Patents by Inventor Stephen F. Badylak

Stephen F. Badylak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210137988
    Abstract: Methods are disclosed herein for increasing retinal ganglion cell survival in a subject in need thereof. These methods include selecting a subject in need of increased retinal ganglion cell survival and administering a therapeutically effective amount of isolated nanovesicles derived from an extracellular matrix (MBVs) to the subject.
    Type: Application
    Filed: May 4, 2018
    Publication date: May 13, 2021
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Stephen F. Badylak, Anne E. Faust, George S. Hussey, Yolandi Van der Merwe, Michael Brandt Steketee
  • Publication number: 20210093751
    Abstract: Methods and compositions for treating diseased or damaged tissue, such as Inflammatory Bowel Disease, e.g., Ulcerative Colitis, include tissue regeneration extracellular matrix hydrogel (ECMH) which stimulates stem cell migration to the damaged tissue. The tissue grafts can be extracellular matrix (ECM) material, such as tissue-specific extracellular matrix (TS-ECM). The methods can also include mucosal resection of the damaged or diseased tissue prior to placement of the graft.
    Type: Application
    Filed: July 7, 2020
    Publication date: April 1, 2021
    Applicants: Regentys Corporation, University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Marc Ramer, Stephen F. Badylak, Timothy Keane
  • Publication number: 20210008251
    Abstract: Provided herein are methods of fractionating extracellular matrix (ECM) materials, producing soluble and structural fractions having different immunological activities. Also provided are compositions and devices comprising the fractions. A method of immune modulation also is provided in which an amount of a soluble or structural ECM fraction prepared according to the methods provided herein is administered to a patient in an amount effective to modulate immune function, for example macrophage function.
    Type: Application
    Filed: April 9, 2020
    Publication date: January 14, 2021
    Inventors: Stephen F. Badylak, Peter F. Slivka
  • Publication number: 20200360565
    Abstract: Provided are methods for preparing non-gelling, solubilized extracellular matrix (ECM) materials useful as cell growth substrates. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the non-gelling, solubilized ECM composition is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient. In another embodiment, the composition is delivered intraarticularly, intrathecally, intraoccularly, intracranially, and into pleural space.
    Type: Application
    Filed: August 6, 2020
    Publication date: November 19, 2020
    Inventors: Stephen F. Badylak, Timothy Joseph Keane, JR., Lisa Jane White
  • Publication number: 20200261624
    Abstract: Articles and methods involving soft tissue repair implants comprising 2-hydroxybutyrate, 3-hydroxybutyrate, 4-hydroxybutyrate, and/or their conjugate acids are generally provided. The 2-hydroxybutyrate, 3-hydroxybutyrate, 4-hydroxybutyrate, and/or the conjugate acid(s) of 2-hydroxybutyrate, 3-hydroxybutyrate, and 4-hydroxybutyrate may be provided in a therapeutically-effective amount for reducing or preventing microbial infection.
    Type: Application
    Filed: October 24, 2018
    Publication date: August 20, 2020
    Applicants: Davol Inc., University of Pittsburgh - of the Commonwealth System of Higher Education
    Inventors: Peter Maughan Crapo, Devang Vijay Shah, Stephen F. Badylak, George Hussey, Catalina Pineda Molina, Brian Sicari
  • Patent number: 10736991
    Abstract: Provided are methods for preparing non-gelling, solubilized extracellular matrix (ECM) materials useful as cell growth substrates. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the non-gelling, solubilized ECM composition is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient. In another embodiment, the composition is delivered intraarticularly, intrathecally, intraoccularly, intracranially, and into pleural space.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: August 11, 2020
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, The University of Nottingham
    Inventors: Stephen F. Badylak, Timothy Joseph Keane, Jr., Lisa Jane White
  • Patent number: 10729813
    Abstract: Provided are methods for preparing gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth scaffolds. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the gelled, solubilized ECM is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: August 4, 2020
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Stephen F. Badylak, Donald Freytes
  • Publication number: 20200030493
    Abstract: Provided are methods for preparing gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth scaffolds. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the gelled, solubilized ECM is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient.
    Type: Application
    Filed: October 4, 2019
    Publication date: January 30, 2020
    Inventors: Stephen F. Badylak, Donald Freytes
  • Publication number: 20200030495
    Abstract: An injectable hydrogel composition that forms a porous gel rapidly after injection fro tissue engineering. The composition comprises a biodegradable, biocompatible, gelling polymer, that is optionally reverse-gelling; an Extra cellular matrix (ECM) material and a biocompatible porogen. Methods of making and using the composition are provided. A kit also is provided comprising the ingredients for making the hydrogel.
    Type: Application
    Filed: April 3, 2018
    Publication date: January 30, 2020
    Inventors: Stephen F. Badylak, Hong Jiang, Hideyoshi Sato, William R. Wagner, Yang Zhu
  • Publication number: 20190374683
    Abstract: Provided are methods for preparing sterilized, gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth substrates. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the gelled, solubilized ECM is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient.
    Type: Application
    Filed: January 3, 2019
    Publication date: December 12, 2019
    Inventors: Stephen F. Badylak, Christopher Lee Dearth, Timothy Joseph Keane, JR., Neill Jordon Turner
  • Publication number: 20190201581
    Abstract: Provided are methods for preparing gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth scaffolds. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the gelled, solubilized ECM is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient.
    Type: Application
    Filed: February 28, 2019
    Publication date: July 4, 2019
    Inventors: Stephen F. Badylak, Donald Freytes
  • Patent number: 10286119
    Abstract: Provided are surgical meshes embedded in a gelled, solubilized extracellular matrix (ECM) composition, methods of making the same, and methods of using the same to repair defects in a body. The surgical mesh may be a synthetic polymer such as polypropylene, and the ECM coating reduces the foreign body response and scarring at the site of implantation. The device is useful for repairing hernias, pelvic floor disorders, and in breast reconstructions.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: May 14, 2019
    Assignee: University of Pittsburgh—of the Commonwealth System of Higher Education
    Inventors: Stephen F. Badylak, Matthew T. Wolf
  • Publication number: 20190076574
    Abstract: Methods and compositions for treating diseased or damaged tissue, such as Inflammatory Bowel Disease, e.g., Ulcerative Colitis, include tissue regeneration using stem cells or tissue grafts which stimulate stem cell migration to the damaged tissue. The tissue grafts can be extracellular matrix (ECM) material, such as tissue-specific extracellular matrix (TS-ECM). The methods can also include mucosal resection of the damaged or diseased tissue prior to placement of the graft.
    Type: Application
    Filed: March 14, 2017
    Publication date: March 14, 2019
    Applicants: Regentys Corporation, University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Marc Ramer, Stephen F. Badylak, Timothy Keane
  • Publication number: 20190060521
    Abstract: Provided are methods for preparing non-gelling, solubilized extracellular matrix (ECM) materials useful as cell growth substrates. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the non-gelling, solubilized ECM composition is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient. In another embodiment, the composition is delivered intraarticularly, intrathecally, intraoccularly, intracranially, and into pleural space.
    Type: Application
    Filed: September 16, 2016
    Publication date: February 28, 2019
    Inventors: Stephen F. Badylak, Timothy Joseph Keane, Jr., Lisa Jane White
  • Patent number: 10213526
    Abstract: Provided are methods for preparing sterilized, gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth substrates. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the gelled, solubilized ECM is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: February 26, 2019
    Assignee: University of Pittsburgh-Of the Commonwealth System of Higher Education
    Inventors: Stephen F. Badylak, Christopher Lee Dearth, Timothy Joseph Keane, Jr., Neill Jordon Turner
  • Publication number: 20190038803
    Abstract: Provided are methods for preparing gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth scaffolds. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the gelled, solubilized ECM is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient.
    Type: Application
    Filed: June 4, 2018
    Publication date: February 7, 2019
    Inventors: Stephen F. Badylak, Donald Freytes
  • Publication number: 20190015552
    Abstract: Provided herein are methods of making an ECM gel from vascular tissue. Also provided herein are ECM compositions prepared from vascular tissue, and methods of use of those compositions, for example in treatment of aneurysms, and for vascularization or re-vascularization.
    Type: Application
    Filed: January 13, 2017
    Publication date: January 17, 2019
    Inventors: Stephen F. Badylak, George R. Fercana, JR., Thomas G. Gleason, Julie Anne Phillippi
  • Publication number: 20180243473
    Abstract: Provided herein is a bilayer medical device (e.g., “patch”) for use in treating ischemic cardiomyopathy as well as for treatment of other conditions. The medical device comprises a first, support layer and a second, ECM-containing layer over the first layer. Methods of making and using the device also are provided herein.
    Type: Application
    Filed: September 9, 2016
    Publication date: August 30, 2018
    Inventors: Stephen F. Badylak, Antonio D'Amore, Matthew T. Wolf, William R. Wagner
  • Publication number: 20180200405
    Abstract: Provided herein is a method for producing decellularized colonic extracellular matrix material. A decellularized colonic extracellular matrix material also is provided, along with uses for the material. Methods of use of the decellularized colonic extracellular matrix material also are provided, including methods of treating a defective, diseased, or damaged tissue or organ in a patient, and/or methods of treating esophageal disease, short bowel syndrome, ulcerative colitis, Crohn's disease, or mucositis in a patient.
    Type: Application
    Filed: July 8, 2016
    Publication date: July 19, 2018
    Inventors: Stephen F. Badylak, Timothy Joseph Keane, Jr.
  • Patent number: 10004827
    Abstract: Provided are methods for preparing gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth scaffolds. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the gelled, solubilized ECM is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient.
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: June 26, 2018
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Stephen F. Badylak, Donald Freytes