Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.

Abstract: An epicyclic gear system having an epicyclic gear stage that includes a sun gear; a carrier, wherein the carrier comprises a plurality of planet gear axles; a plurality of planet gears, each planet gear being located on one of the planet gear axles; a ring gear. The stage also includes an output shaft, wherein the output shaft is connected to the carrier via a biasing mechanism positioned between the carrier and the output shaft, the biasing mechanism being configured to urge the carrier and the output shaft away from one another.

Abstract: The Cascaded Wind Turbine is a new concept of wind turbine design featuring multiple hubs in succession, each hub segment adds another tier that create a cascading blade configuration. Each blade set is connected to a separate rotor via a telescopic shaft.

Abstract: A support device provides elevation and support for a patient's foot, including ankle and heal, and limits lateral and medial rotation of the foot. This protects the knee from injury while healing. The device includes a generally flat main body, two spaced-apart lateral ridges, and a medial depression between the lateral ridges that provides a support surface on which the foot may be positioned. The lateral ridges can extend to a height above the support surface so that inner side surfaces of the lateral ridges are adjacent to a majority of a foot placed in the medial depression. The lateral ridges can terminate below a top of the foot to permit unrestricted ventilation and access to the foot. The lateral ridges can be spaced apart to facilitate placement of a foot onto and removal of the foot from the support surface without manual manipulation of the device.

Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.

Abstract: This invention is an auxiliary wind turbine featuring an aperture. In the preferred embodiment, the device itself is stationary, and mounts onto host objects that move such as wind turbine blades or vehicles. The Aperture Turbine may be oriented on the host object in a plurality of locations to enhance and maximize the intake of kinetic energy from the air moving around and through the Aperture Turbine when in use.

Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.

Abstract: A pill splitter that cuts circular pills into four quarters and prevents a user from having to split a single pill, rotate the split pill, and split the pill again in order to obtain a fourth of a dose. The four-way pill splitter is composed of an upper and lower housing. The upper housing contains blades that meet at a vertex and the lower housing contains an inverted cone-shaped insert that the blades from the upper housing fit into so that the vertexes of the blades and the inverted cone-shaped insert only touch in the closed position.

Abstract: A system and method for voice based social networking is disclosed. The system receives a voice message (and frequently an image) and ultimately delivers it to one or multiple users, placing it within an ongoing context of conversations. The voice and image may be recorded by various devices and the data transmitted in a variety of formats. An alternative implementation places some system functionality in a mobile device such as a smartphone or wearable device, with the remaining functionality resident in system servers attached to the internet. The system can apply rules to select and limit the voice data flowing to each user; rules prioritize the messages using context information such as user interest and user state. An image is fused to the voice message to form a comment. Additional image or voice annotation (or both) identifying the sender may be attached to the comment. Fused image(s) and voice annotation allow the user to quickly deduce the context of the comment.

Abstract: A brake device for braking rotation of an input shaft, comprises a selectively operable trigger brake comprising a preloaded torsion spring rotationally coupled to the input shaft but permitting a limited rotational movement between the trigger brake and the input shaft; and a roller jamming mechanism operable upon the relative rotation between the trigger brake and the input shaft exceeding a predetermined amount to stop rotation of the input shaft upon operation of the trigger brake.

Abstract: A hand truck that is reconfigurable between one or more hand truck operational configurations and a hand truck stowed configuration is provided. The hand truck comprises a primary wheel assembly that is aligned in a primary wheel operational configuration in the multiple hand truck operational configurations and a primary wheel stowed configuration in the hand truck stowed configuration.

Abstract: A re-circulating ballscrew assembly comprises a plurality of balls. A ballnut has a ballnut body with a radially inner surface and a helical ballnut groove formed on the radially inner surface. A ballscrew is disposed within the ballnut, the ballscrew comprising a radially outer surface and a ballscrew groove formed on the outer surface, the ballscrew groove cooperating with the ballnut groove to define a helical raceway for the plurality of balls, the helical raceway having a start point and an end point. The ballscrew assembly comprises a return track for the plurality of balls, the return track disposed radially outward of the radially inner surface of the ballnut and connecting the start point and the end point of the helical raceway. The return track extends at least in part through an annular lubricant bath.

Abstract: A ballscrew assembly comprises a ballnut having a first helical groove and a ballscrew comprising a second helical groove opposed to the first helical groove so as to form a helical raceway. A plurality of balls is disposed in the helical raceway. A first seal is disposed at a first axial end of the ballnut to seal between the ballscrew and the ballnut. A second seal is provided for selectively sealing between the ballscrew and a second axial end of the ballnut, the second seal comprising a ballscrew seal mounted for axial movement with the ballscrew, and configured to make sealing engagement with the ballnut when the ballscrew is in a first axial position relative to the ballnut to form a chamber between the first and second seals, but not to make sealing engagement with the ballnut when the ballscrew assembly is in a second axial position relative thereto.

Abstract: The present disclosure generally relates to work block encroachment warning systems for providing protection for rail workers working in a mobile or fixed work block. For example, a vehicle (V)-aware unit installed on a moving rail vehicle and a work block limit encroachment unit mounted on a railroad may wirelessly communicate with each other to determine a distance between them. When a vehicle is moving toward an occupied work block, the distance may be used to identify potential hazards.

Abstract: Electromechanical polymer (EMP) actuators are used to create haptic effects on a user interface deface, such as a keyboard. The keys of the keyboard may be embossed in a top layer to provide better key definition and to house the EMP actuator. Specifically, an EMP actuator is housed inside an embossed graphic layer that covers a key of the keyboard. Such a keyboard has a significant user interface value. For example, the embossed key provides the tactile effect of the presence of a key with edges, while allowing for the localized control of haptic vibrations. For such applications, an EMP transducer provides high strains, vibrations or both under control of an electric field. Furthermore, the EMP transducer can generate strong vibrations. When the frequency of the vibrations falls within the acoustic range, the EMP transducer can generate audible sound, thereby functioning as an audio speaker.

Abstract: An actuator operable to drive a thrust reverser in a gas turbine engine, wherein the thrust reverser comprises first and second translatable sleeves. The actuator comprises a first actuating member moveable so as to translate the first sleeve and a second actuating member moveable so as to translate the second sleeve. The actuator further comprises an interlock arrangement operable in a locked mode in which the first actuating member and second actuating member are locked so as to move together and in an unlocked mode in which at least one of the first actuating member and second actuator member is free to move independently of the other. Operation of the actuator to open or close the thrust reverser comprises a first mode wherein the interlock arrangement is in the locked mode and a second mode wherein the interlock arrangement is in the unlocked mode.

Abstract: Acoustic absorbers are formed for ultrasound transducers. The acoustic absorber provides desired attenuation, impedance, and thermal conductivity qualities based on a filler of rubber, ceramic, and metal particles. The relative amounts of the different fillers may be adjusted to tune the acoustic attenuation, thermal conductivity, and/or acoustic impedance.

Abstract: A cattle curtain utilizing a wicking action to displace concentrated insecticide to be wiped on animals as they pass through an animal pathway. The cattle curtain includes a reservoir body for holding the concentrated insecticide. A series of ropes is secured within the reservoir body, and the series of ropes is secured through fittings, whereby a metal pin is inserted through each rope. A valve disposed on top of the reservoir body to control flow of the concentrated insecticide into the series of ropes.

Abstract: The Cascaded Wind Turbine is a new concept of wind turbine design featuring multiple hubs in succession, each hub segment adds another tier that create a cascading blade configuration. Each blade set is connected to a separate rotor via a telescopic shaft.

Abstract: A rotary geared actuator, having an input gear, an output gear, a plurality of pinions) arranged in an annular configuration about a central axis (A), each pinion including an input gear element and an output gear element, the input gear element meshingly engaged with the input gear and the output gear element meshingly engaged with the output gear, a static ring gear arranged radially outwardly of the pinions and meshingly engaged with the input gear elements of the pinions, a first support ring gear arranged radially inwardly of the pinions and meshingly engaged with the input gear element, and a second support ring gear arranged radially inwardly of the pinions and meshingly engaged with the output gear element.