Patents by Inventor Stephen J. Howard
Stephen J. Howard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9802358Abstract: Curable prepregs possessing enhanced ability for the removal of gases from within prepregs and between prepreg plies in a prepreg layup prior to and/or during consolidation and curing. Each curable prepreg is a resin-impregnated, woven fabric that has been subjected to a treatment to create an array of openings in at least one major surface. Furthermore, the location of the openings is specific to the weave pattern of the fabric.Type: GrantFiled: December 20, 2013Date of Patent: October 31, 2017Assignee: Cytec Industries Inc.Inventors: Mark Roman, Stephen J. Howard, Jack D. Boyd
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Patent number: 9550734Abstract: Bivalent linkers to be included in or for preparing vitamin, drug, diagnostic agent, and/or imaging agent conjugates are described.Type: GrantFiled: June 22, 2015Date of Patent: January 24, 2017Assignee: Endocyte, Inc.Inventors: Iontcho R. Vlahov, Christopher P. Leamon, Apparao Satyam, Stephen J. Howard
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Publication number: 20160220694Abstract: The invention describes a vitamin receptor binding drug delivery conjugate, and preparations therefor. The drug delivery conjugate consists of a vitamin receptor binding moiety, a bivalent linker (L), and a drug. The vitamin receptor binding moiety includes vitamins, and vitamin receptor binding analogs and derivatives thereof, and the drug includes analogs and derivatives thereof. The vitamin receptor binding moiety is covalently linked to the bivalent linker, and the drug, or the analog or the derivative thereof, is covalently linked to the bivalent linker, wherein the bivalent linker (L) includes components such as spacer linkers, releasable linkers, and heteroatom linkers, and combinations thereof. Methods and pharmaceutical compositions for eliminating pathogenic cell populations using the drug delivery conjugate are also described.Type: ApplicationFiled: August 26, 2015Publication date: August 4, 2016Inventors: Iontcho R. VLAHOV, Christopher P. LEAMON, Matthew A. PARKER, Stephen J. HOWARD, Hari Krishna R. SANTHAPURAM, Apparao SATYAM, Joseph A. REDDY
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Patent number: 9259879Abstract: Curable prepregs possessing enhanced ability for the removal of gases from within prepregs and between prepreg plies in a prepreg layup prior to and/or during consolidation and curing. Each curable prepreg is a resin-impregnated, woven fabric that has been subjected to a treatment to create an array of openings in at least one major surface. The location of the openings is specific to the weave pattern of the fabric. Furthermore, when these prepregs are laid up and subjected to a debulking process to form a composite part, a shorter debulking time can be achieved as compared to using prepregs without the same surface openings.Type: GrantFiled: December 20, 2013Date of Patent: February 16, 2016Assignee: Cytec Industries Inc.Inventors: Mark Roman, Stephen J. Howard, Jack D. Boyd, Scott Lucas
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Publication number: 20160002167Abstract: Bivalent linkers to be included in or for preparing vitamin, drug, diagnostic agent, and/or imaging agent conjugates are described.Type: ApplicationFiled: June 22, 2015Publication date: January 7, 2016Inventors: Iontcho R. Vlahov, Christopher P. Leamon, Apparao Satyam, Stephen J. Howard
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Publication number: 20150284354Abstract: Methods for the production of dehydrated sugars and derivatives of dehydrated sugars using microwave (MW) irradiation and methods of purifying the same are described. The dehydrated sugars derivatives include 5-hydroxymethyl-2-furfural (HMF) and anhydrosugar alcohols such as sorbitans and isosorbide. The derivatives include HMF ethers, levulinic acid esters, and ether derivatives of the anhydrosugar alcohols. The described methods require lower reaction temperatures and shorter reaction times than similar non microwave mediated reactions known in the art. Typical reaction conditions are 120-210° C., and typical reaction times are 30 minutes or less.Type: ApplicationFiled: June 22, 2015Publication date: October 8, 2015Inventors: Stephen J. Howard, Alexandra J. Sanborn
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Patent number: 9090563Abstract: Bivalent linkers to be included in or for preparing vitamin, drug, diagnostic agent, and/or imaging agent conjugates are described.Type: GrantFiled: September 11, 2012Date of Patent: July 28, 2015Assignee: Endocyte, Inc.Inventors: Iontcho Radoslavov Vlahov, Christopher Paul Leamon, Apparao Satyam, Stephen J. Howard
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Patent number: 9090550Abstract: Methods for the production of dehydrated sugars and derivatives of dehydrated sugars using microwave (MW) irradiation and methods of purifying the same are described. The dehydrated sugars derivatives include 5-hydroxymethyl-2-furfural (HMF) and anhydrosugar alcohols such as sorbitans and isosorbide. The derivatives include HMF ethers, levulinic acid esters, and ether derivatives of the anhydrosugar alcohols. The described methods require lower reaction temperatures and shorter reaction times than similar non microwave mediated reactions known in the art. Typical reaction conditions are 120-210° C., and typical reaction times are 30 minutes or less.Type: GrantFiled: July 18, 2011Date of Patent: July 28, 2015Assignee: Archer Daniels Midland CompanyInventors: Stephen J. Howard, Alexandra J. Sanborn
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Publication number: 20140174632Abstract: Curable prepregs possessing enhanced ability for the removal of gases from within prepregs and between prepreg plies in a prepreg layup prior to and/or during consolidation and curing. Each curable prepreg is a resin-impregnated, woven fabric that has been subjected to a treatment to create an array of openings in at least one major surface. The location of the openings is specific to the weave pattern of the fabric. Furthermore, when these prepregs are laid up and subjected to a debulking process to form a composite part, a shorter debulking time can be achieved as compared to using prepregs without the same surface openings.Type: ApplicationFiled: December 20, 2013Publication date: June 26, 2014Inventors: Mark Roman, Stephen J Howard, Jack D Boyd, Scott Lucas
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Publication number: 20140174641Abstract: Curable prepregs possessing enhanced ability for the removal of gases from within prepregs and between prepreg plies in a prepreg layup prior to and/or during consolidation and curing. Each curable prepreg is a resin-impregnated, woven fabric that has been subjected to a treatment to create an array of openings in at least one major surface. Furthermore, the location of the openings is specific to the weave pattern of the fabric.Type: ApplicationFiled: December 20, 2013Publication date: June 26, 2014Applicant: Cytec Industries Inc.Inventors: Mark ROMAN, Stephen J HOWARD, Jack D BOYD
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Patent number: 8748635Abstract: A method for alkylation of an anhydrosugar compound in which a dialkyl carbonate is reacted with an anhydrosugar compound in the presence of a solid phase basic catalyst. A typical anhydrosugar compound is anhydrosugar alcohol, a dianhydromonoether and mixtures thereof. The reaction step uses zeolyte as the solid phase basic catalyst. The zeolite catalyst is typically a zeolite having ammonium groups. The reaction is carried out at a temperature below 240° C. and the reaction time is 2 hours or less.Type: GrantFiled: March 24, 2009Date of Patent: June 10, 2014Assignee: Archer Daniels Midland CompanyInventors: Alexandra J. Sanborn, Stephen J. Howard
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Publication number: 20140058063Abstract: The invention describes a vitamin receptor binding drug delivery conjugate, and preparations therefor. The drug delivery conjugate consists of a vitamin receptor binding moiety, a bivalent linker (L), and a drug. The vitamin receptor binding moiety includes vitamins, and vitamin receptor binding analogs and derivatives thereof, and the drug includes analogs and derivatives thereof. The vitamin receptor binding moiety is covalently linked to the bivalent linker, and the drug, or the analog or the derivative thereof, is covalently linked to the bivalent linker, wherein the bivalent linker (L) includes components such as spacer linkers, releasable linkers, and heteroatom linkers, and combinations thereof. Methods and pharmaceutical compositions for eliminating pathogenic cell populations using the drug delivery conjugate are also described.Type: ApplicationFiled: March 5, 2013Publication date: February 27, 2014Applicant: ENDOCYTE, INC.Inventors: Iontcho R. Vlahov, Christopher P. Leamon, Matthew A. Parker, Stephen J. Howard, Hari Krishna R. Santhapuram, Apparao Satyam, Joseph A. Reddy
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Publication number: 20130158271Abstract: Bivalent linkers to be included in or for preparing vitamin, drug, diagnostic agent, and/or imaging agent conjugates are described.Type: ApplicationFiled: September 11, 2012Publication date: June 20, 2013Inventors: Iontcho Radoslavov VLAHOV, Christopher Paul LEAMON, Apparao SATYAM, Stephen J. HOWARD
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Publication number: 20130123520Abstract: Methods for the production of dehydrated sugars and derivatives of dehydrated sugars using microwave (MW) irradiation and methods of purifying the same are described. The dehydrated sugars derivatives include 5-hydroxymethyl-2-furfural (HMF) and anhydrosugar alcohols such as sorbitans and isosorbide. The derivatives include HMF ethers, levulinic acid esters, and ether derivatives of the anhydrosugar alcohols. The described methods require lower reaction temperatures and shorter reaction times than similar non microwave mediated reactions known in the art. Typical reaction conditions are 120-210° C., and typical reaction times are 30 minutes or less.Type: ApplicationFiled: July 18, 2011Publication date: May 16, 2013Applicant: Archer Daniels Midland CompanyInventors: Stephen J. Howard, Alexandra J. Sanborn
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Patent number: 8288557Abstract: Bivalent linkers derived from compounds of formulae (V), (VI), and (VII), where X1 and X2 are leaving groups and the other variables are as defined in the claims, to be included in or for preparing vitamin, drug, diagnostic agent, and/or imaging agent conjugates are described.Type: GrantFiled: July 22, 2005Date of Patent: October 16, 2012Assignee: Endocyte, Inc.Inventors: Iontcho Radoslavov Vlahov, Christopher Paul Leamon, Apparao Satyam, Stephen J. Howard
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Patent number: 8268926Abstract: Particle-toughened polymer compositions include a base polymer formulation and a plurality of toughening particles. In certain embodiments, the base polymer formulation includes bismaleimides or other polymer resins capable of high temperature service. A first plurality of toughening particles may include core shell rubbers. A second plurality of toughening particles may be selected from a variety of polymer compositions, including polyimides, polyether ketone (PEK), polyether ether ketone (PEEK), polyether ketone ketone (PEKK), polyether imide, polyether sulfones, and polyphenylene oxide. It is found that increasing concentration of the core shell rubbers may improve the toughness of the composition while preserving thermal properties of the composition, such as glass transition temperature.Type: GrantFiled: May 25, 2010Date of Patent: September 18, 2012Assignee: Cytec Technology Corp.Inventors: Mark Richard Bonneau, Jack Douglas Boyd, Gordon T. Emmerson, Scott D. Lucas, Stephen J. Howard, Spencer Donald Jacobs
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Publication number: 20120065149Abstract: The invention describes a vitamin receptor binding drug delivery conjugate, and preparations therefor. The drug delivery conjugate consists of a vitamin receptor binding moiety, a bivalent linker (L), and a drug. The vitamin receptor binding moiety includes vitamins, and vitamin receptor binding analogs and derivatives thereof, and the drug includes analogs and derivatives thereof. The vitamin receptor binding moiety is covalently linked to the bivalent linker, and the drug, or the analog or the derivative thereof, is covalently linked to the bivalent linker, wherein the bivalent linker (L) includes components such as spacer linkers, releasable linkers, and heteroatom linkers, and combinations thereof. Methods and pharmaceutical compositions for eliminating pathogenic cell populations using the drug delivery conjugate are also described.Type: ApplicationFiled: September 7, 2011Publication date: March 15, 2012Inventors: Iontcho R. Vlahov, Christopher P. Leamon, Matthew A. Parker, Stephen J. Howard, Hari Krishna Santhapuram, Apparao Satyam, Joseph Anand Reddy
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Patent number: 8105568Abstract: The invention describes a vitamin receptor binding drug delivery conjugate, and preparations therefor. The drug delivery conjugate consists of a vitamin receptor binding moiety, a bivalent linker (L), and a drug. The vitamin receptor binding moiety includes vitamins, and vitamin receptor binding analogs and derivatives thereof, and the drug includes analogs and derivatives thereof. The vitamin receptor binding moiety is covalently linked to the bivalent linker, and the drug, or the analog or the derivative thereof, is covalently linked to the bivalent linker, wherein the bivalent linker (L) includes components such as spacer linkers, releasable linkers, and heteroatom linkers, and combinations thereof. Methods and pharmaceutical compositions for eliminating pathogenic cell populations using the drug delivery conjugate are also described.Type: GrantFiled: July 10, 2009Date of Patent: January 31, 2012Assignee: Endocyte, Inc.Inventors: Iontcho R. Vlahov, Christopher P. Leamon, Matthew A. Parker, Stephen J. Howard, Hari Krishna R. Santhapuram, Apparao Satyam, Joseph A. Reddy
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Patent number: 8080313Abstract: Particle toughened, fiber-reinforced composites include a fiber region and an interlayer region between the fibers. The fiber region includes a plurality of fibers at least partially within a first polymer composition including a first base polymer formulation and a first plurality of toughening particles. The interlayer region includes a second polymer composition including a second base polymer formulation and at least one of the first plurality of toughening particles and a second plurality of toughening particles. Examples of first and second pluralities of toughening particles, respectively, may include core shell rubbers and polyimides. Increasing concentration of the first plurality of toughening particles may improve the composite toughness while preserving thermal properties of the composite, such as weight loss after extended duration exposure to elevated temperature.Type: GrantFiled: May 25, 2010Date of Patent: December 20, 2011Assignee: Cytec Technology Corp.Inventors: Mark Richard Bonneau, Jack Douglas Boyd, Gordon T. Emmerson, Scott D. Lucas, Stephen J. Howard, Spencer Donald Jacobs
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Publication number: 20100004276Abstract: The invention describes a vitamin receptor binding drug delivery conjugate, and preparations therefor. The drug delivery conjugate consists of a vitamin receptor binding moiety, a bivalent linker (L), and a drug. The vitamin receptor binding moiety includes vitamins, and vitamin receptor binding analogs and derivatives thereof, and the drug includes analogs and derivatives thereof. The vitamin receptor binding moiety is covalently linked to the bivalent linker, and the drug, or the analog or the derivative thereof, is covalently linked to the bivalent linker, wherein the bivalent linker (L) includes components such as spacer linkers, releasable linkers, and heteroatom linkers, and combinations thereof. Methods and pharmaceutical compositions for eliminating pathogenic cell populations using the drug delivery conjugate are also described.Type: ApplicationFiled: July 10, 2009Publication date: January 7, 2010Inventors: Iontcho R. Vlahov, Christopher P. Leamon, Matthew A. Parker, Stephen J. Howard, Hari Krishna Santhapuram, Apparao Satyam, Joseph Anand Reddy