Abstract: Provided herein are screening methods and systems for the identification and evaluation of candidate GABAergic modulators. These candidate agents or compounds are useful for treating or preventing CNS-related disorders.

Abstract: A fluid tip for use with a spray gun. The fluid tip comprises an air cap and a paint nozzle. The air cap comprises an inner surface 206 and the paint nozzle comprises an outer surface 208. The inner and outer surfaces define sides of an air channel 203. The inner and outer surfaces are defined by contours, each contour terminating to form an air channel outlet 207 for discharging an air jet proximal a paint nozzle outlet of the paint nozzle. The contours are configured to provide a velocity profile 400 across the air channel outlet 207 of an air flow 401 through the air channel 203 in which velocities of air radially closer to the paint nozzle outlet are substantially higher than velocities radially further from the paint nozzle outlet.

Abstract: Methods, systems, apparatus, and computer program products related to a distributed ledger platform/system for managing large capital projects are provided. In an example embodiment, the distributed ledger platform/system includes a plurality of nodes, wherein each node is in data communication with the other nodes; a ledger stored in each node; and a transaction verification to verify the at least one transaction information/data. The ledger contains transaction information related to at least one of the following: vendor payments, intellectual property licensing, construction certifications, equipment inspections, vendor qualification, vendor selection criteria, document access, and regulatory compliance.

Abstract: A fluid tip for use with a spray gun. The fluid tip comprises an air cap and a paint nozzle. The air cap comprises an inner surface 206 and the paint nozzle comprises an outer surface 208. The inner and outer surfaces define sides of an air channel 203. The inner and outer surfaces are defined by contours, each contour terminating to form an air channel outlet 207 for discharging an air jet proximal a paint nozzle outlet of the paint nozzle. The contours are configured to provide a velocity profile 400 across the air channel outlet 207 of an air flow 401 through the air channel 203 in which velocities of air radially closer to the paint nozzle outlet are substantially higher than velocities radially further from the paint nozzle outlet.

Abstract: An imaging assembly for an intraluminal imaging device is provided. In one embodiment, the imaging assembly includes an imaging array positioned at a distal portion of the intraluminal imaging device. The imaging array may have a plurality of imaging elements arranged into subarrays. The imaging assembly also may include a micro-beam-former integrated circuit (IC) coupled to the imaging array at the distal portion of the intraluminal imaging device. The micro-beam-former IC includes a plurality of microchannels that may separately beam-form signals received from imaging elements of at least two subarrays. The imaging assembly further includes two or more signal lines that may couple to the micro beam-former IC. Each signal line may correspond to a specific subarray and may receive the beam-formed signals specific to corresponding subarray.

Abstract: A leadscrew assembly includes a screw shaft along which is formed a first helical groove and a primary nut along which is form a second helical groove. The first helical groove and the second helical groove cooperate to define a track. The assembly also includes a secondary nut along which is formed a third helical groove. The first helical groove and the third helical groove cooperate to define a track with a nominal running clearance. A preload X is provided wherein when a load applied to the screw exceeds the predetermined preload, the secondary nut engages with the track such that load of the screw above preload X is transferred through the secondary nut and thus protecting the primary nut.

Abstract: An imaging assembly for an intraluminal imaging device is provided. In one embodiment, the imaging assembly includes an imaging array positioned at a distal portion of the intraluminal imaging device. The imaging array may have a plurality of imaging elements arranged into subarrays. The imaging assembly also may include a micro-beam-former integrated circuit (IC) coupled to the imaging array at the distal portion of the intraluminal imaging device. The micro-beam-former IC includes a plurality of microchannels that may separately beam-form signals received from imaging elements of at least two subarrays. The imaging assembly further includes two or more signal lines that may couple to the micro beam-former IC. Each signal line may correspond to a specific subarray and may receive the beam-formed signals specific to corresponding subarray.

Abstract: A skew sensing apparatus for detecting skew in at least one, or a plurality of control surfaces of a vehicle. The apparatus includes a tension cord which is held under tension between a) a first spring associated with a sensor and a sensor target and b) an opposing second spring. During normal operation, the apparatus is configured to maintain said sensor target in a first position relative to said sensor, thereby indicating said normal operation. During an abnormal operation, the apparatus is configured to shunt said tension cord such that said sensor target is translated to a second position, relative to said sensor thereby indicating said abnormal status.

Abstract: A linear actuator includes a screw shaft comprising a screw thread and having a longitudinal axis A, a nut movable along the screw shaft from a retracted position to an extended position, and a plurality of rollers movable with the nut. Each roller includes a cylindrical surface configured to roll along one or more flanks of the screw thread, such that rotation of the screw shaft causes the rollers to roll along the flank(s) so that the nut translates in an axial direction along the screw shaft. The screw thread has a variable lead angle. The actuator can be part of a power door opening system of an aircraft.

Abstract: A leadscrew assembly includes a screw shaft along which is formed a first helical groove and a primary nut along which is form a second helical groove. The first helical groove and the second helical groove cooperate to define a track. The assembly also includes a secondary nut along which is formed a third helical groove. The first helical groove and the third helical groove cooperate to define a track with a nominal running clearance. A preload X is provided wherein when a load applied to the screw exceeds the predetermined preload, the secondary nut engages with the track such that load of the screw above preload X is transferred through the secondary nut and thus protecting the primary nut.

Abstract: An imaging catheter assembly is provided. The imaging catheter assembly includes an interposer including a multi-layered substrate structure, wherein the multi-layered substrate structure includes a first plurality of conductive contact pads coupled to a second plurality of conductive contact pads via a plurality of conductive lines; an imaging component coupled to the interposer via the first plurality of conductive contact pads; and an electrical cable coupled to the interposer via the second plurality of conductive contact pads and in communication with the imaging component.

Abstract: An imaging catheter assembly is provided. The imaging catheter assembly includes an interposer including a multi-layered substrate structure, wherein the multi-layered substrate structure includes a first plurality of conductive contact pads coupled to a second plurality of conductive contact pads via a plurality of conductive lines; an imaging component coupled to the interposer via the first plurality of conductive contact pads; and an electrical cable coupled to the interposer via the second plurality of conductive contact pads and in communication with the imaging component.

Abstract: A system (10) for converting power comprising a plurality of modules (14) connected in series and having each at least one DC power source. Storage devices (18) are provided with each module (14) to store power from the power source and voltage control circuitry (19) in each module (14) connects the storage device between a maximum module voltage, a minimum module voltage to create a stepwise approximation of a mains signal. A compensator unit (20) is provided in series with the modules (14) including a storage device charged by the power sources. While each of the modules (14) is supplying either its maximum or minimum voltage to the system a control unit ramps up or down the voltage between the input and output of the compensator unit (20) to follow the desired AC signal.

Abstract: A linear actuator includes: a screw shaft that has a screw thread and a longitudinal axis A and a nut movable along the screw shaft from a retracted position to an extended position. The actuator also includes a plurality of rollers movable with the nut, each of which includes a cylindrical surface configured to roll along one or more flanks of the screw thread, such that rotation of the screw shaft causes the rollers to roll along the flank(s) so that the nut translates in an axial direction along the screw shaft. The screw thread includes one or more detents (e.g., grooves) configured to lock the nut in one or more axial positions.

Abstract: A linear actuator includes a screw shaft comprising a screw thread and having a longitudinal axis A, a nut movable along the screw shaft from a retracted position to an extended position, and a plurality of rollers movable with the nut. Each roller includes a cylindrical surface configured to roll along one or more flanks of the screw thread, such that rotation of the screw shaft causes the rollers to roll along the flank(s) so that the nut translates in an axial direction along the screw shaft. The screw thread has a variable lead angle. The actuator can be part of a power door opening system of an aircraft.

Abstract: A ballscrew assembly comprises a ballnut having a first helical groove and a ballscrew comprising a second helical groove opposed to the first helical groove so as to form a helical raceway. A plurality of balls is disposed in the helical raceway. A first seal is disposed at a first axial end of the ballnut to seal between the ballscrew and the ballnut. A second seal is provided for selectively sealing between the ballscrew and a second axial end of the ballnut, the second seal comprising a ballscrew seal mounted for axial movement with the ballscrew, and configured to make sealing engagement with the ballnut when the ballscrew is in a first axial position relative to the ballnut to form a chamber between the first and second seals, but not to make sealing engagement with the ballnut when the ballscrew assembly is in a second axial position relative thereto.

Abstract: A stationary exercise device with a driving assembly with a driving wheel rotating around a driving axle, a first and a second crank each connected to the driving wheel and two pedals, each connected to one of the cranks, a flywheel connected to the driving assembly by at least one gear mechanism, a brake assembly for applying a braking force to the flywheel, at least one measuring device for measuring the position of the first and second crank is provided. A detection device detects several time intervals, in each of which the flywheel is displaced a predetermined angle, the detection device further detects time differences between at least two of the time intervals. A control device determines, through dependence of the time differences between at least two of the time intervals, a torque at the driving wheel or a value dependent on the torque at the driving wheel.

Abstract: An epicyclic gear system having an epicyclic gear stage that includes a sun gear; a carrier, wherein the carrier comprises a plurality of planet gear axles; a plurality of planet gears, each planet gear being located on one of the planet gear axles; a ring gear. The stage also includes an output shaft, wherein the output shaft is connected to the carrier via a biasing mechanism positioned between the carrier and the output shaft, the biasing mechanism being configured to urge the carrier and the output shaft away from one another.

Abstract: Socially provided context-based messaging can include receiving a message content in a messaging system from a user, wherein the content includes objects; matching one or more objects of the message content to socially provided context information, which the socially provided context information is information relevant to an object obtained from a social network to which the user belongs; and displaying the socially provided context information with the message content for a recipient user to receive.

Abstract: A battery pack (10) comprising a plurality of boards (12) having contacts thereon for contacting terminal of a plurality of cells (14). A plurality of cell guides (18) are provided to each receive a plurality of the cells (18). A plurality of tensioning members (32) are provided wherein the tensioning members (32) pass through holes (20) in the boards (12) to engage with first and second endmost boards (12) in order to pull together the boards (12) and thereby engage the terminal of the cells (14) with the contacts on the boards (12).