Patents by Inventor Stephen F. Badylak

Stephen F. Badylak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9861662
    Abstract: Methods of manufacturing a bone-derived extracellular matrix (bECM) product are provided. Also provided are bECM products and methods of using those products.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: January 9, 2018
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, The University of Nottingham
    Inventors: Stephen F. Badylak, Michael J. Sawkins, Kevin M. Shakesheff, Lisa J. White
  • Patent number: 9848987
    Abstract: Provided herein are compositions and medical devices, and in particular, biodegradable scaffolds capable of repairing and replacing cartilagenous meniscuses. Also provided herein are methods of using scaffolds for treating degenerative tissue disorders. In certain embodiments, such scaffolds can promote tissue regeneration of a temporal mandibular joint (TMJ) meniscus.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: December 26, 2017
    Assignee: University of Pittsburgh — Of the Commonwealth System of Higher Education
    Inventors: Stephen F. Badylak, Bryan N. Brown, William L. Chung
  • Patent number: 9814744
    Abstract: Provided herein are methods of making a cell growth scaffold from adipose tissue, cell growth scaffolds having low lipid content and methods of using the cell growth scaffold.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: November 14, 2017
    Assignee: University of Pittsburg—Of the Commonwealth System of Higher Education
    Inventors: Stephen F. Badylak, Bryan N. Brown, John M. Freund, J. Peter Rubin
  • Publication number: 20170173217
    Abstract: Provided are methods for preparing sterilized, gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth substrates. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the gelled, solubilized ECM is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient.
    Type: Application
    Filed: March 20, 2015
    Publication date: June 22, 2017
    Inventors: Stephen F. BADYLAK, Christopher Lee DEARTH, Timothy Joseph KEANE Jr., Neill Jordon TURNER
  • Publication number: 20170112964
    Abstract: Methods and compositions for treating diseased or damaged tissue, such as Inflammatory Bowel Disease, e.g., Ulcerative Colitis, include tissue regeneration using stem cells or tissue grafts which stimulate stem cell migration to the damaged tissue. The tissue grafts can be extracellular matrix (ECM) material, such as tissue-specific extracellular matrix (TS-ECM). The methods can also include mucosal resection of the damaged or diseased tissue prior to placement of the graft.
    Type: Application
    Filed: November 3, 2016
    Publication date: April 27, 2017
    Applicants: Asana Medical, Inc., University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Marc Ramer, Stephen F. Badylak, Timothy Keane
  • Publication number: 20170049932
    Abstract: Provided herein are methods of fractionating extracellular matrix (ECM) materials, producing soluble and structural fractions having different immunological activities. Also provided are compositions and devices comprising the fractions. A method of immune modulation also is provided in which an amount of a soluble or structural ECM fraction prepared according to the methods provided herein is administered to a patient in an amount effective to modulate immune function, for example macrophage function.
    Type: Application
    Filed: April 24, 2015
    Publication date: February 23, 2017
    Inventors: Stephen F. Badylak, Peter F. Slivka
  • Patent number: 9480776
    Abstract: Provided are medical devices for implantation in patients having suffered the loss of or damage to at least part of their esophagus. The medical device connects the esophagus or remaining part thereof with the stomach to form a gastro-esophageal junction that promotes healing and encourages new host tissue growth while distributing the load and decreasing tension at the anastomotic site. The medical device comprises extracellular matrix shaped into a conformation that more closely approximates the geometry of the native gastro-esophageal junction than does direct attachment of the stomach to the shortened esophagus. Molds useful in manufacturing the medical device and methods of use of the device are also described herein.
    Type: Grant
    Filed: December 9, 2014
    Date of Patent: November 1, 2016
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Stephen F. Badylak, Thomas W. Gilbert, Alejandro Nieponice
  • Patent number: 9421307
    Abstract: A biohybrid scaffold is provided that is useful in clinical applications for abdominal wall reconstruction, pelvic floor repair, breast reconstruction, as well as other soft tissue repairs. Methods of making and using the biohybrid scaffold are provided.
    Type: Grant
    Filed: August 17, 2011
    Date of Patent: August 23, 2016
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Nicholas J. Amoroso, Stephen F. Badylak, Yi Hong, Alexander Huber, Keisuke Takanari, William R. Wagner
  • Publication number: 20160143741
    Abstract: Provided herein are compositions and medical devices, and in particular, biodegradable scaffolds capable of repairing and replacing cartilagenous meniscuses. Also provided herein are methods of using scaffolds for treating degenerative tissue disorders. In certain embodiments, such scaffolds can promote tissue regeneration of a temporal mandibular joint (TMJ) meniscus.
    Type: Application
    Filed: January 28, 2016
    Publication date: May 26, 2016
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Stephen F. Badylak, Bryan N. Brown, William L. Chung
  • Patent number: 9340602
    Abstract: Chemoattractant polypeptide compounds for progenitor cells and compositions and drug products comprising the compounds are provided herein. Methods for attracting progenitor cells to a location in or on a patient also are provided along with methods of growing and repairing bone.
    Type: Grant
    Filed: April 9, 2014
    Date of Patent: May 17, 2016
    Assignee: University of Pittsburgh-Of the Commonwealth System of Higher Education
    Inventors: Vineet Agrawal, Stephen F. Badylak, Scott A. Johnson, Stephen Tottey
  • Patent number: 9314340
    Abstract: Provided herein are compositions and medical devices, and in particular, biodegradable scaffolds capable of repairing and replacing cartilagenous meniscuses. Also provided herein are methods of using scaffolds for treating degenerative tissue disorders. In certain embodiments, such scaffolds can promote tissue regeneration of a temporal mandibular joint (TMJ) meniscus.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: April 19, 2016
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Stephen F. Badylak, Bryan N. Brown, William L. Chung
  • Patent number: 9277999
    Abstract: Provided herein are compositions and medical devices, and in particular, biodegradable scaffolds capable of repairing and replacing cartilagenous meniscuses. Also provided herein are methods of using scaffolds for treating degenerative tissue disorders. In certain embodiments, such scaffolds can promote tissue regeneration of a temporal mandibular joint (TMJ) meniscus.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: March 8, 2016
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Stephen F. Badylak, Bryan N. Brown, William L. Chung
  • Publication number: 20160045552
    Abstract: Methods and compositions for treating diseased or damaged tissue, such as Inflammatory Bowel Disease, e.g., Ulcerative Colitis, include tissue regeneration using stem cells or tissue grafts which stimulate stem cell migration to the damaged tissue. The tissue grafts can be extracellular matrix (ECM) material, such as tissue-specific extracellular matrix (TS-ECM). The methods can also include mucosal resection of the damaged or diseased tissue prior to placement of the graft.
    Type: Application
    Filed: April 8, 2014
    Publication date: February 18, 2016
    Applicants: Asana Medical, Inc., University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Marc Ramer, Stephen F. Badylak, Timothy Keane
  • Publication number: 20150297798
    Abstract: Provided are surgical meshes embedded in a gelled, solubilized extracellular matrix (ECM) composition, methods of making the same, and methods of using the same to repair defects in a body. The surgical mesh may be a synthetic polymer such as polypropylene, and the ECM coating reduces the foreign body response and scarring at the site of implantation. The device is useful for repairing hernias, pelvic floor disorders, and in breast reconstructions.
    Type: Application
    Filed: January 23, 2015
    Publication date: October 22, 2015
    Inventors: Stephen F. Badylak, Matthew T. Wolf
  • Publication number: 20150182663
    Abstract: Provided are medical devices for implantation in patients having suffered the loss of or damage to at least part of their esophagus. The medical device connects the esophagus or remaining part thereof with the stomach to form a gastro-esophageal junction that promotes healing and encourages new host tissue growth while distributing the load and decreasing tension at the anastomotic site. The medical device comprises extracellular matrix shaped into a conformation that more closely approximates the geometry of the native gastro-esophageal junction than does direct attachment of the stomach to the shortened esophagus. Molds useful in manufacturing the medical device and methods of use of the device are also described herein.
    Type: Application
    Filed: December 9, 2014
    Publication date: July 2, 2015
    Inventors: Stephen F. Badylak, Thomas W. Gilbert, Alejandro Nieponice
  • Publication number: 20150010510
    Abstract: Methods of manufacturing a bone-derived extracellular matrix (bECM) product are provided. Also provided are bECM products and methods of using those products.
    Type: Application
    Filed: July 3, 2014
    Publication date: January 8, 2015
    Inventors: Stephen F. Badylak, Michael J. Sawkins, Kevin M. Shakesheff, Lisa J. White
  • Patent number: 8927003
    Abstract: Provided are medical devices for implantation in patients having suffered the loss of or damage to at least part of their esophagus. The medical device connects the esophagus or remaining part thereof with the stomach to form a gastro-esophageal junction that promotes healing and encourages new host tissue growth while distributing the load and decreasing tension at the anastomotic site. The medical device comprises extracellular matrix shaped into a conformation that more closely approximates the geometry of the native gastro-esophageal junction than does direct attachment of the stomach to the shortened esophagus. Molds useful in manufacturing the medical device and methods of use of the device are also described herein.
    Type: Grant
    Filed: May 16, 2011
    Date of Patent: January 6, 2015
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Stephen F. Badylak, Thomas W. Gilbert, Alejandro Nieponice
  • Publication number: 20140356331
    Abstract: Methods useful for preparing central nervous system (CNS) derived extracellular matrix (ECM) materials, including powders and gels are provided. Also provided are CNS ECM preparations prepared according to those methods, and methods of treating a patient or mammal with CNS injury.
    Type: Application
    Filed: July 6, 2012
    Publication date: December 4, 2014
    Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Stephen F. Badylak, Bryan N. Brown, Peter M. Crapo, Scott A. Johnson, Christopher J. Medberry
  • Publication number: 20140309739
    Abstract: Provided herein are compositions and medical devices, and in particular, biodegradable scaffolds capable of repairing and replacing cartilagenous meniscuses. Also provided herein are methods of using scaffolds for treating degenerative tissue disorders. In certain embodiments, such scaffolds can promote tissue regeneration of a temporal mandibular joint (TMJ) meniscus.
    Type: Application
    Filed: June 26, 2014
    Publication date: October 16, 2014
    Inventors: Stephen F. Badylak, Bryan N. Brown, William L. Chung
  • Publication number: 20140294918
    Abstract: Chemoattractant polypeptide compounds for progenitor cells and compositions and drug products comprising the compounds are provided herein. Methods for attracting progenitor cells to a location in or on a patient also are provided along with methods of growing and repairing bone.
    Type: Application
    Filed: April 9, 2014
    Publication date: October 2, 2014
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Vineet Agrawal, Stephen F. Badylak, Scott A. Johnson, Stephen Tottey