Abstract: The present invention provides formulations of (E)-6-(4-Phenylcyclohexyl)-5-(3-trifluoromethylbenzyl)-1H-pyrimidine-2,4-dione, and methods of making and using the same.

Abstract: Systems and methods are provided for feedback-driven provision of information in relation to a plurality of information resources.

Abstract: A user input may be received at a user device to begin a breathing sequence. First heart rate information may be presented on a display of the user device during a first phase of the breathing sequence. A fluctuating user interface element may fluctuate on the display of the user device during a second phase of the breathing sequence. Second heart rate information may be presented on the display of the user device during a first phase of the breathing sequence.

Abstract: Provided is a non-invasive system and method for determining a fuel value for a target muscle and potentially at least one indicator muscle. The method includes receiving an ultrasound scan of a target muscle; evaluating at least a portion of the ultrasound scan to determine fuel value within the target muscle; recording the determined fuel value for the muscle as an element of a data set for the muscle; evaluating the fuel data set to determine a value range; and in response to the range being at least above a pre-determined threshold, establishing a target score for the muscle as based on an upper portion of the value range. The method may be repeated to identify ranges for a plurality of muscles, the muscle with the greatest range being identified as an indicator muscle. Based thereon, the muscles estimated fuel level, fuel rating and energy status may be determined.

Abstract: The present disclosure relates to improved biomanufacturing systems and methods with an ability to effectively control process variability to consistently generate high-quality cell-based therapies. In particular, disclosed herein is a using model-based control for determining process parameters in a bioreactor in real time. Additionally disclosed herein is a system for generating an AI digital twin model for a commercial-scale bioreactor.

Abstract: A prosthetic device includes a main body, a first anchor, and a second anchor. The main body has an atrial end and a ventricular end. The main body tapers from the atrial end to the ventricular end. The first and second anchors are coupled to the main body and are movable toward and away from the main body.

Abstract: An endoscopic foam delivery catheter comprising a dissolution solution and methods of their use for treating pancreatic necrosis are disclosed.

Abstract: Disclosed are devices, methods and/or systems for use in protecting items and/or structures that are exposed to, submerged and/or partially submerged in aquatic environments from contamination and/or fouling due to the incursion and/or colonization by specific types and/or kinds of biologic organisms and/or plants, including the protection from micro- and/or macro-fouling for extended periods of time of exposure to aquatic environments.

Abstract: A method of equipment decontamination may include: introducing a cleaning stream comprising hydrogen and a solvent comprising a fatty acid methyl ester and an oxygenated solvent, or alternatively—comprising a—carrier fluid and a hydro-carbon solvent, into the equipment; and introducing a stream comprising nitrogen into the equipment, wherein the equipment comprises deposits and other contaminants.

Abstract: The present invention relates to compounds and derivatives of formula (I) which target KRAS and can be useful as agents for treatment and/or prevention of oncological diseases.

Abstract: The present invention relates to prostate cancer (PC), in particular the identification of certain bacteria in prostate cancer tissues or liquid biopsies and the use of such identification as a prognostic indicator of cancer progression. The present invention also relates to cultures of newly identified bacteria and means for identifying such bacteria in biological samples.

Abstract: An electric heating assembly may include a resistive heating element, a first voltage supply line, a first switching element, a second voltage supply line, a second switching element, and a controller. The first voltage supply line may connect the electric heating assembly to a first voltage source proximal to a first end portion. The first switching element may be disposed along the first voltage supply line to selectively restrict a current from the first voltage source. The second voltage supply line may connect the electric heating assembly to a second voltage source proximal to a second end portion. The second switching element may be disposed along the second voltage supply line to selectively restrict a current from the second voltage source. The controller may be configured to control the first and second switching elements in tandem according to a selected heating cycle.

Abstract: An aerial movement system and method for calibrating same includes, generally, registration points and wireless position transceivers proximate the registration points and the object that communicate with a computer and allow for the computer to determine the appropriate amount of support lines to draw in or release.

Abstract: Systems, apparatuses, and methods are described for prioritized usage of central devices for supporting peripheral devices. Central devices may be present in the surrounding area of a peripheral device. Priorities of the central devices for supporting the peripheral device may be determined based on one or more factors associated with the central devices. The manner in which the central devices are used to support the peripheral device may be determined based on the priorities. The prioritized usage of central devices for the peripheral device may be dynamically updated.

Abstract: In exemplary embodiments, the disclosure provides a Colesevelam Colon Specific Drug Delivery System for use in treatment of pruritus in a patient.

Abstract: A multi-material golf shaft having a butt portion joined to a tip portion and possessing unique relationships, including rigidity relationships, which provide beneficial performance characteristics.

Abstract: A battery holder includes a tubular sleeve defining a longitudinal inner passage having a longitudinal axis and dimensioned to retain a plurality of batteries in a single linear array. In one embodiment it is necessary to insert a spent battery at a first end of the sleeve in order to eject a new battery from a second end of the sleeve and the holder has a barrier extending across the second end of the sleeve, to prevent a battery being pushed out of the holder in the direction of the longitudinal axis, the barrier being arranged to retain the battery in a holding space at the second end of the sleeve, from where it may be pushed out of the holder through a first opening in the sleeve. The battery holder provides for a more secure containment of batteries.

Abstract: A cavity system for use on a vehicle is provided. The cavity has a front edge and/or a rear edge and longitudinal edges. The front and/or rear and longitudinal edges define an opening. The cavity comprises at least one elongate flow partition protruding from a surface adjacent each longitudinal edge of the cavity into the ambient flow outside of the cavity. The at least one flow partition comprise an inboard surface facing predominantly towards the cavity and an outboard surface facing predominantly away from the cavity. An aircraft comprising the cavity system is also provided.

Abstract: A child restraint includes a seat shell and a child-restraint harness coupled to the seat shell. The seat shell is formed to include a child-receiving space configured to hold a child for transportation in a vehicle. The child-restraint harness is fixed to the seat shell and is configured to secure the child to the seat shell within the child-receiving space. The child-restraint harness includes a plurality of harness straps coupled to the seat shell, a pair of harness latches coupled to respective harness straps included in the plurality of harness straps, and a latch anchor coupled to a crotch strap included in the plurality of harness straps.

Abstract: A cavity system (300-600) is provided. The cavity system comprises a cavity (2) and a spoiler (304-604). The spoiler (304-604) comprises at least one plate (4) having a front surface and a rear surface, and an undulating edge. The spoiler (304-604) is positioned in the proximity of a leading edge (14) of the cavity (2), the leading edge (14) being relative to an actual or intended flow direction (3) of a fluid over the cavity (2), and the spoiler (304-604) is arranged with its longitudinal axis (1) perpendicular to or at an oblique angle to the actual or intended flow direction (3) such that the front surface faces towards the flow direction (3).