed of the pump below the minimum pressure pump speed.

Abstract: System for producing a nucleic acid construct of interest, said system comprising: a set of n entry DNAs numbered 1 to n, n being an integer of at least 2, each of said n entry DNAs comprising in this order: (i) a type IIs restriction endonuclease recognition site followed by the cleavage site thereof; (ii) a sequence portion linking the cleavage site of said recognition site of item (i) with the cleavage site of the recognition site of the following item (iii), and (iii) a cleavage site of a further type IIs restriction endonuclease recognition site followed by the recognition site of said cleavage site; the cleavage sites of the type IIs restriction endonuclease recognition sites of item (iii) of entry DNAs 1 to n?1 are complementary to the cleavage sites of the type IIs restriction endonuclease recognition sites of item (i) of entry DNAs 2 to n, respectively; the cleavage site of the type IIs restriction endonuclease recognition site of item (iii) of entry DNA n is complementary to the cleavage site of

Abstract: A rotor nozzle for a high-pressure cleaning apparatus is provided, with a housing having an inlet opening tangentially into the housing and an outlet arranged on an end wall and on which is arranged a pan-shaped, centrally broken recess. A nozzle body arranged in the housing, having a through channel, and supported with a spherical end in the pan-shaped recess has a longitudinal axis tilted toward the longitudinal axis of the housing. The nozzle body is brought into a revolving movement by liquid flowing through the housing and supported on a support surface, of which flow resistance elements, each having one baffle surface, are arranged downstream of on the wall of the housing. A guiding surface is arranged upstream of each baffle surface and is continuously adjoined by the baffle surface, wherein the guiding surface is aligned obliquely to a radial plane of the housing.

Abstract: In a device for producing and/or processing a workpiece, in particular circuit boards, in a work station, in particular for printing a corresponding blank or for checking finished circuit boards, at least one mark is provided on the workpiece. In this arrangement, at least one reference, which can be brought into alignment with the mark, is provided in the work station.

Abstract: A new, reliable, easily scalable and reproducible method for the production of recombinant butyrylcholinesterase (rBuChE) is provided. Through the utilization of a plant transfection procedure, various plant strains have been shown to generate effective and scalable amounts of rBuChE under acceptable manufacturing processes to permit reliable levels of such enzymes for desired nerve agent protection requirements (including tetrameric products). As well, such methods in engineered plant lines have shown suitable production of these enzymes in tetramer form with glycan formation and sialylation (for terminal groups) to allow for optimal potency against organophosphorus agent exposure as well as proper immunogenic response within the plant sources. The overall production method, including the transfection and production within mammalian cells, as well as the process steps involved for such a reliable sourcing platform from plants is thus encompassed within the invention.

Abstract: An operational control device is disclosed for a positive-displacement pump having a motor, means for actuating the motor, state sensor means for detecting an actual operating parameter (e.g., pressure) of the pump, and operating mode means for controlling an operating mode of the pump. A first actuating mode of the operating mode means is set by the actuating means below a first operating-parameter threshold value (P1). This mode brings about a constantly rising pump pressure in the direction of an operating-parameter setpoint value (Pset) in a variable manner, which is dependent on a detected change in the operating parameter over a predefined time interval. A second actuating mode is set as normal operation to the operating-parameter setpoint value by the actuating means above the first operating-parameter threshold value. P1 is fixed or is calculated as a fraction of the operating-parameter setpoint value and/or a pump parameter correlated therewith.

Abstract: An intelligent sea water cooling system including a first fluid cooling loop coupled to a heat exchanger, a second fluid cooling loop coupled to the heat exchanger and including a fluid pump for circulating fluid through the second fluid cooling loop, and a controller operatively connected to the fluid pump. The controller may be configured to monitor an actual temperature in the first fluid cooling loop and to adjust a speed of the fluid pump based on the monitored temperature in order to achieve a desired temperature in the first fluid cooling loop.

Abstract: Disclosed herein are systems and methods for the hot deployment of database procedures embedded in a host software application. In various example embodiments, the database procedures are encapsulated in specially marked methods of the host application, which, when called at runtime, cause the database procedures, and associated procedure stubs through which the database procedures are called, to be created in a database catalog and executed on the database server. When an embedded database procedure is modified in an application by one user during execution of that application by a second user, compilation of the modified database procedure may result in deletion of the original database procedure and/or associated procedure stub from the database, avoiding inconsistencies between database procedure versions during application execution by the second user.

Abstract: A seawater cooling system adapted to mitigate salt crystallization in a seawater cooling loop. The system may include a pump operatively connected to the cooling loop and configured to pump seawater through the cooling loop, a temperature sensor operatively connected to the cooling loop and configured to monitor a temperature of the seawater in the cooling loop, and a controller operatively connected to the temperature sensor and to the pump, the controller configured to issue a warning and to increase a speed of the pump if it is determined that the monitored temperature of the seawater exceeds a predetermined threshold temperature.