Abstract: The invention provides methods to modulate hypoxia-mediated tumor immunity by administration of an O2 carrier polypeptide (e.g., an H-NOX protein). The methods of the invention target both hypoxia inducible factor 1 alpha (HIF-1?) pathways and non-HIF-1? pathways of tumor immunity. Such methods are useful in the treatment of a wide variety of cancers and may be used alone or in combination with other anti-cancer therapies.

Abstract: A particle suppressor can be used in a particle receiver to reduce the particle loss rate. The receiver can include a rotating drum with an inliner. The particle suppressor can include a retaining surface. The retaining surface can be spaced away from and extend concentrically with the inline. A spacing gap between the inliner and the retaining surface can dampen the motion of bouncing particles. The spacing gap can be between 15 mm and 20 mm. In some embodiments, the particle suppressor can include a support ring with a plurality of suppressor segments disposed circumferentially around the support ring. The particle suppressor can include a plurality of suppressor segments coupled directly to the inliner. A heat shield can be coupled to the particle suppressor. A support bracket can suspend the particle suppressor within the receiver.

Abstract: Systems and methods for automated path-based recommendation for risk mitigation are provided. An entity assessment server, responsive to a request for a recommendation for modifying a current risk assessment score of an entity to a target risk assessment score, accesses an input attribute vector for the entity and clusters of entities defined by historical attribute vectors. The entity assessment server assigns the input attribute vector to a particular cluster and determines a requirement on movement from a first point to a second point in a multi-dimensional space based on the statistics computed from the particular cluster. The first point corresponds to the current risk assessment score and the second point corresponds to the target risk assessment score. The entity assessment server computes an attribute-change vector so that a path defined by the attribute-change vector complies with the requirement and generates the recommendation from the attribute-change vector.

Abstract: Microelectronic assemblies, related devices and methods, are disclosed herein. In some embodiments, a microelectronic assembly may include a package substrate, having a surface, including a first conductive pathway electrically coupled to a power source; a first microelectronic component, having an active side electrically coupled to the surface of the package substrate and an opposing back side, surrounded by an insulating material; a second microelectronic component, having an active side electrically coupled to the surface of the package substrate and an opposing back side, surrounded by the insulating material and including a through-substrate via (TSV) electrically coupled to the first conductive pathway; and a redistribution layer (RDL), on the insulating material, including a second conductive pathway electrically coupling the TSV, the second surface of the second microelectronic component, and the second surface of the first microelectronic component.

Abstract: The invention relates to a dispenser (1) for a cord, preferably for a cord for sealing a threaded pipework, comprising a hollow body (10) for receiving the cord, a cover part (30) being arranged on a top edge (13) of the hollow body (10) and having an opening (41) through which the thread can be removed from the hollow body (10), and a cap (60) which is connected to the cover part (30) so as to be pivotable about a pivot axis (40) and, in a closed position, covers the opening (41).

Abstract: Automated workpiece transfer systems and methods of implementing thereof are disclosed. The system includes an autonomous robot and a processor in communication with the robot. The autonomous robot includes a transfer component operable to transfer the workpieces to a picking area, one or more actuator components operable to increase a number of pickable workpieces transferred to the picking area according to a set of actuator operating commands; and an end-of-arm-tooling component operable to retrieve pickable workpieces from the picking area and to transfer the pickable workpieces to a receiving area. The processor is operable to apply a workpiece identification machine-learning model to an image to identify a reference workpiece type associated with the workpieces shown within the image; identify a set of reference operating commands associated with the reference workpiece type; and define the set of actuator operating commands based on the image and the set of reference operating commands.

Abstract: Delivery devices for delivering a cardiac prosthesis to a target site are disclosed. Such devices can be used with a feedback system including haptic elements incorporated into the delivery device for providing tactile and/or audio feedback regarding the loading and/or deployment of the prosthesis. Certain disclosed delivery devices include a handle including an actuator, a sheath interconnected to the handle for selectively sheathing the prosthesis. The feedback system can be provided within the handle and configured to provide one or more feedback indications relating to the position of the sheath with respect to the prosthesis during loading and/or deployment of the prosthesis.

Abstract: In an implanted medical device system, an internal controller, external power transmitter and methods for performing battery conditioning are disclosed. According to one aspect, an internal controller includes processing circuitry configured to cause conditioning of an internal battery of the internal controller responsive to a direction from an external power transmitter in radio communication with the internal controller.

Abstract: Environmentally-clean wildfire inhibitor liquid biochemical solutions produced from an aqueous mixture of alkali metal salt derived from a non-polymerized saturated carboxylic acid such as citric acid, and dissolved in water along with a dispersing and coalescing agent, realized as an ester of a non-polymerized saturated carboxylic acid, and dissolved in the water to provide a liquid fire inhibitor solution that can be sprayed on combustible surfaces to form thin alkali metal salt crystalline coatings on the combustible surfaces when and as water molecules in the liquid fire inhibitor evaporate to the environment during drying operations, to inhibit fire ignition, flame spread and smoke development.

Abstract: A classification model is generated based on historical exercise information. User exercise information is classified into an exercise category using the classification model. Recommendations based on the exercise category is identified. A customized exercise recommendation is determined from the identified recommendations based on a comparison of the user exercise information and expected progress data. This customized recommendation is provided to a user device for consumption.

Abstract: The present invention relates to naphthalene diimides, NDIs, and methods of synthesising them. The NDIs have DNA-quadruplex binding and stabilising activity, and potential in treatment of pancreatic, prostate, and other human cancers.

Abstract: Systems and methods for removing carbon from the pyrolysis reactor are disclosed herein. For example, a pyrolysis reactor according to the present technology can include a combustion component that is fluidly couplable to a combustion fuel supply, as well as a reaction chamber that is thermally coupled to an output of the combustion component. Further, the pyrolysis reactor can include a carbon removal component that is operably coupled to the reaction chamber. The carbon removal component can include an actuator, a rod coupled to the actuator, and a scraper head coupled to the rod and positioned within the reaction chamber. The actuator can drive movement of the rod within the reaction chamber, thereby driving movement of the scraper head. The scraper head can include a plurality of teeth that are positioned to scrape carbon deposits from an interior wall of the reaction chamber.

Abstract: The present invention relates to modified, live Porcine Reproductive and Respiratory Syndrome viruses. Viruses were genetically analyzed and selected based on phylogenetic grouping for modification by repeated passage in tissue culture. The modified, live viruses were assessed for the ability to provide protective immunity to heterologous viruses. The modified, live viruses are useful in vaccines, particularly in vaccines which can treat infection of swine by multiple heterologous viruses.

Abstract: This specification describes a two-wheeled vehicle that is electrically driven and steerable by operation of a rear wheel steering mechanism. The vehicle utilizes a direct drive motor to drive one wheel and may be operated in either direction as desired by a user.

Abstract: Robotic systems and associated methods are described herein. The robotic system may collect measurements from various sensors corresponding to motion of the robotic system, the surrounding environment of the robotic system, or both. The robotic system may generate measurement data based on the collected measurements. Measurements from a particular sensor may be processed in conjunction with different sensors of the robotic system, which may facilitate more accurate or more useful measurement data. The systems and methods of the present disclosure enable the detection, labeling, and locating of features in real time or near real time using the robotic system with little or no reliance on human interaction to detect and map the features. The disclosure provides enhanced accuracy and efficiency as it enhances the functionality and reduces the reliance on human detection of features.

Abstract: Environmentally-clean wildfire inhibitor liquid biochemical solutions produced from an aqueous mixture of alkali metal salt derived from a non-polymerized saturated carboxylic acid such as adipic acid, and dissolved in water along with a dispersing and coalescing agent, realized as an ester of a non-polymerized saturated carboxylic acid, and dissolved in the water to provide a liquid fire inhibitor solution that can be sprayed on combustible surfaces to form thin alkali metal salt crystalline coatings on the combustible surfaces when and as water molecules in the liquid fire inhibitor evaporate to the environment during drying operations, to inhibit fire ignition, flame spread and smoke development.

Abstract: Environmentally-clean wildfire inhibitor liquid biochemical solutions produced from an aqueous mixture of alkali metal salt derived from a non-polymerized saturated carboxylic acid such as malonic acid, and dissolved in water along with a dispersing and coalescing agent, realized as an ester of a non-polymerized saturated carboxylic acid, and dissolved in the water to provide a liquid fire inhibitor solution that can be sprayed on combustible surfaces to form thin alkali metal salt crystalline coatings on the combustible surfaces when and as water molecules in the liquid fire inhibitor evaporate to the environment during drying operations, to inhibit fire ignition, flame spread and smoke development.

Abstract: A scanning probe for a coordinate positioning apparatus, such as a machine tool, is described that includes a probe body connected to a stylus holder by a strain-sensing structure. The strain-sensing structure has an inner portion connected to an outer portion by a plurality of bendable members. A proximal end of each bendable member is attached to the inner portion and a distal end of each bendable member being attached to the outer portion. The inner and outer portions are centred on a central axis and the plurality of bendable members include at least one strain-sensing element. The proximal and distal ends of each bendable member are located at different angles about the central axis. Such an arrangement enables both scanning and touch trigger measurements to be acquired.

Abstract: An expandable liner hanger assembly may include a liner hanger body having a radially expandable tubular. The expandable liner hanger assembly may also include a groove formed in a radially outer surface of the liner hanger body that is configured to extend circumferentially about the liner hanger body. Additionally, the expandable liner hanger assembly may include at least one anchor key having a base portion disposed within the groove. Further, an engagement end of the at least one anchor key may extend radially outward from the groove. The engagement end is configured to engage a casing string in response to expansion of the liner hanger body to anchor into the casing string.

Abstract: Disclosed herein are codon-optimized nucleic acids encoding a reduced-size ATP7A protein. Also disclosed are vectors and recombinant viruses (such as recombinant adeno-associated viruses) including the codon-optimized nucleic acids encoding the reduced-size ATP7A protein and compositions including the disclosed vectors and viruses. Further disclosed herein are methods of treating copper transport disorders, for example by administering a disclosed nucleic acid, vector, or recombinant virus to a subject with a copper transport disorder, such as Menkes disease, occipital horn syndrome, or ATP7A-related distal motor neuropathy.