Patents by Inventor Stephen J. Howard
Stephen J. Howard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20220072738Abstract: Prepreg tapes suitable for automated placement process are formed by slitting a sheet of partially impregnated prepreg. The partially impregnated prepreg is composed of unidirectional fiber tows partially embedded in a resin layer and has a continuous resin surface only on one side. In some embodiments, one or two nonwoven veil(s) is/are incorporated into the partially impregnated prepreg.Type: ApplicationFiled: December 21, 2019Publication date: March 10, 2022Inventors: Scott ROGERS, Stephen J. HOWARD, Scott LUCAS, Dominique PONSOLLE
-
Patent number: 11078174Abstract: A process is provided for making esters of FDCA, in which an aqueous feed comprising glucaric acid is first reacted with a high boiling first alcohol in the presence of an acid catalyst and with removing water during the reaction, to form a first product mixture comprising a first ester of FDCA and the high boiling first alcohol, then unreacted high boiling first alcohol is removed from the first product mixture. The first ester of FDCA and the high boiling first alcohol is then transesterified with a lower boiling second alcohol selected from the group consisting of methanol, ethanol, isopropanol and n-propanol, to form a second product mixture comprising a second ester of FDCA with the lower boiling second alcohol, and the second ester of FDCA with the lower boiling second alcohol is recovered.Type: GrantFiled: June 20, 2018Date of Patent: August 3, 2021Assignee: ARCHER DANIELS MIDLAND COMPANYInventors: Pam Anklam, William Chris Hoffman, Stephen J. Howard, Alexandra Sanborn, Mitchell Schultz, John G. Soper
-
Patent number: 11028063Abstract: An integrated process is useful for producing 2,5-furandicarboxylic acid (FDCA) and/or a derivative thereof from a six-carbon sugar-containing feed. The process includes a) dehydrating a feed containing a six-carbon sugar unit, in the presence of a bromine source and of a solvent, to generate an oxidation feed that contains at least one of 5-hydroxymethylfurfural (HMF) and/or a derivative or derivatives of HMF in the solvent, together with at least one bromine containing species; b) contacting the oxidation feed from step (a) with a metal catalyst and with an oxygen source under oxidation conditions to produce an oxidation product mixture of at least FDCA and/or a derivative thereof, the solvent, and a residual catalyst; c) purifying and separating the mixture obtained in step (b) to obtain FDCA and/or a derivative thereof and the solvent; and d) recycling at least a portion of the solvent obtained in step (c) to step (a).Type: GrantFiled: July 9, 2020Date of Patent: June 8, 2021Assignees: DUPONT INDUSTRIAL BIOSCIENCES USA, LLC, ARCHER-DANIELS-MIDLAND COMPANYInventors: Stephen J. Howard, Kristina A. Kreutzer, Bhuma Rajagopalan, Eric R. Sacia, Alexandra Sanborn, Brennan Smith
-
Publication number: 20210061764Abstract: Bivalent linkers to be included in or for preparing vitamin, drug, diagnostic agent, and/or imaging agent conjugates are described.Type: ApplicationFiled: April 17, 2020Publication date: March 4, 2021Inventors: Iontcho R. Vlahov, Christopher P. Leamon, Apparao Satyam, Stephen J. Howard
-
Patent number: 10821680Abstract: Curable prepregs possessing enhanced ability for the removal of gases from within prepregs and between prepreg plies in a prepreg layup prior to and/or during consolidation and curing. Each curable prepreg is a resin-impregnated, woven fabric that has been subjected to a treatment to create an array of openings in at least one major surface. Furthermore, the location of the openings is specific to the weave pattern of the fabric.Type: GrantFiled: January 22, 2019Date of Patent: November 3, 2020Assignee: CYTEC INDUSTRIES INC.Inventors: Mark Roman, Stephen J. Howard, Jack D. Boyd
-
Publication number: 20200339527Abstract: An integrated process is useful for producing 2,5-furandicarboxylic acid (FDCA) and/or a derivative thereof from a six-carbon sugar-containing feed. The process includes a) dehydrating a feed containing a six-carbon sugar unit, in the presence of a bromine source and of a solvent, to generate an oxidation feed that contains at least one of 5-hydroxymethylfurfural (HMF) and/or a derivative or derivatives of HMF in the solvent, together with at least one bromine containing species; b) contacting the oxidation feed from step (a) with a metal catalyst and with an oxygen source under oxidation conditions to produce an oxidation product mixture of at least FDCA and/or a derivative thereof, the solvent, and a residual catalyst; c) purifying and separating the mixture obtained in step (b) to obtain FDCA and/or a derivative thereof and the solvent; and d) recycling at least a portion of the solvent obtained in step (c) to step (a).Type: ApplicationFiled: July 9, 2020Publication date: October 29, 2020Inventors: Stephen J. HOWARD, Kristina A. Kreutzer, Bhuma Rajagopalan, Eric R. Sacia, Alexandra Sanborn, Brennan Smith
-
Patent number: 10745369Abstract: An integrated process is useful for producing 2,5-furandicarboxylic acid (FDCA) and/or a derivative thereof from a six-carbon sugar-containing feed. The process includes a) dehydrating a feed containing a six-carbon sugar unit, in the presence of a bromine source and of a solvent, to generate an oxidation feed that contains at least one of 5-hydroxymethylfurfural (HMF) and/or a derivative or derivatives of HMF in the solvent, together with at least one bromine containing species; b) contacting the oxidation feed from step (a) with a metal catalyst and with an oxygen source under oxidation conditions to produce an oxidation product mixture of at least FDCA and/or a derivative thereof, the solvent, and a residual catalyst: c) purifying and separating the mixture obtained in step (b) to obtain FDCA and/or a derivative thereof and the solvent; and d) recycling at least a portion of the solvent obtained in step (c) to step (a).Type: GrantFiled: November 26, 2019Date of Patent: August 18, 2020Assignees: DUPONT INDUSTRIAL BIOSCIENCES USA, LLC, ARCHER DANIELS MIDLAND COMPANYInventors: Stephen J. Howard, Kristina A. Kreutzer, Bhuma Rajagopalan, Eric R. Sacia, Alexandra Sanborn, Brennan Smith
-
Patent number: 10647676Abstract: This invention pertains to bivalent linkers, and the synthesis and use thereof. In particular, this invention pertains to the synthesis and use of bivalent linkers in preparing vitamin, drug, diagnostic agent, and/or imaging agent conjugates. The present invention includes divalent linkers, which are alternatively referred to as bivalent linkers, that may be used to couple, link, bond, attach, or otherwise associate two or more chemical entities. This coupling, linking, attachment, or association may be used in the formation of conjugates of such chemical entities. Those chemical entities include targeting ligands and receptor-binding ligands, such as vitamins. Those chemical entities also include drugs for treating various diseases or disease states, and imaging and diagnostic agents for diagnosing, detecting, or otherwise monitoring various diseases or disease states.Type: GrantFiled: June 18, 2019Date of Patent: May 12, 2020Assignee: Endocyte, Inc.Inventors: Iontcho R. Vlahov, Christopher P. Leamon, Apparao Satyam, Stephen J. Howard
-
Publication number: 20200102280Abstract: A process is provided for making esters of FDCA, in which an aqueous feed comprising glucaric acid is first reacted with a high boiling first alcohol in the presence of an acid catalyst and with removing water during the reaction, to form a first product mixture comprising a first ester of FDCA and the high boiling first alcohol, then unreacted high boiling first alcohol is removed from the first product mixture. The first ester of FDCA and the high boiling first alcohol is then transesterified with a lower boiling second alcohol selected from the group consisting of methanol, ethanol, isopropanol and n-propanol, to form a second product mixture comprising a second ester of FDCA with the lower boiling second alcohol, and the second ester of FDCA with the lower boiling second alcohol is recovered.Type: ApplicationFiled: June 20, 2018Publication date: April 2, 2020Applicant: Archer Daniels Midland CompanyInventors: Pam Anklam, William Chris Hoffman, Stephen J. Howard, Alexandra Sanborn, Mitchell Schultz, John G. Soper
-
Publication number: 20200095218Abstract: An integrated process is useful for producing 2,5-furandicarboxylic acid (FDCA) and/or a derivative thereof from a six-carbon sugar-containing feed. The process includes a) dehydrating a feed containing a six-carbon sugar unit, in the presence of a bromine source and of a solvent, to generate an oxidation feed that contains at least one of 5-hydroxymethylfurfural (HMF) and/or a derivative or derivatives of HMF in the solvent, together with at least one bromine containing species; b) contacting the oxidation feed from step (a) with a metal catalyst and with an oxygen source under oxidation conditions to produce an oxidation product mixture of at least FDCA and/or a derivative thereof, the solvent, and a residual catalyst: c) purifying and separating the mixture obtained in step (b) to obtain FDCA and/or a derivative thereof and the solvent; and d) recycling at least a portion of the solvent obtained in step (c) to step (a).Type: ApplicationFiled: November 26, 2019Publication date: March 26, 2020Inventors: Stephen J. HOWARD, Kristina A. Kreutzer, Bhuma Rajagopalan, Eric R. Sacia, Alexandra Sanborn, Brennan Smith
-
Patent number: 10538499Abstract: An integrated process is described for producing 2,5-furandicarboxylic acid and/or a derivative thereof from a six carbon sugar-containing feed, comprising: a) dehydrating a feed comprising a six-carbon sugar unit, in the presence of a bromine source and of a solvent, to generate an oxidation feed comprised of at least one of 5-hydroxymethylfurfural and/or a derivative or derivatives of 5-hydroxymethylfurfural in the solvent, together with at least one bromine containing species; b) contacting the oxidation feed from step (a) with a metal catalyst and with an oxygen source under oxidation conditions to produce an oxidation product mixture comprising 2,5-furandicarboxylic acid (FDCA) and/or a derivative thereof, the solvent, and a residual catalyst; c) purifying and separating the mixture obtained in step (b) to obtain FDCA and/or a derivative thereof and the solvent; and d) recycling at least a portion of the solvent obtained in step (c) to step (a).Type: GrantFiled: April 13, 2016Date of Patent: January 21, 2020Assignees: DUPONT INDUSTRIAL BIOSCIENCES USA, LLC, ARCHER DANIELS MIDLAND COMPANYInventors: Stephen J. Howard, Kristina A. Kreutzer, Bhuma Rajagopalan, Eric R. Sacia, Alexandra Sanborn, Brennan Smith
-
Publication number: 20190300482Abstract: Bivalent linkers to be included in or for preparing vitamin, drug, diagnostic agent, and/or imaging agent conjugates are described.Type: ApplicationFiled: June 18, 2019Publication date: October 3, 2019Inventors: Iontcho R. Vlahov, Christopher P. Leamon, Apparao Satyam, Stephen J. Howard
-
Publication number: 20190216934Abstract: The invention describes a vitamin receptor binding drug delivery conjugate, and preparations therefor. The drug delivery conjugate consists of a vitamin receptor binding moiety, a bivalent linker (L), and a drug. The vitamin receptor binding moiety includes vitamins, and vitamin receptor binding analogs and derivatives thereof, and the drug includes analogs and derivatives thereof. The vitamin receptor binding moiety is covalently linked to the bivalent linker, and the drug, or the analog or the derivative thereof, is covalently linked to the bivalent linker, wherein the bivalent linker (L) includes components such as spacer linkers, releasable linkers, and heteroatom linkers, and combinations thereof. Methods and pharmaceutical compositions for eliminating pathogenic cell populations using the drug delivery conjugate are also described.Type: ApplicationFiled: March 26, 2018Publication date: July 18, 2019Inventors: Iontcho R. VLAHOV, Christopher P. LEAMON, Matthew A. PARKER, Stephen J. HOWARD, Hari Krishna R. SANTHAPURAM, Apparao SATYAM, Joseph A. REDDY
-
Patent number: 10329696Abstract: Curable prepregs possessing enhanced ability for the removal of gases from within prepregs and between prepreg plies in a prepreg layup prior to and/or during consolidation and curing. Each curable prepreg is a resin-impregnated, woven fabric that has been subjected to a treatment to create an array of openings in at least one major surface. Furthermore, the location of the openings is specific to the weave pattern of the fabric.Type: GrantFiled: September 22, 2017Date of Patent: June 25, 2019Assignee: Cytec Industries Inc.Inventors: Mark Roman, Stephen J. Howard, Jack D. Boyd
-
Publication number: 20190153634Abstract: Curable prepregs possessing enhanced ability for the removal of gases from within prepregs and between prepreg plies in a prepreg layup prior to and/or during consolidation and curing. Each curable prepreg is a resin-impregnated, woven fabric that has been subjected to a treatment to create an array of openings in at least one major surface. Furthermore, the location of the openings is specific to the weave pattern of the fabric.Type: ApplicationFiled: January 22, 2019Publication date: May 23, 2019Applicant: CYTEC INDUSTRIES INC.Inventors: Mark ROMAN, Stephen J. HOWARD, Jack D. BOYD
-
Publication number: 20190105399Abstract: The invention describes a vitamin receptor binding drug delivery conjugate, and preparations therefor. The drug delivery conjugate consists of a vitamin receptor binding moiety, a bivalent linker (L), and a drug. The vitamin receptor binding moiety includes vitamins, and vitamin receptor binding analogs and derivatives thereof, and the drug includes analogs and derivatives thereof. The vitamin receptor binding moiety is covalently linked to the bivalent linker, and the drug, or the analog or the derivative thereof, is covalently linked to the bivalent linker, wherein the bivalent linker (L) includes components such as spacer linkers, releasable linkers, and heteroatom linkers, and combinations thereof. Methods and pharmaceutical compositions for eliminating pathogenic cell populations using the drug delivery conjugate are also described.Type: ApplicationFiled: March 26, 2018Publication date: April 11, 2019Inventors: Iontcho R. VLAHOV, Christopher P. LEAMON, Matthew A. PARKER, Stephen J. HOWARD, Hari Krishna R. SANTHAPURAM, Apparao SATYAM, Joseph A. REDDY
-
Publication number: 20190100494Abstract: Bivalent linkers to be included in or for preparing vitamin, drug, diagnostic agent, and/or imaging agent conjugates are described.Type: ApplicationFiled: October 9, 2018Publication date: April 4, 2019Inventors: Iontcho R. Vlahov, Christopher P. Leamon, Apparao Satyam, Stephen J. Howard
-
Publication number: 20180093961Abstract: An integrated process is described for producing 2,5-furandicarboxylic acid and/or a derivative thereof from a six carbon sugar-containing feed, comprising: a) dehydrating a feed comprising a six-carbon sugar unit, in the presence of a bromine source and of a solvent, to generate an oxidation feed comprised of at least one of 5-hydroxymethylfurfural and/or a derivative or derivatives of 5-hydroxymethylfurfural in the solvent, together with at least one bromine containing species; b) contacting the oxidation feed from step (a) with a metal catalyst and with an oxygen source under oxidation conditions to produce an oxidation product mixture comprising 2,5-furandicarboxylic acid (FDCA) and/or a derivative thereof, the solvent, and a residual catalyst; c) purifying and separating the mixture obtained in step (b) to obtain FDCA and/or a derivative thereof and the solvent; and d) recycling at least a portion of the solvent obtained in step (c) to step (a).Type: ApplicationFiled: April 13, 2016Publication date: April 5, 2018Inventors: Stephen J. Howard, Kristina A. Kreutzer, Bhuma Rajagopalan, Eric R. Sacia, Alexandra Sanborn, Brennan Smith
-
Publication number: 20180009176Abstract: Curable prepregs possessing enhanced ability for the removal of gases from within prepregs and between prepreg plies in a prepreg layup prior to and/or during consolidation and curing. Each curable prepreg is a resin-impregnated, woven fabric that has been subjected to a treatment to create an array of openings in at least one major surface. Furthermore, the location of the openings is specific to the weave pattern of the fabric.Type: ApplicationFiled: September 22, 2017Publication date: January 11, 2018Applicant: CYTEC INDUSTRIES INC.Inventors: Mark ROMAN, Stephen J. HOWARD, Jack D. BOYD
-
Publication number: 20170320826Abstract: Bivalent linkers to be included in or for preparing vitamin, drug, diagnostic agent, and/or imaging agent conjugates are described.Type: ApplicationFiled: January 23, 2017Publication date: November 9, 2017Inventors: Iontcho R. Vlahov, Christopher P. Leamon, Apparao Satyam, Stephen J. Howard